Explore
Validate
Learn14064-1-AP
antibody from Proteintech Group
Targeting: MAPK14
CSBP1, CSBP2, CSPB1, Mxi2, p38, PRKM14, PRKM15
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [698]
- Comments [0]
- Validations
- Western blot [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 14064-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- p38 MAPK antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated p38 MAPK antibody (Cat. #14064-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Lymph Node Metastasis-Associated Spatiotemporal Mapping of the TFF3-Linked Niche in Breast Cancer: Integrating Radiogenomic Signatures with Immune-Ecosystem Remodeling.
Enhancement of Psoriasis Treatment by Phellodendri Chinensis Cortex Carbon Dots (PCC-CDs) Through Modulation of the HMGB1/TLR4/MAPK/NF-κB Pathway.
Hsa_circ_0000313/miR-1224-3p/MKNK2 Axis Modulates CD4(+) T Cells by Activating p38 MAPK Signaling in Myasthenia Gravis.
A Novel MAP3K7 Variant Causing Loss of Function Identified in a Family With Cardiospondylocarpofacial Syndrome: Functional Validation and Molecular Insights.
Epithelial Gab1 Restricts Sepsis-Induced Intestinal Injury by Orchestrating TNF/NF-κB Axis.
Berberine Ameliorates Diabetic Kidney Disease by Modulating Macrophage Polarization via Inhibiting IL-17A Signaling.
Gan-Pi-Tong-Zhi Decoction Ameliorates OVA-Induced Asthma Through MAPK and Nrf2 Signaling Pathways and Regulating Gut Microbiota.
Tanshinone IIA prevents septicemia acute kidney injury via regulating the DUSP10/JNK/P38/NLRP3 pathway.
An astragalus polysaccharide-loaded hydrogel dressing enhances diabetic wound healing via dual-mode electrical stimulation.
Rosuvastatin attenuates blood-brain barrier dysfunction after ICH through modulation of CXCL12-associated VEGFR2/p38 MAPK signaling.
Stromal cell-derived itaconate promotes endometriosis via macrophage NRF2 and lysosomal pH modulation.
Farnesol Targets the GSTP1/MAPK Axis to Inhibit Trauma-Induced Tendon Heterotopic Ossification.
Punicalagin Promotes Peripheral Nerve Repair by Enhancing Mitophagy via the TLR4/MAPK Signaling Pathway and Facilitating Angiogenesis.
Isoliquiritigenin restores bone homeostasis in osteoporotic rats by enhancing BMSCs osteogenesis via ERK1/2-mTOR-HIF-1α-glycolytic axis and suppressing inflammation.
Baicalin Restores the Hypoglycemic Effect of Metformin by Regulating the Microbial Imidazole Propionate and Short-Chain Fatty Acids.
Isolation, structural characterization and immunoregulatory activity of a novel acidic polysaccharide from Ganoderma sinense.
An integrative analysis reveals the mechanism of plastic stabilizers inducing breast cancer.
Aloe-emodin inhibits p38 MAPK pathway in Alzheimer's disease treatment: a network pharmacology and experimental verification.
Red Blood Cell-Derived Exosomes Deliver Complement C5 to Exacerbate Neuroinflammation and Neuronal Injury after Intracerebral Hemorrhage.
TNF-α impairs the stria vascularis by inducing pericyte apoptosis via the NF-κB pathway in gentamicin-induced hearing loss.
DSCAML1+ extracellular vesicles revealed by single-vesicle proteomics as a novel biomarker and therapeutic target in myocardial infarction.
Monosodium Glutamate Inhibits Pseudomonas aeruginosa-Induced Acute Lung Injury by Targeting the Type III Secretion Systems and Modulating Host Immunity.
Exploration of the therapeutic potential of magnoflorine against osteoarthritis progression using network pharmacology and in vitro validation.
PKA and PKC signaling pathways mediate vitamin D₃-regulated intestinal phosphorus absorption in broiler chickens.
MAPK14/SLC7A11/GPX4 axis dysregulation drives podocyte ferroptosis via mediating glycerophospholipid metabolism.
Yishen Qianggu Mixture formulation suppresses osteometabolic inflammation by modulating the IL-17/NF-κB/MAPK signaling axis.
Mechanism of HAND2 Regulating Glycolytic Metabolism and Metastasis Through TLR4/NOX2/DUOX2 Signaling Axis in Cervical Cancer.
Precisely regulated physically-crosslinked carriers enable synergetic release of bioactive factors for MSC-mediated cartilage regeneration.
Synergistic Neuroprotective Effects of Taurine and Tauroursodeoxycholic Acid on the Neurovascular Unit in Hypoxia-Reoxygenation Injury.
Design, synthesis, and biological evaluation of novel hydrophobic tag-based degraders targeting JNK1.
High-throughput RNA sequencing identifies hub genes and anti-inflammatory effects of β-caryophyllene in cerebral ischemia-reperfusion via p38MAPK/NF-κB modulation.
ACOT8-mediated palmitate accumulation promotes M1 macrophage polarization in renal ischemia-reperfusion injury via activation of the cGAS-STING pathway.
Finerenone improves doxorubicin-induced cardiotoxicity by inhibiting cardiomyocyte apoptosis through the TAK1-p38 axis.
The role of the IL-33/ST2/MAPK signalling pathway in macrophage polarisation and endometrial fibrosis.
Immunological activity of peach pectins: Insights from cells to animals.
Effects of repetitive transcranial magnetic stimulation on apoptosis and MAPK/PI3K-AKT signaling pathways in rats with spinal cord injury.
Pyraclostrobin induces brain oxidative stress, apoptosis and inflammation through mitochondrial phosphorylation-induced ROS activation of the p38 MAPK pathway.
Curcumin induces apoptosis in osteosarcoma cells by regulating the glycolytic pathway via the MAPK axis: a mechanistic study.
Isomeranzin activates Gnas-AMPK signaling to drive white adipose browning and curb obesity in mice.
Astragalus polysaccharides inhibit arsenic trioxide-induced BMSCs damage through inhibition of Jnk and p38 signaling pathways.
Lobetyolin alleviates microglial inflammation by activating CK2α/Opa1-mediated mitochondrial fusion in ischemic stroke.
Periodontitis pathogen Porphyromonas gingivalis promotes chronic obstructive pulmonary disease via affecting neutrophils chemotaxis and function.
Eleutheroside E alleviates cisplatin-induced ototoxicity by down-regulating MAPK/NF-κB/NLRP3 signaling pathway and inhibiting cochlear cell pyroptosis.
Rab43 mitigates the inflammatory response in acute lung injury via MyD88 ubiquitination.
Adenosine metabolic clearance maintains liver homeostasis by licensing arginine methylation of RIPK1.
Active components and mechanisms of Shuganning injection in lessening acetaminophen-induced acute liver injury.
Multi-Targeted Therapeutic Mechanisms of Huangqi Guizhi Wuwu Decoction Against Rheumatoid Arthritis: An Integrated Approach Combining Serum Pharmacochemistry, Network Pharmacology, Metabolomics, and Experimental Validation.
PDK4-driven metabolic reprogramming enhances mesothelial cell invasion in colorectal cancer peritoneal metastasis.
Cyclovirobuxine D attenuates collagen-induced arthritis by inhibiting PI3K/AKT pathway and macrophage polarization.
Dexmedetomidine alleviates sepsis-associated acute kidney injury by inhibiting renal tubular ferroptosis via JNK/MAPK-LCN2 pathway.
Bu-Shen-Tian-Jing Formula alleviates oxidative-inflammatory stress in granulosa cells of polycystic ovary syndrome through AGEs-RAGE/NOX4/NF-κB pathway.
Esketamine alleviates COPD-depression comorbidity in rats via MAPK/NF-κB inhibition and gut-lung-brain axis modulation.
Vasicine Attenuates Allergic Asthma by Suppressing Mast Cell Degranulation and Th2 Inflammation via Modulation of the FcεRI/Lyn + Syk/MAPK Pathway.
PARP1 stabilizes FOXN3 to suppress pulmonary fibrosis through p38-related feedback regulation.
The mechanism of indigo naturalis and its active ingredients against ulcerative colitis.
Therapeutic effects of the n-butanol extract of Potentilla freyniana Bornm. in hepatocellular carcinoma cells.
Structure characterization and in vitro immunomodulatory effects of a novel galactoglucomannan in cultivated Chinese cordyceps (Cordyceps sinensis).
Integrating UPLC-HR-MS, network pharmacology and experimental validation to reveal the potential mechanism of Fuzheng Bixie granules in treating acute lung injury.
Effects of incompletely degraded galactomannan on growth performance and immune function of cyclophosphamide-induced immunosuppressed broilers.
SERPINE1-Driven MAPK Activation Enhances Cuproptosis Resistance and Angiogenic Potential in Colorectal Cancer.
Combining network pharmacology and experimental validation to demonstrate that salidroside alleviates acute lung injury by inhibiting ferroptosis via the MAPK/GPX4 pathway.
Anti-inflammatory effects and mechanisms of Podophyllum hexandrum rhizomes and fruits in a chronic pelvic inflammatory disease rat model.
Glibenclamide attenuates osteoarthritis by suppressing NLRP3 inflammasome activation in synovial macrophages through the MAPK pathway.
MKRN2 enhances hepatocellular carcinoma proliferation through the p38 MAPK pathway.
STING deficiency alleviates scar formation after glaucoma filtration surgery by suppressing p38 MAPK-induced inflammation in mice.
Exploring the Effects and Mechanisms of Neohesperidin Dihydrochalcone on Acute Lung Injury in Mice with Sepsis Using Network Pharmacology and Machine Learning.
Sphingosine-1-phosphate drives astrocyte pyroptosis via activation of NLRC4 inflammasome in autism spectrum disorder.
Hypoxia-preconditioned cardiomyocyte-derived extracellular vesicles alleviate myocardial ischemic injury by reprogramming macrophage polarization via the Fgl2/NF-κB pathway.
U0126 induces osteoclast differentiation via the p38-NFATc-1 signaling pathway.
The GOLM1-ACLY pathway regulates macrophage-secreted EFEMP1 via H3K27ac modifications to drive tumor progression.
Tanshinone IIA attenuates airway inflammation and airway remodeling in bronchial asthma by inhibiting p38/NF-κB and AKT/HIF-1α.
Intestinal epithelial protection and gut microbiota modulation by Ganoderma lucidum proteoglycan are associated with its hypoglycemic potential in type 2 diabetes.
Zinc-doped carbon dots from natural Isatis Indigotica folium and calamine: SOD/CAT-mimetic activity targets ROS-Ca²⁺-NLRP3 axis for psoriatic dermatitis therapy.
Caffeine inhibited the hyperoxia-induced A2AR-ERK/p38 MAPK-IL-8 pathway in type II alveolar epithelial cells to suppress NETs formation in bronchopulmonary dysplasia.
Brucea Javanica Oil Attenuates Osteosarcoma Progression by Reprogramming Tumor-associated Macrophages via Inhibiting PI3K/AKT Pathway.
Tuihong formula attenuates DNCB-induced atopic dermatitis in mice via suppression of MAPK/NF-κB signaling and epidermal barrier restoration.
USP1 dependent stabilization of LTA4H drives hepatocellular carcinoma angiogenesis.
Bovine serum albumin-coated metal-phenolic nanoplatform for atherosclerosis therapy via targeted delivery and inhibition of vascular smooth muscle cells proliferation.
CSRNP1 Promotes Apoptosis and Mitochondrial Dysfunction via ROS-Mediated JNK/p38 MAPK Pathway Activation in Hepatocellular Carcinoma.
FTO Alleviates Hepatic Ischemia-Reperfusion Injury by Regulating Apoptosis and Autophagy.
Volatile Oil From Acorus Gramineus Rhizoma Synergizes with Crebanine to Alleviate Oxidative Stress and Endoplasmic Reticulum Stress in Myocardial Ischemia-Reperfusion Injury by Suppressing GRP78-PERK/ATF6-CHOP and MAPK-NF-κB-TNF-α Signaling Pathways.
VOPP1 as a Novel Susceptibility Gene in Rheumatoid Arthritis: Insights Into Its Mechanisms From Mendelian Randomization and Experimental Validation.
Lasalocid inhibits melanoma by down-regulating FOXM1 through PI3K/AKT and JNK/P38 MAPK pathways.
Study on the mechanism of gracillin inhibiting the proliferation of lung cancer NCI-H1299 cells based on MAPK signaling pathway.
Identification and validation of the VEGF/p38MAPK/HSP27 pro-tumor inflammatory pathway: screening of active components from Patrinia villosa and evaluation of their drug-likeness.
FKBP5-CCL5 interaction promotes neuroinflammation and neuronal apoptosis in ischemic stroke by regulating the MAPK pathway and enhancing NET formation.
Identification and evaluation of a pinocembrin analog as a TRPV1 inhibitor with analgesic properties in murine pain models.
Desulfovibrio vulgaris exacerbates sepsis by inducing inflammation and oxidative stress in multiple organs.
Enhancing pancreatic cancer treatment: the role of H101 oncolytic virus in irreversible electroporation.
Zirconia/dental pulp stem cell composite scaffolds repair osteogenic defect via regulating macrophages.
Kisspeptin Suppresses the Growth of Primary Pterygial Cells via Inhibiting Chemokine (C-X-C Motif) Ligands in Microenvironment.
