11009-1-AP

antibody from Proteintech Group

Targeting: MDK FLJ27379, MK, NEGF2

Provider product page for 11009-1-AP

Western blot

ELISA

Immunocytochemistry

Antibody data

Antibody Data
Antigen structure
References [27]
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Validations
Immunocytochemistry [1]

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Product number: 11009-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11009-1-AP, RRID:AB_2250619
Product name: Midkine antibody
Antibody type: Polyclonal
Description: KD/KO validated Midkine antibody (Cat. #11009-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: WB, ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

MDK protein structure - 11009-1-AP shown in red.

Submitted references Multi-omics driven immune classification of colorectal cancer: Implications for immunotherapy efficacy prediction and enhancement with WNT signaling inhibition.

Hu C, Cai D, You W, Zhou Z, Liu J, Li CH, Lv MY, Gai BW, Chen C, Huang X, Wang RX, Wu XJ, Hu P, Gao F
Cancer letters 2026 May 28;646:218425

RASSF1A inhibits gastric cancer metastasis by reducing neutrophil infiltration and neutrophil extracellular trap formation via ribosome biogenesis.

Chen Y, Dai L, Chen G, Deng S, Liu R, Xue W, Hu Y, Yi J
International immunopharmacology 2026 May 1;176:116475

Peritumoural adipose tissue drives immune evasion in colorectal cancer via adipose-mesenchymal transformation.

Wang JH, Zheng YQ, Qian ZY, Pan YQ, Tian T, Duan XT, Wang RB, Wang LY, Peng JH, Mo HY, Zhang YY, Han Y, Liao K, Li T, Yang W, Shi GJ, Wu J, Liu ZX, Lin JZ, Xu RH, Ju HQ
Nature cell biology 2026 Mar;28(3):581-595

Unveiling critical signaling pathways in the murine salivary gland and the role of midkine.

Wrynn T, Osinski J, Sinha S, Romano RA
iScience 2026 Mar 20;29(3):114852

Characterization of gRNA-dependent and gRNA-independent off-target binding sites of PspCas13b and RfxCas13d in mammalian cells.

Feng H, Li Z, Zhang H, Zheng Y, Xu B, Zhang Y, Zou L, Wu L
Nucleic acids research 2026 Feb 5;54(4)

Cancer Cell-Intrinsic Cholesterol Induces Lipid-Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression.

Peng S, Lin W, Li Z, Zhuang R, Peng S, Li B, Chen B, Luo Y, Ou Y, Zhuang W, Du T, Li K, Huang H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(19):e08588

Single cell deciphering of pruritic keloids: the interaction between fibroblasts and Schwann cells through the Midkine signaling.

Yang E, Xu R, Tu L, Zhang H, Luo S, Liang H, Liu Y, Gu S, Zhao Y, Huang X, Zan T
Burns & trauma 2025;13:tkaf057

The Discovery and Characterization of HBS-101, a Novel Inhibitor of Midkine, as a Therapeutic Agent for the Treatment of Triple-Negative Breast Cancer.

Mahajan M, Rodriguez Sanchez AL, Jayamohan S, Vijayan DK, Johnson JD, Xie H, Wang Y, Liang D, Sanchez JR 2nd, Subbarayalu P, Rao MK, Vadlamudi RK, Sareddy GR, Nair HB, Viswanadhapalli S
Molecular cancer therapeutics 2025 Sep 2;24(9):1308-1319

Unraveling the Role of MDK-SDC4 Interaction in Pancreatic Cancer-Associated New-Onset Diabetes by Single-Cell Transcriptomic Analysis.

Feng Z, Lou J, Lin C, Yu H, Tu Y, Gong J, Li X, Wu Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(39):e09987

Multi-omics analysis unveils the role of cancer-associated fibroblasts in cutaneous squamous cell carcinoma.

Wang X, Li T, Jin Y, Chen J, XinYang, Guan Z, Jin M, Zhang J, Xu L, Tao S, Li C, Ao C
Cancer cell international 2025 Nov 19;25(1):417

Targeting the MDK/c-Myc complex to overcome temozolomide resistance in glioma.

Xi X, Ding X, Wang Q, Liu N, Wang B, Wang G, Zhong W, Lu Y
Clinical and translational medicine 2025 Jun;15(6):e70359

Chromatin accessibility module identified by single-cell sequencing underlies the diagnosis and prognosis of hepatocellular carcinoma.

Xi XL, Yang YD, Liu HL, Jiang J, Wu B
World journal of hepatology 2025 Jun 27;17(6):107329

LBX2-AS1 in acceleration of glycolysis and cancer angiogenesis via miR-491-5p/MDK signaling axis in colorectal cancer: an experimental study.

