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Immunoprecipitation
Blocking/NeutralizingAntibody data
- Antibody Data
- Antigen structure
- References [43]
- Comments [0]
- Validations
- Immunoprecipitation [1]
- Flow cytometry [2]
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- Product number
- DDX0700P-100 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Mouse Monoclonal IL-7R alpha/CD127 Antibody
- Antibody type
- Monoclonal
- Description
- Ion exchange chromatography.
- Reactivity
- Human, Canine
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 0.1 mg
- Concentration
- 0.5 mg/ml
- Storage
- Store at -20C. Avoid freeze-thaw cycles.
Submitted references IL-7 receptor recovery on CD8 T-cells isolated from HIV+ patients is inhibited by the HIV Tat protein.
An immunological biomarker to predict MTX response in early RA.
TNF superfamily member TL1A elicits type 2 innate lymphoid cells at mucosal barriers.
GATA binding protein 3⁺ group 2 innate lymphoid cells are present in cord blood and in higher proportions in male than in female neonates.
Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease.
Crosstalk between human DC subsets promotes antibacterial activity and CD8+ T-cell stimulation in response to bacille Calmette-Guérin.
Decreases in colonic and systemic inflammation in chronic HIV infection after IL-7 administration.
Tubulation of endosomal structures in human dendritic cells by Toll-like receptor ligation and lymphocyte contact accompanies antigen cross-presentation.
Generation of multipotent early lymphoid progenitors from human embryonic stem cells.
High numbers of differentiated effector CD4 T cells are found in patients with cancer and correlate with clinical response after neoadjuvant therapy of breast cancer.
Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues.
Rho-family GTPase Cdc42 controls migration of Langerhans cells in vivo.
IL-7 downregulates IL-7Rα expression in human CD8 T cells by two independent mechanisms.
CD4 T follicular helper cell dynamics during SIV infection.
NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.
Increased intake of oily fish in pregnancy: effects on neonatal immune responses and on clinical outcomes in infants at 6 mo.
HIV infection of thymocytes inhibits IL-7 activity without altering CD127 expression.
Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161.
Low-dose rabbit antithymocyte globulin induction therapy results in prolonged selective lymphocyte depletion irrespective of maintenance immunosuppression.
Numbers of CD25+Foxp3+ T cells that lack the IL-7 receptor are increased intra-articularly and have impaired suppressive function in RA patients.
Soluble IL-7R alpha (sCD127) inhibits IL-7 activity and is increased in HIV infection.
Transient beta-catenin stabilization modifies lineage output from human thymic CD34+CD1a- progenitors.
Association of two clones allows for optimal detection of human FOXP3.
Lineage-specific T-cell reconstitution following in vivo CD4+ and CD8+ lymphocyte depletion in nonhuman primates.
Diminished expression of ICOS, GITR and CTLA-4 at the mRNA level in T regulatory cells of children with newly diagnosed type 1 diabetes.
Upregulation of interleukin 7 receptor alpha and programmed death 1 marks an epitope-specific CD8+ T-cell response that disappears following primary Epstein-Barr virus infection.
Regulatory activity of azabisphosphonate-capped dendrimers on human CD4+ T cell proliferation enhances ex-vivo expansion of NK cells from PBMCs for immunotherapy.
IL-7 and the HIV Tat protein act synergistically to down-regulate CD127 expression on CD8 T cells.
Increased numbers of IL-7 receptor molecules on CD4+CD25-CD107a+ T-cells in patients with autoimmune diseases affecting the central nervous system.
CD8+ T-cell interleukin-7 receptor alpha expression as a potential indicator of disease status in HIV-infected children.
Low pre-infection levels and loss of central memory CD4+ T cells may predict rapid progression in SIV-infected pigtail macaques.
IL-7 activates the phosphatidylinositol 3-kinase/AKT pathway in normal human thymocytes but not normal human B cell precursors.
IL-7 activates the phosphatidylinositol 3-kinase/AKT pathway in normal human thymocytes but not normal human B cell precursors.
Idiopathic CD4+ lymphocytopenia: natural history and prognostic factors.
Malignant and non-malignant lung tissue areas are differentially populated by natural killer cells and regulatory T cells in non-small cell lung cancer.
Human regulatory T cells inhibit polarization of T helper cells toward antigen-presenting cells via a TGF-beta-dependent mechanism.
Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells.
Interleukin 7 requirement for survival of T-cell acute lymphoblastic leukemia and human thymocytes on bone marrow stroma.
Interleukin 7 requirement for survival of T-cell acute lymphoblastic leukemia and human thymocytes on bone marrow stroma.
Effects of lymphocyte isolation and timing of processing on detection of CD127 expression on T cells in human immunodeficiency virus-infected patients.
Differential regulation of human blood dendritic cell subsets by IFNs.
Differential regulation of human blood dendritic cell subsets by IFNs.
Growth inhibitory and agonistic signals of interleukin-7 (IL-7) can be mediated through the CDw127 IL-7 receptor.
Faller EM, McVey MJ, MacPherson PA
PloS one 2014;9(7):e102677
PloS one 2014;9(7):e102677
An immunological biomarker to predict MTX response in early RA.
Ponchel F, Goëb V, Parmar R, El-Sherbiny Y, Boissinot M, El Jawhari J, Burska A, Vital EM, Harrison S, Conaghan PG, Hensor E, Emery P
Annals of the rheumatic diseases 2014 Nov;73(11):2047-53
Annals of the rheumatic diseases 2014 Nov;73(11):2047-53
TNF superfamily member TL1A elicits type 2 innate lymphoid cells at mucosal barriers.
Yu X, Pappu R, Ramirez-Carrozzi V, Ota N, Caplazi P, Zhang J, Yan D, Xu M, Lee WP, Grogan JL
Mucosal immunology 2014 May;7(3):730-40
Mucosal immunology 2014 May;7(3):730-40
GATA binding protein 3⁺ group 2 innate lymphoid cells are present in cord blood and in higher proportions in male than in female neonates.
Forsberg A, Bengtsson M, Eringfält A, Ernerudh J, Mjösberg J, Jenmalm MC
The Journal of allergy and clinical immunology 2014 Jul;134(1):228-30
The Journal of allergy and clinical immunology 2014 Jul;134(1):228-30
Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease.
Munneke JM, Björklund AT, Mjösberg JM, Garming-Legert K, Bernink JH, Blom B, Huisman C, van Oers MH, Spits H, Malmberg KJ, Hazenberg MD
Blood 2014 Jul 31;124(5):812-21
Blood 2014 Jul 31;124(5):812-21
Crosstalk between human DC subsets promotes antibacterial activity and CD8+ T-cell stimulation in response to bacille Calmette-Guérin.
Lozza L, Farinacci M, Faé K, Bechtle M, Stäber M, Dorhoi A, Bauer M, Ganoza C, Weber S, Kaufmann SH
European journal of immunology 2014 Jan;44(1):80-92
European journal of immunology 2014 Jan;44(1):80-92
Decreases in colonic and systemic inflammation in chronic HIV infection after IL-7 administration.
Sereti I, Estes JD, Thompson WL, Morcock DR, Fischl MA, Croughs T, Beq S, Lafaye de Micheaux S, Yao MD, Ober A, Wilson EM, Natarajan V, Imamichi H, Boulassel MR, Lederman MM, Routy JP
PLoS pathogens 2014 Jan;10(1):e1003890
PLoS pathogens 2014 Jan;10(1):e1003890
Tubulation of endosomal structures in human dendritic cells by Toll-like receptor ligation and lymphocyte contact accompanies antigen cross-presentation.
Compeer EB, Flinsenberg TW, Boon L, Hoekstra ME, Boes M
The Journal of biological chemistry 2014 Jan 3;289(1):520-8
The Journal of biological chemistry 2014 Jan 3;289(1):520-8
Generation of multipotent early lymphoid progenitors from human embryonic stem cells.
Larbi A, Mitjavila-Garcia MT, Flamant S, Valogne Y, Clay D, Usunier B, l'Homme B, Féraud O, Casal I, Gobbo E, Divers D, Chapel A, Turhan AG, Bennaceur-Griscelli A, Haddad R
Stem cells and development 2014 Dec 15;23(24):2983-95
Stem cells and development 2014 Dec 15;23(24):2983-95
High numbers of differentiated effector CD4 T cells are found in patients with cancer and correlate with clinical response after neoadjuvant therapy of breast cancer.
