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- Antibody Data
- Antigen structure
- References [140]
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- Product number
- 66665-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- Beclin 1 antibody
- Antibody type
- Monoclonal
- Description
- Beclin 1 antibody (Cat. #66665-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, Mouse, Rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 1C10C4
- Vial size
- 20ul, 150ul
Submitted references PSAT1 inhibits mTORC1 activation by preventing Rag heterodimer formation in lung adenocarcinoma.
Complement protein C1q induces endothelial apoptosis through C1qBP regulation of mitochondrial function in lung endothelial cells in systemic sclerosis.
Hydrogen sulfide promotes proliferation and regeneration of human cerebral microvascular endothelial cells via the sonic hedgehog signaling pathway.
The mechanisms by which hypothalamic neuroinflammation induced by neonatal cerebral ischemia-hypoxia leads to decreased thymic function via the HPA axis.
IRF4 Enhances Radiosensitivity of Cervical Cancer by Inhibiting the PI3K/Akt/mTOR Pathway to Regulate Autophagy.
E3 ubiquitin ligase NEDD4 inhibits PEDV infection through ubiquitination and degradation of the viral primase NSP8.
miR-512-3p/RPS6KA2 Axis Regulates Cisplatin Resistance in Ovarian Cancer via Autophagy and Ferroptosis.
Mitophagy-associated biomarkers and macrophage involvement in pulmonary arterial hypertension: identification and functional implications.
Cdk5 mediates impaired autophagy by regulating NGF/Sirt1 axis to cause diabetic islet β cell damage.
Comparative hepatoprotective effects of AMK and PAMK via Nrf2 signaling in broiler breeders.
Rhizoma Panacis Majoris ameliorates rheumatoid arthritis by restoring apoptosis and autophagy dysregulation through reducing HMGB1 expression.
Luteolin alleviates right ventricular hypertrophy in high altitude pulmonary hypertension rats by regulating PI3K/AKT/mTOR signalling pathway.
Cdk5 Contributes to Diabetic Islet β Cell and Kidney Injury by Impairing Autophagy.
Role of neuroglia cell-derived microvesicles in cobalt chloride-induced mitochondrial autophagy in neurons.
TBRG4 regulates ubiquitination of Beclin1 and participates in autophagy pathway to inhibit intervertebral disc degeneration.
S-palmitoylation coordinates the trafficking of ATG9A to mediate autophagy initiation.
Biliverdin alleviates cerebral ischemia-reperfusion injury by inhibiting autophagy via the lncRNA TUG1 /miR-204-5p/P4HB axis.
Therapeutic Potential of MCC950 in Restoring Autophagy and Cognitive Function in STZ-Induced Rat Model of Alzheimer's Disease.
Activation of sigma 1 receptor attenuates doxorubicin-induced cardiotoxicity by alleviating oxidative stress, mitochondria dysfunction, ER stress-related apoptosis, and autophagy impairment.
Dendrimer nanocarriers for targeted co-delivery of MiR-146b-3p and 5-ALA to synergistic photodynamic therapy in secondary hyperparathyroidism.
Regulation of N-degron recognin-mediated autophagy by the SARS-CoV-2 PLpro ubiquitin deconjugase.
Compound probiotics alleviate hyperuricemia-induced renal injury via restoring gut microbiota and metabolism.
Autophagy modulation by hADSCs and green light therapy alleviates inflammation and promotes functional recovery after spinal cord injury.
Overexpression of Tgm2 in Chinese Hamster Ovary Cells Enhances Recombinant Monoclonal Antibody Expression and Promotes Cell Proliferation through Reduction of Apoptosis.
Edaravone inhibits neuronal ferroptosis and alleviates acute Central nervous system injury induced by diquat via enhancement of METTL14-mediated m6A methylation of Aldh1l1.
Runchangningshen paste activates NLRP6 inflammasome-mediated autophagy to stimulate colonic mucin-2 secretion and modulates mucosal microbiota in functional constipation.
Differences in Starvation-Induced Autophagy Response and miRNA Expression Between Rat Mammary Epithelial and Cancer Cells: Uncovering the Role of miR-218-5p.
Activated mTORC1 signaling pathway aggravates cisplatin induced oxidative damage by inhibiting autophagy in mouse cochlear hair cells.
TMEM106B knockdown exhibits a neuroprotective effect in Parkinson's disease models via regulating autophagy-lysosome pathway.
Isoliquiritin targeting m5C RNA methylation improves mitophagy in doxorubicin-induced myocardial cardiotoxicity.
Regulation of pancreatic cancer cells by suppressing KIN17 through the PI3K/AKT/mTOR signaling pathway.
Lysosomal cation channel TRPML1 suppression sensitizes acute myeloid leukemia cells to chemotherapeutics by inhibiting autophagy.
N(6)-Methyladenosine modification mediated by METTL3 promotes DNA-PKcs expression to induce anlotinib resistance in osteosarcoma.
THSWD upregulates the LTF/AMPK/mTOR/Becn1 axis and promotes lysosomal autophagy in hepatocellular carcinoma cells by regulating gut flora and metabolic reprogramming.
Metformin inhibits the growth of SCLC cells by inducing autophagy and apoptosis via the suppression of EGFR and AKT signalling.
Apigenin attenuates the atherosclerotic lesions through enhancing selective autophagy/lipophagy and promoting RCT process.
Beclin1-mediated vascular autophagy negatively regulates angiogenesis and secondary neural damage in the thalamus following cerebral cortical infarction.
Study on the molecular mechanism of KPNA2 regulation of myocardial ischemia/delayed reperfusion injury through mitophagy.
The role and mechanism of autophagy-regulated Keap1/Nrf2 pathway in oxidative stress-induced cartilage endplate cell apoptosis.
Discovery and Structural Optimization of Novel 2-Aminopyrimidine Derivatives as Potent and Selective IKKβ Inhibitors for the Treatment of Colorectal Cancer.
6-Shogaol Alleviates Post-Cardiopulmonary Resuscitation Brain Injury in Rats by Regulating the miRNA-26a-5p/DAPK1.
Calcineurin/NFAT1/Smad2 signaling regulates microglial autophagy that contributes to neuroinflammation and cognitive deficit in mice with sepsis-associated encephalopathy.
Cadmium induces autophagy via IRE1 signaling pathway activated by Ca(2 +) in GC-2spd cells.
Cordycepin Ameliorates Kainic Acid-Induced HT22 Cell Neurotoxicity by Activating GPR120-Mediated Mitophagy.
TRIM36 Inhibits the Development of AOM/DSS-Induced Colitis-Associated Colorectal Cancer by Promoting the Ubiquitination and Degradation of GRB7.
Regulatory factor X1 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by transcriptional regulation of BECN1.
LncRNA NEAT1-206 regulates autophagy of human umbilical cord mesenchymal stem cells through the WNT5A/Ca(2+) signaling pathway under senescence stress.
Punicalagin relieves hepatic injury by antioxidation and enhancement of autophagy in diet-induced nonalcoholic steatohepatitis.
Inhibition of esophageal squamous cell carcinoma progression by MIR210HG and activation of the P53 signaling pathway to promote apoptosis and autophagy.
Comprehensive profiling of lipid metabolic reprogramming expands precision medicine for HCC.
Stimulation by exosomes from hypoxia-preconditioned hair follicle mesenchymal stem cells facilitates mitophagy by inhibiting the PI3K/AKT/mTOR signaling pathway to alleviate ulcerative colitis.
Autophagy in Multiple Sclerosis: Phagocytosis and Autophagy of Oligodendrocyte Precursor Cells.
Targeting translocator protein protects against myocardial ischemia/reperfusion injury by alleviating mitochondrial dysfunction.
Autophagy defects at weaning impair complement-dependent synaptic pruning and induce behavior deficits.
Potassium ion channel Kir2.1 negatively regulates protective responses to Mycobacterium bovis BCG.
Oxidative stress induces ferroptosis in tendon stem cells by regulating mitophagy through cGAS-STING pathway.
Avermectin B1 mediates antitumor activity and induces autophagy in osteosarcoma through the AMPK/ULK1 signaling pathway.
Bunyavirus SFTSV NSs utilizes autophagy to escape the antiviral innate immune response.
Piperine induces autophagy of colon cancer cells: Dual modulation of AKT/mTOR signaling pathway and ROS production.
Glutamine maintains the stability of alveolar structure and function after lung transplantation by inhibiting autophagy.
Hesperetin alleviates aflatoxin B1 induced liver toxicity in mice: Modulating lipid peroxidation and ferritin autophagy.
Spexin inhibits excessive autophagy-induced ferroptosis to alleviate doxorubicin-induced cardiotoxicity by upregulating Beclin 1.
Mitochondrial tRNA(Glu) 14693A > G Mutation, an "Enhancer" to the Phenotypic Expression of Leber's Hereditary Optic Neuropathy.
Trehalose Alleviates D-Galactose-Induced Aging-Related Granulosa Cell Death in Ovaries.
