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- References [118]
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- Product number
- 17811-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17811-1-AP, RRID:AB_2161218
- Product name
- PGK1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PGK1 antibody (Cat. #17811-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Single-cell and spatial transcriptomics identify PGK1-sensitized hypoxia macrophages as a therapeutic target to overcome PDT resistance in glioma.
USP5-mediated CD73 deubiquitination drives osimertinib resistance via PI3K/AKT and glycolysis activation in LUAD.
Pharmacological inhibition of PGK1 by genipin reduces inflammation and oxidative damage in osteoarthritis.
Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.
Phosphoglycerate kinase 1 as a potential biomarker and therapeutic target for diabetic sarcopenia.
A Unique Chimeric RNA: ERCC1-iASPP Drives Benzo[a]pyrene-Induced Lung Carcinogenesis via Dual Coding and Non-Coding Mechanisms.
RAC1 directly phosphorylates both PKM2 and FBP1 to promote radioresistance in hepatocellular carcinoma.
Mechanistic Insights Into Qidan Yixin Decoction for Diabetic Cardiomyopathy via Macrophage Polarization.
Phosphoglycerate kinase 1 as a potential prognostic biomarker in papillary thyroid carcinoma.
JARID1D-dependent androgen receptor and JunD signaling activation of osteoclast differentiation inhibits prostate cancer bone metastasis through demethylating H3K4.
METTL1 drives glioma progression by promoting N7-methylguanosine (m7G) modification of glycolysis-related enzyme PGK1.
Inhibition of PGK1 ameliorates acute kidney injury through inactivating the PKM2/ALOX12/ferroptosis pathway in a study with male mice.
Pgk1 activation restores endothelial metabolic homeostasis to alleviate vascular aging and atherosclerosis.
Prognostic evaluation of glycolysis markers in hepatocellular carcinoma: insights from meta-analysis and multi-omics approaches.
TRIM8-dependent K63-ubiquitinated PGK1 promotes glycolysis and angiogenesis in gastric cancer via interaction with ACAT1.
Ginsenoside Rh2 as a novel PIN1 inhibitor disrupting the cancer stem cell-like phenotype in non-small cell lung cancer.
Rab GTPases are evolutionarily conserved signals mediating selective autophagy.
DUSP4 inhibited tumor cell proliferation by downregulating glycolysis via p-ERK/p-PGK1 signaling in ovarian cancer.
Identification of biomarkers associated with macrophage polarization in diabetic cardiomyopathy based on bioinformatics and machine learning approaches.
PGK1 phosphorylates NLRP3 and mediates inflammasome activation independent of its glycolytic activity.
Adipocytes-induced ANGPTL4/KLF4 axis drives glycolysis and metastasis in triple-negative breast cancer.
Lactylation associated biomarkers and immune infiltration in aortic dissection.
PGK1 Is Involved in the HIF-1 Signaling Pathway as a Hub Gene for Ferroptosis After Traumatic Brain Injury.
TRIM2 promotes metabolic adaptation to glutamine deprivation via enhancement of CPT1A activity.
Gboxin Induced Apoptosis and Ferroptosis of Cervical Cancer Cells by Promoting Autophagy-Mediated Inhibition of Nrf2 Signaling Under Low-Glucose Conditions.
circ_0004662 contributes to colorectal cancer progression by interacting with hnRNPM.
ITGA3 promotes pancreatic cancer progression through HIF1α- and c-Myc-driven glycolysis in a collagen I-dependent autocrine manner.
HSP90 co-regulates the formation and nuclear distribution of the glycolytic output complex to promote resistance and poor prognosis in gastric cancer patients.
LBX2-AS1 in acceleration of glycolysis and cancer angiogenesis via miR-491-5p/MDK signaling axis in colorectal cancer: an experimental study.
ACSF2-PGK1 interaction promotes ferroptosis in renal tubular epithelial cells of diabetic nephropathy by regulating Keap1/Nrf2 signaling.
PRAS40 promotes colorectal cancer stemness by enhancing glycolysis through triggering PGK1 acetylation.
Polo-like kinase 1 drives hypoxia-induced renal fibrosis via PTEN/PGK1-mediated glycolytic activation.
Annexin A2 binds the 3'-UTR of H2AX mRNA and regulates histone-H2AX-derived hypoxia-inducible factor 1-alpha activation.
H4K79 and H4K91 histone lactylation, newly identified lactylation sites enriched in breast cancer.
Phosphoglycerate kinase 1 contributes to diabetic kidney disease through enzyme-dependent and independent manners.
Effects of PGK1 on immunoinfiltration by integrated single-cell and bulk RNA-sequencing analysis in sepsis.
LINC00908 attenuates LUAD tumorigenesis through DEAD-box helicase 54.
Lamivudine protects mice from gastric ulcer by activating PGK1 to suppress ferroptosis.
G protein pathway suppressor 2 suppresses aerobic glycolysis through RACK1-mediated HIF-1α degradation in breast cancer.
Sodium citrate targeting Ca(2+)/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer.
Identification of TPI1 As a potential therapeutic target in pancreatic cancer with dependency of TP53 mutation using multi-omics analysis.
Eicosapentaenoic acid-mediated activation of PGAM2 regulates skeletal muscle growth and development via the PI3K/AKT pathway.
Energy stress-induced circDDX21 promotes glycolysis and facilitates hepatocellular carcinogenesis.
Increased NAD(+) levels protect female mouse reproductive system against zearalenone-impaired glycolysis, lipid metabolism, antioxidant capacity and inflammation.
CircGLIS3 promotes gastric cancer progression by regulating the miR-1343-3p/PGK1 pathway and inhibiting vimentin phosphorylation.
Histone lactylation promotes malignant progression by facilitating USP39 expression to target PI3K/AKT/HIF-1α signal pathway in endometrial carcinoma.
Ubiquitinome Analysis Uncovers Alterations in Synaptic Proteins and Glucose Metabolism Enzymes in the Hippocampi of Adolescent Mice Following Cold Exposure.
Glycolytic enzyme PGK1 promotes M1 macrophage polarization and induces pyroptosis of acute lung injury via regulation of NLRP3.
The oncogenic role and regulatory mechanism of PGK1 in human non-small cell lung cancer.
Acetyltransferase P300 Regulates Glucose Metabolic Reprogramming through Catalyzing Succinylation in Lung Cancer.
LINC01977 promotes colorectal cancer growth and metastasis by enhancing aerobic glycolysis via the ERK/c-Myc axis.
PRMT1-mediated PGK1 arginine methylation promotes colorectal cancer glycolysis and tumorigenesis.
Downregulation of tRNA methyltransferase FTSJ1 by PM2.5 promotes glycolysis and malignancy of NSCLC via facilitating PGK1 expression and translation.
Hypoxia-induced downregulation of PGK1 crotonylation promotes tumorigenesis by coordinating glycolysis and the TCA cycle.
METTL3-mediated RanGAP1 promotes colorectal cancer progression through the MAPK pathway by recruiting YTHDF1.
Terazosin attenuates abdominal aortic aneurysm formation by downregulating Peg3 expression to inhibit vascular smooth muscle cell apoptosis and senescence.
The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity.
Phosphorylation and acetylation responses of glycolytic enzymes in meat to different chilling rates.