Ovotransferrin ameliorated intestinal barrier dysfunction in DSS-induced ulcerative colitis mice via inhibition of PI3K-Akt/MAPK signaling pathways and modulation of tissue metabolism.
IFITM1 promotes proliferation, migration and macrophage-like transdifferentiation of vascular smooth muscle cells via c-Src/MAPK/GATA2/E2F2 pathway in atherosclerosis.
Pharmacological role of MLN4924 in cisplatin-induced acute kidney injury.
Xinbao pill attenuated water retention by regulating the CaSR/AQP2 pathway in LAD-induced chronic heart failure rats.
Deciphering functional landscapes of rumen microbiota unveils the role of Prevotella bryantii in milk fat synthesis in goats.
Comparison of Quercetin and Isoquercitrin's Anti-Heart Failure Activity via MAPK Inflammatory Pathway and Caspase Apoptosis Pathway.
Discovery of 3g as an Orally Bioavailable, TIR Domain Selective, and Potent MyD88 Inhibitor for the Treatment of Acute Lung Injury.
Systematic reevaluation on the antipyretic, analgesic effects, and uncover the mechanisms of Chaiqin Qingning capsule, a traditional Chinese medicine, via establishing lipopolysaccharide - induced fever models, physical and chemical - stimuli pain models.
Transcriptomic bioinformatics analysis proposes a novel BCL2-MAPK14-TXN oxidative stress diagnostic model of sepsis and identifies TXN as an oxidative stress-related signature gene in sepsis.
Colla Corii Asini regulate collagen regeneration in UV exposure-induced skin photoaging in mice.
Chronic Waterborne Exposure to Polystyrene Microplastics Induces Kupffer Cell Polarization Imbalance and Hepatic Lipid Accumulation.
Dapagliflozin promotes metabolic reprogramming against myocardial infarction through the MAPK-FOXO3-STC1 and HIF-1a-STC1 pathways.
Bushen Jiangu decoction alleviates osteoporosis by inhibiting MMP2 expression and activation of the MAPK pathway in vitro.
ZAKα Induces Pyroptosis of Colonic Epithelium Via the Caspase-11/GSDMD Pathway to Aggravate Colitis.
The SLCO4A1-Mediated Transmembrane Transport of Lysionotin Attenuates Acute Lung Injury Through Activating the AMPK/Nrf2 Signaling Pathway.
Self-propelled gas nanomotor-integrated microneedles for melanoma therapy: Dual-action in situ eradication and metastatic suppression.
Idebenone attenuates RANKL-induced osteoclastogenesis and improves bone mass in ovariectomized mice.
DUSP1-mediated suppression of p38 MAPK signaling pathway reduces ferroptosis in cerebral ischemia-reperfusion injury.
Ganoderic acid a derivative induces apoptosis of cervical cancer cells by inhibiting JNK pathway.
Removal and toxic intervention of polystyrene microplastics and nanoplastics by magnetic nano-Fe(3)O(4) in spermatogonial GC-1 cells.
Eimeria tenella aspartyl protease is identified as a potential TLR15 ligand and activates macrophages and dendritic cells in chickens.
OTSSP167 suppresses TNBC brain metastasis via ROS-driven P38/JNK and FAK/ERK pathways.
Multi-omics and network pharmacology approaches reveal the mechanism of action of KeKe tablet against post-infectious cough.
Chamazulene Induces Metabolic Reprogramming and Mitigates Inflammation in Photoaged Skin: PPARα/γ as Potential Regulators.
1,8-Cineole alleviates spinal cord injury by inhibiting microglial pyroptosis via the P38 MAPK and PI3K/AKT/NLRP3 signaling pathways to protects neurons.
Paeonol reduces IL-1β induced apoptosis and degeneration by regulating MAPK pathway in nucleus pulposus cells.
Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer's disease.
Nano-Self-Assembled Particles Loaded with Aldehyde Dehydrogenase 2 Agonist Inhibit Ischemia-Reperfusion Injury of Transplanted Kidneys.
A cell-free TLR5(high) MSC membrane nanoparticle therapy for Crohn's disease: Targeted immunomodulation via the flagellin/TLR5 axis.
Crinis Carbonisatus-Derived Carbon Dot Suspension Alleviates Temporal Lobe Epilepsy.
Salvianolic Acid A Mitigates Osteoporotic Bone Loss by Repressing Reactive Oxygen Species via the Nrf2-HO-1 Pathway.
The β-glucan from Lentinus alleviates UVB-induced dermal fibroblasts senescence and skin photoaging.
Lysyl oxidase-like 2 inhibition alleviates subretinal fibrosis in neovascular age-related macular degeneration model.
Intestinal taurine acts as a novel immunometabolic modulator of IBD by degrading redundant mitochondrial RNA.
Chrysin inhibits PEDV replication by antagonizing apoptosis via the ROS/JNK/p53 axis.
BMAL1 modulates respiratory syncytial virus-induced inflammation through p38 mitogen-activated protein kinase pathway: insights into circadian regulation.
Platycodin D attenuates diabetic renal ischemia/reperfusion injury by enhancing mitophagy and suppressing MAPK/NF-κB signaling activation.
MAP30 inhibits proliferation and metastasis of bladder cancer by increasing EGR1 expression and promoting the transcriptional activation of DUSP1.
Arsenic trioxide-based nanoparticles for enhanced chemotherapy by activating pyroptosis.
iRGD-modified co-loaded curcumin piperine liposomes inhibit angiogenesis in non-small cell lung cancer through the VEGFR2/P38/MK2 signaling axis.
Exploration of new azole derivatives containing ethanolamine moiety as anti-UC agents by inhibiting NF-κB/MAPK pathways.
Helicobacter pylori Lipopolysaccharide Upregulates MDM2 via the TLR4/MAPK/AP-1 Pathway to Promote Gastric Cancer Progression.
Circulating FABP5 released by dying macrophages function as a DAMP to exacerbate septic inflammation.
TIM3 attenuates morphine antinociceptive tolerance and microglial neuroinflammation by suppressing the TRAF6/NF-κB pathway in male mice.
A glucose kinase-independent HK2 activity prevents TNF-induced cell death by phosphorylating RIPK1.
CpG ODN Activates TLR9 and Upregulates TLR3 via the p38 MAPK-ATF3 Signaling Axis to Synergistically Enhance Dendritic Cell Vaccine Efficacy.
Targeting the p38/MAPK pathway to induce apoptosis: a multidimensional mechanistic exploration of Mentha and its active compound diosmetin against liver cancer.
Harnessing engineered adaptive nanoparticles to modulate macrophages for treating corneal alkali burns.
Aregs-IGFBP3-mediated SMC-like cells apoptosis impairs beige adipocytes formation in aged mice.
Flammulina velutipes polysaccharide exerts immunomodulatory function involving RSAD2 to regulate the NF-κB/MAPK signaling pathway in RAW264.7 macrophage cells and in mouse spleen cells.
METTL3-mediated m6A modification of PAK6 drives cervical cancer progression through activating MAPK14.
Cyclic RGD modified dextran-quercetin polymer micelles for targeted therapy of breast cancer.
The Potential Hepatocyte Differentiation Targets and MSC Proliferation by FH1.
Targeting HPK1 inhibits neutrophil responses to mitigate post-stroke lung and cerebral injuries.
Melatonin Promotes Osteogenic Differentiation of Rat Adipose-Derived Stem Cells via the p38/MAPK Signaling Pathway.
Targeting BATF2-RGS2 axis reduces T-cell exhaustion and restores anti-tumor immunity.
Ethanol extract of Moschus attenuates glutamate-induced cytotoxicity in HT22 cells by regulating the Nrf2 and MAPK pathways.
Aqueous Polygalae Radix extract (PRE) prolongs the lifespan of C. elegans and alleviates D-galactose-induced oxidative stress in the mouse liver and brain by modulating PPARγ/MAPK.
Inflammation-responsive biomimetic nanoparticles with epigallocatechin-3-gallate for acute lung injury therapy via autophagy enhancement.
Multi-Omics Unveils Inflammatory Regulation of Fermented Sini Decoction Dregs in Broilers Infected with Avian Pathogenic Escherichia coli.
Dendrobium nobile lindl extract modulates integrin αIIbβ3-mediated signaling pathways to inhibit platelet activation and thrombosis.
Allocryptopine Attenuates Inflammatory Responses in Microglial Cells Via TLR4-Dependent NF-κB and p38 MAPK Pathways.
Protective Effects of Lactoferrin Treatment Against Sodium Arsenite Exposure-Induced Nephrotoxicity.
Egln3 expression in microglia enhances the neuroinflammatory responses in Alzheimer's disease.
4-Octyl Itaconate Alleviates Myocardial Ischemia-Reperfusion Injury Through Promoting Angiogenesis via ERK Signaling Activation.
Network pharmacology and in vivo study: Unraveling the therapeutic mechanisms of Panax ginseng in potentially treating ulcerative colitis.
Integrative network pharmacology, transcriptomics, and proteomics reveal the material basis and mechanism of the Shen Qing Weichang Formula against gastric cancer.
N-Acetylcysteine as a Host-Directed Therapy Against Clarithromycin-Resistant Mycobacterium abscessus.
Discovery of Novel Oxazolo[4,3-f]purine Derivatives as Antitumor Agents through PPIA Interaction.
H3K18 lactylation-mediated nucleotide-binding oligomerization domain-2 (NOD2) expression promotes bilirubin-induced pyroptosis of astrocytes.
Harnessing Anti-Inflammatory and Regenerative Potential: GelMA Hydrogel Loaded with IL-10 and Kartogenin for Intervertebral Disc Degeneration Therapy.
Hamayou () protein hydrolysate ameliorates depression by regulating the mitogen-activated protein kinase pathway.
Negative Effect of Gst-35 on the Health Span of Caenorhabditis elegans Through Lysosomal Dysfunction via the Pmk-1 and Skr Genes.
ULBP2 promotes progression of head and neck squamous cell carcinoma by modulating MAPK signaling pathway.
Luteolin ameliorates kainic acid-induced seizure by modulating GADD45B and reducing oxidative stress in hippocampal neurons.
Rhein induces apoptosis of AGS and MGC803 cells by regulating the Ras/PI3K/AKT and p38/MAPK signaling pathway.
Neutrophil-derived exosomes promote sepsis-related multiple organ dysfunction through the induction of neutrophil extracellular trap formation.
Sea Cucumber Fucoidan Inhibits Helicobacter pylori Gastritis via MAPK/NF-κB Signaling and Gut Microbiota Modulation.
GDF11 Regulates M1 and M2 Polarization of BV2 Microglial Cells via p38 MAPK Signaling Pathway.
Formononetin Alleviates the Inflammatory Response Induced by Carotid Balloon Injury in Rats via the PP2A/MAPK Axis.
Senescent macrophages induce ferroptosis in skeletal muscle and accelerate osteoarthritis-related muscle atrophy.
The Polarization of Macrophages Regulated by KCNG3 via the Activation of ASK1 Mediated by Potassium Ion Efflux.
Andrographolide and its sulfated metabolite alleviated DSS-induced inflammatory bowel disease through regulating inflammation and immune via MAPK/NLRP3 pathways and the balance of Th17/Treg cells.
MiR-100-5p as a biomarker in hand-arm vibration disease: Mediating pathogenesis through angiogenesis suppression.
CD8a + GZMK + T Cells Inhibit Osteoclastogenesis in Postmenopausal Osteoporosis via the p38-MAPK Pathway.
Colchicine alleviates ischemic white matter lesions and cognitive deficits by inhibiting microglia inflammation via the TAK1/MAPK/NF-κB signaling pathway.
Dibutyl phthalate promotes central precocious puberty through primordial follicle activation by downregulating BMP15.
Kushenol I combats ulcerative colitis via intestinal barrier preservation and gut microbiota optimization.
Negative Air Ions Attenuate Nicotine-Induced Vascular Endothelial Dysfunction by Suppressing AP1-Mediated FN1 and SPP1.
Pharmacological evaluation of physcion as a TRPV1 inhibitor with multimodal analgesic efficacy in experimental pain models.
TEAD4-mediated upregulation of LPAR3 augments hepatic stellate cell activation in portal hypertension.
Poly (β-amino esters)/Mobil Composition of Matter 41-mediated delivery of siIL-1β alleviates deep vein thrombosis in rat hind limbs.
Cortisol suppresses lipopolysaccharide-induced in vitro inflammatory response of large yellow croaker (Larimichthys crocea) via the glucocorticoid receptor and p38 mitogen-activated protein kinase pathways.
Role of semaphorin7A in epithelial-mesenchymal transition and proliferative vitreoretinopathy.
PINK1 modulates Prdx2 to reduce lipotoxicity-induced apoptosis and attenuate cardiac dysfunction in heart failure mice with a preserved ejection fraction.
Trans-cinnamic acid alleviates high-fat diet-induced renal injury via JNK/ERK/P38 MAPK pathway.
Hyperlipidemia exacerbates acute pancreatitis via interactions between P38MAPK and oxidative stress.
Pharmacodynamics of huaier aqueous extract against papillary thyroid carcinoma in vivo and in vitro.
G(1-5)-EM2, a multi-targeted agonist to opioid and growth hormone secretagogue receptors exhibited nontolerance forming antinociceptive effects in a mouse model of burn pain.
Ferrostatin-1 inhibits osteoclast differentiation and prevents osteoporosis by suppressing lipid peroxidation.
Galactin-8 DNA methylation mediates macrophage autophagy through the MAPK/mTOR pathway to alleviate atherosclerosis.