Akt/mTOR Pathway Agonist SC79 Inhibits Autophagy and Apoptosis of Oligodendrocyte Precursor Cells Associated with Neonatal White Matter Dysplasia.
Modulation of autophagy affected tumorigenesis induced by the envelope glycoprotein of JSRV.
Paeoniflorin Promotes Ovarian Development in Mice by Activating Mitophagy and Preventing Oxidative Stress.
Inhibition of autophagy induced by tetrandrine promotes the accumulation of reactive oxygen species and sensitizes efficacy of tetrandrine in pancreatic cancer.
Teadenol B as a Component of Microorganism-Fermented Tea Extract Inhibited Breast Cancers by Promoting Autophagy.
Ro 90-7501 suppresses colon cancer progression by inducing immunogenic cell death and promoting RIG-1-mediated autophagy.
IDH1/MDH1 deacetylation promotes NETosis by regulating OPA1 and autophagy.
Potential Effects of Indomethacin on Alleviating Osteoarthritis Progression in Vitro.
Induction of Peroxiredoxin 1 by Hypoxia Promotes Cellular Autophagy and Cell Proliferation in Oral Leukoplakia via HIF-1α/BNIP3 Pathway.
The GBA1 K198E Variant Is Associated with Suppression of Glucocerebrosidase Activity, Autophagy Impairment, Oxidative Stress, Mitochondrial Damage, and Apoptosis in Skin Fibroblasts.
Canagliflozin attenuates post-resuscitation myocardial dysfunction in diabetic rats by inhibiting autophagy through the PI3K/Akt/mTOR pathway.
Rapamycin inhibits B16 melanoma cell viability invitro and invivo by inducing autophagy and inhibiting the mTOR/p70‑S6k pathway.
Ebastine exerts antitumor activity and induces autophagy by activating AMPK/ULK1 signaling in an IPMK-dependent manner in osteosarcoma.
Palmatine treats urticaria by reducing inflammation and increasing autophagy.
Glycyrrhizin arginine salt protects against cisplation-induced acute liver injury by repressing BECN1-mediated ferroptosis.
EGCG identified as an autophagy inducer for rosacea therapy.
Glucosamine-loaded injectable hydrogel promotes autophagy and inhibits apoptosis after cartilage injury.
Intermittent fasting combined with exercise training reduces body mass and alleviates hypothalamic disorders induced by high-fat diet intake.
Combination of Kaempferol and Docetaxel Induces Autophagy in Prostate Cancer Cells In Vitro and In Vivo.
Obatoclax Rescues FUS-ALS Phenotypes in iPSC-Derived Neurons by Inducing Autophagy.
PTP1B knockdown alleviates BMSCs senescence via activating AMPK-mediated mitophagy and promotes osteogenesis in senile osteoporosis.
Knockdown of LIMD2 inhibits the progression of ovarian carcinoma through ERK1/2 pathway.
Plasma metabonomic study on the effect of Para‑hydroxybenzaldehyde intervention in a rat model of transient focal cerebral ischemia.
Crosstalk between autophagy inhibitor and salidroside-induced apoptosis: A novel strategy for autophagy-based treatment of hepatocellular cancer.
TRAF6 triggers Mycobacterium-infected host autophagy through Rab7 ubiquitination.
Electroacupuncture alleviates intrauterine adhesion through regulating autophagy in rats.
Natural exosome-like nanoparticles derived from ancient medicinal insect Periplaneta americana L. as a novel diabetic wound healing accelerator.
A Novel Phenazine Analog, CPUL1, Suppresses Autophagic Flux and Proliferation in Hepatocellular Carcinoma: Insight from Integrated Transcriptomic and Metabolomic Analysis.
Ferredoxin 1 regulates granulosa cell apoptosis and autophagy in polycystic ovary syndrome.
Protective Effect and Mechanism of Kuntai Capsule on Angiotensin II -Induced Hypertension in Ovariectomized Rats.
DANCR promotes glioma cell autophagy and proliferation via the miR‑33b/DLX6/ATG7 axis.
Stomatin-like protein 2 deficiency exacerbates adverse cardiac remodeling.
Hypoxia dissociates HDAC6/FOXO1 complex and aggregates them into nucleus to regulate autophagy and osteogenic differentiation.
Pancreatic Acinar Cells-Derived Sphingosine-1-Phosphate Contributes to Fibrosis of Chronic Pancreatitis via Inducing Autophagy and Activation of Pancreatic Stellate Cells.
SS31 Ameliorates Oxidative Stress via the Restoration of Autophagic Flux to Protect Aged Mice From Hind Limb Ischemia.
Hugan Buzure Induces Autophagy and Apoptosis in Hepatocellular Carcinoma by Inhibiting PI3K/Akt/mTOR Signaling Pathway.
Exosomes Derived From M2 Microglia Cells Attenuates Neuronal Impairment and Mitochondrial Dysfunction in Alzheimer's Disease Through the PINK1/Parkin Pathway.
Coxsackievirus B3 infection induces glycolysis to facilitate viral replication.
Injectable cartilage matrix hydrogel loaded with cartilage endplate stem cells engineered to release exosomes for non-invasive treatment of intervertebral disc degeneration.
Moxidectin induces autophagy arrest in colorectal cancer.
RhFGF21 Protects Epidermal Cells against UVB-Induced Apoptosis through Activating AMPK-Mediated Autophagy.
Acrylamide induces intrinsic apoptosis and inhibits protective autophagy via the ROS mediated mitochondrial dysfunction pathway in U87-MG cells.
PACS-2 Ameliorates Tubular Injury by Facilitating Endoplasmic Reticulum-Mitochondria Contact and Mitophagy in Diabetic Nephropathy.
USP11 regulates autophagy-dependent ferroptosis after spinal cord ischemia-reperfusion injury by deubiquitinating Beclin 1.
Oncostatin M receptor regulates osteoblast differentiation via extracellular signal-regulated kinase/autophagy signaling.
1α,25(OH)(2)D(3)(VD3) promotes Raddeanin A-induced anti-proliferative effects on HeLa cell apoptosis and autophagy through negative regulation of HPV18E6-E7/PD-L1/VDR axis.
Rab21 Protein Is Degraded by Both the Ubiquitin-Proteasome Pathway and the Autophagy-Lysosome Pathway.
Long noncoding RNA ZFAS1 suppresses osteogenic differentiation of bone marrow-derived mesenchymal stem cells by upregulating miR-499-EPHA5 axis.
Dapagliflozin alleviates advanced glycation end product induced podocyte injury through AMPK/mTOR mediated autophagy pathway.
Modulatory effects of curcumin on Singapore grouper iridovirus infection-associated apoptosis and autophagy in vitro.
Chronic rapamycin treatment decreases hepatic IL-6 protein, but increases autophagy markers as a protective effect against the overtraining-induced tissue damage.
Downregulation of FAPP2 gene induces cell autophagy and inhibits PI3K/AKT/mTOR pathway in T-cell acute lymphoblastic leukemia.
HucMSC-derived exosomes delivered BECN1 induces ferroptosis of hepatic stellate cells via regulating the xCT/GPX4 axis.
PPT1 Reduction Contributes to Erianin-Induced Growth Inhibition in Oral Squamous Carcinoma Cells.
Evodiamine Inhibits Gastric Cancer Cell Proliferation via PTEN-Mediated EGF/PI3K Signaling Pathway.
17β-Estradiol promotes LC3B-associated phagocytosis in trained immunity of female mice against sepsis.
Sinensetin Reduces Osteoarthritis Pathology in the Tert-Butyl Hydroperoxide-Treated Chondrocytes and the Destabilization of the Medial Meniscus Model Mice via the AMPK/mTOR Signaling Pathway.
Keratinocyte autophagy enables the activation of keratinocytes and fibroblastsand facilitates wound healing.
Sitagliptin attenuates endothelial dysfunction independent of its blood glucose controlling effect.
Inhibition of autophagy with Chloroquine enhanced apoptosis induced by 5-aminolevulinic acid-photodynamic therapy in secondary hyperparathyroidism primary cells and organoids.
EphA2 inhibits SRA01/04 cells apoptosis by suppressing autophagy via activating PI3K/Akt/mTOR pathway.
Bone marrow-derived mesenchymal stem cells attenuate silica-induced pulmonary fibrosis by inhibiting apoptosis and pyroptosis but not autophagy in rats.
IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation.
Vascular endothelial cell-secreted exosomes facilitate osteoarthritis pathogenesis by promoting chondrocyte apoptosis.
XPA serves as an autophagy and apoptosis inducer by suppressing hepatocellular carcinoma in a PI3K/Akt/mTOR dependent manner.
DpdtC-Induced EMT Inhibition in MGC-803 Cells Was Partly through Ferritinophagy-Mediated ROS/p53 Pathway.