Péguillet I, Milder M, Louis D, Vincent-Salomon A, Dorval T, Piperno-Neumann S, Scholl SM, Lantz O
Cancer research 2014 Apr 15;74(8):2204-16
Cancer research 2014 Apr 15;74(8):2204-16
Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues.
Bernink JH, Peters CP, Munneke M, te Velde AA, Meijer SL, Weijer K, Hreggvidsdottir HS, Heinsbroek SE, Legrand N, Buskens CJ, Bemelman WA, Mjösberg JM, Spits H
Nature immunology 2013 Mar;14(3):221-9
Nature immunology 2013 Mar;14(3):221-9
Rho-family GTPase Cdc42 controls migration of Langerhans cells in vivo.
Luckashenak N, Wähe A, Breit K, Brakebusch C, Brocker T
Journal of immunology (Baltimore, Md. : 1950) 2013 Jan 1;190(1):27-35
Journal of immunology (Baltimore, Md. : 1950) 2013 Jan 1;190(1):27-35
IL-7 downregulates IL-7Rα expression in human CD8 T cells by two independent mechanisms.
Ghazawi FM, Faller EM, Sugden SM, Kakal JA, MacPherson PA
Immunology and cell biology 2013 Feb;91(2):149-58
Immunology and cell biology 2013 Feb;91(2):149-58
CD4 T follicular helper cell dynamics during SIV infection.
Petrovas C, Yamamoto T, Gerner MY, Boswell KL, Wloka K, Smith EC, Ambrozak DR, Sandler NG, Timmer KJ, Sun X, Pan L, Poholek A, Rao SS, Brenchley JM, Alam SM, Tomaras GD, Roederer M, Douek DC, Seder RA, Germain RN, Haddad EK, Koup RA
The Journal of clinical investigation 2012 Sep;122(9):3281-94
The Journal of clinical investigation 2012 Sep;122(9):3281-94
NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.
Yatim A, Benne C, Sobhian B, Laurent-Chabalier S, Deas O, Judde JG, Lelievre JD, Levy Y, Benkirane M
Molecular cell 2012 Nov 9;48(3):445-58
Molecular cell 2012 Nov 9;48(3):445-58
Increased intake of oily fish in pregnancy: effects on neonatal immune responses and on clinical outcomes in infants at 6 mo.
Noakes PS, Vlachava M, Kremmyda LS, Diaper ND, Miles EA, Erlewyn-Lajeunesse M, Williams AP, Godfrey KM, Calder PC
The American journal of clinical nutrition 2012 Feb;95(2):395-404
The American journal of clinical nutrition 2012 Feb;95(2):395-404
HIV infection of thymocytes inhibits IL-7 activity without altering CD127 expression.
Young CD, Angel JB
Retrovirology 2011 Sep 16;8:72
Retrovirology 2011 Sep 16;8:72
Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161.
Mjösberg JM, Trifari S, Crellin NK, Peters CP, van Drunen CM, Piet B, Fokkens WJ, Cupedo T, Spits H
Nature immunology 2011 Sep 11;12(11):1055-62
Nature immunology 2011 Sep 11;12(11):1055-62
Low-dose rabbit antithymocyte globulin induction therapy results in prolonged selective lymphocyte depletion irrespective of maintenance immunosuppression.
Pankewycz O, Leca N, Kohli R, Wallace PK, Said M, Feng L, Alnimri M, Patel S, Laftavi MR
Transplantation proceedings 2011 Mar;43(2):462-5
Transplantation proceedings 2011 Mar;43(2):462-5
Numbers of CD25+Foxp3+ T cells that lack the IL-7 receptor are increased intra-articularly and have impaired suppressive function in RA patients.
van Roon JA, Hartgring SA, van der Wurff-Jacobs KM, Bijlsma JW, Lafeber FP
Rheumatology (Oxford, England) 2010 Nov;49(11):2084-9
Rheumatology (Oxford, England) 2010 Nov;49(11):2084-9
Soluble IL-7R alpha (sCD127) inhibits IL-7 activity and is increased in HIV infection.
Crawley AM, Faucher S, Angel JB
Journal of immunology (Baltimore, Md. : 1950) 2010 May 1;184(9):4679-87
Journal of immunology (Baltimore, Md. : 1950) 2010 May 1;184(9):4679-87
Transient beta-catenin stabilization modifies lineage output from human thymic CD34+CD1a- progenitors.