Cardiotoxicity of polystyrene nanoplastics and associated mechanism of myocardial cell injury in mice.
Mechanism of dihydroartemisinin in the treatment of ischaemia/reperfusion-induced acute kidney injury via network pharmacology, molecular dynamics simulation and experiments.
The Shh-p38-NFATc1 signaling pathway is essential for osteoclastogenesis during tooth eruption.
Reciprocal tumor-platelet interaction through the EPHB1-EFNB1 axis in the liver metastatic niche promotes metastatic tumor outgrowth in pancreatic ductal adenocarcinoma.
MAPK14/AIFM2 pathway regulates mitophagy-dependent apoptosis to improve atrial fibrillation.
HSPA1A inhibits pyroptosis and neuroinflammation after spinal cord injury via DUSP1 inhibition of the MAPK signaling pathway.
Ginkgetin delays the progression of osteoarthritis by inhibiting the NF-κB and MAPK signaling pathways.
Exploring macrophage and nerve interaction in endometriosis-associated pain: the inductive role of IL-33.
ADCY5 Gene Affects Seasonal Reproduction in Dairy Goats by Regulating Ovarian Granulosa Cells Steroid Hormone Synthesis.
Liuwei Anshen Capsule alleviates cognitive impairment induced by sleep deprivation by reducing neuroapoptosis and inflammation.
Integrative network pharmacology and multi-omics to study the potential mechanism of Niuhuang Shangqing Pill on acute pharyngitis.
MAP6D1 Silencing alleviates high glucose-induced injury of trophoblast cells during gestational diabetes mellitus.
Sophoridine inhibits proliferation and migration by targeting PIM1 in breast cancer.
PINK1 overexpression suppresses p38 MAPK/NF‑κB signaling to attenuate chondrocyte senescence in osteoarthritis.
Xuebijing injection alleviates septic acute kidney injury by modulating inflammation, mitochondrial dysfunction, and endoplasmic reticulum stress.
Vitexin enhances mitophagy and improves renal ischemia-reperfusion injury by regulating the p38/MAPK pathway.
RAB3GAP2 silencing alleviates oxidative stress in cataracts by enhancing Mfn2-mediated mitochondrial autophagy by activating JNK/STAT3.
Co-fermentation of honeysuckle-Cassia seeds by Lactobacillus acidophilus and Bacillus subtilis: A new approach to attenuate alcohol-induced acute gastric mucosal damage and modulate immune response.
Modulation of lipid droplet biogenesis by p38 MAPK and caspase-1 in docosahexaenoic acid-induced EA.hy926 endothelial cell apoptosis.
UBE2M inhibits neoplastic cell proliferation via MKK7-JNK-EGR1 axis in melanoma.
The mechanism of S100A8/A9 heterodimer promoting atherosclerotic thrombosis.
Sestrin2 Knockdown Impairs Proliferation, Migration, Invasion, and Apoptosis in OSCC Cells via PI3K/AKT/mTOR and MAPK Pathways.
Liensinine can improve vascular remodeling in hypertension through the ferroptosis-related TLR4 inflammatory pathway.
Melatonin attenuates glandular cystitis via modulation of THBS1 and TLR4/p38 MAPK/STAT3 signaling.
Hsa_circ_0000437 promotes the progression of rheumatic valvular heart disease by activating the mitogen-activated protein kinase signaling pathways after sponging let-7f-5p and targeting RAS-like proto-oncogene B.
Anti-Inflammatory Effect of a Polysaccharide Derived from Artocarpus heterophyllus Lam. Pulp on Lipopolysaccharide-Stimulated RAW264.7 Macrophages Through Inhibiting MAPK/ERK Signaling Pathway.
Pla2g7 regulates bone homeostasis via Alox12/12-HETE/Gpr31 signaling axis.
Resolvin D1 Modulates the Inflammatory Processes of Human Periodontal Ligament Cells via NF-κB and MAPK Signaling Pathways.
Taxifolin Inhibits Platelet Activation and Thrombosis by Regulating the PI3K/Akt and MAPK Signaling Pathways.
Analgesic Mechanism of Emodin in Neuropathic Pain Through Inhibiting P2X4 Purinoceptor Signaling.
A novel variant in the MAP3K1 genomic locus reveals abnormal cell apoptosis as a potential pathogenic mechanism in 46, XY disorders of sex development.
Macrocyclic diterpenoids from Stellera chamaejasme roots alleviate imiquimod-induced psoriasiform inflammation via STAT1/S100A9 signalling pathway.
Chemical discovery of a novel MD2/ADAM17 dual-target inhibitor as a potential therapeutic candidate for saturated fatty acid-induced myocardial inflammatory injury.
METTL11A serves as a novel therapeutic target for acute myeloid leukemia through regulation of the p38-MAPK pathway.
Pyrazolamide derivative T1 inhibits hepatocellular carcinoma cell proliferation through MAPK pathway modulation.
Membrane protein CRISPR screen identifies RPSA as an essential host factor for porcine epidemic diarrhea virus replication.
Per2 deficiency in microglia alleviates motor dysfunction by inhibiting ferroptosis in spinal cord injury.
Selenoprotein K-dependent MyD88 palmitoylation promotes hepatic metaflammation in high-fat diet fed mice.
The chemokine receptor type 5 inhibitor maraviroc alleviates sepsis-associated liver injury by regulating MAPK/NF-κB signaling.
Crucial role of low molecular weight chondroitin sulfate from hybrid sturgeon cartilage in osteoarthritis improvement: Focusing on apoptosis, systemic inflammation, and intestinal flora.
Pinocembrin alleviates renal ischemia-reperfusion injury/unilateral ureteral obstruction (UUO)-generated renal fibrosis by targeting the CYP1B1/ROS/MAPK axis.
Carfilzomib inhibits the progression of hepatocellular cancer by upregulating GADD45α expression.
TGR5 attenuates DOCA-salt hypertension through regulating histone H3K4 methylation of ENaC in the kidney.
Berberine Alleviates 1-Methyl-3-Nitro-1-Nitrosoguanidine- Induced Chronic Atrophic Gastritis in Rats.
Febrile temperature-regulated TRPV1 in CD4(+) T cells mediates neuroinflammation in complex febrile seizures.
Deletion of HIF-2α in Dendritic Cells Attenuates Anti-Glomerular Basement Membrane Nephritis.
Xifeng Jiannao pill mitigates MPTP-induced neuronal apoptosis by reducing inflammation and oxidative stress via MAPK signaling.
Alleviation of obesity cardiomyopathy by Fisetin through the inhibition of NF-κB/MAPK signaling.
Luteolin 7-Glucuronide in Artemisia rupestris L. Extract Attenuates Pulmonary Fibrosis by Inhibiting Fibroblast Activation and FMT via Targeting of TGF-β1.
Tanshinone IIA alleviates tri-ortho-cresyl phosphate-induced ovarian damage through Hippo signaling pathway activation in mice.
Impact of Escherichia coli and Lipopolysaccharide on the MAPK Signaling Pathway, MMPs, TIMPs, and the uPA System in Bovine Mammary Epithelial Cells.
Canolol Alleviates Ethanol-Induced Gastric Ulcer by Inhibiting p38 MAPK/NF-κB/NLRP3 Pathway.
Asparagine transporter supports macrophage inflammation via histone phosphorylation.
Sodium Tanshinone IIA Sulfonate Protects Primary Cardiomyocytes Against Radiation-Induced Myocardial Injury via the p38 Pathway.
Quercetin of huoxuehuayu tongluo decoction and azithromycin combination therapy effectively improves rat tubal factor infertility by inhibiting inflammation.
FBLN5 was Regulated by PRDM9, and Promoted Senescence and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells.
Modified Zuo Gui Wan Ameliorates Ovariectomy-Induced Osteoporosis in Rats by Regulating the SCFA-GPR41-p38MAPK Signaling Pathway.
Rhein alleviates MPTP-induced Parkinson's disease by suppressing neuroinflammation via MAPK/IκB pathway.
Downregulation of Circular RNA Gla Reduced Astrocyte Inflammatory Status by Regulating miR-488/MEKK1 Levels and Promoted Functional Recovery After Spinal Cord Injury.
Cross-border regulation of the STK39/MAPK14 pathway by Lycium barbarum miR166a to inhibit triple-negative breast cancer.
Cistanche deserticola polysaccharide alleviates constipation by regulating intestinal barrier function and intestinal microbiota and their metabolites.
PSAT1 mediated EMT of colorectal cancer cells by regulating Pl3K/AKT signaling pathway.
Gut microbiota derived metabolite trimethylamine N-oxide influences prostate cancer progression via the p38/HMOX1 pathway.
Anillin contributes to prostate cancer progression through the regulation of IGF2BP1 to promote c-Myc and MAPK signaling.
Jianpi Huayu Prescription Prevents Atherosclerosis by Improving Inflammation and Reshaping the Intestinal Microbiota in ApoE(-/-) Mice.
ABT‑737 increases cisplatin sensitivity through the ROS‑ASK1‑JNK MAPK signaling axis in human ovarian cancer cisplatin‑resistant A2780/DDP cells.
WIP1-mediated regulation of p38 MAPK signaling attenuates pyroptosis in sepsis-associated acute kidney injury.
The effects and mechanisms of AM1241 in alleviating cerebral ischemia-reperfusion injury.
Tumoral EIF4EBP1 regulates the crosstalk between tumor-associated macrophages and tumor cells in MRTK.
Spinster homolog 2/S1P signaling ameliorates macrophage inflammatory response to bacterial infections by balancing PGE(2) production.
Esketamine mitigates mechanical ventilation-induced lung injury in chronic obstructive pulmonary disease rats via inhibition of the MAPK/NF-κB signaling pathway and reduction of oxidative stress.
β-chitosan attenuates hepatic macrophage-driven inflammation and reverses aging-related cognitive impairment.
Chemical Composition, Antioxidant Capacity, and Anticancerous Effects against Human Lung Cancer Cells of a Terpenoid-Rich Fraction of Inula viscosa.
Neohesperidin Attenuates DSS-Induced Ulcerative Colitis by Inhibiting Inflammation, Reducing Intestinal Barrier Damage, and Modulating Intestinal Flora Composition.
CREB1 promotes cholangiocarcinoma metastasis through transcriptional regulation of the LAYN-mediated TLN1/β1 integrin axis: CREB1 promotes cholangiocarcinoma metastasis through regulating LAYN/TLN1/β1 integrin axis.
Umbilical cord blood-derived exosomes attenuate dopaminergic neuron damage of Parkinson's disease mouse model.
Structure characterization and immunological activity of capsular polysaccharide from live and heat-killed Lacticaseibacillus paracasei 6235.
EREG silencing inhibits tumorigenesis via inactivating ERK/p38 MAPK pathway in pancreatic ductal adenocarcinoma.
Schisandra chinensis lignans regulate and cooperate with endogenous cannabinoid systems to ameliorate intestinal barrier injury associated with depression.
MAPK signaling pathway participates in the regulation of intestinal phosphorus and calcium absorption in broiler chickens via 1,25-dihydroxyvitamin D(3).
Orally Administered Ginkgolide C Alleviates MPTP-Induced Neurodegeneration by Suppressing Neuroinflammation and Oxidative Stress through Microbiota-Gut-Brain Axis in Mice.
Exploring the Effect of Fidgetin-Like 1 on Colorectal Cancer Through Tissue Chip and In Vitro Experiments.
Lactobacillus paracasei subsp. paracasei NTU 101 prevents obesity by regulating AMPK pathways and gut microbiota in obese rat.
Exploring the anti-inflammatory and immune regulatory effects of Taohe Chengqi decoction in sepsis-induced lung injury.
Erianin inhibits the progression of pancreatic cancer by directly targeting AKT and ASK1.
p38 MAPK inhibitor SB202190 suppresses ferroptosis in the glutamate-induced retinal excitotoxicity glaucoma model.
Exosomal miR-552-3p isolated from BALF of patients with silicosis induces fibroblast activation.
Enhancing DOX efficacy against NSCLC through UDCA-mediated modulation of the TGF-β/MAPK autophagy pathways.
Hypoxanthine Produces Rapid Antidepressant Effects by Suppressing Inflammation in Serum and Hippocampus.
Low-Medium Polarity Ginsenosides from Wild Ginseng Improves Immunity by Activating the AhR/MAPK Pathway through Tryptophan Metabolism Driven by Gut Microbiota.
Palmitoylation licenses RIPK1 kinase activity and cytotoxicity in the TNF pathway.
Programmed cell death-related ABI1 is a critical mediator of abdominal aortic aneurysm.
Non-Sugar Sweetener Rubusoside Alleviates Lipid Metabolism Disorder In Vivo and In Vitro by Targeting PPARγ/α, Lgals3, and Mknk2.
Carthamin yellow alleviates dextran sodium sulfate-induced ulcerative colitis by repairing the intestinal barrier and activating the Nrf2/GPX4 axis.
7-hydroxycoumarin ameliorates ulcerative colitis in mice by inhibiting the MAPK pathway and alleviating gut microbiota dysbiosis.
IL1RAP Exacerbates Sepsis-Induced Pulmonary and Spleen Injury Through Regulating CD4(+) T Lymphocyte Differentiation.
circUSP13 facilitates the fast-to-slow myofiber shift via the MAPK/ERK signaling pathway in goat skeletal muscles.
Alcohol extract of Rubia yunnanensis: Metabolic alterations and preventive effects against OGD/R‑induced oxidative damage in HT22 cells.