LINC02774 inhibits glycolysis in glioma to destabilize HIF-1α dependent on transcription factor RP58.
Phosphoglycerate kinase (PGK) 1 succinylation modulates epileptic seizures and the blood-brain barrier.
Downregulation of pro-surfactant protein B contributes to the recurrence of early-stage non-small cell lung cancer by activating PGK1-mediated Akt signaling.
An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus.
Comprehensive analysis of lncRNA-mRNA co-expression networks in HPV-driven cervical cancer reveals the pivotal function of LINC00511-PGK1 in tumorigenesis.
Inhibition of phosphoglycerate kinase 1 attenuates autoimmune myocarditis by reprogramming CD4+ T cell metabolism.
Targeting the Glycolytic Enzyme PGK1 to Inhibit the Warburg Effect: A New Strategy for Keloid Therapy.
DNMT3B-mediated FAM111B methylation promotes papillary thyroid tumor glycolysis, growth and metastasis.
Long noncoding RNA MIR210HG is induced by hypoxia-inducible factor 1α and promotes cervical cancer progression.
TRIM16 promotes aerobic glycolysis and pancreatic cancer metastasis by modulating the NIK-SIX1 axis in a ligase-independent manner.
Development and validation of a novel hypoxia-related signature for prognostic and immunogenic evaluation in head and neck squamous cell carcinoma.
Lactate Dehydrogenase B Is Required for Pancreatic Cancer Cell Immortalization Through Activation of Telomerase Activity.
Transcriptional Repression of Aerobic Glycolysis by OVOL2 in Breast Cancer.
Long non-coding RNA NRSN2-AS1, transcribed by SOX2, promotes progression of esophageal squamous cell carcinoma by regulating the ubiquitin-degradation of PGK1.
A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1β and IL-6.
De novo pyrimidine synthesis fuels glycolysis and confers chemoresistance in gastric cancer.
Urinary extracellular vesicles signature for diagnosis of kidney disease.
Jumonji-C domain-containing protein 5 suppresses proliferation and aerobic glycolysis in pancreatic cancer cells in a c-Myc-dependent manner.
HPV16 E6/E7 stabilize PGK1 protein by reducing its poly-ubiquitination in cervical cancer.
MYB proto-oncogene like 2 promotes hepatocellular carcinoma growth and glycolysis via binding to the Optic atrophy 3 promoter and activating its expression.
lncRNA SNHG26 promoted the growth, metastasis, and cisplatin resistance of tongue squamous cell carcinoma through PGK1/Akt/mTOR signal pathway.
Integrated metabolism and epigenetic modifications in the macrophages of mice in responses to cold stress.
Circ_0076305 facilitates prostate cancer development via sponging miR-411-5p and regulating PGK1.
Quxie Capsule Alleviates Colitis-associated Colorectal Cancer Through Modulating the Gut Microbiota and Suppressing A. fumigatus-induced Aerobic Glycolysis.
Parkinson's disease protein PARK7 prevents metabolite and protein damage caused by a glycolytic metabolite.
PGK1 represses autophagy-mediated cell death to promote the proliferation of liver cancer cells by phosphorylating PRAS40.
The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis.
Long non-coding RNA CTSLP8 mediates ovarian cancer progression and chemotherapy resistance by modulating cellular glycolysis and regulating c-Myc expression through PKM2.
Polydopamine-mediated graphene oxide and nanohydroxyapatite-incorporated conductive scaffold with an immunomodulatory ability accelerates periodontal bone regeneration in diabetes.
Candida tropicalis induces NLRP3 inflammasome activation via glycogen metabolism-dependent glycolysis and JAK-STAT1 signaling pathway in myeloid-derived suppressor cells to promote colorectal carcinogenesis.
U2 small nuclear RNA auxiliary factor 2, transcriptionally activated by the transcription factor Dp-1/E2F transcription factor 1 complex, enhances the growth and aerobic glycolysis of leiomyosarcoma cells.
SIX1 Activation Is Involved in Cell Proliferation, Migration, and Anti-inflammation of Acute Ischemia/Reperfusion Injury in Mice.
Peri-tumoral brain edema associated with glioblastoma correlates with tumor recurrence.
PGK1 Is a Key Target for Anti-Glycolytic Therapy of Ovarian Cancer: Based on the Comprehensive Analysis of Glycolysis-Related Genes.
FOXO3A-induced LINC00926 suppresses breast tumor growth and metastasis through inhibition of PGK1-mediated Warburg effect.
Reciprocal regulation of LOXL2 and HIF1α drives the Warburg effect to support pancreatic cancer aggressiveness.
Low chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk.
MicroRNA-16-1-3p Represses Breast Tumor Growth and Metastasis by Inhibiting PGK1-Mediated Warburg Effect.
Protein Lysine Acetylation in Ovarian Granulosa Cells Affects Metabolic Homeostasis and Clinical Presentations of Women With Polycystic Ovary Syndrome.
A glycolytic shift in Schwann cells supports injured axons.
Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma.
Perturbation of phosphoglycerate kinase 1 (PGK1) only marginally affects glycolysis in cancer cells.
Activator of thyroid and retinoid receptor increases sorafenib resistance in hepatocellular carcinoma by facilitating the Warburg effect.
Targeting G6PD reverses paclitaxel resistance in ovarian cancer by suppressing GSTP1.
Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression.
Collagen prolyl 4-hydroxylase 2 predicts worse prognosis and promotes glycolysis in cervical cancer.
ACTL6A regulates follicle-stimulating hormone-driven glycolysis in ovarian cancer cells via PGK1.
Long non-coding RNA GBCDRlnc1 induces chemoresistance of gallbladder cancer cells by activating autophagy.
Yes-associated protein (YAP) binds to HIF-1α and sustains HIF-1α protein stability to promote hepatocellular carcinoma cell glycolysis under hypoxic stress.
The Long Noncoding RNA Lncenc1 Maintains Naive States of Mouse ESCs by Promoting the Glycolysis Pathway.
Transcriptional Regulation of the Warburg Effect in Cancer by SIX1.
Systematic In-Depth Proteomic Analysis of Mitochondria-Associated Endoplasmic Reticulum Membranes in Mouse and Human Testes.
Dysfunction of pseudogene PGK1P2 is involved in preeclampsia by acting as a competing endogenous RNA of PGK1.
PGK1 and GRP78 overexpression correlates with clinical significance and poor prognosis in Chinese endometrial cancer patients.
AAED1 modulates proliferation and glycolysis in gastric cancer.
Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission.
Impact of Leishmania infection on host macrophage nuclear physiology and nucleopore complex integrity.
cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.
Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1.
An iTRAQ based quantitative proteomic strategy to explore novel secreted proteins in metastatic hepatocellular carcinoma cell lines.
Yan X, Hu J, Han X, Xu L, Zhou L, He J, Yang F, Zhou L, Niu Y, Geng M, Yuan W, Zhao D, Du J, Hu S
Journal of photochemistry and photobiology. B, Biology 2026 May;278:113430
Journal of photochemistry and photobiology. B, Biology 2026 May;278:113430
USP5-mediated CD73 deubiquitination drives osimertinib resistance via PI3K/AKT and glycolysis activation in LUAD.