Melatonin Protects Goat Spermatogonial Stem Cells against Oxidative Damage during Cryopreservation by Improving Antioxidant Capacity and Inhibiting Mitochondrial Apoptosis Pathway.
Homoharringtonine Exerts an Antimyeloma Effect by Promoting Excess Parkin-Dependent Mitophagy.
The vicious cycle between ferritinophagy and ROS production triggered EMT inhibition of gastric cancer cells was through p53/AKT/mTor pathway.
Moderate, but Not Excessive, Training Attenuates Autophagy Machinery in Metabolic Tissues.
A mosquito salivary protein promotes flavivirus transmission by activation of autophagy.
The Combination of Fasting, Acute Resistance Exercise, and Protein Ingestion Led to Different Responses of Autophagy Markers in Gastrocnemius and Liver Samples.
Beclin 1, LC3, and p62 expression in paraquat-induced pulmonary fibrosis.
XIAOPI formula promotes breast cancer chemosensitivity via inhibiting CXCL1/HMGB1-mediated autophagy.
Co-delivery of doxorubicin and shRNA of Beclin1 by folate receptor targeted pullulan-based multifunctional nanomicelles for combinational cancer therapy.
Hepatoprotective effect of quercetin via TRAF6/JNK pathway in acute hepatitis.
Liu Y, Cheng Z, Zhang J, Zhang Y, Zhao T, Sun L, Wen G, Han T, Wang J
Autophagy 2026 Mar;22(3):468-483
Autophagy 2026 Mar;22(3):468-483
Complement protein C1q induces endothelial apoptosis through C1qBP regulation of mitochondrial function in lung endothelial cells in systemic sclerosis.
Yi Z, Liu K, Shabin M
Molecular medicine (Cambridge, Mass.) 2026 Mar 5;32(1)
Molecular medicine (Cambridge, Mass.) 2026 Mar 5;32(1)
Hydrogen sulfide promotes proliferation and regeneration of human cerebral microvascular endothelial cells via the sonic hedgehog signaling pathway.
Chen HY, Huang JM, Zheng P, Yang GX, Qin BB, Zang MX, Wang J, Li XB
Open life sciences 2026 Jan;21(1):20251242
Open life sciences 2026 Jan;21(1):20251242
The mechanisms by which hypothalamic neuroinflammation induced by neonatal cerebral ischemia-hypoxia leads to decreased thymic function via the HPA axis.
Liu GG, Shuang LY, Zhang Q, Su GJ, Huang Y, Xue JH, Jiang LX, Huang C, Chen T, Huang ZH, Cao S
Cell & bioscience 2026 Feb 23;16(1)
Cell & bioscience 2026 Feb 23;16(1)
IRF4 Enhances Radiosensitivity of Cervical Cancer by Inhibiting the PI3K/Akt/mTOR Pathway to Regulate Autophagy.
Gao M, Cui Z, Song H, Li Y, Li A, Zheng J, Liu L, Lin X, Fu W, Sun Y
Cancer science 2026 Apr;117(4):958-971
Cancer science 2026 Apr;117(4):958-971
E3 ubiquitin ligase NEDD4 inhibits PEDV infection through ubiquitination and degradation of the viral primase NSP8.
Guo X, Zhao X, He J, Lu Y, Jin S, Ma Z, Li Z, Zheng Z, Li Y, Feng Y, Xu L, Liu X, Zhang J, Wei Z, Zheng H, Xiao S
Journal of virology 2026 Apr 21;100(4):e0215625
Journal of virology 2026 Apr 21;100(4):e0215625
miR-512-3p/RPS6KA2 Axis Regulates Cisplatin Resistance in Ovarian Cancer via Autophagy and Ferroptosis.
Wu J, Chen H, Wang S, Peng L, Hu X, Liu Z
Oncology research 2025;34(1):26
Oncology research 2025;34(1):26
Mitophagy-associated biomarkers and macrophage involvement in pulmonary arterial hypertension: identification and functional implications.
Zhang X, Cheng L, Xie J, Ma X, Gui W, Chen J, Liu K, Ma R
Frontiers in physiology 2025;16:1673181
Frontiers in physiology 2025;16:1673181
Cdk5 mediates impaired autophagy by regulating NGF/Sirt1 axis to cause diabetic islet β cell damage.
Tao Y, Liu Y, Hou S, Tang L, Wei K, Zheng S, Zhang Y, Wang Z, Liu S
Frontiers in cell and developmental biology 2025;13:1613081
Frontiers in cell and developmental biology 2025;13:1613081
Comparative hepatoprotective effects of AMK and PAMK via Nrf2 signaling in broiler breeders.
Lu B, He J, Pan S, Wei J, Li B, Cao N, Huang Y, Tian Y, Cheong N, Chen Y, Xu D, Li W
Frontiers in veterinary science 2025;12:1672417
Frontiers in veterinary science 2025;12:1672417
Rhizoma Panacis Majoris ameliorates rheumatoid arthritis by restoring apoptosis and autophagy dysregulation through reducing HMGB1 expression.
Pang X, Song R, Li Z, Shi X, Zhang Z, Liu Y, Xu H, Song Z, Zhou R, Tang Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156943
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156943
Luteolin alleviates right ventricular hypertrophy in high altitude pulmonary hypertension rats by regulating PI3K/AKT/mTOR signalling pathway.
Hou B, Su S, Ji L, Huayu M, Yang N, Yang Z, Li Z, Lu D
European journal of pharmacology 2025 Sep 15;1003:177898
European journal of pharmacology 2025 Sep 15;1003:177898
Cdk5 Contributes to Diabetic Islet β Cell and Kidney Injury by Impairing Autophagy.
Tao Y, Wang L, Liu Y, Wei Y, Wang R, Sha S, Zheng S, Hou S, Liu S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 31;39(20):e71134
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 31;39(20):e71134
Role of neuroglia cell-derived microvesicles in cobalt chloride-induced mitochondrial autophagy in neurons.
Li H, Zheng F, Shao W, Yu G, Hu H, Guo Z, Wu S, Tang Y, Li H
Toxicology 2025 Nov;517:154214
Toxicology 2025 Nov;517:154214
TBRG4 regulates ubiquitination of Beclin1 and participates in autophagy pathway to inhibit intervertebral disc degeneration.
Cui X, Zhang F, Cui D, Zhang W, Wu H, Chen X, Yu H
The spine journal : official journal of the North American Spine Society 2025 Nov;25(11):2569-2584
The spine journal : official journal of the North American Spine Society 2025 Nov;25(11):2569-2584
S-palmitoylation coordinates the trafficking of ATG9A to mediate autophagy initiation.
Xia F, Li W, Wang W, Liu J, Li X, Cai J, Shan H, Cai Z, Cui J
Autophagy 2025 Nov;21(11):2422-2442
Autophagy 2025 Nov;21(11):2422-2442
Biliverdin alleviates cerebral ischemia-reperfusion injury by inhibiting autophagy via the lncRNA TUG1 /miR-204-5p/P4HB axis.
Zhou G, Bai W, Jiang H, Li J, Huangfu J, Li X, Shu S, Liu J, Shao J
Life sciences 2025 Nov 1;380:123967
Life sciences 2025 Nov 1;380:123967
Therapeutic Potential of MCC950 in Restoring Autophagy and Cognitive Function in STZ-Induced Rat Model of Alzheimer's Disease.
Naeem A, Waseem A, Khan MA, Robertson AA, Raza SS
Molecular neurobiology 2025 May;62(5):6041-6058
Molecular neurobiology 2025 May;62(5):6041-6058
Activation of sigma 1 receptor attenuates doxorubicin-induced cardiotoxicity by alleviating oxidative stress, mitochondria dysfunction, ER stress-related apoptosis, and autophagy impairment.
Al-Maamari A, Sultan M, Wu S, Zhang T, Wang C, Han B, Duan Y, Ding SS, Chen N, Zhang H, Sun F, Chen X, Yu D, Su S
International journal of biological macromolecules 2025 May;310(Pt 4):143549
International journal of biological macromolecules 2025 May;310(Pt 4):143549
Dendrimer nanocarriers for targeted co-delivery of MiR-146b-3p and 5-ALA to synergistic photodynamic therapy in secondary hyperparathyroidism.
Wen Y, Zou Z, Li Y, Zhang D, Liu Z, Liu H, Li X, Wu W, Zeng L, Zou Q, Yi W
International journal of biological macromolecules 2025 May;310(Pt 1):143307
International journal of biological macromolecules 2025 May;310(Pt 1):143307
Regulation of N-degron recognin-mediated autophagy by the SARS-CoV-2 PLpro ubiquitin deconjugase.
Ayala-Torres C, Liu J, Dantuma NP, Masucci MG
Autophagy 2025 May;21(5):1019-1038
Autophagy 2025 May;21(5):1019-1038
Compound probiotics alleviate hyperuricemia-induced renal injury via restoring gut microbiota and metabolism.
