PB9076

antibody from Boster Biological Technology

Targeting: BECN1 ATG6, VPS30

Provider product page for PB9076

Western blot

Immunocytochemistry

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Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [33]
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Immunohistochemistry [1]

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Product number: PB9076 - Provider product page
Provider: Boster Biological Technology
Product name: Anti-Beclin 1/BECN1 Antibody Picoband™
Antibody type: Polyclonal
Description: Polyclonal antibody for Beclin 1/BECN1 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: WB, IHC-P, ICC/IF, FCM. Reactive species: Human;Mouse;Rat. Beclin 1/BECN1 information: Molecular Weight: 51896 MW; Subcellular Localization: Cytoplasm . Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein . Endoplasmic reticulum membrane ; Peripheral membrane protein . Mitochondrion membrane ; Peripheral membrane protein . Endosome . Cytoplasmic vesicle, autophagosome . Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity); Tissue Specificity: Ubiquitous.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Vial size: 100μg/vial
Concentration: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Storage: At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquoted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
Handling: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

BECN1 protein structure - PB9076 shown in red.

Submitted references Circ_0002331 Interacts with ELAVL1 to Improve ox-LDL-Induced Vascular Endothelial Cell Dysfunction via Regulating CCND2 mRNA Stability.

Chen F, Yu X
Cardiovascular toxicology 2024 Jul;24(7):625-636

Buyang Huanwu Decoction alleviates cerebral ischemic injury through modulating caveolin-1-mediated mitochondrial quality control.

Xu Y, Chen B, Yi J, Tian F, Liu Y, Ouyang Y, Yuan C, Liu B
Frontiers in pharmacology 2023;14:1137609

LncRNA THRIL, transcriptionally activated by AP-1 and stabilized by METTL14-mediated m6A modification, accelerates LPS-evoked acute injury in alveolar epithelial cells.

Shi Q, Li Z, Dong Y, Yang G, Li M
International immunopharmacology 2023 Oct;123:110740

RORα overexpression reduced interleukin-33 expression and prevented mast cell degranulation and inflammation by inducing autophagy in allergic rhinitis.

Yu W, Du J, Peng L, Zhang T
Immunity, inflammation and disease 2023 Oct;11(10):e1017

Activation of autophagy after blast-induced traumatic brain injury in mice.

Zhou Y, Song Y, Zhu L
Neuroreport 2023 Oct 4;34(15):759-766

ACKR4a induces autophagy to block NF-κB signaling and apoptosis to facilitate Vibrio harveyi infection.

Chen Y, Cao B, Zheng W, Xu T
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Strontium Ranelate Inhibits Osteoclastogenesis through NF-κB-Pathway-Dependent Autophagy.

Wu D, Sun X, Zhao Y, Liu Y, Gan Z, Zhang Z, Chen X, Cao Y
Bioengineering (Basel, Switzerland) 2023 Mar 16;10(3)

RNF113A targeted by miR-197 promotes proliferation and inhibits autophagy via CXCR4/CXCL12/AKT/ERK/Beclin1 axis in cervical cancer.

Zhang Q, Song J, Cao L, Sun M, Xu T, Yang S, Li S, Wang H, Fu X
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CAV1 alleviated CaOx stones formation via suppressing autophagy-dependent ferroptosis.

Yang Y, Hong S, Lu Y, Wang Q, Wang S, Xun Y
PeerJ 2022;10:e14033

eIF3k inhibits NF-κB signaling by targeting MyD88 for ATG5-mediated autophagic degradation in teleost fish.

Chen Y, Cao B, Zheng W, Sun Y, Xu T
The Journal of biological chemistry 2022 Mar;298(3):101730

Endogenous dipeptide-carnosine supplementation ameliorates hypobaric hypoxia-induced skeletal muscle loss via attenuating endoplasmic reticulum stress response and maintaining proteostasis.

Agrawal A, Rathor R, Kumar R, Singh SN, Kumar B, Suryakumar G
IUBMB life 2022 Jan;74(1):101-116

Regulation of the autophagy plays an important role in acute kidney injury induced acute lung injury.

Wang R, Shen S, Jian L, Liu S, Yuan Q, Guo H, Huang J, Chen P, Huang R
Renal failure 2022 Dec;44(1):1754-1768

Sodium Butyrate Attenuates AGEs-Induced Oxidative Stress and Inflammation by Inhibiting Autophagy and Affecting Cellular Metabolism in THP-1 Cells.

Yan M, Li X, Sun C, Tan J, Liu Y, Li M, Qi Z, He J, Wang D, Wu L
Molecules (Basel, Switzerland) 2022 Dec 9;27(24)

Autophagic Degradation of Gasdermin D Protects against Nucleus Pulposus Cell Pyroptosis and Retards Intervertebral Disc Degeneration In Vivo.

Liao Z, Li S, Liu R, Feng X, Shi Y, Wang K, Li S, Zhang Y, Wu X, Yang C
Oxidative medicine and cellular longevity 2021;2021:5584447

The Protein-Independent Role of Phosphate in the Progression of Chronic Kidney Disease.

Duayer IF, Duque EJ, Fujihara CK, de Oliveira IB, Dos Reis LM, Machado FG, Graciolli FG, Jorgetti V, Zatz R, Elias RM, Moysés RMA
Toxins 2021 Jul 19;13(7)

Hydrogen sulfide exacerbated periodontal inflammation and induced autophagy in experimental periodontitis.

Ni K, Hua Y
International immunopharmacology 2021 Apr;93:107399

Exogenous Hydrogen Sulfide Ameliorates Diabetic Myocardial Fibrosis by Inhibiting Cell Aging Through SIRT6/AMPK Autophagy.