Chen R, Han XH, Zhang Z, Han XJ, Xie J
iScience 2026 Mar 20;29(3):114916
iScience 2026 Mar 20;29(3):114916
Pharmacological inhibition of PGK1 by genipin reduces inflammation and oxidative damage in osteoarthritis.
Li M, Peng Y, Xiao Q, Chen S, Zhang C, Chen H, Zhao Y, Chang S, Qiu L, Zhang L, Guo X, Fu Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157729
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157729
Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.
Chao L, Xu Y, Yang Y, Ao X, Liang J
World journal of surgical oncology 2026 Jan 22;24(1):77
World journal of surgical oncology 2026 Jan 22;24(1):77
Phosphoglycerate kinase 1 as a potential biomarker and therapeutic target for diabetic sarcopenia.
Li F, Wang Q, Li R, Gao Y, Wang Y, Chen Q
QJM : monthly journal of the Association of Physicians 2026 Jan 1;119(1):23-33
QJM : monthly journal of the Association of Physicians 2026 Jan 1;119(1):23-33
A Unique Chimeric RNA: ERCC1-iASPP Drives Benzo[a]pyrene-Induced Lung Carcinogenesis via Dual Coding and Non-Coding Mechanisms.
Shan M, Xiao M, Zhang L, Wang S, Wu J, Cao K, Li Y, Zhang G, Xie J, Lu X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(8):e07217
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(8):e07217
RAC1 directly phosphorylates both PKM2 and FBP1 to promote radioresistance in hepatocellular carcinoma.
Jiang Y, Zhou K, Wei X, Feng J, Zhou B, Liu C, Sun J, Zhu H, Liu Z, Yuan N, Li Y, Meng X, Cao J, Jiao Y, Cheng S
Molecular therapy : the journal of the American Society of Gene Therapy 2026 Feb 4;34(2):1201-1214
Molecular therapy : the journal of the American Society of Gene Therapy 2026 Feb 4;34(2):1201-1214
Mechanistic Insights Into Qidan Yixin Decoction for Diabetic Cardiomyopathy via Macrophage Polarization.
Liu Y, Zhang J, Gao W, Han Q, Xue Y, Liu X
Journal of diabetes research 2025;2025:7578626
Journal of diabetes research 2025;2025:7578626
Phosphoglycerate kinase 1 as a potential prognostic biomarker in papillary thyroid carcinoma.
Shi XQ, Liu XT, Liu XH, Geng HW, Zhang Z, Wang WY, Chen X, Zhao X, Jue BL, Qin B, Liu PP
Frontiers in pharmacology 2025;16:1542159
Frontiers in pharmacology 2025;16:1542159
JARID1D-dependent androgen receptor and JunD signaling activation of osteoclast differentiation inhibits prostate cancer bone metastasis through demethylating H3K4.
Hu Y, Zhao Z, Xie Q, Li H, Zhang C, He X, Ma Y, Zhang C, Li Q, Shi C
Theranostics 2025;15(4):1320-1337
Theranostics 2025;15(4):1320-1337
METTL1 drives glioma progression by promoting N7-methylguanosine (m7G) modification of glycolysis-related enzyme PGK1.
Fan B, Wang Y, Qin X, Yan Z, Du W
Pathology, research and practice 2025 Oct;274:156174
Pathology, research and practice 2025 Oct;274:156174
Inhibition of PGK1 ameliorates acute kidney injury through inactivating the PKM2/ALOX12/ferroptosis pathway in a study with male mice.
Zhu XX, Meng XY, Zhang AY, Zhao CY, Wei YT, Wen YY, Su JB, Fu X, Chen G, Xu AJ, Wang MY, Ji LM, Bao N, Bao ZY, Li N, Lu QB, Sun HJ
Nature communications 2025 Oct 24;16(1):9436
Nature communications 2025 Oct 24;16(1):9436
Pgk1 activation restores endothelial metabolic homeostasis to alleviate vascular aging and atherosclerosis.
Lu J, Wang J, Liu Y, Zhang C, Zhang G, Ge Y, Liu L
Cardiovascular diabetology 2025 Nov 8;24(1):427
Cardiovascular diabetology 2025 Nov 8;24(1):427
Prognostic evaluation of glycolysis markers in hepatocellular carcinoma: insights from meta-analysis and multi-omics approaches.
Li G, Li Y, Zhou J, Tang S, Guo H, Lin J
BMC medical genomics 2025 Nov 8;18(1):179
BMC medical genomics 2025 Nov 8;18(1):179
TRIM8-dependent K63-ubiquitinated PGK1 promotes glycolysis and angiogenesis in gastric cancer via interaction with ACAT1.
Feng A, Zhang J, Wang Z, Chen Z, Fang K, Li Z, Jiang H, Leng Z, Zhang S, Chu Y, Lian J, Chen T, Ye L, Xu M, He L
Cell death & disease 2025 Nov 3;16(1):780
Cell death & disease 2025 Nov 3;16(1):780
Ginsenoside Rh2 as a novel PIN1 inhibitor disrupting the cancer stem cell-like phenotype in non-small cell lung cancer.
Liu X, Mao Z, Yang J, Zhu Q, Dong X, Huang G, Shen X, Zhang L, Yang H
Journal of translational medicine 2025 Nov 10;23(1):1256
Journal of translational medicine 2025 Nov 10;23(1):1256
Rab GTPases are evolutionarily conserved signals mediating selective autophagy.
Zhao P, Tian R, Song D, Zhu Q, Ding X, Zhang J, Cao B, Zhang M, Xu Y, Fang J, Tan J, Yi C, Xia H, Liu W, Zou W, Sun Q
The Journal of cell biology 2025 May 5;224(5)
The Journal of cell biology 2025 May 5;224(5)
DUSP4 inhibited tumor cell proliferation by downregulating glycolysis via p-ERK/p-PGK1 signaling in ovarian cancer.
Xiong Y, Zhang X, Xie W, Yin Y, Qian Y, Ying X, Zheng X, Wang X
Cancer cell international 2025 Mar 13;25(1):87
Cancer cell international 2025 Mar 13;25(1):87
Identification of biomarkers associated with macrophage polarization in diabetic cardiomyopathy based on bioinformatics and machine learning approaches.
Liu Y, Zhang J, Han Q, Li Y, Xue Y, Liu X
Life sciences 2025 Mar 1;364:123443
Life sciences 2025 Mar 1;364:123443
PGK1 phosphorylates NLRP3 and mediates inflammasome activation independent of its glycolytic activity.
Ma Z, Wu Y, Rao Z, Han C, Sun N, Li J, Zeng Q, Zhang Z, Ding D, Qiao J, Li W, Fang Y, Yang S, Li J, Zhang J, Chen Y
Cell reports 2025 Jun 24;44(6):115785
Cell reports 2025 Jun 24;44(6):115785
Adipocytes-induced ANGPTL4/KLF4 axis drives glycolysis and metastasis in triple-negative breast cancer.
Yin D, Fang N, Zhu Y, Bao X, Yang J, Zhang Q, Wang R, Huang J, Wu Q, Ma F, Wei X
Journal of experimental & clinical cancer research : CR 2025 Jul 4;44(1):192
Journal of experimental & clinical cancer research : CR 2025 Jul 4;44(1):192
Lactylation associated biomarkers and immune infiltration in aortic dissection.
