RA0409

antibody from Oursmab

Targeting: IL7R CD127, IL7RA

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

RA0409

Provider

Oursmab

Product name

Bempikibart (Biosimilar Reference Antibody) (IL7R)

Antibody type

Monoclonal

Description

Bempikibart (also known as ADX-914) is a fully human monoclonal antibody designed to act as an antagonist by selectively targeting the Interleukin-7 receptor alpha subunit (IL-7Ralpha). Its mechanism is unique as the IL-7Ralpha subunit is a shared component of two distinct, critical signaling pathways: those driven by Interleukin-7 (IL-7) and Thymic Stromal Lymphopoietin (TSLP). By binding to and blocking IL-7Ralpha, Bempikibart achieves simultaneous inhibition of both the IL-7 and TSLP signaling pathways. This dual blockade is intended to suppress the pathogenic activity of various T-helper cell subtypes (Th1 and Th2) and related downstream inflammation.

Reactivity

Human

Isotype

IgG

Vial size

100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg

Concentration

Bottled at the concentration indicated on the vial.

Storage

Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.

Western blot

Supportive validation

Submitted by

Oursmab (provider)

Main image

Experimental details

Bempikibart (Biosimilar Reference Antibody) (IL7R)-RA0409-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.