Li Y, Liu M, Song X, Zheng X, Yi J, Liu D, Wang S, Chu C, Yang J
Frontiers in pharmacology 2020;11:1150

Galectin-3 mediates pulmonary vascular endothelial cell dynamics via TRPC1/4 under acute hypoxia.

Li Y, Chen X, Zeng X, Chen S, Yang X, Zhang L
Journal of biochemical and molecular toxicology 2020 May;34(5):e22463

MicroRNA 30a Mediated Autophagy and Imatinib Response in Egyptian Chronic Myeloid Leukemia Patients.

Khalil NA, Desouky MN, Diab IH, Hamed NAM, Mannaa HF
Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion 2020 Jul;36(3):491-497

MicroRNA-375 exacerbates knee osteoarthritis through repressing chondrocyte autophagy by targeting ATG2B.

Li H, Li Z, Pi Y, Chen Y, Mei L, Luo Y, Xie J, Mao X
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Compressive force-induced autophagy in periodontal ligament cells downregulates osteoclastogenesis during tooth movement.

Chen L, Mo S, Hua Y
Journal of periodontology 2019 Oct;90(10):1170-1181

PTEN-Induced Putative Kinase 1 (PINK1)/Parkin-Mediated Mitophagy Protects PC12 Cells Against Cisplatin-Induced Neurotoxicity.

Zhang Y, Liu Q, Li Y, Li C, Zhu Y, Xia F, Xu S, Li W
Medical science monitor : international medical journal of experimental and clinical research 2019 Nov 21;25:8797-8806

Dopamine-melanin nanoparticles scavenge reactive oxygen and nitrogen species and activate autophagy for osteoarthritis therapy.

Zhong G, Yang X, Jiang X, Kumar A, Long H, Xie J, Zheng L, Zhao J
Nanoscale 2019 Jun 20;11(24):11605-11616

miRNA-335-5p relieves chondrocyte inflammation by activating autophagy in osteoarthritis.

Zhong G, Long H, Ma S, Shunhan Y, Li J, Yao J
Life sciences 2019 Jun 1;226:164-172

Association of astragaloside IV-inhibited autophagy and mineralization in vascular smooth muscle cells with lncRNA H19 and DUSP5-mediated ERK signaling.

Song Z, Wei D, Chen Y, Chen L, Bian Y, Shen Y, Chen J, Pan Y
Toxicology and applied pharmacology 2019 Feb 1;364:45-54

Melatonin Enhances Proliferation and Modulates Differentiation of Neural Stem Cells Via Autophagy in Hyperglycemia.

Li H, Zhang Y, Liu S, Li F, Wang B, Wang J, Cao L, Xia T, Yao Q, Chen H, Zhang Y, Zhu X, Li Y, Li G, Wang J, Li X, Ni S
Stem cells (Dayton, Ohio) 2019 Apr;37(4):504-515

Lactone Component From Ligusticum chuanxiong Alleviates Myocardial Ischemia Injury Through Inhibiting Autophagy.

Wang G, Dai G, Song J, Zhu M, Liu Y, Hou X, Ke Z, Zhou Y, Qiu H, Wang F, Jiang N, Jia X, Feng L
Frontiers in pharmacology 2018;9:301

Expression of miR-551b and its effect on apoptosis in human gastric carcinoma.

Wang Y, Fan X, Xu F, Zhang P, Wei Y, Cheng S, Zhao P
International journal of clinical and experimental pathology 2018;11(5):2912-2919

Recombinant Newcastle disease virus expressing human IFN-λ1 (rL-hIFN-λ1)-induced apoptosis of A549 cells is connected to endoplasmic reticulum stress pathways.

Yan Y, Liu S, Li M, Zhao Y, Shao X, Hang M, Bu X
Thoracic cancer 2018 Nov;9(11):1437-1452

Umbilical Cord Mesenchymal Stem Cells Conditioned Medium Promotes Aβ25-35 phagocytosis by Modulating Autophagy and Aβ-Degrading Enzymes in BV2 Cells.

Xu Z, Nan W, Zhang X, Sun Y, Yang J, Lu K, Liu Y, Gao Y, Yang F, Mao W, Xing X, Du J, Li H, Li Y, Feng H, Yuan Z, Lin J
Journal of molecular neuroscience : MN 2018 Jun;65(2):222-233

Suppression of the toll-like receptor 7-dependent type I interferon production pathway by autophagy resulting from enterovirus 71 and coxsackievirus A16 infections facilitates their replication.

Song J, Hu Y, Li J, Zheng H, Wang J, Guo L, Shi H, Liu L
Archives of virology 2018 Jan;163(1):135-144

Andrographolide Induces Autophagic Cell Death and Inhibits Invasion and Metastasis of Human Osteosarcoma Cells in An Autophagy-Dependent Manner.

Liu Y, Zhang Y, Zou J, Yan L, Yu X, Lu P, Wu X, Li Q, Gu R, Zhu D
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;44(4):1396-1410

Tetrahydrocurcumin induces mesenchymal-epithelial transition and suppresses angiogenesis by targeting HIF-1α and autophagy in human osteosarcoma.

Zhang Y, Liu Y, Zou J, Yan L, Du W, Zhang Y, Sun H, Lu P, Geng S, Gu R, Zhang H, Bi Z
Oncotarget 2017 Oct 31;8(53):91134-91149

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Submitted by: Boster Biological Technology (provider)
Main image
Experimental details: Anti-Beclin 1 Picoband antibody, PB9076-1.JPGIHC(P): Mouse Intestine Tissue
Additional image