Ye J, Fu Y, Ke Y, Liu H, Fang S, Lei Y, Mao Y, Yan L, Wang Y
Scientific reports 2025 Jul 1;15(1):21536
Scientific reports 2025 Jul 1;15(1):21536
PGK1 Is Involved in the HIF-1 Signaling Pathway as a Hub Gene for Ferroptosis After Traumatic Brain Injury.
Wang Z, Tian J, Wang L, Yan H, Feng S, Zhang Y
Molecular neurobiology 2025 Jan;62(1):233-245
Molecular neurobiology 2025 Jan;62(1):233-245
TRIM2 promotes metabolic adaptation to glutamine deprivation via enhancement of CPT1A activity.
Liao K, Liu K, Wang Z, Zhao K, Mei Y
The FEBS journal 2025 Jan;292(2):275-293
The FEBS journal 2025 Jan;292(2):275-293
Gboxin Induced Apoptosis and Ferroptosis of Cervical Cancer Cells by Promoting Autophagy-Mediated Inhibition of Nrf2 Signaling Under Low-Glucose Conditions.
Liu W, Lu J, Li J, Wang L, Chen Y, Wu Y, Zhang Z, Zhang J, Gao F, Jia C, Bao Y, Yang X, Song Z
International journal of molecular sciences 2025 Jan 9;26(2)
International journal of molecular sciences 2025 Jan 9;26(2)
circ_0004662 contributes to colorectal cancer progression by interacting with hnRNPM.
Zhang Y, Wang J, Quan R, Lyu L
International journal of oncology 2025 Feb;66(2)
International journal of oncology 2025 Feb;66(2)
ITGA3 promotes pancreatic cancer progression through HIF1α- and c-Myc-driven glycolysis in a collagen I-dependent autocrine manner.
Li R, Ji Q, Fu S, Gu J, Liu D, Wang L, Yuan X, Wen Y, Dai C, Li H
Cancer gene therapy 2025 Feb;32(2):240-253
Cancer gene therapy 2025 Feb;32(2):240-253
HSP90 co-regulates the formation and nuclear distribution of the glycolytic output complex to promote resistance and poor prognosis in gastric cancer patients.
Shen G, Liu S, Cao Y, Chen Z, Wang G, Yu L, Sun L, Ran Y
Journal of translational medicine 2025 Feb 10;23(1):172
Journal of translational medicine 2025 Feb 10;23(1):172
LBX2-AS1 in acceleration of glycolysis and cancer angiogenesis via miR-491-5p/MDK signaling axis in colorectal cancer: an experimental study.
Wang J, Li C, Wu G, Xu J
Annals of medicine 2025 Dec;57(1):2564284
Annals of medicine 2025 Dec;57(1):2564284
ACSF2-PGK1 interaction promotes ferroptosis in renal tubular epithelial cells of diabetic nephropathy by regulating Keap1/Nrf2 signaling.
Liu X, Chen C, Zhu S, Luo X, Gao L, Hu Z, Ma Y, Jiang L, Wu Y
Redox report : communications in free radical research 2025 Dec;30(1):2529618
Redox report : communications in free radical research 2025 Dec;30(1):2529618
PRAS40 promotes colorectal cancer stemness by enhancing glycolysis through triggering PGK1 acetylation.
Zhang C, Bo Y, Zhang T, Chen X, Zhang T, Teng H, Wang Y, Luo Y, Sun J, Wang L, Wang X, Huang L
Oncogenesis 2025 Dec 27;15(1):2
Oncogenesis 2025 Dec 27;15(1):2
Polo-like kinase 1 drives hypoxia-induced renal fibrosis via PTEN/PGK1-mediated glycolytic activation.
Jiang A, Chen S, Yu X, Jia Y, Sun J, Bian Y, Du X, Gu X
International journal of biological macromolecules 2025 Aug;319(Pt 1):145305
International journal of biological macromolecules 2025 Aug;319(Pt 1):145305
Annexin A2 binds the 3'-UTR of H2AX mRNA and regulates histone-H2AX-derived hypoxia-inducible factor 1-alpha activation.
Zhang S, Wang YS, Li Y, To KI, Zhang ET, Jin YH
Cellular signalling 2025 Aug;132:111781
Cellular signalling 2025 Aug;132:111781
H4K79 and H4K91 histone lactylation, newly identified lactylation sites enriched in breast cancer.
Liu J, Zhao L, Yan M, Jin S, Shang L, Wang J, Wang Q, Zhao S, Shen Z, Liu T, Wu H, Pang D
Journal of experimental & clinical cancer research : CR 2025 Aug 23;44(1):252
Journal of experimental & clinical cancer research : CR 2025 Aug 23;44(1):252
Phosphoglycerate kinase 1 contributes to diabetic kidney disease through enzyme-dependent and independent manners.
Sun HJ, Lu QB, Liu SJ, Fu X, Yu CL, Su JB, Meng XY, Guo X, Shao X, Li JH, Sun QY, Zhu XX, Shan JJ, Zhou W
Cell reports. Medicine 2025 Aug 19;6(8):102241
Cell reports. Medicine 2025 Aug 19;6(8):102241
Effects of PGK1 on immunoinfiltration by integrated single-cell and bulk RNA-sequencing analysis in sepsis.
Liu Y, Li W, Lei L, Zhou Y, Huang M, Li Y, Zhang X, Jiang Y, Wu H, Zheng Z, Ma K, Tang C
Frontiers in immunology 2024;15:1449975
Frontiers in immunology 2024;15:1449975
LINC00908 attenuates LUAD tumorigenesis through DEAD-box helicase 54.
Zhao J, Yang X, Gong W, Zhang L, Li C, Han X, Zhang Y, Chu X
American journal of cancer research 2024;14(5):2371-2389
American journal of cancer research 2024;14(5):2371-2389
Lamivudine protects mice from gastric ulcer by activating PGK1 to suppress ferroptosis.
Meng X, Liu J, Kang J, Wang M, Guan Z, Tian D, Chen X
Biochemical pharmacology 2024 Sep;227:116440
Biochemical pharmacology 2024 Sep;227:116440
G protein pathway suppressor 2 suppresses aerobic glycolysis through RACK1-mediated HIF-1α degradation in breast cancer.
Si Y, Ou H, Jin X, Gu M, Sheng S, Peng W, Yang D, Zhan X, Zhang L, Yu Q, Liu X, Liu Y
Free radical biology & medicine 2024 Sep;222:478-492
Free radical biology & medicine 2024 Sep;222:478-492
Sodium citrate targeting Ca(2+)/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer.
Wu Y, Jia C, Liu W, Zhan W, Chen Y, Lu J, Bao Y, Wang S, Yu C, Zheng L, Sun L, Song Z
Journal of advanced research 2024 Nov;65:89-104
Journal of advanced research 2024 Nov;65:89-104
Identification of TPI1 As a potential therapeutic target in pancreatic cancer with dependency of TP53 mutation using multi-omics analysis.
Toyoda T, Miura N, Kato S, Masuda T, Ohashi R, Matsushita A, Matsuda F, Ohtsuki S, Katakura A, Honda K
Cancer science 2024 Nov;115(11):3622-3635
Cancer science 2024 Nov;115(11):3622-3635
Eicosapentaenoic acid-mediated activation of PGAM2 regulates skeletal muscle growth and development via the PI3K/AKT pathway.
