19142-1-AP

antibody from Proteintech Group

Targeting: MSTN GDF8

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

19142-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#19142-1-AP, RRID:AB_10638615

Product name

GDF8/Myostatin antibody

Antibody type

Polyclonal

Description

KD/KO validated GDF8/Myostatin antibody (Cat. #19142-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

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Efficient and Specific Generation of MSTN-Edited Hu Sheep Using C-CRISPR.

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The Effect of MSTN Mutation on Bile Acid Metabolism and Lipid Metabolism in Cattle.

Wu D, Wang S, Hai C, Wang L, Pei D, Bai C, Su G, Liu X, Zhao Y, Liu Z, Yang L, Li G
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Capsaicin alleviates cisplatin-induced muscle loss and atrophy in vitro and in vivo.

Huang KC, Chiang YF, Huang TC, Chen HY, Lin PH, Ali M, Hsia SM
Journal of cachexia, sarcopenia and muscle 2023 Feb;14(1):182-197

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Carboxyl-terminal modulator protein (CTMP) deficiency mitigates denervation-induced skeletal muscle atrophy.

Wang J, Tierney L, Wilson C, Phillips V, Goldman L, Mumaw C, Muang E, Walker CL
Biochemical and biophysical research communications 2023 Feb 12;644:155-161

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Phosphate depletion in insulin-insensitive skeletal muscle drives AMPD activation and sarcopenia in chronic kidney disease.

Andres-Hernando A, Cicerchi C, Garcia GE, Orlicky DJ, Stenvinkel P, Johnson RJ, Lanaspa MA
iScience 2023 Apr 21;26(4):106355

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Fish Protein Promotes Skeletal Muscle Hypertrophy via the Akt/mTOR Signaling Pathways.

Morisasa M, Yoshida E, Fujitani M, Kimura K, Uchida K, Kishida T, Mori T, Goto-Inoue N
Journal of nutritional science and vitaminology 2022;68(1):23-31

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Creatine modulates cellular energy metabolism and protects against cancer cachexia-associated muscle wasting.

Wei L, Wang R, Lin K, Jin X, Li L, Wazir J, Pu W, Lian P, Lu R, Song S, Zhao Q, Li J, Wang H
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Expression patterns and correlation analyses of muscle-specific genes in the process of sheep myoblast differentiation.

Wang H, Dou M, Li J, Cao P, Li J, Guo T, Zhao D, Khan A, Li Y, Li B, Qin J, Du R
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Differential Protein Metabolism and Regeneration in Gastrocnemius Muscles in High-fat Diet Fed Mice and Pre-hibernation Daurian Ground Squirrels: A Comparison between Pathological and Healthy Obesity.

Yan X, Niu Q, Gao X, Shen S, He N, Wang H, Fang R, Gao Y, Chang H
Zoological studies 2021;60:e6

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Renal Ischemia/Reperfusion Early Induces Myostatin and PCSK9 Expression in Rat Kidneys and HK-2 Cells.

Barisione C, Verzola D, Garibaldi S, Ferrari PF, Garibotto G, Ameri P, Pane B, Spinella G, Pratesi G, Palombo D
International journal of molecular sciences 2021 Sep 13;22(18)

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Vitellogenin 2 promotes muscle development and stimulates the browning of white fat.

Li Y, Sun X, Bai Y, Ji Y, Ren H, Yu X, Yan Y, He X, Dong Y, Zhang L, Luo X, Wang H
Aging 2021 Oct 5;13(19):22985-23003

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Inhibition of heat shock protein (HSP) 90 reverses signal transducer and activator of transcription (STAT) 3-mediated muscle wasting in cancer cachexia mice.

Niu M, Song S, Su Z, Wei L, Li L, Pu W, Zhao C, Ding Y, Wang J, Cao W, Gao Q, Wang H
British journal of pharmacology 2021 Nov;178(22):4485-4500

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Heat stress during late pregnancy of sows influences offspring longissimus dorsi muscle growth at weaning.

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Research in veterinary science 2021 May;136:336-342

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The Prophylactic Effects of Glutamine on Muscle Protein Synthesis and Degradation in Rats with Ethanol-Induced Liver Damage.

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Yan X, Gao X, Niu Q, Peng X, Zhang J, Ma X, Wei Y, Wang H, Gao Y, Chang H
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Skeletal Muscle Anti-Atrophic Effects of Leucine Involve Myostatin Inhibition.

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Enhanced myostatin expression and signalling promote tubulointerstitial inflammation in diabetic nephropathy.

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Zhu P, Li H, Huang G, Cui J, Zhang R, Cui K, Yang S, Shi D
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Indoxyl sulfate potentiates skeletal muscle atrophy by inducing the oxidative stress-mediated expression of myostatin and atrogin-1.

Enoki Y, Watanabe H, Arake R, Sugimoto R, Imafuku T, Tominaga Y, Ishima Y, Kotani S, Nakajima M, Tanaka M, Matsushita K, Fukagawa M, Otagiri M, Maruyama T
Scientific reports 2016 Aug 23;6:32084

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Isozygous and selectable marker-free MSTN knockout cloned pigs generated by the combined use of CRISPR/Cas9 and Cre/LoxP.

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Scientific reports 2016 Aug 17;6:31729

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Myostatin, follistatin and activin type II receptors are highly expressed in adenomyosis.

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Fertility and sterility 2015 Sep;104(3):744-52.e1

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

mouse heart tissue were subjected to SDS PAGE followed by western blot with 19142-1-AP( MSTN Antibody) at dilution of 1:600

Sample type

tissue

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human heart using 19142-1-AP(MSTN antibody) at dilution of 1:50 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The GDF8/Myostatin antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human GDF8/Myostatin. This antibody recognizes human,mouse,rat antigen. The GDF8/Myostatin antibody has been validated for the following applications: ELISA, IHC, WB analysis.

Appendix

19142-1-AP.pdf

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