The prognostic significance and potential mechanism of DBF4 zinc finger in hepatocellular carcinoma.
D-mannose alleviates intervertebral disc degeneration through glutamine metabolism.
Inhibition of macrophage MAPK/NF-κB pathway and Th2 axis by mangiferin ameliorates MC903-induced atopic dermatitis.
Readily Available Oral Prebiotic Protein Reactive Oxygen Species Nanoscavengers for Synergistic Therapy of Inflammation and Fibrosis in Inflammatory Bowel Disease.
ECHDC2 inhibits the proliferation of gastric cancer cells by binding with NEDD4 to degrade MCCC2 and reduce aerobic glycolysis.
Glycyrrhizic Acid Alleviates Semen Strychni-Induced Neurotoxicity Through the Inhibition of HMGB1 Phosphorylation and Inflammatory Responses.
Oral Administration of Deer Bone Collagen Peptide Can Enhance the Skin Hydration Ability and Antioxidant Ability of Aging Mice Induced by D-Gal, and Regulate the Synthesis and Degradation of Collagen.
Naringin attenuates Actinobacillus pleuropneumoniae-induced acute lung injury via MAPK/NF-κB and Keap1/Nrf2/HO-1 pathway.
The Effects of Resveratrol and Apigenin on Jejunal Oxidative Injury in Ducks and on Immortalized Duck Intestinal Epithelial Cells Exposed to H(2)O(2).
Overexpressing of the GIPC1 protects against pathological cardiac remodelling.
Helicobacter pylori disrupts gastric mucosal homeostasis by stimulating macrophages to secrete CCL3.
Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop.
VSIG4 inhibits RANKL-induced osteoclastogenesis by enhancing Nrf2-dependent antioxidant response against reactive oxygen species production.
Caffeic acid-grafted chitooligosaccharides downregulate MAPK and NF-kB in RAW264.7 cells.
PARP5A and RNF146 phase separation restrains RIPK1-dependent necroptosis.
Spinosin inhibits activated hepatic stellate cell to attenuate liver fibrosis by targeting Nur77/ASK1/p38 MAPK signaling pathway.
Protective Effects of Carbonated Chitosan Montmorillonite on Vomitoxin-Induced Intestinal Inflammation.
Soybean-derived antihypertensive hydrolysates attenuate Ang II-induced renal damage by modulating MAPK and NF-κB signaling pathways.
Association of TRAIL receptor with phosphatase SHP-1 enables repressing T cell receptor signaling and T cell activation through inactivating Lck.
L-Theanine alleviates heat stress through modulation of gut microbiota and immunity.
Study on the effect and mechanism of Zhenzhu Tongluo pills in treating diabetic peripheral neuropathy injury.
Myricanol attenuates sepsis-induced inflammatory responses by nuclear factor erythroid 2-related factor 2 signaling and nuclear factor kappa B/mitogen-activated protein kinase pathway via upregulating Sirtuin 1.
Prednisone combined with Dihydroartemisinin attenuates systemic lupus erythematosus by regulating M1/M2 balance through the MAPK signaling pathway.
Tris (2-chloroisopropyl) phosphate and Tris (nonylphenyl) phosphite Promote Human Renal Cell Apoptosis through the ERK/CEPBA/Long Non-Coding RNA Cytoskeleton Regulator Axis.
Network pharmacology and biochemical experiments reveal the antiapoptotic mechanism of huperzine A for treating diabetic retinopathy.
Daphnetin Ameliorates Neuropathic Pain via Regulation of Microglial Responses and Glycerophospholipid Metabolism in the Spinal Cord.
Orientin alleviates the inflammatory response in psoriasis like dermatitis in BALB/c mice by inhibiting the MAPK signaling pathway.
Structural elucidation and anti-psoriasis activity of a novel polysaccharide from Saussurea Costus.
STAU1 exhibits a dual function by promoting amyloidogenesis and tau phosphorylation in cultured cells.
Microglial uptake of hADSCs-Exo mitigates neuroinflammation in ICH.
Myeloid-derived growth factor ameliorates dextran sodium sulfate-induced colitis by regulating macrophage polarization.
CDK5-USP30 signaling pathway regulates MAVS-mediated inflammation via suppressing mitophagy in MPTP/MPP(+) PD model.
Exposure to volatile organic compounds induces cardiovascular toxicity that may involve DNA methylation.
Study on the molecular mechanism of dihydromyricetin in alleviating liver cirrhosis based on network pharmacology.
Trimethylamine-N oxide enhances post-stroke depression progression via ROS-p38/MAPK signaling.
Corilagin relieves atherosclerosis via the toll-like receptor 4 signaling pathway in vascular smooth muscle cells.
Gestational exposure to 1-NP induces ferroptosis in placental trophoblasts via CYP1B1/ERK signaling pathway leading to fetal growth restriction.
Protective Effect of Artocarpus heterophyllus Lam. (Jackfruit) Polysaccharides on Liver Injury Induced by Cyclophosphamide in Mice.
Cholinergic signaling of muscarinic receptors directly involves in the neuroprotection of muscone by inducing Ca(2+) antagonism and maintaining mitochondrial function.
Prepared Radix Polygoni Multiflori and emodin alleviate lipid droplet accumulation in nonalcoholic fatty liver disease through MAPK signaling pathway inhibition.
The protective effect of Ergolide in osteoarthritis: In vitro and in vivo studies.
Bioinformatics and experimental studies jointly reveal that Sacubitril Valsartan improves myocardial oxidative stress and inflammation by regulating the MAPK signaling pathway to treat chemotherapy related cardiotoxicity.
Icariin decreases cell proliferation and inflammation of rheumatoid arthritis-fibroblast like synoviocytes via GAREM1/MAPK signaling pathway.
Tobacco introduced Perilla frutescens and Ocimum basilicum genes attenuates neutrophilic inflammation in lung tissues of COPD rats.
Targeting ROCK1 in diabetic kidney disease: Unraveling mesangial fibrosis mechanisms and introducing myricetin as a novel antagonist.
Exploration of costunolide derivatives as potential anti-inflammatory agents for topical treatment of atopic dermatitis by inhibiting MAPK/NF-κB pathways.
Orally administered neohesperidin attenuates MPTP-induced neurodegeneration by inhibiting inflammatory responses and regulating intestinal flora in mice.
Warm Acupuncture Reduces Pain and Inflammation in Rats with Lumbar Disc Herniation Induced by Autologous Nucleus Pulposus Transplantation via Regulating p38MAPK/NF-κB Pathway.
Resveratrol-laden mesoporous silica nanoparticles regulate the autophagy and apoptosis via ROS-mediated p38-MAPK/HIF-1a /p53 signaling in hypertrophic scar fibroblasts.
Aggresome formation promotes ASK1/JNK signaling activation and stemness maintenance in ovarian cancer.
Sasanquasaponin from Camellia oleifera Abel Exerts an Anti-Inflammatory Effect in RAW 264.7 Cells via Inhibition of the NF-κB/MAPK Signaling Pathways.
Therapeutic potential of Lacticaseibacillus rhamnosus grx10 and its derived postbiotic through gut microbiota and MAPK/MLCK/MLC pathway-mediated intestinal barrier repairment in ulcerative colitis.
Active Targets and Potential Mechanisms of Erhuang Quzhi Formula in Treating NAFLD: Network Analysis and Experimental Assessment.
Pseudorabies virus UL13 primes inflammatory response through downregulating heat shock factor 1.
Folic acid mitigates the developmental and neurotoxic effects of bisphenol A in zebrafish by inhibiting the oxidative stress/JNK signaling pathway.
Pharmacological Network Analysis of the Functions and Mechanism of Quercetin From Jisuikang (JSK) in Spinal Cord Injury (SCI).
Protocatechuic acid attenuates intestinal inflammation through TLR4/p38 and NF-κB pathways in heat-stressed broilers.
The ellagitannin metabolite urolithin C attenuated cognitive impairment by inhibiting neuroinflammation via downregulation of MAPK/NF-kB signaling pathways in aging mice.
Engineered Magneto-Piezoelectric Nanoparticles-Enhanced Scaffolds Disrupt Biofilms and Activate Oxidative Phosphorylation in Icam1(+) Macrophages for Infectious Bone Defect Regeneration.
NLRP12 c.1382dup promotes the development of Crohn's disease through the ERK/NLRP3/ IL-1β pathway.
Discovery of Novel MyD88 Inhibitor A5S to Alleviate Acute Lung Injury with Favorable Drug-like Properties.
MS4A3 regulates hematopoietic myeloid differentiation through ROS/TGF-β/p38MAPK pathway.
Contribution of inwardly rectifying potassium channel 4.1 in orofacial neuropathic pain: Regulation of pannexin 3 via the reactive oxygen species-activated P38 MAPK signal pathway.
High Dose of Estrogen Protects the Lungs from Ischemia-Reperfusion Injury by Downregulating the Angiotensin II Signaling Pathway.
Can thymosin beta 10 function both as a non-invasive biomarker and chemotherapeutic target in human colorectal cancer?
The Role of KDM2A and H3K36me2 Demethylation in Modulating MAPK Signaling During Neurodevelopment.
Fungal metabolite altersolanol a exhibits potent cytotoxicity against human placental trophoblasts in vitro via mitochondria-mediated apoptosis.
GPR124 promotes trophoblast proliferation, migration, and invasion and inhibits trophoblast cell apoptosis and inflammation via JNK and P38 MAPK pathways.
Mannan-binding lectin inhibits oxidative stress-induced senescence via the NAD+/Sirt1 pathway.
Extract of Phyllanthus emblica L. fruit stimulates basal glucose uptake and ameliorates palmitate-induced insulin resistance through AMPK activation in C2C12 myotubes.
Emodin suppresses alkali burn-induced corneal inflammation and neovascularization by the vascular endothelial growth factor receptor 2 signaling pathway.
Pimpinellin ameliorates macrophage inflammation by promoting RNF146-mediated PARP1 ubiquitination.
HBI-8000 improves heart failure with preserved ejection fraction via the TGF-β1/MAPK signalling pathway.
Defective prelamin A processing promotes unconventional necroptosis driven by nuclear RIPK1.
TuBG1 promotes hepatocellular carcinoma via ATR/P53-apoptosis and cycling pathways.
Osthole Activates the Cholinergic Anti-Inflammatory Pathway via α7nAChR Upregulation to Alleviate Inflammatory Responses.
Hesperidin ameliorates H(2)O(2)-induced bovine mammary epithelial cell oxidative stress via the Nrf2 signaling pathway.
Differences in Airway Remodeling and Emphysematous Lesions between Rats Exposed to Smoke from New-Type and Conventional Tobacco Varieties.
The role of FPR2-mediated ferroptosis in formyl peptide-induced acute lung injury against endothelial barrier damage and protective effect of the mitochondria-derived peptide MOTS-c.
Verapamil Attenuates the Severity of Tendinopathy by Mitigating Mitochondrial Dysfunction through the Activation of the Nrf2/HO-1 Pathway.
Study on the Mechanism of Jiaotai Pill Intervention on Insomnia Animal Model Based on Gut Microbiome and Metabolomics.
Vitamin K2 (MK-7) attenuates LPS-induced acute lung injury via inhibiting inflammation, apoptosis, and ferroptosis.
Adiponectin inhibits TGF-β1-induced skin fibroblast proliferation and phenotype transformation via the p38 MAPK signaling pathway.
The Protective Effect of Selenium Nanoparticles in Osteoarthritis: In vitro and in vivo Studies.
Acupuncture Relieves Cervical Spondylosis Radiculopathy by Regulating Spinal Microglia Activation Through MAPK Signaling Pathway in Rats.
Establishment of Risk Model and Analysis of Immunoinfiltration Based on Mitophagy-Related Associated Genes in Atrial Fibrillation.
Exploration of the mechanism of aloin ameliorates of combined allergic rhinitis and asthma syndrome based on network pharmacology and experimental validation.
Levetiracetam attenuates diabetes-associated cognitive impairment and microglia polarization by suppressing neuroinflammation.
Fibroblast growth factor 1 ameliorates thin endometrium in rats through activation of the autophagic pathway.
Arctiin-encapsulated DSPE-PEG bubble-like nanoparticles inhibit alveolar epithelial type 2 cell senescence to alleviate pulmonary fibrosis via the p38/p53/p21 pathway.
The anti-photoaging effect of C-phycocyanin on ultraviolet B-irradiated BALB/c-nu mouse skin.
Apelin-Overexpressing Neural Stem Cells in Conjunction with a Silk Fibroin Nanofiber Scaffold for the Treatment of Traumatic Brain Injury.
Exogenous spermidine alleviates diabetic cardiomyopathy via suppressing reactive oxygen species, endoplasmic reticulum stress, and Pannexin-1-mediated ferroptosis.
3,5,6-Trichloro-2-pyridinol confirms ototoxicity in mouse cochlear organotypic cultures and induces cytotoxicity in HEI-OC1 cells.
Nephroprotective Effects of Cardamonin on Renal Ischemia Reperfusion Injury/UUO-Induced Renal Fibrosis.
DHX9 Strengthens Atherosclerosis Progression By Promoting Inflammation in Macrophages.
Treatment with S-adenosylmethionine ameliorates irinotecan-induced intestinal barrier dysfunction and intestinal microbial disorder in mice.