Li C, Cao H, Ren Y, Jia J, Yang G, Jin J, Shi X
International journal of biological macromolecules 2024 May;268(Pt 2):131547
International journal of biological macromolecules 2024 May;268(Pt 2):131547
Energy stress-induced circDDX21 promotes glycolysis and facilitates hepatocellular carcinogenesis.
Luo J, Yang Y, Zhang G, Fang D, Liu K, Mei Y, Wang F
Cell death & disease 2024 May 21;15(5):354
Cell death & disease 2024 May 21;15(5):354
Increased NAD(+) levels protect female mouse reproductive system against zearalenone-impaired glycolysis, lipid metabolism, antioxidant capacity and inflammation.
Dai C, Hou M, Yang X, Wang Z, Sun C, Wu X, Wang S
Reproductive toxicology (Elmsford, N.Y.) 2024 Mar;124:108530
Reproductive toxicology (Elmsford, N.Y.) 2024 Mar;124:108530
CircGLIS3 promotes gastric cancer progression by regulating the miR-1343-3p/PGK1 pathway and inhibiting vimentin phosphorylation.
Zhang Y, Wang X, Liu W, Lei T, Qiao T, Feng W, Song W
Journal of translational medicine 2024 Mar 8;22(1):251
Journal of translational medicine 2024 Mar 8;22(1):251
Histone lactylation promotes malignant progression by facilitating USP39 expression to target PI3K/AKT/HIF-1α signal pathway in endometrial carcinoma.
Wei S, Zhang J, Zhao R, Shi R, An L, Yu Z, Zhang Q, Zhang J, Yao Y, Li H, Wang H
Cell death discovery 2024 Mar 8;10(1):121
Cell death discovery 2024 Mar 8;10(1):121
Ubiquitinome Analysis Uncovers Alterations in Synaptic Proteins and Glucose Metabolism Enzymes in the Hippocampi of Adolescent Mice Following Cold Exposure.
Li XY, Yin X, Lu JJ, Li QR, Xing WQ, Han Q, Ji H, Li SZ, Yang HM, Guo JR, Wang ZQ, Xu B
Cells 2024 Mar 25;13(7)
Cells 2024 Mar 25;13(7)
Glycolytic enzyme PGK1 promotes M1 macrophage polarization and induces pyroptosis of acute lung injury via regulation of NLRP3.
Zhu G, Yu H, Peng T, Yang K, Xu X, Gu W
Respiratory research 2024 Jul 30;25(1):291
Respiratory research 2024 Jul 30;25(1):291
The oncogenic role and regulatory mechanism of PGK1 in human non-small cell lung cancer.
Tian T, Leng Y, Tang B, Dong X, Ren Q, Liang J, Liu T, Liu Y, Feng W, Liu S, Zhou Y, Zhao H, Shen L
Biology direct 2024 Jan 2;19(1):1
Biology direct 2024 Jan 2;19(1):1
Acetyltransferase P300 Regulates Glucose Metabolic Reprogramming through Catalyzing Succinylation in Lung Cancer.
Ma Q, Zeng Q, Wang K, Qian M, Li J, Wang H, Zhang H, Jiang J, Chen Z, Huang W
International journal of molecular sciences 2024 Jan 15;25(2)
International journal of molecular sciences 2024 Jan 15;25(2)
LINC01977 promotes colorectal cancer growth and metastasis by enhancing aerobic glycolysis via the ERK/c-Myc axis.
Wu J, Chen Q, Wang Y, Wang R, Chen Q, Wang Y, Qi X, Gao Y, Chen K
Journal of gastrointestinal oncology 2024 Feb 29;15(1):271-285
Journal of gastrointestinal oncology 2024 Feb 29;15(1):271-285
PRMT1-mediated PGK1 arginine methylation promotes colorectal cancer glycolysis and tumorigenesis.
Liu H, Chen X, Wang P, Chen M, Deng C, Qian X, Bai J, Li Z, Yu X
Cell death & disease 2024 Feb 24;15(2):170
Cell death & disease 2024 Feb 24;15(2):170
Downregulation of tRNA methyltransferase FTSJ1 by PM2.5 promotes glycolysis and malignancy of NSCLC via facilitating PGK1 expression and translation.
Wang Y, Wen Y, Chen Q, Huang Y, Zhou D, Yang W, Yang L, Xiong J, Gao K, Sun L, Zhai R
Cell death & disease 2024 Dec 18;15(12):911
Cell death & disease 2024 Dec 18;15(12):911
Hypoxia-induced downregulation of PGK1 crotonylation promotes tumorigenesis by coordinating glycolysis and the TCA cycle.
Guo Z, Zhang Y, Wang H, Liao L, Ma L, Zhao Y, Yang R, Li X, Niu J, Chu Q, Fu Y, Li B, Yang C
Nature communications 2024 Aug 12;15(1):6915
Nature communications 2024 Aug 12;15(1):6915
METTL3-mediated RanGAP1 promotes colorectal cancer progression through the MAPK pathway by recruiting YTHDF1.
Yang R, Yang C, Su D, Song Y, Min J, Qian Z, Shen X, Li J, Su H
Cancer gene therapy 2024 Apr;31(4):562-573
Cancer gene therapy 2024 Apr;31(4):562-573
Terazosin attenuates abdominal aortic aneurysm formation by downregulating Peg3 expression to inhibit vascular smooth muscle cell apoptosis and senescence.
Wei X, Li Y, Jiang T, Luo P, Dai Y, Wang Q, Xu M, Yan J, Li Y, Gao J, Liu L, Zhang C, Liu Y
European journal of pharmacology 2024 Apr 5;968:176397
European journal of pharmacology 2024 Apr 5;968:176397
The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity.
Sun X, He L, Liu H, Thorne RF, Zeng T, Liu L, Zhang B, He M, Huang Y, Li M, Gao E, Ma M, Cheng C, Meng F, Lang C, Li H, Xiong W, Pan S, Ren D, Dang B, Yang Y, Wu M, Liu L
Cell metabolism 2023 Sep 5;35(9):1563-1579.e8
Cell metabolism 2023 Sep 5;35(9):1563-1579.e8
Phosphorylation and acetylation responses of glycolytic enzymes in meat to different chilling rates.
Bai Y, Ren C, Hou C, Chen L, Wang Z, Li X, Zhang D
Food chemistry 2023 Sep 30;421:135896
Food chemistry 2023 Sep 30;421:135896
LINC02774 inhibits glycolysis in glioma to destabilize HIF-1α dependent on transcription factor RP58.
Chen Y, Liu Y, Xiong J, Ouyang L, Tang M, Mao C, Li L, Xiao D, Liu S, Yang Z, Huang J, Tao Y
MedComm 2023 Oct;4(5):e364
MedComm 2023 Oct;4(5):e364
Phosphoglycerate kinase (PGK) 1 succinylation modulates epileptic seizures and the blood-brain barrier.
Luo Y, Yang J, Zhang L, Tai Z, Huang H, Xu Z, Zhang H
Experimental animals 2023 Nov 9;72(4):475-489
Experimental animals 2023 Nov 9;72(4):475-489
Downregulation of pro-surfactant protein B contributes to the recurrence of early-stage non-small cell lung cancer by activating PGK1-mediated Akt signaling.