Liu P, Hu P, Jin M, Sun W, Wu J, Tang Y, Shi D, Xie T, Tong Y, Huang L, Zhang D, Zheng H, Xu X, He H
BMC microbiology 2025 May 8;25(1):280
BMC microbiology 2025 May 8;25(1):280
Autophagy modulation by hADSCs and green light therapy alleviates inflammation and promotes functional recovery after spinal cord injury.
Chen J, He Q, Xie H, Gu B, Zhou L, Jiang D, Xie H, Liang L, Zhou Z, Zhang H
Stem cell research & therapy 2025 May 22;16(1):256
Stem cell research & therapy 2025 May 22;16(1):256
Overexpression of Tgm2 in Chinese Hamster Ovary Cells Enhances Recombinant Monoclonal Antibody Expression and Promotes Cell Proliferation through Reduction of Apoptosis.
Zhang HJ, Zhao Q, Zhang M, Yang LL, Abiti J, Han MM, Gao YP, Lu JT, Wang JN, Ji MY, Zhang X, Wang W, Qiu LL, Wang XY, Wang TY, Jia YL
ACS synthetic biology 2025 May 16;14(5):1802-1812
ACS synthetic biology 2025 May 16;14(5):1802-1812
Edaravone inhibits neuronal ferroptosis and alleviates acute Central nervous system injury induced by diquat via enhancement of METTL14-mediated m6A methylation of Aldh1l1.
Wu L, Luo Z, Luo F, Huang T, Cen Y, Rao G, Zhao Z, Ou R, Zhou M
Free radical research 2025 Mar;59(3):274-288
Free radical research 2025 Mar;59(3):274-288
Runchangningshen paste activates NLRP6 inflammasome-mediated autophagy to stimulate colonic mucin-2 secretion and modulates mucosal microbiota in functional constipation.
Liu XJ, Ye-Er-Tai YL, Jia YB, Wu CH, Wang XX, Yang KM, Yao X, Ling JH
World journal of gastroenterology 2025 Mar 7;31(9):102256
World journal of gastroenterology 2025 Mar 7;31(9):102256
Differences in Starvation-Induced Autophagy Response and miRNA Expression Between Rat Mammary Epithelial and Cancer Cells: Uncovering the Role of miR-218-5p.
Gotowiec M, Smoliński A, Marcinkowska K, Pascal W, Włodarski PK
Cancers 2025 Jul 23;17(15)
Cancers 2025 Jul 23;17(15)
Activated mTORC1 signaling pathway aggravates cisplatin induced oxidative damage by inhibiting autophagy in mouse cochlear hair cells.
Xu NN, Wen YC, Pan J, Shu F, Qu JX, Qi XF, Tang J
Neuropharmacology 2025 Jul 1;272:110433
Neuropharmacology 2025 Jul 1;272:110433
TMEM106B knockdown exhibits a neuroprotective effect in Parkinson's disease models via regulating autophagy-lysosome pathway.
Liu Y, Qin K, Dou K, Ren J, Hou B, Xie A
Biochimica et biophysica acta. Molecular basis of disease 2025 Jan;1871(1):167553
Biochimica et biophysica acta. Molecular basis of disease 2025 Jan;1871(1):167553
Isoliquiritin targeting m5C RNA methylation improves mitophagy in doxorubicin-induced myocardial cardiotoxicity.
Fu J, Cheng L, Zhang J, Sun R, Yu M, Wu M, Li S, Cui X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156293
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156293
Regulation of pancreatic cancer cells by suppressing KIN17 through the PI3K/AKT/mTOR signaling pathway.
Li Q, Yang Y, Lin X, Chu LT, Chen H, Chen L, Tang J, Zeng T
Oncology reports 2025 Feb;53(2)
Oncology reports 2025 Feb;53(2)
Lysosomal cation channel TRPML1 suppression sensitizes acute myeloid leukemia cells to chemotherapeutics by inhibiting autophagy.
Dai M, Lin B, Li H, Wang Y, Wu M, Wei Y, Zeng W, Qu L, Cang C, Wang X
Molecular and cellular biochemistry 2025 Feb;480(2):1209-1224
Molecular and cellular biochemistry 2025 Feb;480(2):1209-1224
N(6)-Methyladenosine modification mediated by METTL3 promotes DNA-PKcs expression to induce anlotinib resistance in osteosarcoma.
Zhang Y, Shen G, Zhang D, Meng T, Lv Z, Chen L, Li J, Li K
Clinical and translational medicine 2025 Feb;15(2):e70228
Clinical and translational medicine 2025 Feb;15(2):e70228
THSWD upregulates the LTF/AMPK/mTOR/Becn1 axis and promotes lysosomal autophagy in hepatocellular carcinoma cells by regulating gut flora and metabolic reprogramming.
Zhu Z, Zuo S, Zhu Z, Wang C, Du Y, Chen F
International immunopharmacology 2025 Feb 20;148:114091
International immunopharmacology 2025 Feb 20;148:114091
Metformin inhibits the growth of SCLC cells by inducing autophagy and apoptosis via the suppression of EGFR and AKT signalling.
Xia H, Tai XJ, Cheng W, Wu Y, He D, Wang LF, Liu H, Zhang SY, Sun YT, Liu HZ, Liu DD, Zhao HZ, Ji FY, Li XH
Scientific reports 2025 Feb 19;15(1):6081
Scientific reports 2025 Feb 19;15(1):6081
Apigenin attenuates the atherosclerotic lesions through enhancing selective autophagy/lipophagy and promoting RCT process.
Hu Z, Li Y, Yao N, Gan H, Zeng Q, Huang X, Huang D, Cai D, Chen Y
Pharmaceutical biology 2025 Dec;63(1):387-401
Pharmaceutical biology 2025 Dec;63(1):387-401
Beclin1-mediated vascular autophagy negatively regulates angiogenesis and secondary neural damage in the thalamus following cerebral cortical infarction.
Liu M, Chen Y, Fan X, Gu J, Xing S
IBRO neuroscience reports 2025 Dec;19:290-299
IBRO neuroscience reports 2025 Dec;19:290-299
Study on the molecular mechanism of KPNA2 regulation of myocardial ischemia/delayed reperfusion injury through mitophagy.
Tao E, Tao Z, Wang F, Bai S, Lai S, Li X, Bai Y, Peng C, Wan L
Cellular signalling 2025 Dec;136:112157
Cellular signalling 2025 Dec;136:112157
The role and mechanism of autophagy-regulated Keap1/Nrf2 pathway in oxidative stress-induced cartilage endplate cell apoptosis.
Wang W, Deng K, Chen W, Du L, Chen J
Cellular signalling 2025 Dec;136:112153
Cellular signalling 2025 Dec;136:112153
Discovery and Structural Optimization of Novel 2-Aminopyrimidine Derivatives as Potent and Selective IKKβ Inhibitors for the Treatment of Colorectal Cancer.
Wang K, Hu Y, Liu P, Shi C, Yuan J, Zang Y, He Y, Li B, Zheng J, Tong J, Chen C, Huang L, Zhang F, Zheng X, Liu Z
Journal of medicinal chemistry 2025 Dec 11;68(23):24986-25010
Journal of medicinal chemistry 2025 Dec 11;68(23):24986-25010
6-Shogaol Alleviates Post-Cardiopulmonary Resuscitation Brain Injury in Rats by Regulating the miRNA-26a-5p/DAPK1.
Rao O, Hu J, Zhu N, Li Y, Xie S, Tao J, Li Y, Liu Y
Neurochemical research 2025 Dec 1;51(1):8
Neurochemical research 2025 Dec 1;51(1):8
Calcineurin/NFAT1/Smad2 signaling regulates microglial autophagy that contributes to neuroinflammation and cognitive deficit in mice with sepsis-associated encephalopathy.
Ding R, Hu N, Zhang X, Jiang F, Feng Y, Li Z, Tang S, Li W, Shi H, Si Y
Free radical biology & medicine 2025 Dec 1;240:15-28
Free radical biology & medicine 2025 Dec 1;240:15-28
Cadmium induces autophagy via IRE1 signaling pathway activated by Ca(2 +) in GC-2spd cells.
Han Y, Dai J, Cheng J, He Y, Zhao C, Li R, Zhang Y, Zhang L, Zhou T, Shi Y
Reproductive toxicology (Elmsford, N.Y.) 2025 Aug;135:108950
Reproductive toxicology (Elmsford, N.Y.) 2025 Aug;135:108950
Cordycepin Ameliorates Kainic Acid-Induced HT22 Cell Neurotoxicity by Activating GPR120-Mediated Mitophagy.
San Y, Wang M
Developmental neurobiology 2025 Apr;85(2):e22961
Developmental neurobiology 2025 Apr;85(2):e22961
TRIM36 Inhibits the Development of AOM/DSS-Induced Colitis-Associated Colorectal Cancer by Promoting the Ubiquitination and Degradation of GRB7.