Wang J, Li C, Wu G, Xu J
Annals of medicine 2025 Dec;57(1):2564284

Metabolic reprogramming of arachidonic acid in clear cell renal carcinoma promotes an immunosuppressive microenvironment by activating MDK signaling pathway.

Yao J, Xu T, Wang C, Xie J, Jiang Q
Clinical and experimental medicine 2025 Aug 13;25(1):291

Fibroblasts facilitate lymphatic vessel formation in transplanted heart.

Gong H, Wang T, Sun X, Zhang Y, Qiu Y, Sun W, Zhang Y, Teng P, Hu Y, Hu X, Ma L, Xu Q, Zhao H
Theranostics 2024;14(5):1886-1908

Midkine as a driver of age-related changes and increase in mammary tumorigenesis.

Yan P, Jimenez ER, Li Z, Bui T, Seehawer M, Nishida J, Foidart P, Stevens LE, Xie Y, Gomez MM, Park SY, Long HW, Polyak K
Cancer cell 2024 Nov 11;42(11):1936-1954.e9

Midkine promotes renal fibrosis by stabilizing C/EBPβ to facilitate endothelial-mesenchymal transition.

Xu C, Chen J, Liang L, Chen S, Niu X, Sang R, Yang C, Rong R
Communications biology 2024 May 7;7(1):544

Single cell transcriptome profiling of infrapatellar fat pad highlights the role of interstitial inflammatory fibroblasts in osteoarthritis.

Pu H, Gao C, Zou Y, Zhao L, Li G, Liu C, Zhao L, Zheng M, Sheng G, Sun X, Hao X, Wang C, He X, Xiao J
International immunopharmacology 2024 Apr 20;131:111888

Ikzf1 as a novel regulator of microglial homeostasis in inflammation and neurodegeneration.

Ballasch I, García-García E, Vila C, Pérez-González A, Sancho-Balsells A, Fernández J, Soto D, Puigdellívol M, Gasull X, Alberch J, Rodríguez MJ, Canals JM, Giralt A
Brain, behavior, and immunity 2023 Mar;109:144-161

Roles of the m(6)A Modification of RNA in the Glioblastoma Microenvironment as Revealed by Single-Cell Analyses.

Yuan F, Cai X, Cong Z, Wang Y, Geng Y, Aili Y, Du C, Zhu J, Yang J, Tang C, Zhang A, Zhao S, Ma C
Frontiers in immunology 2022;13:798583

Targeting MDK Abrogates IFN-γ-Elicited Metastasis inCancers of Various Origins.

Zheng L, Liu Q, Li R, Chen S, Tan J, Li L, Dong X, Huang C, Wen T, Liu J
Frontiers in oncology 2022;12:885656

Combined Usage of MDK Inhibitor Augments Interferon-γ Anti-Tumor Activity in the SKOV3 Human Ovarian Cancer Cell Line.

Liu Q, Tan J, Zhao Z, Li R, Zheng L, Chen X, Li L, Dong X, Wen T, Liu J
Biomedicines 2022 Dec 21;11(1)

Midkine promotes breast cancer cell proliferation and migration by upregulating NR3C1 expression and activating the NF-κB pathway.

Zhang L, Song L, Xu Y, Xu Y, Zheng M, Zhang P, Wang Q
Molecular biology reports 2022 Apr;49(4):2953-2961

Midkine promotes glioblastoma progression via PI3K-Akt signaling.

Hu B, Qin C, Li L, Wei L, Mo X, Fan H, Lei Y, Wei F, Zou D
Cancer cell international 2021 Sep 23;21(1):509

Identification of Overexpressed Genes in Malignant Pleural Mesothelioma.

Morani F, Bisceglia L, Rosini G, Mutti L, Melaiu O, Landi S, Gemignani F
International journal of molecular sciences 2021 Mar 8;22(5)

Electroacupuncture Alleviated Neuronal Apoptosis Following Ischemic Stroke in Rats via Midkine and ERK/JNK/p38 Signaling Pathway.

Xing Y, Yang SD, Wang MM, Dong F, Feng YS, Zhang F
Journal of molecular neuroscience : MN 2018 Sep;66(1):26-36

Mesenchymal glucocorticoid receptor regulates the development of multiple cell layers of the mouse lung.

Bird AD, Choo YL, Hooper SB, McDougall AR, Cole TJ
American journal of respiratory cell and molecular biology 2014 Feb;50(2):419-28

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using MDK antibody 11009-1-AP at 1:50 dilution and FITC-labeled donkey anti-rabbit IgG (green).
Sample type: cell line