Cocktail of three isoquinoline alkaloids derived from Glaucium grandiflorum Boiss. & A. Huet subsp. refractum (Nábelek) Mory inhibits the production of LPS-induced ROS, pro-inflammatory cytokines, and mediators through the down-regulation of p38 MAPK in BV-2 cells.
Anti-rheumatoid arthritis effects of total saponins from Rhizoma Panacis Majoris on adjuvant-induced arthritis in rats and rheumatoid arthritis fibroblast-like synoviocytes.
A network pharmacology approach to investigate dehydrocostus lactone inhibits the proliferation and epithelial-mesenchymal transition of human gastric cancer cells via regulating the PI3K/Akt and extracellular signal-regulated kinases/mitogen-activated protein kinase signalling pathways.
Lycium barbarum glycopeptide alleviates neuroinflammation in spinal cord injury via modulating docosahexaenoic acid to inhibiting MAPKs/NF-kB and pyroptosis pathways.
Sirtuin1 Mediates the Protective Effects of Echinacoside against Sepsis-Induced Acute Lung Injury via Regulating the NOX4-Nrf2 Axis.
Macrophages originated IL-33/ST2 inhibits ferroptosis in endometriosis via the ATF3/SLC7A11 axis.
Ulinastatin inhibits the metastasis of nasopharyngeal carcinoma by involving uPA/uPAR signaling.
Polydatin inhibited TNF-α-induced apoptosis of skeletal muscle cells through AKT-mediated p38 MAPK and NF-κB pathways.
Linderalactone mitigates diabetic cardiomyopathy in mice via suppressing the MAPK/ATF6 pathway.
Tanshinone I attenuates gastric precancerous lesions by inhibiting epithelial mesenchymal transition through the p38/STAT3 pathway.
Deficiency of S100A8/A9 attenuates pulmonary microvascular leakage in septic mice.
Extracts of Oldenlandia diffusa protects chondrocytes via inhibiting apoptosis and associated inflammatory response in osteoarthritis.
Prognosis-related VDAC1 regulates the proliferation and apoptosis of osteosarcoma cells via the MAPK signaling pathway.
Boris knockout eliminates AOM/DSS-induced in situ colorectal cancer by suppressing DNA damage repair and inflammation.
Multi-omics analysis of a drug-induced model of bipolar disorder in zebrafish.
Methionine sulfoxide suppresses adipogenic differentiation by regulating the mitogen-activated protein kinase signaling pathway.
Pharmacological network analysis of the functions and mechanism of kaempferol from Du Zhong in intervertebral disc degeneration (IDD).
11β-Hydroxysteroid dehydrogenase type 1 amplifies inflammation in LPS-induced THP-1 cells.
Antiangiogenic potential of Lepista nuda extract suppressing MAPK/p38 signaling-mediated developmental angiogenesis in zebrafish and HUVECs.
The antimicrobial peptide LK2(6)A(L) exhibits anti-inflammatory activity by binding to the myeloid differentiation 2 domain and protects against LPS-induced acute lung injury in mice.
ROS-activated MAPK/ERK pathway regulates crosstalk between Nrf2 and Hif-1α to promote IL-17D expression protecting the intestinal epithelial barrier under hyperoxia.
Calcitonin gene-related peptide ameliorates sepsis-induced intestinal injury by suppressing NLRP3 inflammasome activation.
Naringenin Attenuates Isoprenaline-Induced Cardiac Hypertrophy by Suppressing Oxidative Stress through the AMPK/NOX2/MAPK Signaling Pathway.
Erxian decoction alleviates cisplatin-induced premature ovarian failure in rats by reducing oxidation levels in ovarian granulosa cells.
Inhibition of fatty acid synthase protects obese mice from acute lung injury via ameliorating lung endothelial dysfunction.
Corilagin ameliorates macrophages inflammation in atherosclerosis through TLR4-NFκB/MAPK pathway.
RNA aptamers with specific binding affinity to CD40 (CD40Apt) represents a promising antagonist of the CD40-CD40L signaling for thyroid-associated ophthalmopathy (TAO) treatment in mouse.
Arsenic interferes with spermatogenesis involving Rictor/mTORC2-mediated blood-testis barrier disruption in mice.
Deficiency of S100 calcium binding protein A9 attenuates vascular dysfunction in aged mice.
The role of calcium-sensing receptor in ginsenoside Rg1 promoting reendothelialization to inhibit intimal hyperplasia after balloon injury.
Suramin ameliorates osteoarthritis by acting on the Nrf2/HO-1 and NF-κB signaling pathways in chondrocytes and promoting M2 polarization in macrophages.
Cangfu Daotan Wan alleviates polycystic ovary syndrome with phlegm-dampness syndrome via disruption of the PKP3/ERCC1/MAPK axis.
Embryonic Exposure to UV-328 Impairs the Cell Cycle in Zebrafish (Danio rerio) by Inhibiting the p38 MAPK/p53/Gadd45a Signaling Pathway.
MicroRNA profiling reveals the role of miR-133b-3p in promoting apoptosis and inhibiting cell proliferation and testosterone synthesis in mouse TM3 cells.
Blocking circadian clock factor Rev-erbα inhibits growth plate chondrogenesis via up-regulating MAPK-ERK1/2 pathway.
Metastatic effects of environmental carcinogens mediated by MAPK and UPR pathways with an in vivo Drosophila Model.
Angiotensin-(1-7) ameliorates sepsis-induced cardiomyopathy by alleviating inflammatory response and mitochondrial damage through the NF-κB and MAPK pathways.
Enhanced De Novo Lipid Synthesis Mediated by FASN Induces Chemoresistance in Colorectal Cancer.
Recombinant human angiotensin-converting enzyme 2 plays a protective role in mice with sepsis-induced cardiac dysfunction through multiple signaling pathways dependent on converting angiotensin II to angiotensin 1-7.
Pharmacological vitamin C inhibits mTOR signaling and tumor growth by degrading Rictor and inducing HMOX1 expression.
Oxymatrine attenuated isoproterenol-induced heart failure via the TLR4/NF-κB and MAPK pathways in vivo and in vitro.
Luteoloside Induces G0/G1 Phase Arrest of Neuroblastoma Cells by Targeting p38 MAPK.
Deciphering the underlying wound healing mechanisms of Streptocaulon juventas (Lour.) Merr. by integrating network pharmacology, transcriptomics, and experimental validation.
Metformin exhibits antineoplastic effects on Pten-deficient endometrial cancer by interfering with TGF-β and p38/ERK MAPK signalling.
Antinociceptive and neuroprotective effect of echinacoside on peripheral neuropathic pain in mice through inhibiting P2X7R/FKN/CX3CR1 pathway.
Liensinine improves AngII-induced vascular remodeling via MAPK/TGF-β1/Smad2/3 signaling.
Studies of the Immunomodulatory Activity of Polysaccharides from the Stem of Cynomorium songaricum Based on Intestinal Microbial Analysis.
Mitochondrion-targeted carboxymethyl chitosan hybrid nanoparticles loaded with Coenzyme Q10 protect cardiac grafts against cold ischaemia‒reperfusion injury in heart transplantation.
Cell and rat serum, urine and tissue metabolomics analysis elucidates the key pathway changes associated with chronic nephropathy and reveals the mechanism of action of rhein.
Thymosin β4 Exerts a Cytoprotective Function and Attenuates Liver Injury in Murine Hepatic Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation.
The role of ROS/p38 MAPK/NLRP3 inflammasome cascade in arsenic-induced depression-/anxiety-like behaviors of mice.
CHMP4A stimulates CD8+ T-lymphocyte infiltration and inhibits breast tumor growth via the LSD1/IFNβ axis.
Oxidative Stress-mediated Sprouty-related Protein with an EVH1 Domain 1 Down-regulation Contributes to Resisting Oxidative Injury in Microglia.
WITHDRAWN: Expression of Tmem41b and MMP13 associated with poor outcome in osteosarcomas.
Neuroprotection of β-caryophyllene against cerebral ischemia/reperfusion injury by inhibiting P38 MAPK/NLRP3 signaling pathway.
Mucin2 regulated by Ho1/p38/IL-10 axis plays a protective role in polystyrene nanoplastics-mediated intestinal toxicity.
SARS-CoV-2 E protein-induced THP-1 pyroptosis is reversed by Ruscogenin.
Perilla frutescens L. alleviates trimethylamine N-oxide-induced apoptosis in the renal tubule by regulating ASK1-JNK phosphorylation.
Parecoxib attenuates inflammation injury in septic H9c2 cells by regulating the MAPK signaling pathway.
Inhibition effect of 1-acetoxy-6α-(2-methylbutyryl)eriolanolide toward soluble epoxide hydrolase: Multispectral analysis, molecular dynamics simulation, biochemical, and in vitro cell-based studies.
AKR1B1 Represses Glioma Cell Proliferation through p38 MAPK-Mediated Bcl-2/BAX/Caspase-3 Apoptotic Signaling Pathways.
Docosahexaenoic Acid Attenuates Radiation-Induced Myocardial Fibrosis by Inhibiting the p38/ET-1 Pathway in Cardiomyocytes.
CMTM6 as a candidate risk gene for cervical cancer: Comprehensive bioinformatics study.
Suppression of SMOC2 alleviates myocardial fibrosis via the ILK/p38 pathway.
Mechanism of HSP90 Inhibitor in the Treatment of DSS-induced Colitis in Mice by Inhibiting MAPK Pathway and Synergistic Effect of Compound Sophorae Decoction.
Protective Effects of Herba Houttuyniae Aqueous Extract against OVA-Induced Airway Hyperresponsiveness and Inflammation in Asthmatic Mice.
Cholecystokinin Octapeptide Promotes ANP Secretion through Activation of NOX4-PGC-1α-PPARα/PPARγ Signaling in Isolated Beating Rat Atria.
Study on the Potential Mechanism of Semen Strychni against Myasthenia Gravis Based on Network Pharmacology and Molecular Docking with Experimental Verification.
Tanshinone IIA Accomplished Protection against Radiation-Induced Cardiomyocyte Injury by Regulating the p38/p53 Pathway.
PCNP is a novel regulator of proliferation, migration, and invasion in human thyroid cancer.
Gamma synuclein promotes cancer metastasis through the MKK3/6-p38MAPK cascade.
The Immune-Enhancing Properties of Hwanglyeonhaedok-Tang-Mediated Biosynthesized Gold Nanoparticles in Macrophages and Splenocytes.
Effects of Uremic Clearance Granules on p38 MAPK/NF-κB Signaling Pathway, Microbial and Metabolic Profiles in End-Stage Renal Disease Rats Receiving Peritoneal Dialysis.
Therapeutic effects of shaogan fuzi decoction in rheumatoid arthritis: Network pharmacology and experimental validation.
Theaflavin-3,3'-Digallate from Black Tea Inhibits Neointima Formation Through Suppression of the PDGFRβ Pathway in Vascular Smooth Muscle Cells.
Mapk14 is a Prognostic Biomarker and Correlates with the Clinicopathological Features and Immune Infiltration of Colorectal Cancer.
Kukoamine A inhibits C-C motif chemokine receptor 5 to attenuate lipopolysaccharide-induced lung injury.
The caspase-1 inhibitor VX765 upregulates connexin 43 expression and improves cell-cell communication after myocardial infarction via suppressing the IL-1β/p38 MAPK pathway.
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.
HIV-1 Tat Protein-Mediated Inflammatory Response Inhibits the Erythroid Hematopoietic Support Function of Bone Marrow Mesenchymal Stem Cells.
Analgesic effect of nobiletin against neuropathic pain induced by the chronic constriction injury of the sciatic nerve in mice.
Hylocereus undatus flower extract suppresses OVA-induced allergic asthma in BALb/c mice by reducing airway inflammation and modulating gut microbiota.
Neobavaisoflavone inhibits allergic inflammatory responses by suppressing mast cell activation.
Effects of growth hormone/estrogen/androgen on COVID-19-type proinflammatory responses in normal human lung epithelial BEAS-2B cells.
Oleuropein ameliorated lung ischemia-reperfusion injury by inhibiting TLR4 signaling cascade in alveolar macrophages.
Electroacupuncture attenuates chronic salpingitis transforming growth factor-β1/p38 mitogen-activated protein kinase signaling pathway.
Effect of propiconazole on neutrophil extracellular traps formation: Assessing the role of autophagy.
LncRNA LINC00281/Annexin A2 Regulates Vascular Smooth Muscle Cell Phenotype Switching via the Nuclear Factor-Kappa B Signaling Pathway.
Triclocarban evoked neutrophil extracellular trap formation in common carp (Cyprinus carpio L.) by modulating SIRT3-mediated ROS crosstalk with ERK1/2/p38 signaling.
Synthesis and anti-inflammatory activity of paeonol derivatives with etherized aryl urea by regulating TLR4/MyD88 signaling pathway in RAW264.7 cell.
7-Methoxyisoflavone suppresses vascular endothelial inflammation by inhibiting the expression of endothelial adhesion molecules.
RNA m6A reader IGF2BP3 promotes metastasis of triple-negative breast cancer via SLIT2 repression.
Losartan attenuates sepsis-induced cardiomyopathy by regulating macrophage polarization via TLR4-mediated NF-κB and MAPK signaling.
SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation.
CircRNA DDX21 acts as a prognostic factor and sponge of miR-1264/QKI axis to weaken the progression of triple-negative breast cancer.
Forkhead Box q1 promotes invasion and metastasis in colorectal cancer by activating the epidermal growth factor receptor pathway.