Wu J, Yang Z, Chen X, Hou S, Li N, Chang Y, Yin J, Xu J
Molecular carcinogenesis 2025 Apr;64(4):668-679
Molecular carcinogenesis 2025 Apr;64(4):668-679
Regulatory factor X1 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by transcriptional regulation of BECN1.
Yang Z, Yuan Y, Niu Y, Zuo D, Liu W, Li K, Shi Y, Qiu Z, Li K, Lin Z, Zhong C, Huang Z, He W, Guan X, Yuan Y, Zeng W, Qiu J, Li B
Cellular oncology (Dordrecht, Netherlands) 2025 Apr;48(2):505-522
Cellular oncology (Dordrecht, Netherlands) 2025 Apr;48(2):505-522
LncRNA NEAT1-206 regulates autophagy of human umbilical cord mesenchymal stem cells through the WNT5A/Ca(2+) signaling pathway under senescence stress.
Wang W, Wang Y, Duan C, Tian W, Gao L
Non-coding RNA research 2025 Apr;11:234-248
Non-coding RNA research 2025 Apr;11:234-248
Punicalagin relieves hepatic injury by antioxidation and enhancement of autophagy in diet-induced nonalcoholic steatohepatitis.
Ma L, Sun H, Xiang N, Xu Q
Scientific reports 2025 Apr 25;15(1):14516
Scientific reports 2025 Apr 25;15(1):14516
Inhibition of esophageal squamous cell carcinoma progression by MIR210HG and activation of the P53 signaling pathway to promote apoptosis and autophagy.
Wang J, Zhang Z, Song L, Liu X, He X
European journal of medical research 2025 Apr 11;30(1):269
European journal of medical research 2025 Apr 11;30(1):269
Comprehensive profiling of lipid metabolic reprogramming expands precision medicine for HCC.
Liu Q, Zhang X, Qi J, Tian X, Dovjak E, Zhang J, Du H, Zhang N, Zhao J, Zhang Y, Wang L, Wei Y, Liu C, Qian R, Xiang L, Li W, Xiu P, Ma C, Yu Y, Jiang S
Hepatology (Baltimore, Md.) 2025 Apr 1;81(4):1164-1180
Hepatology (Baltimore, Md.) 2025 Apr 1;81(4):1164-1180
Stimulation by exosomes from hypoxia-preconditioned hair follicle mesenchymal stem cells facilitates mitophagy by inhibiting the PI3K/AKT/mTOR signaling pathway to alleviate ulcerative colitis.
Li N, Zhao L, Geng X, Liu J, Zhang X, Hu Y, Qi J, Chen H, Qiu J, Zhang X, Jin S
Theranostics 2024;14(11):4278-4296
Theranostics 2024;14(11):4278-4296
Autophagy in Multiple Sclerosis: Phagocytosis and Autophagy of Oligodendrocyte Precursor Cells.
Wang JQ, Li Q, He JY, Zhou F, Huang ZH, Wang LB, Zhang Y, Li X
Molecular neurobiology 2024 Sep;61(9):6920-6933
Molecular neurobiology 2024 Sep;61(9):6920-6933
Targeting translocator protein protects against myocardial ischemia/reperfusion injury by alleviating mitochondrial dysfunction.
Wen C, Jiang Y, Chen W, Xu Y, Chen G, Zhou Q, Liu Q, Jiang H, Liu Y, Cao X, Yao Y, Zhang R, Qiu Z, Liu S
Experimental and therapeutic medicine 2024 Sep;28(3):349
Experimental and therapeutic medicine 2024 Sep;28(3):349
Autophagy defects at weaning impair complement-dependent synaptic pruning and induce behavior deficits.
Su X, Wang G, Liu S, Li J, Shao M, Yang Y, Song M, Han Y, Li W, Lv L
Journal of neuroinflammation 2024 Sep 27;21(1):239
Journal of neuroinflammation 2024 Sep 27;21(1):239
Potassium ion channel Kir2.1 negatively regulates protective responses to Mycobacterium bovis BCG.
Sinha V, Singh A, Singh A, Saraswati SSK, Rana AK, Kalra K, Natarajan K
Journal of leukocyte biology 2024 Sep 2;116(3):644-656
Journal of leukocyte biology 2024 Sep 2;116(3):644-656
Oxidative stress induces ferroptosis in tendon stem cells by regulating mitophagy through cGAS-STING pathway.
Gao Y, Sun W, Wang J, Zhao D, Tian H, Qiu Y, Ji S, Wang S, Fu Q, Zhang F, Zhang Z, Wang F, Shao J, Zheng S, Meng J
International immunopharmacology 2024 Sep 10;138:112652
International immunopharmacology 2024 Sep 10;138:112652
Avermectin B1 mediates antitumor activity and induces autophagy in osteosarcoma through the AMPK/ULK1 signaling pathway.
Fei X, Li Z, Pan Z, Liang Y, Tan C, Cheng D, Yang Q
Cancer chemotherapy and pharmacology 2024 Oct;94(4):599-613
Cancer chemotherapy and pharmacology 2024 Oct;94(4):599-613
Bunyavirus SFTSV NSs utilizes autophagy to escape the antiviral innate immune response.
Li ZM, Duan SH, Yu TM, Li B, Zhang WK, Zhou CM, Yu XJ
Autophagy 2024 Oct;20(10):2133-2145
Autophagy 2024 Oct;20(10):2133-2145
Piperine induces autophagy of colon cancer cells: Dual modulation of AKT/mTOR signaling pathway and ROS production.
Xia J, Guo P, Yang J, Zhang T, Pan K, Wei H
Biochemical and biophysical research communications 2024 Oct 8;728:150340
Biochemical and biophysical research communications 2024 Oct 8;728:150340
Glutamine maintains the stability of alveolar structure and function after lung transplantation by inhibiting autophagy.
Tan J, Wang Z, Huang Z, Huang A, Zhang H, Huang L, Song N, Xin G, Jiang K, Sun X
Biochemical and biophysical research communications 2024 Oct 1;727:150308
Biochemical and biophysical research communications 2024 Oct 1;727:150308
Hesperetin alleviates aflatoxin B1 induced liver toxicity in mice: Modulating lipid peroxidation and ferritin autophagy.
Song C, Wang Z, Cao J, Dong Y, Chen Y
Ecotoxicology and environmental safety 2024 Oct 1;284:116854
Ecotoxicology and environmental safety 2024 Oct 1;284:116854
Spexin inhibits excessive autophagy-induced ferroptosis to alleviate doxorubicin-induced cardiotoxicity by upregulating Beclin 1.
Ou W, Liu H, Chen C, Yang C, Zhao X, Zhang Y, Zhang Z, Huang S, Mo H, Lu W, Wang X, Chen A, Yan J, Song X
British journal of pharmacology 2024 Nov;181(21):4195-4213
British journal of pharmacology 2024 Nov;181(21):4195-4213
Mitochondrial tRNA(Glu) 14693A > G Mutation, an "Enhancer" to the Phenotypic Expression of Leber's Hereditary Optic Neuropathy.
Jin L, Gan D, He W, Wu N, Xiang S, Wei Y, Eriani G, Ji Y, Guan MX, Wang M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(41):e2401856
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(41):e2401856
Trehalose Alleviates D-Galactose-Induced Aging-Related Granulosa Cell Death in Ovaries.
Xi H, Chen X, Liang K, Wang X, Jiang F, Li Y, Niu D
International journal of molecular sciences 2024 Nov 25;25(23)
International journal of molecular sciences 2024 Nov 25;25(23)
Akt/mTOR Pathway Agonist SC79 Inhibits Autophagy and Apoptosis of Oligodendrocyte Precursor Cells Associated with Neonatal White Matter Dysplasia.
Li Z, Zhang F, Huang L, Deng J, Pan Y, Xu T, Liu J, Gao N, Duan R, Shao C, Wu C, Wang M, Lu L
Neurochemical research 2024 Mar;49(3):670-683
Neurochemical research 2024 Mar;49(3):670-683
Modulation of autophagy affected tumorigenesis induced by the envelope glycoprotein of JSRV.
Zhang L, Yang H, Duan X, Li H, Xu S, Chen H, Wang J, Wang Y, Liu S
Virology 2024 Jun;594:110059
Virology 2024 Jun;594:110059
Paeoniflorin Promotes Ovarian Development in Mice by Activating Mitophagy and Preventing Oxidative Stress.
Xi H, Wang Z, Li M, Duan X, Li Y
International journal of molecular sciences 2024 Jul 30;25(15)
International journal of molecular sciences 2024 Jul 30;25(15)
Inhibition of autophagy induced by tetrandrine promotes the accumulation of reactive oxygen species and sensitizes efficacy of tetrandrine in pancreatic cancer.
Wang Y, Xu T, Wang H, Xia G, Huang X
Cancer cell international 2024 Jul 10;24(1):241
Cancer cell international 2024 Jul 10;24(1):241
Teadenol B as a Component of Microorganism-Fermented Tea Extract Inhibited Breast Cancers by Promoting Autophagy.
