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- Antibody Data
- Antigen structure
- References [5]
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- Validations
- Western blot [1]
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- Product number
- 10456-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10456-1-AP, RRID:AB_2216327
- Product name
- NELF-A antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated NELF-A antibody (Cat. #10456-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references An essential signaling function of cytoplasmic NELFB is independent of RNA polymerase II pausing.
ERK-mediated NELF-A phosphorylation promotes transcription elongation of immediate-early genes by releasing promoter-proximal pausing of RNA polymerase II.
RNA polymerase II pausing factor NELF in CD8(+) T cells promotes antitumor immunity.
SPT5 stabilization of promoter-proximal RNA polymerase II.
Multiple P-TEFbs cooperatively regulate the release of promoter-proximally paused RNA polymerase II.
Pan H, Cheng X, RodrÃguez PFG, Zhang X, Chung I, Jin VX, Li W, Hu Y, Li R
The Journal of biological chemistry 2023 Nov;299(11):105259
The Journal of biological chemistry 2023 Nov;299(11):105259
ERK-mediated NELF-A phosphorylation promotes transcription elongation of immediate-early genes by releasing promoter-proximal pausing of RNA polymerase II.
Ohe S, Kubota Y, Yamaguchi K, Takagi Y, Nashimoto J, Kozuka-Hata H, Oyama M, Furukawa Y, Takekawa M
Nature communications 2022 Dec 3;13(1):7476
Nature communications 2022 Dec 3;13(1):7476
RNA polymerase II pausing factor NELF in CD8(+) T cells promotes antitumor immunity.
Wu B, Zhang X, Chiang HC, Pan H, Yuan B, Mitra P, Qi L, Simonyan H, Young CN, Yvon E, Hu Y, Zhang N, Li R
Nature communications 2022 Apr 20;13(1):2155
Nature communications 2022 Apr 20;13(1):2155
SPT5 stabilization of promoter-proximal RNA polymerase II.
Aoi Y, Takahashi YH, Shah AP, Iwanaszko M, Rendleman EJ, Khan NH, Cho BK, Goo YA, Ganesan S, Kelleher NL, Shilatifard A
Molecular cell 2021 Nov 4;81(21):4413-4424.e5
Molecular cell 2021 Nov 4;81(21):4413-4424.e5
Multiple P-TEFbs cooperatively regulate the release of promoter-proximally paused RNA polymerase II.
Lu X, Zhu X, Li Y, Liu M, Yu B, Wang Y, Rao M, Yang H, Zhou K, Wang Y, Chen Y, Chen M, Zhuang S, Chen LF, Liu R, Chen R
Nucleic acids research 2016 Aug 19;44(14):6853-67
Nucleic acids research 2016 Aug 19;44(14):6853-67
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The NELF-A antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human NELF-A. This antibody recognizes human, mouse antigen. The NELF-A antibody has been validated for the following applications: ELISA, WB analysis.