Valencia J, Hernández-López C, Martínez VG, Hidalgo L, Zapata AG, Vicente A, Varas A, Sacedón R
Journal of leukocyte biology 2010 Mar;87(3):405-14
Journal of leukocyte biology 2010 Mar;87(3):405-14
Association of two clones allows for optimal detection of human FOXP3.
Presicce P, Moreno-Fernandez ME, Lages CS, Orsborn KI, Chougnet CA
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2010 Jun;77(6):571-9
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2010 Jun;77(6):571-9
Lineage-specific T-cell reconstitution following in vivo CD4+ and CD8+ lymphocyte depletion in nonhuman primates.
Engram JC, Cervasi B, Borghans JA, Klatt NR, Gordon SN, Chahroudi A, Else JG, Mittler RS, Sodora DL, de Boer RJ, Brenchley JM, Silvestri G, Paiardini M
Blood 2010 Aug 5;116(5):748-58
Blood 2010 Aug 5;116(5):748-58
Diminished expression of ICOS, GITR and CTLA-4 at the mRNA level in T regulatory cells of children with newly diagnosed type 1 diabetes.
Łuczyński W, Wawrusiewicz-Kurylonek N, Stasiak-Barmuta A, Urban R, Iłendo E, Urban M, Hryszko M, Kretowski A, Górska M
Acta biochimica Polonica 2009;56(2):361-70
Acta biochimica Polonica 2009;56(2):361-70
Upregulation of interleukin 7 receptor alpha and programmed death 1 marks an epitope-specific CD8+ T-cell response that disappears following primary Epstein-Barr virus infection.
Sauce D, Larsen M, Abbott RJ, Hislop AD, Leese AM, Khan N, Papagno L, Freeman GJ, Rickinson AB
Journal of virology 2009 Sep;83(18):9068-78
Journal of virology 2009 Sep;83(18):9068-78
Regulatory activity of azabisphosphonate-capped dendrimers on human CD4+ T cell proliferation enhances ex-vivo expansion of NK cells from PBMCs for immunotherapy.
Portevin D, Poupot M, Rolland O, Turrin CO, Fournié JJ, Majoral JP, Caminade AM, Poupot R
Journal of translational medicine 2009 Sep 24;7:82
Journal of translational medicine 2009 Sep 24;7:82
IL-7 and the HIV Tat protein act synergistically to down-regulate CD127 expression on CD8 T cells.
Faller E, Kakal J, Kumar R, Macpherson P
International immunology 2009 Mar;21(3):203-16
International immunology 2009 Mar;21(3):203-16
Increased numbers of IL-7 receptor molecules on CD4+CD25-CD107a+ T-cells in patients with autoimmune diseases affecting the central nervous system.
Vudattu NK, Kuhlmann-Berenzon S, Khademi M, Seyfert V, Olsson T, Maeurer MJ
PloS one 2009 Aug 6;4(8):e6534
PloS one 2009 Aug 6;4(8):e6534
CD8+ T-cell interleukin-7 receptor alpha expression as a potential indicator of disease status in HIV-infected children.
Sharma TS, Hughes J, Murillo A, Riley J, Soares A, Little F, Mitchell CD, Hanekom WA
PloS one 2008;3(12):e3986
PloS one 2008;3(12):e3986
Low pre-infection levels and loss of central memory CD4+ T cells may predict rapid progression in SIV-infected pigtail macaques.
Mason RD, Rose RD, Seddiki N, Kelleher AD, Kent SJ
Virology 2008 Nov 10;381(1):11-5
Virology 2008 Nov 10;381(1):11-5
IL-7 activates the phosphatidylinositol 3-kinase/AKT pathway in normal human thymocytes but not normal human B cell precursors.
Johnson SE, Shah N, Bajer AA, LeBien TW
Journal of immunology (Baltimore, Md. : 1950) 2008 Jun 15;180(12):8109-17
Journal of immunology (Baltimore, Md. : 1950) 2008 Jun 15;180(12):8109-17
IL-7 activates the phosphatidylinositol 3-kinase/AKT pathway in normal human thymocytes but not normal human B cell precursors.
Johnson SE, Shah N, Bajer AA, LeBien TW
Journal of immunology (Baltimore, Md. : 1950) 2008 Jun 15;180(12):8109-17
Journal of immunology (Baltimore, Md. : 1950) 2008 Jun 15;180(12):8109-17
Idiopathic CD4+ lymphocytopenia: natural history and prognostic factors.