Estrogen-related Receptor α (ERRα) Functions in The Hypoxic Injury of Microglial Cells.
Effects of runt-related transcription factor 2 (RUNX2) on the autophagy of rapamycin-treated osteoblasts.
Daidzein suppresses TGF-β1-induced cardiac fibroblast activation via the TGF-β1/SMAD2/3 signaling pathway.
Sclareol ameliorates hyperglycemia-induced renal injury through inhibiting the MAPK/NF-κB signaling pathway.
CPSF1 mediates retinal vascular dysfunction in diabetes mellitus via the MAPK/ERK pathway.
6-Gingerol exerts a protective effect against hypoxic injury through the p38/Nrf2/HO-1 and p38/NF-κB pathway in H9c2 cells.
Synthesis and structure-activity relationship study of a potent MHO7 analogue as potential anti-triple negative breast cancer agent.
A long-term anti-inflammation markedly alleviated high-fat diet-induced obesity by repeated administrations of overexpressing IL10 human umbilical cord-derived mesenchymal stromal cells.
Neurotoxicity and gene expression alterations in zebrafish larvae in response to manganese exposure.
KGF-2 Regulates STAP-2-Mediated Signal Transducer and Activator of Transcription 3 Signaling and Reduces Skin Scar Formation.
GCN5 participates in KLF4-VEGFA feedback to promote endometrial angiogenesis.
Study on the new anti-atherosclerosis activity of different Herba patriniae through down-regulating lysophosphatidylcholine of the glycerophospholipid metabolism pathway.
Fine particulate matter induces endoplasmic reticulum stress-mediated apoptosis in human SH-SY5Y cells.
Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.
Acacetin attenuates Streptococcus suis virulence by simultaneously targeting suilysin and inflammation.
TSH-TSHR axis promotes tumor immune evasion.
Salidroside alleviates oxidative stress and apoptosis via AMPK/Nrf2 pathway in DHT-induced human granulosa cell line KGN.
Xiaoyao powder improves endometrial receptivity via VEGFR-2-mediated angiogenesis through the activation of the JNK and P38 signaling pathways.
Immune-enhancing effects of postbiotic produced by Bacillus velezensis Kh2-2 isolated from Korea Foods.
Phycocyanin inhibits Helicobacter pylori-induced hyper-proliferation in AGS cells via activation of the ROS/MAPK signaling pathway.
Berberine ameliorates erectile dysfunction in rats with streptozotocin-induced diabetes mellitus through the attenuation of apoptosis by inhibiting the SPHK1/S1P/S1PR2 and MAPK pathways.
L-Theanine mediates the p38MAPK signaling pathway to alleviate heat-induced oxidative stress and inflammation in mice.
Prenatal exposure to environmentally relevant levels of PBDE-99 leads to testicular dysgenesis with steroidogenesis disorders.
Endoglin Modulates TGFβR2 Induced VEGF and Proinflammatory Cytokine Axis Mediated Angiogenesis in Prolonged DEHP-Exposed Breast Cancer Cells.
Injection of YiQiFuMai powder protects against heart failure via inhibiting p38 and ERK1/2 MAPKs activation.
Mild hypothermia ameliorates hepatic ischemia reperfusion injury by inducing RBM3 expression.
Biotransformation of 18β-Glycyrrhetinic Acid by Human Intestinal Fungus Aspergillus niger RG13B1 and the Potential Anti-Inflammatory Mechanism of Its Metabolites.
microRNA-338-3p suppresses lipopolysaccharide-induced inflammatory response in HK-2 cells.
Resveratrol reduces p38 mitogen-activated protein kinase phosphorylation by activating Sirtuin 1 to alleviate cognitive dysfunction after traumatic brain injury in mice.
Rhodococcus equi-Derived Extracellular Vesicles Promoting Inflammatory Response in Macrophage through TLR2-NF-κB/MAPK Pathways.
Overexpression of NCAPG in ovarian cancer is associated with ovarian cancer proliferation and apoptosis via p38 MAPK signaling pathway.
Hypothermic oxygenated perfusion combined with TJ-M2010-5 alleviates hepatic ischemia-reperfusion injury in donation after circulatory death.
Mechanism exploration of ancient pharmaceutic processing (Paozhi) improving the gastroprotective efficacy of Aucklandiae Radix.
Gentiopicroside Inhibits Cell Growth and Migration on Cervical Cancer via the Reciprocal MAPK/Akt Signaling Pathways.
PICK1 Deficiency Exacerbates Sepsis-Associated Acute Kidney Injury.
BMSCs Regulate Astrocytes through TSG-6 to Protect the Blood-Brain Barrier after Subarachnoid Hemorrhage.
Baicalin Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy via Nrf2 and MAPK Signaling Pathway.
Punicalin Attenuates Breast Cancer-Associated Osteolysis by Inhibiting the NF-κB Signaling Pathway of Osteoclasts.
BCI Suppresses RANKL-Mediated Osteoclastogenesis and Alleviates Ovariectomy-Induced Bone Loss.
Exploring the Critical Components and Therapeutic Mechanisms of Perilla frutescens L. in the Treatment of Chronic Kidney Disease via Network Pharmacology.
Isovitexin Inhibits Ginkgolic Acids-Induced Inflammation Through Downregulating SHP2 Activation.
The EIF4A3/CASC2/RORA Feedback Loop Regulates the Aggressive Phenotype in Glioblastomas.
IL-1β Promotes Vasculogenic Mimicry of Breast Cancer Cells Through p38/MAPK and PI3K/Akt Signaling Pathways.
The effects of mTOR or Vps34-mediated autophagy on methylmercury-induced neuronal apoptosis in rat cerebral cortex.
Diurnal regulation of oxidative phosphorylation restricts hepatocyte proliferation and inflammation.
Sympathetic activity is correlated with satellite cell aging and myogenesis via β2-adrenoceptor.
Quercitrin Rapidly Alleviated Depression-like Behaviors in Lipopolysaccharide-Treated Mice: The Involvement of PI3K/AKT/NF-κB Signaling Suppression and CREB/BDNF Signaling Restoration in the Hippocampus.
Paternal exposure to microcystin-LR triggers developmental neurotoxicity in zebrafish offspring via an epigenetic mechanism involving MAPK pathway.
miR-128 participates in the pathogenesis of chronic constipation by regulating the p38α/M-CSF inflammatory signaling pathway.
Knockdown of ST6Gal-I expression in human hepatocellular carcinoma cells inhibits their exosome-mediated proliferation- and migration-promoting effects.
RABL2A-CCDC34 Axis Promotes Sorafenib Resistance in Hepatocellular Carcinoma.
The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist-resistant prolactinomas.
Drug-containing serum of rhubarb-astragalus capsule inhibits the epithelial-mesenchymal transformation of HK-2 by downregulating TGF-β1/p38MAPK/Smad2/3 pathway.
1,10-Seco-Eudesmane sesquiterpenoids as a new type of anti-neuroinflammatory agents by suppressing TLR4/NF-κB/MAPK pathways.
The synthesis and bioactivity of pyrrolo[2,3-d]pyrimidine derivatives as tyrosine kinase inhibitors for NSCLC cells with EGFR mutations.
Overexpression of FOXA2 attenuates cigarette smoke-induced cellular senescence and lung inflammation through inhibition of the p38 and Erk1/2 MAPK pathways.
Anti-osteoporotic effects of alisol C 23-acetate via osteoclastogenesis inhibition.
Downregulation of CD151 restricts VCAM-1 mediated leukocyte infiltration to reduce neurobiological injuries after experimental stroke.
Simvastatin Enhances the Chondrogenesis But Not the Osteogenesis of Adipose-Derived Stem Cells in a Hyaluronan Microenvironment.
ZnO NPs delay the recovery of psoriasis-like skin lesions through promoting nuclear translocation of p-NFκB p65 and cysteine deficiency in keratinocytes.
Asenapine maleate inhibits angiotensin II-induced proliferation and activation of cardiac fibroblasts via the ROS/TGFβ1/MAPK signaling pathway.
A human β-casein-derived peptide BCCY-1 modulates the innate immune response.
Long noncoding RNA AFAP1-AS1 promotes tumor progression and invasion by regulating the miR-2110/Sp1 axis in triple-negative breast cancer.
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
Cytotoxicity of apigenin toward multiple myeloma cell lines and suppression of iNOS and COX-2 expression in STAT1-transfected HEK293 cells.
MCLR induces dysregulation of calcium homeostasis and endoplasmic reticulum stress resulting in apoptosis in Sertoli cells.
NDUFA4L2 in smooth muscle promotes vascular remodeling in hypoxic pulmonary arterial hypertension.
Pro-protein convertase subtilisin/kexin type 9 promotes intestinal tumor development by activating Janus kinase 2/signal transducer and activator of transcription 3/SOCS3 signaling in Apc(Min/+) mice.
Critical roles of sphingosine kinase 1 in the regulation of neuroinflammation and neuronal injury after spinal cord injury.
Bioactive constituents of Mosla chinensis-cv. Jiangxiangru ameliorate inflammation through MAPK signaling pathways and modify intestinal microbiota in DSS-induced colitis mice.
Diterpenoid alkaloids from Delphinium forrestii var. viride and their anti-inflammation activity.
Shockwave Treatment Enhanced Extracellular Matrix Production in Articular Chondrocytes Through Activation of the ROS/MAPK/Nrf2 Signaling Pathway.
The effects of Omarigliptin on promoting osteoblastic differentiation.
Protective effect of combination of anakinra and MCC950 against acute lung injury is achieved through suppression of the NF-κB-mediated-MAPK and NLRP3-caspase pathways.
The miR-223-3p/MAP1B axis aggravates TGF-β-induced proliferation and migration of BPH-1 cells.
Guanosine and uridine alleviate airway inflammation via inhibition of the MAPK and NF-κB signals in OVA-induced asthmatic mice.
Suramin attenuates intervertebral disc degeneration by inhibiting NF-κB signalling pathway.
Polysaccharides from Ulva prolifera O.F. Müller inhibit cell proliferation via activating MAPK signaling in A549 and H1650 cells.
Fab Fragment of Immunoglobulin Y Modulates NF-κB and MAPK Signaling through TLR4 and αVβ3 Integrin and Inhibits the Inflammatory Effect on R264.7 Macrophages.
Ophiocordyceps lanpingensis polysaccharides alleviate chronic kidney disease through MAPK/NF-κB pathway.
Anti-thrombotic activity of phenolic acids obtained from Salvia miltiorrhiza f. alba in TNF-α-stimulated endothelial cells via the NF-κB/JNK/p38 MAPK signaling pathway.
The orphan nuclear receptor Nurr1 agonist amodiaquine mediates neuroprotective effects in 6-OHDA Parkinson's disease animal model by enhancing the phosphorylation of P38 mitogen-activated kinase but not PI3K/AKT signaling pathway.
KLF5-mediated Eppk1 expression promotes cell proliferation in cervical cancer via the p38 signaling pathway.
Ginsenoside Rh4 alleviates antibiotic-induced intestinal inflammation by regulating the TLR4-MyD88-MAPK pathway and gut microbiota composition.
CDKN2a/p16 Antagonizes Hepatic Stellate Cell Activation and Liver Fibrosis by Modulating ROS Levels.
WJ-39, an Aldose Reductase Inhibitor, Ameliorates Renal Lesions in Diabetic Nephropathy by Activating Nrf2 Signaling.
Rhein Suppresses Neuroinflammation via Multiple Signaling Pathways in LPS-Stimulated BV2 Microglia Cells.
Protein Kinase A Is Involved in Neuropathic Pain by Activating the p38MAPK Pathway to Mediate Spinal Cord Cell Apoptosis.
Thymoquinone Protects against Hyperlipidemia-Induced Cardiac Damage in Low-Density Lipoprotein Receptor-Deficient (LDL-R(-/-)) Mice via Its Anti-inflammatory and Antipyroptotic Effects.
Antiprolactinoma Effect of Hordenine by Inhibiting MAPK Signaling Pathway Activation in Rats.
25-Hydroxycholesterol protects against myocardial ischemia-reperfusion injury via inhibiting PARP activity.
Changes in inflammatory factors in SV40MES13 mesangial cells after silencing ApoM gene.
Fatty acid extracts facilitate cutaneous wound healing through activating AKT, ERK, and TGF-β/Smad3 signaling and promoting angiogenesis.
Recombinant Dual-target MDM2/MDMX Inhibitor Reverses Doxorubicin Resistance through Activation of the TAB1/TAK1/p38 MAPK Pathway in Wild-type p53 Multidrug-resistant Breast Cancer Cells.
Huangkui Capsule Ameliorates Renal Fibrosis in a Unilateral Ureteral Obstruction Mouse Model Through TRPC6 Dependent Signaling Pathways.
Corilagin Ameliorates Atherosclerosis in Peripheral Artery Disease via the Toll-Like Receptor-4 Signaling Pathway in vitro and in vivo.
DHZCP Modulates Microglial M1/M2 Polarization via the p38 and TLR4/NF-κB Signaling Pathways in LPS-Stimulated Microglial Cells.
Inhibiting MAPK14 showed anti-prolactinoma effect.
A multifunctional anti-inflammatory drug that can specifically target activated macrophages, massively deplete intracellular H(2)O(2), and produce large amounts CO for a highly efficient treatment of osteoarthritis.
Effect of autophagy on irradiation‑induced damage in osteoblast‑like MC3T3‑E1 cells.