Luo H, Li Q, Wang RT, Zhang L, Zhang W, Deng MS, Luo YY, Ji X, Wen Y, Zhou XR, Xu B, Wang D, Hu B, Jin H, Xu CX
Experimental hematology & oncology 2023 Nov 9;12(1):94
Experimental hematology & oncology 2023 Nov 9;12(1):94
An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus.
Navickas A, Asgharian H, Winkler J, Fish L, Garcia K, Markett D, Dodel M, Culbertson B, Miglani S, Joshi T, Yin K, Nguyen P, Zhang S, Stevers N, Hwang HW, Mardakheh F, Goga A, Goodarzi H
Nature cell biology 2023 Jun;25(6):892-903
Nature cell biology 2023 Jun;25(6):892-903
Comprehensive analysis of lncRNA-mRNA co-expression networks in HPV-driven cervical cancer reveals the pivotal function of LINC00511-PGK1 in tumorigenesis.
Xin X, Jia-Yin Y, Jun-Yang H, Rui W, Xiong-Ri K, Long-Rui D, Liu J, Jue-Yu Z
Computers in biology and medicine 2023 Jun;159:106943
Computers in biology and medicine 2023 Jun;159:106943
Inhibition of phosphoglycerate kinase 1 attenuates autoimmune myocarditis by reprogramming CD4+ T cell metabolism.
Lu Y, Zhao N, Wu Y, Yang S, Wu Q, Dong Q, Du Y
Cardiovascular research 2023 Jun 13;119(6):1377-1389
Cardiovascular research 2023 Jun 13;119(6):1377-1389
Targeting the Glycolytic Enzyme PGK1 to Inhibit the Warburg Effect: A New Strategy for Keloid Therapy.
Wang P, Wang Q, Yang X, An Y, Wang J, Nie F, Pan B, Bi H, Qin Z
Plastic and reconstructive surgery 2023 Jun 1;151(6):970e-980e
Plastic and reconstructive surgery 2023 Jun 1;151(6):970e-980e
DNMT3B-mediated FAM111B methylation promotes papillary thyroid tumor glycolysis, growth and metastasis.
Zhu X, Xue C, Kang X, Jia X, Wang L, Younis MH, Liu D, Huo N, Han Y, Chen Z, Fu J, Zhou C, Yao X, Du Y, Cai W, Kang L, Lyu Z
International journal of biological sciences 2022;18(11):4372-4387
International journal of biological sciences 2022;18(11):4372-4387
Long noncoding RNA MIR210HG is induced by hypoxia-inducible factor 1α and promotes cervical cancer progression.
Hu XL, Huang XT, Zhang JN, Liu J, Wen LJ, Xu X, Zhou JY
American journal of cancer research 2022;12(6):2783-2797
American journal of cancer research 2022;12(6):2783-2797
TRIM16 promotes aerobic glycolysis and pancreatic cancer metastasis by modulating the NIK-SIX1 axis in a ligase-independent manner.
Zhou B, Huang Y, Feng Q, Zhu H, Xu Z, Chen L, Peng X, Yang W, Xu D, Qiu Y
American journal of cancer research 2022;12(11):5205-5225
American journal of cancer research 2022;12(11):5205-5225
Development and validation of a novel hypoxia-related signature for prognostic and immunogenic evaluation in head and neck squamous cell carcinoma.
Li SR, Man QW, Liu B
Frontiers in oncology 2022;12:943945
Frontiers in oncology 2022;12:943945
Lactate Dehydrogenase B Is Required for Pancreatic Cancer Cell Immortalization Through Activation of Telomerase Activity.
Wang R, Li J, Zhang C, Guan X, Qin B, Jin R, Qin L, Xu S, Zhang X, Liu R, Ye Q, Cheng L
Frontiers in oncology 2022;12:821620
Frontiers in oncology 2022;12:821620
Transcriptional Repression of Aerobic Glycolysis by OVOL2 in Breast Cancer.
Zhang X, Luo F, Luo S, Li L, Ren X, Lin J, Liang Y, Ma C, Ding L, Zhang D, Ye T, Lin Y, Jin B, Gao S, Ye Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Sep;9(27):e2200705
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Sep;9(27):e2200705
Long non-coding RNA NRSN2-AS1, transcribed by SOX2, promotes progression of esophageal squamous cell carcinoma by regulating the ubiquitin-degradation of PGK1.
Xu T, Yan Z, Lu J, Chen L, Li X, Li Y, Dong Z, Guo W
Clinical & experimental metastasis 2022 Oct;39(5):757-769
Clinical & experimental metastasis 2022 Oct;39(5):757-769
A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1β and IL-6.
Liao L, Dang W, Lin T, Yu J, Liu T, Li W, Xiao S, Feng L, Huang J, Fu R, Li J, Liu L, Wang M, Tao H, Jiang H, Chen K, Diao X, Zhou B, Shen X, Luo C
Acta pharmaceutica Sinica. B 2022 Nov;12(11):4180-4192
Acta pharmaceutica Sinica. B 2022 Nov;12(11):4180-4192
De novo pyrimidine synthesis fuels glycolysis and confers chemoresistance in gastric cancer.
He D, Chen M, Chang L, Gu J, Liu F, Gao X, Ruan Y
Cancer letters 2022 Nov 28;549:215837
Cancer letters 2022 Nov 28;549:215837
Urinary extracellular vesicles signature for diagnosis of kidney disease.
Takizawa K, Ueda K, Sekiguchi M, Nakano E, Nishimura T, Kajiho Y, Kanda S, Miura K, Hattori M, Hashimoto J, Hamasaki Y, Hisano M, Omori T, Okamoto T, Kitayama H, Fujita N, Kuramochi H, Ichiki T, Oka A, Harita Y
iScience 2022 Nov 18;25(11):105416
iScience 2022 Nov 18;25(11):105416
Jumonji-C domain-containing protein 5 suppresses proliferation and aerobic glycolysis in pancreatic cancer cells in a c-Myc-dependent manner.
Wang H, Wang J, Liu J, Wang Y, Xia G, Huang X
Cellular signalling 2022 May;93:110282
Cellular signalling 2022 May;93:110282
HPV16 E6/E7 stabilize PGK1 protein by reducing its poly-ubiquitination in cervical cancer.
Liu S, Song L, Yao H, Zhang L
Cell biology international 2022 Mar;46(3):370-380
Cell biology international 2022 Mar;46(3):370-380
MYB proto-oncogene like 2 promotes hepatocellular carcinoma growth and glycolysis via binding to the Optic atrophy 3 promoter and activating its expression.
Liu M, Du Q, Mao G, Dai N, Zhang F
Bioengineered 2022 Mar;13(3):5344-5356
Bioengineered 2022 Mar;13(3):5344-5356
lncRNA SNHG26 promoted the growth, metastasis, and cisplatin resistance of tongue squamous cell carcinoma through PGK1/Akt/mTOR signal pathway.
Jiang Q, Wang Z, Qi Q, Li J, Xin Y, Qiu J
Molecular therapy oncolytics 2022 Mar 17;24:355-370
Molecular therapy oncolytics 2022 Mar 17;24:355-370
Integrated metabolism and epigenetic modifications in the macrophages of mice in responses to cold stress.