Zonios DI, Falloon J, Bennett JE, Shaw PA, Chaitt D, Baseler MW, Adelsberger JW, Metcalf JA, Polis MA, Kovacs SB, Kovacs JA, Davey RT, Lane HC, Masur H, Sereti I
Blood 2008 Jul 15;112(2):287-94
Blood 2008 Jul 15;112(2):287-94
Malignant and non-malignant lung tissue areas are differentially populated by natural killer cells and regulatory T cells in non-small cell lung cancer.
Esendagli G, Bruderek K, Goldmann T, Busche A, Branscheid D, Vollmer E, Brandau S
Lung cancer (Amsterdam, Netherlands) 2008 Jan;59(1):32-40
Lung cancer (Amsterdam, Netherlands) 2008 Jan;59(1):32-40
Human regulatory T cells inhibit polarization of T helper cells toward antigen-presenting cells via a TGF-beta-dependent mechanism.
Esquerré M, Tauzin B, Guiraud M, Müller S, Saoudi A, Valitutti S
Proceedings of the National Academy of Sciences of the United States of America 2008 Feb 19;105(7):2550-5
Proceedings of the National Academy of Sciences of the United States of America 2008 Feb 19;105(7):2550-5
Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells.
Hartigan-O'Connor DJ, Poon C, Sinclair E, McCune JM
Journal of immunological methods 2007 Jan 30;319(1-2):41-52
Journal of immunological methods 2007 Jan 30;319(1-2):41-52
Interleukin 7 requirement for survival of T-cell acute lymphoblastic leukemia and human thymocytes on bone marrow stroma.
Scupoli MT, Perbellini O, Krampera M, Vinante F, Cioffi F, Pizzolo G
Haematologica 2007 Feb;92(2):264-6
Haematologica 2007 Feb;92(2):264-6
Interleukin 7 requirement for survival of T-cell acute lymphoblastic leukemia and human thymocytes on bone marrow stroma.
Scupoli MT, Perbellini O, Krampera M, Vinante F, Cioffi F, Pizzolo G
Haematologica 2007 Feb;92(2):264-6
Haematologica 2007 Feb;92(2):264-6
Effects of lymphocyte isolation and timing of processing on detection of CD127 expression on T cells in human immunodeficiency virus-infected patients.
Higgins J, Metcalf JA, Stevens RA, Baseler M, Nason MC, Lane HC, Sereti I
Clinical and diagnostic laboratory immunology 2005 Jan;12(1):228-30
Clinical and diagnostic laboratory immunology 2005 Jan;12(1):228-30
Differential regulation of human blood dendritic cell subsets by IFNs.
Ito T, Amakawa R, Inaba M, Ikehara S, Inaba K, Fukuhara S
Journal of immunology (Baltimore, Md. : 1950) 2001 Mar 1;166(5):2961-9
Journal of immunology (Baltimore, Md. : 1950) 2001 Mar 1;166(5):2961-9
Differential regulation of human blood dendritic cell subsets by IFNs.
Ito T, Amakawa R, Inaba M, Ikehara S, Inaba K, Fukuhara S
Journal of immunology (Baltimore, Md. : 1950) 2001 Mar 1;166(5):2961-9
Journal of immunology (Baltimore, Md. : 1950) 2001 Mar 1;166(5):2961-9
Growth inhibitory and agonistic signals of interleukin-7 (IL-7) can be mediated through the CDw127 IL-7 receptor.
Pandrau-Garcia D, de Saint-Vis B, Saeland S, Renard N, Ho S, Moreau I, Banchereau J, Galizzi JP
Blood 1994 Jun 15;83(12):3613-9
Blood 1994 Jun 15;83(12):3613-9
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunoprecipitation: IL-7 R alpha/CD127 Antibody (R34-34) [DDX0700P-100] - R34-34 antigen from 125I-surface labelled Pre-Alp cells
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Flow Cytometry: IL-7 R alpha/CD127 Antibody (R34-34) [DDX0700P-100] - Facs staining of R34-34- transfected Cos7 cells
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Flow Cytometry: IL-7 R alpha/CD127 Antibody (R34-34) [DDX0700P-100] - Facs staining of PBL with R34-34