Daidzein ameliorates LPS-induced hepatocyte injury by inhibiting inflammation and oxidative stress.
The anti-inflammatory potential of protein-bound anthocyanin compounds from purple sweet potato in LPS-induced RAW264.7 macrophages.
Enhancement of anti-acne effect of Scutellaria baicalensis extract by fermentation with symbiotic fungus Penicillium decumbens.
The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies.
Long-wave Ultraviolet Ray Promotes Inflammation in Keloid-derived Fibroblasts by Activating P38-NFκB1 Signaling Pathway.
Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice.
Downregulation of GLYR1 contributes to microsatellite instability colorectal cancer by targeting p21 via the p38MAPK and PI3K/AKT pathways.
In vitro and in vivo anti-Listeria effect of Succinoglycan Riclin through regulating MAPK/IL-6 axis and metabolic profiling.
Sodium acetate alleviated high-carbohydrate induced intestinal inflammation by suppressing MAPK and NF-κB signaling pathways in Nile tilapia (Oreochromis niloticus).
Synthesis and biological evaluation of myricetin-pentadienone hybrids as potential anti-inflammatory agents in vitro and in vivo.
TXNIP deficiency mitigates podocyte apoptosis via restraining the activation of mTOR or p38 MAPK signaling in diabetic nephropathy.
Sodium tanshinone IIA sulfonate prevents radiation-induced damage in primary rat cardiac fibroblasts.
Antioxidants suppress radiation-induced apoptosis via inhibiting MAPK pathway in nasopharyngeal carcinoma cells.
BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer.
Si-Miao-Yong-An decoction attenuates cardiac fibrosis via suppressing TGF-β1 pathway and interfering with MMP-TIMPs expression.
Discovery of novel TNNI3K inhibitor suppresses pyroptosis and apoptosis in murine myocardial infarction injury.
Gamabufotalin induces a negative feedback loop connecting ATP1A3 expression and the AQP4 pathway to promote temozolomide sensitivity in glioblastoma cells by targeting the amino acid Thr794.
Spondin 2 promotes the proliferation, migration and invasion of gastric cancer cells.
Protective effects of Salidroside on spermatogenesis in streptozotocin induced type-1 diabetic male mice by inhibiting oxidative stress mediated blood-testis barrier damage.
Alisol A-24-acetate promotes glucose uptake via activation of AMPK in C2C12 myotubes.
Isorhamnetin attenuates Streptococcus suis virulence by inhibiting the inflammatory response.
PP2A alleviates oxidized LDL-induced endothelial dysfunction by regulating LOX-1/ROS/MAPK axis.
Mincle/Syk Signalling Promotes Intestinal Mucosal Inflammation Through Induction of Macrophage Pyroptosis in Crohn's Disease.
Increased Blood Pressure Causes Lymphatic Endothelial Dysfunction via Oxidative Stress in Spontaneously Hypertensive Rats.
Baicalein Alleviates Erectile Dysfunction Associated With Streptozotocin-Induced Type I Diabetes by Ameliorating Endothelial Nitric Oxide Synthase Dysfunction, Inhibiting Oxidative Stress and Fibrosis.
Reelin Promotes Cisplatin Resistance by Induction of Epithelial-Mesenchymal Transition via p38/GSK3β/Snail Signaling in Non-Small Cell Lung Cancer.
Chlorogenic acid attenuates cyclophosphamide-induced rat interstitial cystitis.
HMGB1 Mediates Paraquat-Induced Neuroinflammatory Responses via Activating RAGE Signaling Pathway.
A Combination of Formic Acid and Monolaurin Attenuates Enterotoxigenic Escherichia coli Induced Intestinal Inflammation in Piglets by Inhibiting the NF-κB/MAPK Pathways with Modulation of Gut Microbiota.
The protective effects of β-sitosterol and vermicularin from Thamnolia vermicularis (Sw.) Ach. against skin aging in vitro.
Protective Effect of Methane-Rich Saline on Acetic Acid-Induced Ulcerative Colitis via Blocking the TLR4/NF-κB/MAPK Pathway and Promoting IL-10/JAK1/STAT3-Mediated Anti-inflammatory Response.
Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-β1/Smad3 and TGF-β1/p38 MAPK Pathways.
Bu Shen Zhu Yun Decoction Improves Endometrial Receptivity via VEGFR-2-Mediated Angiogenesis.
Dual-target MDM2/MDMX inhibitor increases the sensitization of doxorubicin and inhibits migration and invasion abilities of triple-negative breast cancer cells through activation of TAB1/TAK1/p38 MAPK pathway.
L-Cysteine-Derived H(2)S Promotes Microglia M2 Polarization via Activation of the AMPK Pathway in Hypoxia-Ischemic Neonatal Mice.
Adipose-derived mesenchymal stem cells ameliorate the inflammatory reaction in CLP-induced septic acute lung injury rats via sTNFR1.
N‑acetyl cysteine inhibits lipopolysaccharide‑induced apoptosis of human umbilical vein endothelial cells via the p38MAPK signaling pathway.
The Potential of Neoagaro-Oligosaccharides as a Treatment of Type II Diabetes in Mice.
Up-regulated cathepsin C induces macrophage M1 polarization through FAK-triggered p38 MAPK/NF-κB pathway.
Regulation of circadian rhythms by NEAT1 mediated TMAO-induced endothelial proliferation: A protective role of asparagus extract.
PM(2.5) upregulates rat mesenteric arteries 5-HT(2A) receptor via inflammatory-mediated mitogen-activated protein kinases signaling pathway.
Dehydroepiandrosterone alleviates E. Coli O157:H7-induced inflammation by preventing the activation of p38 MAPK and NF-κB pathways in mice peritoneal macrophages.
CD146 Regulates Growth Factor-Induced mTORC2 Activity Independent of the PI3K and mTORC1 Pathways.
Caveolin-1 promotes Rfng expression via Erk-Jnk-p38 signaling pathway in mouse hepatocarcinoma cells.
Association and clinicopathologic significance of p38MAPK-ERK-JNK-CDC25C with polyploid giant cancer cell formation.
Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs.
NRP1 regulates HMGB1 in vascular endothelial cells under high homocysteine condition.
Chitosan Hydrogel Delivery System Containing Herbal Compound Functions as a Potential Antineuroinflammatory Agent.
Caveolin-1 promotes invasion and metastasis by upregulating Pofut1 expression in mouse hepatocellular carcinoma.
Small molecule inhibitor of TGF-β signaling enables robust osteogenesis of autologous GMSCs to successfully repair minipig severe maxillofacial bone defects.
Chlorogenic acid: A potent molecule that protects cardiomyocytes from TNF-α-induced injury via inhibiting NF-κB and JNK signals.
Red yeast rice ameliorates high-fat diet-induced atherosclerosis in Apoe(-/-) mice in association with improved inflammation and altered gut microbiota composition.
Isosteviol Sodium Protects Neural Cells Against Hypoxia-Induced Apoptosis Through Inhibiting MAPK and NF-κB Pathways.
PKP3 interactions with MAPK-JNK-ERK1/2-mTOR pathway regulates autophagy and invasion in ovarian cancer.
Tobacco smoke induced hepatic cancer stem cell-like properties through IL-33/p38 pathway.
Catalpol promotes the osteogenic differentiation of bone marrow mesenchymal stem cells via the Wnt/β-catenin pathway.
Intermedin in Paraventricular Nucleus Attenuates Sympathoexcitation and Decreases TLR4-Mediated Sympathetic Activation via Adrenomedullin Receptors in Rats with Obesity-Related Hypertension.
Activation of the Omega-3 Fatty Acid Receptor GPR120 Protects against Focal Cerebral Ischemic Injury by Preventing Inflammation and Apoptosis in Mice.
Protective effects of betaine on diabetic induced disruption of the male mice blood-testis barrier by regulating oxidative stress-mediated p38 MAPK pathways.
Grape Seed Proanthocyanidins Induce Autophagy and Modulate Survivin in HepG2 Cells and Inhibit Xenograft Tumor Growth in Vivo.
Dietary resveratrol supplementation inhibits heat stress-induced high-activated innate immunity and inflammatory response in spleen of yellow-feather broilers.
Quercetin reduces Streptococcus suis virulence by inhibiting suilysin activity and inflammation.
Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation.
Immunomodulatory effects of an acidic polysaccharide fraction from herbal Gynostemma pentaphyllum tea in RAW264.7 cells.
SIRT6 Suppresses NFATc4 Expression and Activation in Cardiomyocyte Hypertrophy.
Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1β Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes.
The Long Noncoding RNA 150Rik Promotes Mesangial Cell Proliferation via miR-451/IGF1R/p38 MAPK Signaling in Diabetic Nephropathy.
PPP5C promotes cell proliferation and survival in human prostate cancer by regulating of the JNK and ERK1/2 phosphorylation.
Apoptosis of bone marrow mesenchymal stromal/stem cells via the MAPK and endoplasmic reticulum stress signaling pathways.
Prostaglandin F(2α) Facilitates Hepatic Glucose Production Through CaMKIIγ/p38/FOXO1 Signaling Pathway in Fasting and Obesity.
New insights into meningitic Escherichia coli infection of brain microvascular endothelial cells from quantitative proteomics analysis.
Neuroprotective Effect of Oxysophocarpine by Modulation of MAPK Pathway in Rat Hippocampal Neurons Subject to Oxygen-Glucose Deprivation and Reperfusion.
All-Trans Retinoic Acid Ameliorates the Early Experimental Cerebral Ischemia-Reperfusion Injury in Rats by Inhibiting the Loss of the Blood-Brain Barrier via the JNK/P38MAPK Signaling Pathway.
Network pharmacology-based strategy for predicting active ingredients and potential targets of Yangxinshi tablet for treating heart failure.
Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-α pathway in mice.
Asperuloside and Asperulosidic Acid Exert an Anti-Inflammatory Effect via Suppression of the NF-κB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages.
Neuroprotective Effect of Curcumin Against Cerebral Ischemia-Reperfusion Via Mediating Autophagy and Inflammation.
Correlation of TGN-020 with the analgesic effects via ERK pathway activation after chronic constriction injury.
Scandoside Exerts Anti-Inflammatory Effect Via Suppressing NF-κB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages.
Metformin Protects against LPS-Induced Intestinal Barrier Dysfunction by Activating AMPK Pathway.
Cold atmospheric plasma conveys selectivity on triple negative breast cancer cells both in vitro and in vivo.
l-Homocysteine-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinaemia.
LPS‑induced proinflammatory cytokine expression in human airway epithelial cells and macrophages via NF‑κB, STAT3 or AP‑1 activation.
IAPP modulates cellular autophagy, apoptosis, and extracellular matrix metabolism in human intervertebral disc cells.
Salidroside pretreatment attenuates apoptosis and autophagy during hepatic ischemia-reperfusion injury by inhibiting the mitogen-activated protein kinase pathway in mice.
Anti-inflammatory activity of coptisine free base in mice through inhibition of NF-κB and MAPK signaling pathways.
Spiroplasma eriocheiris induces mouse 3T6-Swiss albino cell apoptosis that associated with the infection mechanism.
Hepatoprotective effect of quercetin against LPS/d-GalN induced acute liver injury in mice by inhibiting the IKK/NF-κB and MAPK signal pathways.
The liver protection of propylene glycol alginate sodium sulfate preconditioning against ischemia reperfusion injury: focusing MAPK pathway activity.
Antioxidation, anti-inflammation and anti-apoptosis by paeonol in LPS/d-GalN-induced acute liver failure in mice.
Diosmetin exerts anti-oxidative, anti-inflammatory and anti-apoptotic effects to protect against endotoxin-induced acute hepatic failure in mice.
Interactions between Sirt1 and MAPKs regulate astrocyte activation induced by brain injury in vitro and in vivo.
Chemical characterization of a novel polysaccharide ASKP-1 from Artemisia sphaerocephala Krasch seed and its macrophage activation via MAPK, PI3k/Akt and NF-κB signaling pathways in RAW264.7 cells.
Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells.
The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis.
Protective effect of resveratrol against nigrostriatal pathway injury in striatum via JNK pathway.
Sinomenine hydrochloride attenuates the proliferation, migration, invasiveness, angiogenesis and epithelial-mesenchymal transition of clear-cell renal cell carcinoma cells via targeting Smad in vitro.
Polysaccharides from Citrus grandis L. Osbeck suppress inflammation and relieve chronic pharyngitis.
Anti-colon cancer effect of caffeic acid p-nitro-phenethyl ester in vitro and in vivo and detection of its metabolites.
Radiation promotes epithelial-to-mesenchymal transition and invasion of pancreatic cancer cell by activating carcinoma-associated fibroblasts.
Charaterization and immunomodulatory activities of polysaccharide isolated from Pleurotus eryngii.
The p38 MAPK inhibitor BIRB796 enhances the antitumor effects of VX680 in cervical cancer.
High Expression of Rab-like 3 (Rabl3) is Associated with Poor Survival of Patients with Non-Small Cell Lung Cancer via Repression of MAPK8/9/10-Mediated Autophagy.
Clinicopathological significance of p38β, p38γ, and p38δ and its biological roles in esophageal squamous cell carcinoma.
Arsenic-induced anti-angiogenesis via miR-425-5p-regulated CCM3.
Preventive Effects of a Novel Polysaccharide from Sepia esculenta Ink on Ovarian Failure and Its Action Mechanisms in Cyclophosphamide-Treated Mice.