Zhao Y, Ding ZG, Yan YJ, Yang R, Qi MM, Pan SK, Xie JL, Sun YH, Xiang J
Molecules (Basel, Switzerland) 2024 Feb 16;29(4)
Molecules (Basel, Switzerland) 2024 Feb 16;29(4)
Ro 90-7501 suppresses colon cancer progression by inducing immunogenic cell death and promoting RIG-1-mediated autophagy.
Zhao X, Zhang Z, Wang J, Feng S, Jiang L, Chen L, Lei K, Wang T
International immunopharmacology 2024 Dec 25;143(Pt 3):113631
International immunopharmacology 2024 Dec 25;143(Pt 3):113631
IDH1/MDH1 deacetylation promotes NETosis by regulating OPA1 and autophagy.
Wang Y, Guo J, Zhang D, Shi C, Zhang X, Gong Z
International immunopharmacology 2024 Dec 25;143(Pt 1):113270
International immunopharmacology 2024 Dec 25;143(Pt 1):113270
Potential Effects of Indomethacin on Alleviating Osteoarthritis Progression in Vitro.
Zhao X, Wang T, Li N, Meng Z, Wang W, Wang B, Song D
Journal of musculoskeletal & neuronal interactions 2024 Dec 1;24(4):409-419
Journal of musculoskeletal & neuronal interactions 2024 Dec 1;24(4):409-419
Induction of Peroxiredoxin 1 by Hypoxia Promotes Cellular Autophagy and Cell Proliferation in Oral Leukoplakia via HIF-1α/BNIP3 Pathway.
Li J, Li W, Li L, Wang W, Zhang M, Tang X
Journal of molecular histology 2024 Aug;55(4):403-413
Journal of molecular histology 2024 Aug;55(4):403-413
The GBA1 K198E Variant Is Associated with Suppression of Glucocerebrosidase Activity, Autophagy Impairment, Oxidative Stress, Mitochondrial Damage, and Apoptosis in Skin Fibroblasts.
Perez-Abshana LP, Mendivil-Perez M, Jimenez-Del-Rio M, Velez-Pardo C
International journal of molecular sciences 2024 Aug 25;25(17)
International journal of molecular sciences 2024 Aug 25;25(17)
Canagliflozin attenuates post-resuscitation myocardial dysfunction in diabetic rats by inhibiting autophagy through the PI3K/Akt/mTOR pathway.
Huang Q, Shi W, Wang M, Zhang L, Zhang Y, Hu Y, Pan S, Ling B, Zhu H, Xiao W, Hua T, Yang M
iScience 2024 Aug 16;27(8):110429
iScience 2024 Aug 16;27(8):110429
Rapamycin inhibits B16 melanoma cell viability invitro and invivo by inducing autophagy and inhibiting the mTOR/p70‑S6k pathway.
Wang P, Zhang H, Guo K, Liu C, Chen S, Pu B, Chen S, Feng T, Jiao H, Gao C
Oncology letters 2024 Apr;27(4):140
Oncology letters 2024 Apr;27(4):140
Ebastine exerts antitumor activity and induces autophagy by activating AMPK/ULK1 signaling in an IPMK-dependent manner in osteosarcoma.
Pan Z, Li SJ, Guo H, Li ZH, Fei X, Chang SM, Yang QC, Cheng DD
International journal of biological sciences 2023;19(2):537-551
International journal of biological sciences 2023;19(2):537-551
Palmatine treats urticaria by reducing inflammation and increasing autophagy.
Xiao T, Yu X, Yang L, Duan X
Frontiers in immunology 2023;14:1268467
Frontiers in immunology 2023;14:1268467
Glycyrrhizin arginine salt protects against cisplation-induced acute liver injury by repressing BECN1-mediated ferroptosis.
Guo J, Yin J, Liu P, Zhang X, Wei J, Wang M, Xiao Y, Zhen Y, Lin Y, Li J
Frontiers in pharmacology 2023;14:1219486
Frontiers in pharmacology 2023;14:1219486
EGCG identified as an autophagy inducer for rosacea therapy.
Zhou L, Zhong Y, Wang Y, Deng Z, Huang Y, Wang Q, Xie H, Zhang Y, Li J
Frontiers in pharmacology 2023;14:1092473
Frontiers in pharmacology 2023;14:1092473
Glucosamine-loaded injectable hydrogel promotes autophagy and inhibits apoptosis after cartilage injury.
Chang Y, Wang Y, Liu J, Chen X, Ma X, Hu Y, Tian H, Wang X, Mu C
Heliyon 2023 Sep;9(9):e19879
Heliyon 2023 Sep;9(9):e19879
Intermittent fasting combined with exercise training reduces body mass and alleviates hypothalamic disorders induced by high-fat diet intake.
Oliveira LDC, Morais GP, de Oliveira FP, Mata MM, Veras ASC, da Rocha AL, Elias LLK, Teixeira GR, de Moraes C, Cintra DE, Ropelle ER, de Moura LP, Pauli JR, de Freitas EC, Rorato R, da Silva ASR
The Journal of nutritional biochemistry 2023 Sep;119:109372
The Journal of nutritional biochemistry 2023 Sep;119:109372
Combination of Kaempferol and Docetaxel Induces Autophagy in Prostate Cancer Cells In Vitro and In Vivo.
Zhou Q, Fang G, Pang Y, Wang X
International journal of molecular sciences 2023 Sep 25;24(19)
International journal of molecular sciences 2023 Sep 25;24(19)
Obatoclax Rescues FUS-ALS Phenotypes in iPSC-Derived Neurons by Inducing Autophagy.
Castillo Bautista CM, Eismann K, Gentzel M, Pelucchi S, Mertens J, Walters HE, Yun MH, Sterneckert J
Cells 2023 Sep 11;12(18)
Cells 2023 Sep 11;12(18)
PTP1B knockdown alleviates BMSCs senescence via activating AMPK-mediated mitophagy and promotes osteogenesis in senile osteoporosis.
Yang Q, Zou Y, Wei X, Ye P, Wu Y, Ai H, Zhang Z, Tan J, Zhou J, Yang Y, Dai Q, Dou C, Luo F
Biochimica et biophysica acta. Molecular basis of disease 2023 Oct;1869(7):166795
Biochimica et biophysica acta. Molecular basis of disease 2023 Oct;1869(7):166795
Knockdown of LIMD2 inhibits the progression of ovarian carcinoma through ERK1/2 pathway.
Hu H, Wang Y, Dong Y, Wang L, Chen Y, Zhou Y, Sun L
Molecular biology reports 2023 Nov;50(11):8985-8993
Molecular biology reports 2023 Nov;50(11):8985-8993
Plasma metabonomic study on the effect of Para‑hydroxybenzaldehyde intervention in a rat model of transient focal cerebral ischemia.
Yu X, Luo Y, Yang L, Duan X
Molecular medicine reports 2023 Nov;28(5)
Molecular medicine reports 2023 Nov;28(5)
Crosstalk between autophagy inhibitor and salidroside-induced apoptosis: A novel strategy for autophagy-based treatment of hepatocellular cancer.
Jiang B, Cui Y, Ma X, Zhang Y, Feng X, Yang T, Feng L, Guo W, Li Y, Wang T, Guo H, Li H, Duan Y, Su H
International immunopharmacology 2023 Nov;124(Pt B):111040
International immunopharmacology 2023 Nov;124(Pt B):111040
TRAF6 triggers Mycobacterium-infected host autophagy through Rab7 ubiquitination.
Ma Q, Yu J, Liu L, Ma X, Zhang J, Zhang J, Wang X, Deng G, Wu X
Cell death discovery 2023 Nov 28;9(1):427
Cell death discovery 2023 Nov 28;9(1):427
Electroacupuncture alleviates intrauterine adhesion through regulating autophagy in rats.
Liu J, Zhu Q, Pan Y, Hao S, Wang Z, Cui C, Li J, Huang Y, Xia L, Xu T, Cheng J, Shen J, Xia Y
Molecular human reproduction 2023 Nov 1;29(11)
Molecular human reproduction 2023 Nov 1;29(11)
Natural exosome-like nanoparticles derived from ancient medicinal insect Periplaneta americana L. as a novel diabetic wound healing accelerator.
Liao Q, Su L, Pang L, Li J, Li H, Li J, Liu Y, Zhang J
Journal of nanobiotechnology 2023 May 26;21(1):169
Journal of nanobiotechnology 2023 May 26;21(1):169
A Novel Phenazine Analog, CPUL1, Suppresses Autophagic Flux and Proliferation in Hepatocellular Carcinoma: Insight from Integrated Transcriptomic and Metabolomic Analysis.
Chen J, Feng D, Lu Y, Zhang Y, Jiang H, Yuan M, Xu Y, Zou J, Zhu Y, Zhang J, Ge C, Wang Y
Cancers 2023 Mar 5;15(5)
Cancers 2023 Mar 5;15(5)
Ferredoxin 1 regulates granulosa cell apoptosis and autophagy in polycystic ovary syndrome.
