BAF306

antibody from R&D Systems

Targeting: IL7R CD127, IL7RA

Western blot (Data presented on provider website)

Antibody Data

Product number

BAF306

Provider

R&D Systems

Product name

Human IL-7R alpha/CD127 Biotinylated Antibody

Antibody type

Polyclonal

Description

Antigen Affinity-purified. Detects human IL-7 R alpha in Western blots.

Reactivity

Human

Host

Goat

Conjugate

Biotin

Isotype

IgG

Vial size

50 ug

Concentration

LYOPH

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

References

Submitted references

CD56^bright NK IL-7Rα expression negatively associates with HCV level, and IL-7-induced NK function is impaired during HCV and HIV infections.

Judge CJ, Kostadinova L, Sherman KE, Butt AA, Falck-Ytter Y, Funderburg NT, Landay AL, Lederman MM, Sieg SF, Sandberg JK, Anthony DD
Journal of leukocyte biology 2017 Jul;102(1):171-184

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Reduced plasma levels of soluble interleukin-7 receptor during graft-versus-host disease (GVHD) in children and adults.

Poiret T, Rane L, Remberger M, Omazic B, Gustafsson-Jernberg A, Vudattu NK, Ahmed R, Ernberg I, Winiarski J, Magalhaes I, Ringden O, Maeurer M
BMC immunology 2014 Jun 19;15:25

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Decreased systemic IL-7 and soluble IL-7Rα in multiple sclerosis patients.

Kreft KL, Verbraak E, Wierenga-Wolf AF, van Meurs M, Oostra BA, Laman JD, Hintzen RQ
Genes and immunity 2012 Oct;13(7):587-92

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IL-7 restores lymphocyte functions in septic patients.

Venet F, Foray AP, Villars-Méchin A, Malcus C, Poitevin-Later F, Lepape A, Monneret G
Journal of immunology (Baltimore, Md. : 1950) 2012 Nov 15;189(10):5073-81

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Functionally significant differences in expression of disease-associated IL-7 receptor alpha haplotypes in CD4 T cells and dendritic cells.

Hoe E, McKay FC, Schibeci SD, Gandhi K, Heard RN, Stewart GJ, Booth DR
Journal of immunology (Baltimore, Md. : 1950) 2010 Mar 1;184(5):2512-7

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Identification and biochemical characterization of human plasma soluble IL-7R: lower concentrations in HIV-1-infected patients.

Rose T, Lambotte O, Pallier C, Delfraissy JF, Colle JH
Journal of immunology (Baltimore, Md. : 1950) 2009 Jun 15;182(12):7389-97