MAB306

antibody from R&D Systems

Targeting: IL7R CD127, IL7RA

Western blot (Recommended by provider)

Flow cytometry (Recommended by provider)

Antibody Data

Product number

MAB306

Provider

R&D Systems

Product name

Anti-Human IL-7 R alpha/CD127 Monoclonal Antibody (Clone 40131)

Antibody type

Monoclonal

Antigen

Mouse myeloma cell line NS0-derived recombinant human IL-7 Rα, Extracellular domain

Description

Protein A or G purified from ascites

Reactivity

Human

Host

Mouse

Isotype

IgG

Vial size

500 µg

References

Submitted references

CD56^bright NK IL-7Rα expression negatively associates with HCV level, and IL-7-induced NK function is impaired during HCV and HIV infections.

Judge CJ, Kostadinova L, Sherman KE, Butt AA, Falck-Ytter Y, Funderburg NT, Landay AL, Lederman MM, Sieg SF, Sandberg JK, Anthony DD
Journal of leukocyte biology 2017 Jul;102(1):171-184

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Regulatory T cells inhibit CD34+ cell differentiation into NK cells by blocking their proliferation.

Pedroza-Pacheco I, Shah D, Domogala A, Luevano M, Blundell M, Jackson N, Thrasher A, Madrigal A, Saudemont A
Scientific reports 2016 Feb 26;6:22097

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IL-7 Receptor Mutations and Steroid Resistance in Pediatric T cell Acute Lymphoblastic Leukemia: A Genome Sequencing Study.

Li Y, Buijs-Gladdines JG, Canté-Barrett K, Stubbs AP, Vroegindeweij EM, Smits WK, van Marion R, Dinjens WN, Horstmann M, Kuiper RP, Buijsman RC, Zaman GJ, van der Spek PJ, Pieters R, Meijerink JP
PLoS medicine 2016 Dec;13(12):e1002200

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The clinical correlation of regulatory T cells and cyclic adenosine monophosphate in enterovirus 71 infection.

Wang SM, Chen IC, Liao YT, Liu CC
PloS one 2014;9(7):e102025

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Decreased systemic IL-7 and soluble IL-7Rα in multiple sclerosis patients.

Kreft KL, Verbraak E, Wierenga-Wolf AF, van Meurs M, Oostra BA, Laman JD, Hintzen RQ
Genes and immunity 2012 Oct;13(7):587-92

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Interleukin-7 compartmentalizes its receptor signaling complex to initiate CD4 T lymphocyte response.

Rose T, Pillet AH, Lavergne V, Tamarit B, Lenormand P, Rousselle JC, Namane A, Thèze J
The Journal of biological chemistry 2010 May 14;285(20):14898-908

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Functionally significant differences in expression of disease-associated IL-7 receptor alpha haplotypes in CD4 T cells and dendritic cells.

Hoe E, McKay FC, Schibeci SD, Gandhi K, Heard RN, Stewart GJ, Booth DR
Journal of immunology (Baltimore, Md. : 1950) 2010 Mar 1;184(5):2512-7

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Identification and biochemical characterization of human plasma soluble IL-7R: lower concentrations in HIV-1-infected patients.

Rose T, Lambotte O, Pallier C, Delfraissy JF, Colle JH
Journal of immunology (Baltimore, Md. : 1950) 2009 Jun 15;182(12):7389-97

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Establishment and characterization of SRIK-NKL: a novel CD8+ natural killer/T cell line derived from a patient with leukemic phase of acute lymphoblastic lymphoma.

Srivastava BI, Srivastava MD
Leukemia research 2005 Jul;29(7):771-83