Xing J, Qiao G, Luo X, Liu S, Chen S, Ye G, Zhang C, Yi J
Clinical science (London, England : 1979) 2023 Mar 31;137(6):453-468
Clinical science (London, England : 1979) 2023 Mar 31;137(6):453-468
Protective Effect and Mechanism of Kuntai Capsule on Angiotensin II -Induced Hypertension in Ovariectomized Rats.
Ge XF, Li SS, Liu YH, Lu MQ, Su HN, Yang X, Sun XW
Chinese journal of integrative medicine 2023 Jun;29(6):526-533
Chinese journal of integrative medicine 2023 Jun;29(6):526-533
DANCR promotes glioma cell autophagy and proliferation via the miR‑33b/DLX6/ATG7 axis.
Yu W, Ma L, Li X
Oncology reports 2023 Feb;49(2)
Oncology reports 2023 Feb;49(2)
Stomatin-like protein 2 deficiency exacerbates adverse cardiac remodeling.
Hu Y, Jiang H, Xu Y, Chen G, Fan R, Zhou Y, Liu Y, Yao Y, Liu R, Chen W, Zhang K, Chen X, Wang R, Qiu Z
Cell death discovery 2023 Feb 14;9(1):63
Cell death discovery 2023 Feb 14;9(1):63
Hypoxia dissociates HDAC6/FOXO1 complex and aggregates them into nucleus to regulate autophagy and osteogenic differentiation.
Xu Y, Wang Y, Xiao H, Li Y
Journal of periodontal research 2023 Dec;58(6):1248-1260
Journal of periodontal research 2023 Dec;58(6):1248-1260
Pancreatic Acinar Cells-Derived Sphingosine-1-Phosphate Contributes to Fibrosis of Chronic Pancreatitis via Inducing Autophagy and Activation of Pancreatic Stellate Cells.
Wang D, Han S, Lv G, Hu Y, Zhuo W, Zeng Z, Tang J, Huang Y, Wang F, Wang J, Zhao Y, Zhao G
Gastroenterology 2023 Dec;165(6):1488-1504.e20
Gastroenterology 2023 Dec;165(6):1488-1504.e20
SS31 Ameliorates Oxidative Stress via the Restoration of Autophagic Flux to Protect Aged Mice From Hind Limb Ischemia.
Yang Q, Li C, Chen Q
Frontiers in cardiovascular medicine 2022;9:789331
Frontiers in cardiovascular medicine 2022;9:789331
Hugan Buzure Induces Autophagy and Apoptosis in Hepatocellular Carcinoma by Inhibiting PI3K/Akt/mTOR Signaling Pathway.
Meng X, Li M, Qiao M, Li X, Yang J, Hu J
Evidence-based complementary and alternative medicine : eCAM 2022;2022:1618491
Evidence-based complementary and alternative medicine : eCAM 2022;2022:1618491
Exosomes Derived From M2 Microglia Cells Attenuates Neuronal Impairment and Mitochondrial Dysfunction in Alzheimer's Disease Through the PINK1/Parkin Pathway.
Li N, Shu J, Yang X, Wei W, Yan A
Frontiers in cellular neuroscience 2022;16:874102
Frontiers in cellular neuroscience 2022;16:874102
Coxsackievirus B3 infection induces glycolysis to facilitate viral replication.
Qian Y, Yang Y, Qing W, Li C, Kong M, Kang Z, Zuo Y, Wu J, Yu M, Yang Z
Frontiers in microbiology 2022;13:962766
Frontiers in microbiology 2022;13:962766
Injectable cartilage matrix hydrogel loaded with cartilage endplate stem cells engineered to release exosomes for non-invasive treatment of intervertebral disc degeneration.
Luo L, Gong J, Wang Z, Liu Y, Cao J, Qin J, Zuo R, Zhang H, Wang S, Zhao P, Yang D, Zhang M, Wang Y, Zhang J, Zhou Y, Li C, Ni B, Tian Z, Liu M
Bioactive materials 2022 Sep;15:29-43
Bioactive materials 2022 Sep;15:29-43
Moxidectin induces autophagy arrest in colorectal cancer.
Mao Y, Xie H, Shu D, Cheng L, Lan J, Pan K
Medical oncology (Northwood, London, England) 2022 Sep 29;39(12):211
Medical oncology (Northwood, London, England) 2022 Sep 29;39(12):211
RhFGF21 Protects Epidermal Cells against UVB-Induced Apoptosis through Activating AMPK-Mediated Autophagy.
Zhao Y, Lin J, Li J, Bwalya C, Xu Y, Niu Y, Zhang Y, Wu J, Xu Y, Chen J, Ye S, Lin L
International journal of molecular sciences 2022 Oct 18;23(20)
International journal of molecular sciences 2022 Oct 18;23(20)
Acrylamide induces intrinsic apoptosis and inhibits protective autophagy via the ROS mediated mitochondrial dysfunction pathway in U87-MG cells.
Deng L, Zhao M, Cui Y, Xia Q, Jiang L, Yin H, Zhao L
Drug and chemical toxicology 2022 Nov;45(6):2601-2612
Drug and chemical toxicology 2022 Nov;45(6):2601-2612
PACS-2 Ameliorates Tubular Injury by Facilitating Endoplasmic Reticulum-Mitochondria Contact and Mitophagy in Diabetic Nephropathy.
Li C, Li L, Yang M, Yang J, Zhao C, Han Y, Zhao H, Jiang N, Wei L, Xiao Y, Liu Y, Xiong X, Xi Y, Luo S, Deng F, Chen W, Yuan S, Zhu X, Xiao L, Sun L
Diabetes 2022 May 1;71(5):1034-1050
Diabetes 2022 May 1;71(5):1034-1050
USP11 regulates autophagy-dependent ferroptosis after spinal cord ischemia-reperfusion injury by deubiquitinating Beclin 1.
Rong Y, Fan J, Ji C, Wang Z, Ge X, Wang J, Ye W, Yin G, Cai W, Liu W
Cell death and differentiation 2022 Jun;29(6):1164-1175
Cell death and differentiation 2022 Jun;29(6):1164-1175
Oncostatin M receptor regulates osteoblast differentiation via extracellular signal-regulated kinase/autophagy signaling.
Zhou J, Yang J, Dong Y, Shi Y, Zhu E, Yuan H, Li X, Wang B
Stem cell research & therapy 2022 Jun 28;13(1):278
Stem cell research & therapy 2022 Jun 28;13(1):278
1α,25(OH)(2)D(3)(VD3) promotes Raddeanin A-induced anti-proliferative effects on HeLa cell apoptosis and autophagy through negative regulation of HPV18E6-E7/PD-L1/VDR axis.
Li Z, Xu B, Sun Y, Zhou L, Tao Y, Hou W, Bao J, Liu J, Fan W
Bioengineered 2022 Jan;13(1):357-369
Bioengineered 2022 Jan;13(1):357-369
Rab21 Protein Is Degraded by Both the Ubiquitin-Proteasome Pathway and the Autophagy-Lysosome Pathway.
Liu P, Wu A, Li H, Zhang J, Ni J, Quan Z, Qing H
International journal of molecular sciences 2022 Jan 20;23(3)
International journal of molecular sciences 2022 Jan 20;23(3)
Long noncoding RNA ZFAS1 suppresses osteogenic differentiation of bone marrow-derived mesenchymal stem cells by upregulating miR-499-EPHA5 axis.
Wu J, Lin T, Gao Y, Li X, Yang C, Zhang K, Wang C, Zhou X
Molecular and cellular endocrinology 2022 Jan 1;539:111490
Molecular and cellular endocrinology 2022 Jan 1;539:111490
Dapagliflozin alleviates advanced glycation end product induced podocyte injury through AMPK/mTOR mediated autophagy pathway.
Yang L, Liang B, Li J, Zhang X, Chen H, Sun J, Zhang Z
Cellular signalling 2022 Feb;90:110206
Cellular signalling 2022 Feb;90:110206
Modulatory effects of curcumin on Singapore grouper iridovirus infection-associated apoptosis and autophagy in vitro.
Wang Y, Xu S, Han C, Huang Y, Wei J, Wei S, Qin Q
Fish & shellfish immunology 2022 Dec;131:84-94
Fish & shellfish immunology 2022 Dec;131:84-94
Chronic rapamycin treatment decreases hepatic IL-6 protein, but increases autophagy markers as a protective effect against the overtraining-induced tissue damage.
Pinto AP, da Rocha AL, Marafon BB, Nogueira JE, Branco LGS, Pauli JR, de Moura LP, Cintra DE, Ropelle ER, da Silva ASR
Clinical and experimental pharmacology & physiology 2022 Aug;49(8):893-902
Clinical and experimental pharmacology & physiology 2022 Aug;49(8):893-902
Downregulation of FAPP2 gene induces cell autophagy and inhibits PI3K/AKT/mTOR pathway in T-cell acute lymphoblastic leukemia.
