BS7966

antibody from Bioworld Technology, Inc

Targeting: TFPI2 PP5, REF1, TFPI-2

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

BS7966

Provider

Bioworld Technology, Inc

Product name

TFPI2 polyclonal antibody

Antibody type

Polyclonal

Antigen

Recombinant full length Human TFPI2.

Description

The extrinsic pathway of blood coagulation is initiated by contact of plasma Factor VII with tissue factor, a cellular membrane glycoprotein that normally is segregated from the bloodstream but can be exposed after tissue injury or newly synthesized in endothelial cells or leukocytes after stimulation by endotoxin and cytokines. Inhibition of Factor VIIA tissue factor activity requires a plasma component (tissue factor pathway inhibitor (TFPI), lipoprotein-associated coagulation inhibitor (LACI) or extrinsic pathway inhibitor (EPI)) and Factor XA. TFPI directly inhibits Factor XA, and, in an XA-dependent fashion, also inhibits the Factor VIIA tissue factor catalytic complex. TFPI is a multivalent, Kunitz-type proteinase inhibitor that circulates in association with plasma lipoproteins VLDL, LDL and HDL. TFPI-2 (also known as placental protein 5) is a related glycoprotein that was originally isolated from human placenta. The genes which encode for TFPI and TFPI-2 map to human chromosomes 2q31-q32.1 and 7q22, respectively.

Reactivity

Human

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.