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- Antigen structure
- References [11]
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- Western blot [1]
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- Product number
- 13927-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13927-1-AP, RRID:AB_2111647
- Product name
- GNAQ antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated GNAQ antibody (Cat. #13927-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Protective role of RGS2 in PM2.5-induced ovarian injury in rats: Modulation of Gq/11 signaling to maintain granulosa cell [Ca(2 +) ]i stability.
Critical Residues in the Gβ Subunit Mediate Selective Recruitment of the Gαq Heterotrimer to Activated G Protein-Coupled Receptors.
Gαq/11 Signaling Modulates Fibroblast Growth Factor 23 Production and Contributes to Acute Kidney Injury.
RGS2 attenuates alveolar macrophage damage by inhibiting the Gq/11-Ca(2+) pathway during cowshed PM2.5 exposure, and aberrant RGS2 expression is associated with TLR2/4 activation.
Disruption of the interaction between mutationally activated Gα(q) and Gβγ attenuates aberrant signaling.
Enhanced membrane binding of oncogenic G protein αqQ209L confers resistance to inhibitor YM-254890.
Copper ionophore elesclomol selectively targets GNAQ/11-mutant uveal melanoma.
Uncovering a novel role of PLCβ4 in selectively mediating TCR signaling in CD8+ but not CD4+ T cells.
Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility.
G protein subunit α q regulates gastric cancer growth via the p53/p21 and MEK/ERK pathways.
iTRAQ-based proteomic analysis of dioscin on human HCT-116 colon cancer cells.
Ma Z, Du X, Zhao C, Sun Y, Jia Y, Liang X, Yu X, Gao Y
Ecotoxicology and environmental safety 2025 Sep 1;302:118537
Ecotoxicology and environmental safety 2025 Sep 1;302:118537
Critical Residues in the Gβ Subunit Mediate Selective Recruitment of the Gαq Heterotrimer to Activated G Protein-Coupled Receptors.
Yao Y, Wang D, Wang S, Ouyang X, Zhao L, Chen H, Xu J
ACS pharmacology & translational science 2025 Jul 11;8(7):2048-2060
ACS pharmacology & translational science 2025 Jul 11;8(7):2048-2060
Gαq/11 Signaling Modulates Fibroblast Growth Factor 23 Production and Contributes to Acute Kidney Injury.
Jiang J, Zhang Y, Zuo Y, Bai Y, He Q
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Apr 30;39(8):e70544
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Apr 30;39(8):e70544
RGS2 attenuates alveolar macrophage damage by inhibiting the Gq/11-Ca(2+) pathway during cowshed PM2.5 exposure, and aberrant RGS2 expression is associated with TLR2/4 activation.
Ma Z, Du X, Sun Y, Sun K, Zhang X, Wang L, Zhu Y, Basang W, Gao Y
Toxicology and applied pharmacology 2024 Jun;487:116976
Toxicology and applied pharmacology 2024 Jun;487:116976
Disruption of the interaction between mutationally activated Gα(q) and Gβγ attenuates aberrant signaling.
Aumiller JL, Wedegaertner PB
The Journal of biological chemistry 2023 Feb;299(2):102880
The Journal of biological chemistry 2023 Feb;299(2):102880
Enhanced membrane binding of oncogenic G protein αqQ209L confers resistance to inhibitor YM-254890.
Randolph CE, Dwyer MB, Aumiller JL, Dixon AJ, Inoue A, Osei-Owusu P, Wedegaertner PB
The Journal of biological chemistry 2022 Nov;298(11):102538
The Journal of biological chemistry 2022 Nov;298(11):102538
Copper ionophore elesclomol selectively targets GNAQ/11-mutant uveal melanoma.
Li Y, Yang J, Zhang Q, Xu S, Sun W, Ge S, Xu X, Jager MJ, Jia R, Zhang J, Fan X
Oncogene 2022 Jul;41(27):3539-3553
Oncogene 2022 Jul;41(27):3539-3553
Uncovering a novel role of PLCβ4 in selectively mediating TCR signaling in CD8+ but not CD4+ T cells.
Sasai M, Ma JS, Okamoto M, Nishino K, Nagaoka H, Takashima E, Pradipta A, Lee Y, Kosako H, Suh PG, Yamamoto M
The Journal of experimental medicine 2021 Jul 5;218(7)
The Journal of experimental medicine 2021 Jul 5;218(7)
Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility.
Zhang DL, Sun YJ, Ma ML, Wang YJ, Lin H, Li RR, Liang ZL, Gao Y, Yang Z, He DF, Lin A, Mo H, Lu YJ, Li MJ, Kong W, Chung KY, Yi F, Li JY, Qin YY, Li J, Thomsen ARB, Kahsai AW, Chen ZJ, Xu ZG, Liu M, Li D, Yu X, Sun JP
eLife 2018 Feb 2;7
eLife 2018 Feb 2;7
G protein subunit α q regulates gastric cancer growth via the p53/p21 and MEK/ERK pathways.
Wang Y, Xiao H, Wu H, Yao C, He H, Wang C, Li W
Oncology reports 2017 Apr;37(4):1998-2006
Oncology reports 2017 Apr;37(4):1998-2006
iTRAQ-based proteomic analysis of dioscin on human HCT-116 colon cancer cells.
Chen H, Xu L, Yin L, Xu Y, Han X, Qi Y, Zhao Y, Liu K, Peng J
Proteomics 2014 Jan;14(1):51-73
Proteomics 2014 Jan;14(1):51-73
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The GNAQ antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human GNAQ. This antibody recognizes human, mouse antigen. The GNAQ antibody has been validated for the following applications: ELISA, WB analysis.