Lu J, Fu S, Dai J, Hu J, Li S, Ji H, Wang Z, Yu J, Bao J, Xu B, Guo J, Yang H
Journal of Zhejiang University. Science. B 2022 Jun 15;23(6):461-480
Journal of Zhejiang University. Science. B 2022 Jun 15;23(6):461-480
Circ_0076305 facilitates prostate cancer development via sponging miR-411-5p and regulating PGK1.
Ding X, Sun J, Zhang X
Andrologia 2022 Jul;54(6):e14406
Andrologia 2022 Jul;54(6):e14406
Quxie Capsule Alleviates Colitis-associated Colorectal Cancer Through Modulating the Gut Microbiota and Suppressing A. fumigatus-induced Aerobic Glycolysis.
Zhang Z, Chen Y, Zheng Y, Wang L, Shen S, Yang G, Yang Y, Wang T
Integrative cancer therapies 2022 Jan-Dec;21:15347354221138534
Integrative cancer therapies 2022 Jan-Dec;21:15347354221138534
Parkinson's disease protein PARK7 prevents metabolite and protein damage caused by a glycolytic metabolite.
Heremans IP, Caligiore F, Gerin I, Bury M, Lutz M, Graff J, Stroobant V, Vertommen D, Teleman AA, Van Schaftingen E, Bommer GT
Proceedings of the National Academy of Sciences of the United States of America 2022 Jan 25;119(4)
Proceedings of the National Academy of Sciences of the United States of America 2022 Jan 25;119(4)
PGK1 represses autophagy-mediated cell death to promote the proliferation of liver cancer cells by phosphorylating PRAS40.
Zhang T, Wang Y, Yu H, Zhang T, Guo L, Xu J, Wei X, Wang N, Wu Y, Wang X, Huang L
Cell death & disease 2022 Jan 20;13(1):68
Cell death & disease 2022 Jan 20;13(1):68
The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis.
Zhu Y, Jin L, Shi R, Li J, Wang Y, Zhang L, Liang CZ, Narayana VK, De Souza DP, Thorne RF, Zhang LR, Zhang XD, Wu M
Molecular cell 2022 Feb 3;82(3):542-554.e6
Molecular cell 2022 Feb 3;82(3):542-554.e6
Long non-coding RNA CTSLP8 mediates ovarian cancer progression and chemotherapy resistance by modulating cellular glycolysis and regulating c-Myc expression through PKM2.
Li X, Zhang Y, Wang X, Lin F, Cheng X, Wang Z, Wang X
Cell biology and toxicology 2022 Dec;38(6):1027-1045
Cell biology and toxicology 2022 Dec;38(6):1027-1045
Polydopamine-mediated graphene oxide and nanohydroxyapatite-incorporated conductive scaffold with an immunomodulatory ability accelerates periodontal bone regeneration in diabetes.
Li Y, Yang L, Hou Y, Zhang Z, Chen M, Wang M, Liu J, Wang J, Zhao Z, Xie C, Lu X
Bioactive materials 2022 Dec;18:213-227
Bioactive materials 2022 Dec;18:213-227
Candida tropicalis induces NLRP3 inflammasome activation via glycogen metabolism-dependent glycolysis and JAK-STAT1 signaling pathway in myeloid-derived suppressor cells to promote colorectal carcinogenesis.
Zhang Z, Chen Y, Yin Y, Chen Y, Chen Q, Bing Z, Zheng Y, Hou Y, Shen S, Chen Y, Wang T
International immunopharmacology 2022 Dec;113(Pt B):109430
International immunopharmacology 2022 Dec;113(Pt B):109430
U2 small nuclear RNA auxiliary factor 2, transcriptionally activated by the transcription factor Dp-1/E2F transcription factor 1 complex, enhances the growth and aerobic glycolysis of leiomyosarcoma cells.
Li Y, Chen S, Zhang X, Zhuo N
Bioengineered 2022 Apr;13(4):10200-10212
Bioengineered 2022 Apr;13(4):10200-10212
SIX1 Activation Is Involved in Cell Proliferation, Migration, and Anti-inflammation of Acute Ischemia/Reperfusion Injury in Mice.
Jin Y, Zhang M, Li M, Zhang H, Zhao L, Qian C, Li S, Zhang H, Gao M, Pan B, Li R, Wan X, Cao C
Frontiers in molecular biosciences 2021;8:725319
Frontiers in molecular biosciences 2021;8:725319
Peri-tumoral brain edema associated with glioblastoma correlates with tumor recurrence.
Qin X, Liu R, Akter F, Qin L, Xie Q, Li Y, Qiao H, Zhao W, Jian Z, Liu R, Wu S
Journal of Cancer 2021;12(7):2073-2082
Journal of Cancer 2021;12(7):2073-2082
PGK1 Is a Key Target for Anti-Glycolytic Therapy of Ovarian Cancer: Based on the Comprehensive Analysis of Glycolysis-Related Genes.
Gou R, Hu Y, Liu O, Dong H, Gao L, Wang S, Zheng M, Li X, Lin B
Frontiers in oncology 2021;11:682461
Frontiers in oncology 2021;11:682461
FOXO3A-induced LINC00926 suppresses breast tumor growth and metastasis through inhibition of PGK1-mediated Warburg effect.
Chu Z, Huo N, Zhu X, Liu H, Cong R, Ma L, Kang X, Xue C, Li J, Li Q, You H, Zhang Q, Xu X
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Sep 1;29(9):2737-2753
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Sep 1;29(9):2737-2753
Reciprocal regulation of LOXL2 and HIF1α drives the Warburg effect to support pancreatic cancer aggressiveness.
Li R, Li H, Zhu L, Zhang X, Liu D, Li Q, Ni B, Hu L, Zhang Z, Zhang Y, Wang X, Jiang SH
Cell death & disease 2021 Nov 26;12(12):1106
Cell death & disease 2021 Nov 26;12(12):1106
Low chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk.
Wang XH, Xu S, Zhou XY, Zhao R, Lin Y, Cao J, Zang WD, Tao H, Xu W, Li MQ, Zhao SM, Jin LP, Zhao JY
Nature communications 2021 Jun 8;12(1):3428
Nature communications 2021 Jun 8;12(1):3428
MicroRNA-16-1-3p Represses Breast Tumor Growth and Metastasis by Inhibiting PGK1-Mediated Warburg Effect.
Ye T, Liang Y, Zhang D, Zhang X
Frontiers in cell and developmental biology 2020;8:615154
Frontiers in cell and developmental biology 2020;8:615154
Protein Lysine Acetylation in Ovarian Granulosa Cells Affects Metabolic Homeostasis and Clinical Presentations of Women With Polycystic Ovary Syndrome.
Min Z, Long X, Zhao H, Zhen X, Li R, Li M, Fan Y, Yu Y, Zhao Y, Qiao J
Frontiers in cell and developmental biology 2020;8:567028
Frontiers in cell and developmental biology 2020;8:567028
A glycolytic shift in Schwann cells supports injured axons.
Babetto E, Wong KM, Beirowski B
Nature neuroscience 2020 Oct;23(10):1215-1228
Nature neuroscience 2020 Oct;23(10):1215-1228
Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma.