Yuan T, Wang J, Shi C, Wang Y, Xia B, Xu W, Yang H, Yang Y, Ye MT, Khalid S, Liang Y, Tian C, You MJ, Wang Y
Hematological oncology 2022 Apr;40(2):249-257
Hematological oncology 2022 Apr;40(2):249-257
HucMSC-derived exosomes delivered BECN1 induces ferroptosis of hepatic stellate cells via regulating the xCT/GPX4 axis.
Tan Y, Huang Y, Mei R, Mao F, Yang D, Liu J, Xu W, Qian H, Yan Y
Cell death & disease 2022 Apr 8;13(4):319
Cell death & disease 2022 Apr 8;13(4):319
PPT1 Reduction Contributes to Erianin-Induced Growth Inhibition in Oral Squamous Carcinoma Cells.
Luo Q, Li X, Gan G, Yang M, Chen X, Chen F
Frontiers in cell and developmental biology 2021;9:764263
Frontiers in cell and developmental biology 2021;9:764263
Evodiamine Inhibits Gastric Cancer Cell Proliferation via PTEN-Mediated EGF/PI3K Signaling Pathway.
Yang R, Wen J, Yang T, Dai C, Zhao Y
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5570831
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5570831
17β-Estradiol promotes LC3B-associated phagocytosis in trained immunity of female mice against sepsis.
Sun Z, Qu J, Xia X, Pan Y, Liu X, Liang H, Dou H, Hou Y
International journal of biological sciences 2021;17(2):460-474
International journal of biological sciences 2021;17(2):460-474
Sinensetin Reduces Osteoarthritis Pathology in the Tert-Butyl Hydroperoxide-Treated Chondrocytes and the Destabilization of the Medial Meniscus Model Mice via the AMPK/mTOR Signaling Pathway.
Zhou W, Shi Y, Wang H, Yu C, Zhu H, Wu A
Frontiers in pharmacology 2021;12:713491
Frontiers in pharmacology 2021;12:713491
Keratinocyte autophagy enables the activation of keratinocytes and fibroblastsand facilitates wound healing.
Qiang L, Yang S, Cui YH, He YY
Autophagy 2021 Sep;17(9):2128-2143
Autophagy 2021 Sep;17(9):2128-2143
Sitagliptin attenuates endothelial dysfunction independent of its blood glucose controlling effect.
Chang XM, Xiao F, Pan Q, Wang XX, Guo LX
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2021 Sep 1;25(5):425-437
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2021 Sep 1;25(5):425-437
Inhibition of autophagy with Chloroquine enhanced apoptosis induced by 5-aminolevulinic acid-photodynamic therapy in secondary hyperparathyroidism primary cells and organoids.
Zeng L, Zou Q, Huang P, Xiong L, Cheng Y, Chen Q, Li Y, He H, Yi W, Wei W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Oct;142:111994
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Oct;142:111994
EphA2 inhibits SRA01/04 cells apoptosis by suppressing autophagy via activating PI3K/Akt/mTOR pathway.
Han J, Wang L, Lv H, Liu J, Dong Y, Shi L, Ji Q
Archives of biochemistry and biophysics 2021 Oct 30;711:109024
Archives of biochemistry and biophysics 2021 Oct 30;711:109024
Bone marrow-derived mesenchymal stem cells attenuate silica-induced pulmonary fibrosis by inhibiting apoptosis and pyroptosis but not autophagy in rats.
Zhao Q, Hao C, Wei J, Huang R, Li C, Yao W
Ecotoxicology and environmental safety 2021 Jun 15;216:112181
Ecotoxicology and environmental safety 2021 Jun 15;216:112181
IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation.
Hu F, Song D, Yan Y, Huang C, Shen C, Lan J, Chen Y, Liu A, Wu Q, Sun L, Xu F, Hu F, Chen L, Luo X, Feng Y, Huang S, Hu J, Wang G
Nature communications 2021 Jun 15;12(1):3651
Nature communications 2021 Jun 15;12(1):3651
Vascular endothelial cell-secreted exosomes facilitate osteoarthritis pathogenesis by promoting chondrocyte apoptosis.
Yang RZ, Zheng HL, Xu WN, Zheng XF, Li B, Jiang LS, Jiang SD
Aging 2021 Feb 1;13(3):4647-4662
Aging 2021 Feb 1;13(3):4647-4662
XPA serves as an autophagy and apoptosis inducer by suppressing hepatocellular carcinoma in a PI3K/Akt/mTOR dependent manner.
Deng Y, Chen QS, Huang WF, Dai JW, Wu ZJ
Journal of gastrointestinal oncology 2021 Aug;12(4):1797-1810
Journal of gastrointestinal oncology 2021 Aug;12(4):1797-1810
DpdtC-Induced EMT Inhibition in MGC-803 Cells Was Partly through Ferritinophagy-Mediated ROS/p53 Pathway.
Feng J, Li C, Xu R, Li Y, Hou Q, Feng R, Wang S, Zhang L, Li C
Oxidative medicine and cellular longevity 2020;2020:9762390
Oxidative medicine and cellular longevity 2020;2020:9762390
Melatonin Protects Goat Spermatogonial Stem Cells against Oxidative Damage during Cryopreservation by Improving Antioxidant Capacity and Inhibiting Mitochondrial Apoptosis Pathway.
Feng TY, Li Q, Ren F, Xi HM, Lv DL, Li Y, Hu JH
Oxidative medicine and cellular longevity 2020;2020:5954635
Oxidative medicine and cellular longevity 2020;2020:5954635
Homoharringtonine Exerts an Antimyeloma Effect by Promoting Excess Parkin-Dependent Mitophagy.
Zhang Y, Huang N, Xu J, Zheng W, Cui X
Drug design, development and therapy 2020;14:4749-4763
Drug design, development and therapy 2020;14:4749-4763
The vicious cycle between ferritinophagy and ROS production triggered EMT inhibition of gastric cancer cells was through p53/AKT/mTor pathway.
Xu Z, Feng J, Li Y, Guan D, Chen H, Zhai X, Zhang L, Li C, Li C
Chemico-biological interactions 2020 Sep 1;328:109196
Chemico-biological interactions 2020 Sep 1;328:109196
Moderate, but Not Excessive, Training Attenuates Autophagy Machinery in Metabolic Tissues.
da Rocha AL, Pinto AP, Morais GP, Marafon BB, Rovina RL, Veras ASC, Teixeira GR, Pauli JR, de Moura LP, Cintra DE, Ropelle ER, Rivas DA, da Silva ASR
International journal of molecular sciences 2020 Nov 10;21(22)
International journal of molecular sciences 2020 Nov 10;21(22)
A mosquito salivary protein promotes flavivirus transmission by activation of autophagy.
Sun P, Nie K, Zhu Y, Liu Y, Wu P, Liu Z, Du S, Fan H, Chen CH, Zhang R, Wang P, Cheng G
Nature communications 2020 Jan 14;11(1):260
Nature communications 2020 Jan 14;11(1):260
The Combination of Fasting, Acute Resistance Exercise, and Protein Ingestion Led to Different Responses of Autophagy Markers in Gastrocnemius and Liver Samples.
Pinto AP, Vieira TS, Marafon BB, Batitucci G, Cabrera EMB, da Rocha AL, Kohama EB, Rodrigues KCC, de Moura LP, Pauli JR, Cintra DE, Ropelle ER, de Freitas EC, da Silva ASR
Nutrients 2020 Feb 28;12(3)
Nutrients 2020 Feb 28;12(3)
Beclin 1, LC3, and p62 expression in paraquat-induced pulmonary fibrosis.
Xu G, Wang X, Yu H, Wang C, Liu Y, Zhao R, Zhang G
Human & experimental toxicology 2019 Jul;38(7):794-802
Human & experimental toxicology 2019 Jul;38(7):794-802
XIAOPI formula promotes breast cancer chemosensitivity via inhibiting CXCL1/HMGB1-mediated autophagy.
Wang N, Yang B, Muhetaer G, Wang S, Zheng Y, Lu J, Li M, Zhang F, Situ H, Lin Y, Wang Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Dec;120:109519
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Dec;120:109519
Co-delivery of doxorubicin and shRNA of Beclin1 by folate receptor targeted pullulan-based multifunctional nanomicelles for combinational cancer therapy.
Chen L, Qian M, Zhang L, Xia J, Bao Y, Wang J, Guo L, Li Y
RSC advances 2018 May 14;8(32):17710-17722
RSC advances 2018 May 14;8(32):17710-17722
Hepatoprotective effect of quercetin via TRAF6/JNK pathway in acute hepatitis.
Wu L, Wang C, Li J, Li S, Feng J, Liu T, Xu S, Wang W, Lu X, Chen K, Xia Y, Fan X, Guo C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Dec;96:1137-1146
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Dec;96:1137-1146
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