Maitituoheti M, Keung EZ, Tang M, Yan L, Alam H, Han G, Singh AK, Raman AT, Terranova C, Sarkar S, Orouji E, Amin SB, Sharma S, Williams M, Samant NS, Dhamdhere M, Zheng N, Shah T, Shah A, Axelrad JB, Anvar NE, Lin YH, Jiang S, Chang EQ, Ingram DR, Wang WL, Lazar A, Lee MG, Muller F, Wang L, Ying H, Rai K
Cell reports 2020 Oct 20;33(3):108293
Cell reports 2020 Oct 20;33(3):108293
Perturbation of phosphoglycerate kinase 1 (PGK1) only marginally affects glycolysis in cancer cells.
Jin C, Zhu X, Wu H, Wang Y, Hu X
The Journal of biological chemistry 2020 May 8;295(19):6425-6446
The Journal of biological chemistry 2020 May 8;295(19):6425-6446
Activator of thyroid and retinoid receptor increases sorafenib resistance in hepatocellular carcinoma by facilitating the Warburg effect.
Ma L, Liu W, Xu A, Ji Q, Ma Y, Tai Y, Wang Y, Shen C, Liu Y, Wang T, Han J, Zhao C
Cancer science 2020 Jun;111(6):2028-2040
Cancer science 2020 Jun;111(6):2028-2040
Targeting G6PD reverses paclitaxel resistance in ovarian cancer by suppressing GSTP1.
Feng Q, Li X, Sun W, Sun M, Li Z, Sheng H, Xie F, Zhang S, Shan C
Biochemical pharmacology 2020 Aug;178:114092
Biochemical pharmacology 2020 Aug;178:114092
Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression.
Weng ML, Chen WK, Chen XY, Lu H, Sun ZR, Yu Q, Sun PF, Xu YJ, Zhu MM, Jiang N, Zhang J, Zhang JP, Song YL, Ma D, Zhang XP, Miao CH
Nature communications 2020 Apr 20;11(1):1869
Nature communications 2020 Apr 20;11(1):1869
Collagen prolyl 4-hydroxylase 2 predicts worse prognosis and promotes glycolysis in cervical cancer.
Li Q, Wang Q, Zhang Q, Zhang J, Zhang J
American journal of translational research 2019;11(11):6938-6951
American journal of translational research 2019;11(11):6938-6951
ACTL6A regulates follicle-stimulating hormone-driven glycolysis in ovarian cancer cells via PGK1.
Zhang J, Zhang J, Wei Y, Li Q, Wang Q
Cell death & disease 2019 Oct 24;10(11):811
Cell death & disease 2019 Oct 24;10(11):811
Long non-coding RNA GBCDRlnc1 induces chemoresistance of gallbladder cancer cells by activating autophagy.
Cai Q, Wang S, Jin L, Weng M, Zhou D, Wang J, Tang Z, Quan Z
Molecular cancer 2019 Apr 5;18(1):82
Molecular cancer 2019 Apr 5;18(1):82
Yes-associated protein (YAP) binds to HIF-1α and sustains HIF-1α protein stability to promote hepatocellular carcinoma cell glycolysis under hypoxic stress.
Zhang X, Li Y, Ma Y, Yang L, Wang T, Meng X, Zong Z, Sun X, Hua X, Li H
Journal of experimental & clinical cancer research : CR 2018 Sep 4;37(1):216
Journal of experimental & clinical cancer research : CR 2018 Sep 4;37(1):216
The Long Noncoding RNA Lncenc1 Maintains Naive States of Mouse ESCs by Promoting the Glycolysis Pathway.
Sun Z, Zhu M, Lv P, Cheng L, Wang Q, Tian P, Yan Z, Wen B
Stem cell reports 2018 Sep 11;11(3):741-755
Stem cell reports 2018 Sep 11;11(3):741-755
Transcriptional Regulation of the Warburg Effect in Cancer by SIX1.
Li L, Liang Y, Kang L, Liu Y, Gao S, Chen S, Li Y, You W, Dong Q, Hong T, Yan Z, Jin S, Wang T, Zhao W, Mai H, Huang J, Han X, Ji Q, Song Q, Yang C, Zhao S, Xu X, Ye Q
Cancer cell 2018 Mar 12;33(3):368-385.e7
Cancer cell 2018 Mar 12;33(3):368-385.e7
Systematic In-Depth Proteomic Analysis of Mitochondria-Associated Endoplasmic Reticulum Membranes in Mouse and Human Testes.
Wang X, Wen Y, Dong J, Cao C, Yuan S
Proteomics 2018 Jul;18(14):e1700478
Proteomics 2018 Jul;18(14):e1700478
Dysfunction of pseudogene PGK1P2 is involved in preeclampsia by acting as a competing endogenous RNA of PGK1.
Tong J, Yang J, Lv H, Lv S, Zhang C, Chen ZJ
Pregnancy hypertension 2018 Jul;13:37-45
Pregnancy hypertension 2018 Jul;13:37-45
PGK1 and GRP78 overexpression correlates with clinical significance and poor prognosis in Chinese endometrial cancer patients.
Guo S, Xiao Y, Li D, Jiang Q, Zhu L, Lin D, Jiang H, Chen W, Wang L, Liu C, Fang W, Lin L
Oncotarget 2018 Jan 2;9(1):680-690
Oncotarget 2018 Jan 2;9(1):680-690
AAED1 modulates proliferation and glycolysis in gastric cancer.
Zhang B, Wu J, Cai Y, Luo M, Wang B, Gu Y
Oncology reports 2018 Aug;40(2):1156-1164
Oncology reports 2018 Aug;40(2):1156-1164
Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission.
Wang L, Zhang T, Wang L, Cai Y, Zhong X, He X, Hu L, Tian S, Wu M, Hui L, Zhang H, Gao P
The EMBO journal 2017 May 15;36(10):1330-1347
The EMBO journal 2017 May 15;36(10):1330-1347
Impact of Leishmania infection on host macrophage nuclear physiology and nucleopore complex integrity.
Isnard A, Christian JG, Kodiha M, Stochaj U, McMaster WR, Olivier M
PLoS pathogens 2015 Mar;11(3):e1004776
PLoS pathogens 2015 Mar;11(3):e1004776
cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.
Sun L, Song L, Wan Q, Wu G, Li X, Wang Y, Wang J, Liu Z, Zhong X, He X, Shen S, Pan X, Li A, Wang Y, Gao P, Tang H, Zhang H
Cell research 2015 Apr;25(4):429-44
Cell research 2015 Apr;25(4):429-44
Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1.
Ma X, Li C, Sun L, Huang D, Li T, He X, Wu G, Yang Z, Zhong X, Song L, Gao P, Zhang H
Nature communications 2014 Oct 10;5:5212
Nature communications 2014 Oct 10;5:5212
An iTRAQ based quantitative proteomic strategy to explore novel secreted proteins in metastatic hepatocellular carcinoma cell lines.
Yu Y, Pan X, Ding Y, Liu X, Tang H, Shen C, Shen H, Yang P
The Analyst 2013 Aug 21;138(16):4505-11
The Analyst 2013 Aug 21;138(16):4505-11
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 17811-1-AP(PGK1 antibody) at dilution of 1:1200
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PGK1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PGK1. This antibody recognizes human, mouse antigen. The PGK1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