Ghrelin protects against palmitic acid or lipopolysaccharide-induced hepatocyte apoptosis through inhibition of MAPKs/iNOS and restoration of Akt/eNOS pathways.
Paper-based microreactor array for rapid screening of cell signaling cascades.
Protective effects of p-nitro caffeic acid phenethyl ester on acute myocardial ischemia-reperfusion injury in rats.
Knee loading inhibits osteoclast lineage in a mouse model of osteoarthritis.
RhNRG-1β Protects the Myocardium against Irradiation-Induced Damage via the ErbB2-ERK-SIRT1 Signaling Pathway.
Astaxanthin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy via the ROS/MAPK Pathway in Mice.
Polychlorinated biphenyl quinone induces endothelial barrier dysregulation by setting the cross talk between VE-cadherin, focal adhesion, and MAPK signaling.
Effect of baicalin-copper on the induction of apoptosis in human hepatoblastoma cancer HepG2 cells.
Neohesperidin Dihydrochalcone versus CCl₄-Induced Hepatic Injury through Different Mechanisms: The Implication of Free Radical Scavenging and Nrf2 Activation.
Cai D, Zhu C, Huang H, Cao Y, Cai G, Chen Z, Feng J, Zhang W, Mao W, Lai J
Research (Washington, D.C.) 2026;9:1016
Research (Washington, D.C.) 2026;9:1016
Enhancement of Psoriasis Treatment by Phellodendri Chinensis Cortex Carbon Dots (PCC-CDs) Through Modulation of the HMGB1/TLR4/MAPK/NF-κB Pathway.
Tian X, Kong H, Wang S, Zhang X, He C, Huang Y, Liu R, Dai E, Shang G, Zhang Y, Jinjun C, Sun Z, Qu H, Zhao Y
International journal of nanomedicine 2026;21:578399
International journal of nanomedicine 2026;21:578399
Hsa_circ_0000313/miR-1224-3p/MKNK2 Axis Modulates CD4(+) T Cells by Activating p38 MAPK Signaling in Myasthenia Gravis.
Li Y, Kong X, Cai H, Tian W, Ren Y, Xu F, Peng S, Niu J, Xin G, Wang J, Zhang H, Wang L
Mediators of inflammation 2026;2026(1):e2877539
Mediators of inflammation 2026;2026(1):e2877539
A Novel MAP3K7 Variant Causing Loss of Function Identified in a Family With Cardiospondylocarpofacial Syndrome: Functional Validation and Molecular Insights.
Zhu T, Shi J, Li J, Zhou T, Fu X, Xu F, Gu C, Wang D, Wu R, Liu L, Shen J, Wang D
Human mutation 2026;2026:8024677
Human mutation 2026;2026:8024677
Epithelial Gab1 Restricts Sepsis-Induced Intestinal Injury by Orchestrating TNF/NF-κB Axis.
Jin W, Wu Y, Cheng X, Pan Y, He L, Xu Y, Xu J, Zhang X
Mediators of inflammation 2026;2026:5486971
Mediators of inflammation 2026;2026:5486971
Berberine Ameliorates Diabetic Kidney Disease by Modulating Macrophage Polarization via Inhibiting IL-17A Signaling.
Fan J, Liu Y, Zheng C, Liu J, Liu W, Geng R, Zhao A, Wang Y, Wang R, Qi Z
Journal of inflammation research 2026;19:580534
Journal of inflammation research 2026;19:580534
Gan-Pi-Tong-Zhi Decoction Ameliorates OVA-Induced Asthma Through MAPK and Nrf2 Signaling Pathways and Regulating Gut Microbiota.
Liu J, Zhao Y, Xu L
Journal of inflammation research 2026;19:570124
Journal of inflammation research 2026;19:570124
Tanshinone IIA prevents septicemia acute kidney injury via regulating the DUSP10/JNK/P38/NLRP3 pathway.
Wen D, Deng Q, Zeng Y, Li L, Yang X, Chen Q, Yan Y, Lv J
American journal of translational research 2026;18(1):190-206
American journal of translational research 2026;18(1):190-206
An astragalus polysaccharide-loaded hydrogel dressing enhances diabetic wound healing via dual-mode electrical stimulation.
Chen Z, Huo X, Wu Z, Ji G, Liu B, Tian H, Tang T, Deng J, Zhao Q, Li F
Bioactive materials 2026 Sep;63:885-903
Bioactive materials 2026 Sep;63:885-903
Rosuvastatin attenuates blood-brain barrier dysfunction after ICH through modulation of CXCL12-associated VEGFR2/p38 MAPK signaling.
Yuan M, Zhou H, Pan H, Xiao Z, Wu H, Wu W
Neuropharmacology 2026 Sep 1;295:110998
Neuropharmacology 2026 Sep 1;295:110998
Stromal cell-derived itaconate promotes endometriosis via macrophage NRF2 and lysosomal pH modulation.
Zhong Z, Wang S, Ren Q, Jiao X, Xu L, Dong X, Li N, Guan H, Chu R, Yuan M, Liu J, Du Y, Wei K, Yan L, Wang G
Redox biology 2026 May;92:104101
Redox biology 2026 May;92:104101
Farnesol Targets the GSTP1/MAPK Axis to Inhibit Trauma-Induced Tendon Heterotopic Ossification.
Deng X, Li T, Li G, Zhu T, Kong Y, Fu B, Li JJ, Chen C, Lei W, Jiang G, Zhang K
Phytotherapy research : PTR 2026 May;40(5):2692-2709
Phytotherapy research : PTR 2026 May;40(5):2692-2709
Punicalagin Promotes Peripheral Nerve Repair by Enhancing Mitophagy via the TLR4/MAPK Signaling Pathway and Facilitating Angiogenesis.
Guo A, Wang K, Liang J, Xia C, Luo K, Alqadhi S, Zhang H, Xiao S, Lin T, Zhang Z, Wu L, Yan H
Phytotherapy research : PTR 2026 May;40(5):2632-2650
Phytotherapy research : PTR 2026 May;40(5):2632-2650
Isoliquiritigenin restores bone homeostasis in osteoporotic rats by enhancing BMSCs osteogenesis via ERK1/2-mTOR-HIF-1α-glycolytic axis and suppressing inflammation.
Chang H, Li Y, Wang Z, Fang Z, Chen H, Xu C, Jiao X, Gan Y
International immunopharmacology 2026 May 1;176:116440
International immunopharmacology 2026 May 1;176:116440
Baicalin Restores the Hypoglycemic Effect of Metformin by Regulating the Microbial Imidazole Propionate and Short-Chain Fatty Acids.
Wang A, Miao Z, Huang B, Zeng J, Yuan M, Yan D
Phytotherapy research : PTR 2026 Mar;40(3):1060-1073
Phytotherapy research : PTR 2026 Mar;40(3):1060-1073
Isolation, structural characterization and immunoregulatory activity of a novel acidic polysaccharide from Ganoderma sinense.
Zhang M, Wu J, Xu J, Hu X, Shi H, Huang W, Song L, Zhu J, Tan H, Yu R
International journal of biological macromolecules 2026 Mar;352:151196
International journal of biological macromolecules 2026 Mar;352:151196
An integrative analysis reveals the mechanism of plastic stabilizers inducing breast cancer.
Huo X, Duan X, Huang X, Xue L, Zhao L, Li Y, Zhang X, Zhou N
PLoS computational biology 2026 Mar;22(3):e1014025
PLoS computational biology 2026 Mar;22(3):e1014025
Aloe-emodin inhibits p38 MAPK pathway in Alzheimer's disease treatment: a network pharmacology and experimental verification.
Ouyang Z, Liu F, Lu Q, Wang Y, Shao N, Liu H, Cai B
Journal of molecular histology 2026 Mar 7;57(2)
Journal of molecular histology 2026 Mar 7;57(2)
Red Blood Cell-Derived Exosomes Deliver Complement C5 to Exacerbate Neuroinflammation and Neuronal Injury after Intracerebral Hemorrhage.
Chen Q, Min J, Lu X, Gao Z, Xiong Y
Inflammation 2026 Mar 5;49(1)
Inflammation 2026 Mar 5;49(1)
TNF-α impairs the stria vascularis by inducing pericyte apoptosis via the NF-κB pathway in gentamicin-induced hearing loss.
Li G, Chen G, Hu R, Zeng J, Liu P, Liang M, Zheng Y
Journal of neuroinflammation 2026 Mar 28;23(1)
Journal of neuroinflammation 2026 Mar 28;23(1)
DSCAML1+ extracellular vesicles revealed by single-vesicle proteomics as a novel biomarker and therapeutic target in myocardial infarction.
Liu N, Wei G, Wang H, Zhang Y, Sun X, Lai F, Zheng Y, Hu K, Xu T, Su G, Huang R, Tong L
Journal of nanobiotechnology 2026 Mar 23;24(1)
Journal of nanobiotechnology 2026 Mar 23;24(1)
Monosodium Glutamate Inhibits Pseudomonas aeruginosa-Induced Acute Lung Injury by Targeting the Type III Secretion Systems and Modulating Host Immunity.
Xu J, Wang W, Zhou Y, Zhang H, Shang Z, Zhang Z, Li B, Bai Y, Zhang J
Microorganisms 2026 Mar 23;14(3)
Microorganisms 2026 Mar 23;14(3)
Exploration of the therapeutic potential of magnoflorine against osteoarthritis progression using network pharmacology and in vitro validation.
Wang C, Cui L, Tantai M, Feng G, Cai Z, Feng Y
Naunyn-Schmiedeberg's archives of pharmacology 2026 Mar 17;
Naunyn-Schmiedeberg's archives of pharmacology 2026 Mar 17;
PKA and PKC signaling pathways mediate vitamin D₃-regulated intestinal phosphorus absorption in broiler chickens.
Liu M, Xi L, Zhou Y, Chen M, Qu H, Ma B, Zhang L, Shi C, Chen G, Ren Z, Cao J, Han J
Poultry science 2026 Mar 12;105(6):106762
Poultry science 2026 Mar 12;105(6):106762
MAPK14/SLC7A11/GPX4 axis dysregulation drives podocyte ferroptosis via mediating glycerophospholipid metabolism.
Qiu S, Xie D, Guo S, Wang Z, Cai Y, Wang X, Hu Z, Wang S, Lin C, Yao H, Yang Q, Guan Y, Zhao Q, Tang S, Sun W, Xie Y, Zhang A
Cell death discovery 2026 Mar 11;12(1)
Cell death discovery 2026 Mar 11;12(1)
Yishen Qianggu Mixture formulation suppresses osteometabolic inflammation by modulating the IL-17/NF-κB/MAPK signaling axis.
Zhao J, Peng GG, Xiao D, Fu CJ, Chen HZ, Luo SJ, Wu HQ, Huang M
Journal of ethnopharmacology 2026 Mar 1;358:121011
Journal of ethnopharmacology 2026 Mar 1;358:121011
Mechanism of HAND2 Regulating Glycolytic Metabolism and Metastasis Through TLR4/NOX2/DUOX2 Signaling Axis in Cervical Cancer.
Yang H, Li Y, Xiao Z, Kuang M
Molecular carcinogenesis 2026 Jun;65(6):699-714
Molecular carcinogenesis 2026 Jun;65(6):699-714
Precisely regulated physically-crosslinked carriers enable synergetic release of bioactive factors for MSC-mediated cartilage regeneration.
Dou Y, Zhang F, Jiang Z, Mao J, Guo H, Li Y, Wang W, Meng X, Fan Q, Wang J, Jiang D
Bioactive materials 2026 Jun;60:113-127
Bioactive materials 2026 Jun;60:113-127
Synergistic Neuroprotective Effects of Taurine and Tauroursodeoxycholic Acid on the Neurovascular Unit in Hypoxia-Reoxygenation Injury.
Du X, Li SY, Wu GL, Cai HY, Sun CY, Lin H, Cai YF, Wang Q
Rejuvenation research 2026 Jun;29(3):131-145
Rejuvenation research 2026 Jun;29(3):131-145
Design, synthesis, and biological evaluation of novel hydrophobic tag-based degraders targeting JNK1.
Huang Y, Chi M, Zhang Y, Cai W, Huang W, Ren S, Gu W, Yuan Y, Hou S, Ma L, Chen X
Bioorganic chemistry 2026 Jun 15;174:109756
Bioorganic chemistry 2026 Jun 15;174:109756
High-throughput RNA sequencing identifies hub genes and anti-inflammatory effects of β-caryophyllene in cerebral ischemia-reperfusion via p38MAPK/NF-κB modulation.
Liu J, Li Z, Wen J, Liu S, Ji J, Yang J, Wang S, Wang Y, Liu H
Brain research bulletin 2026 Jun 1;239:111857
Brain research bulletin 2026 Jun 1;239:111857
ACOT8-mediated palmitate accumulation promotes M1 macrophage polarization in renal ischemia-reperfusion injury via activation of the cGAS-STING pathway.
Zhang H, Liu X, Ji X, Zhang G, Wang B, Xiong F, Sun D, Wang C
International immunopharmacology 2026 Jun 1;178:116558
International immunopharmacology 2026 Jun 1;178:116558
Finerenone improves doxorubicin-induced cardiotoxicity by inhibiting cardiomyocyte apoptosis through the TAK1-p38 axis.
Lai X, Wang Y, Zhang J, Xie H, Wu S, Wang L
Biochemical pharmacology 2026 Jul;249:117877
Biochemical pharmacology 2026 Jul;249:117877
The role of the IL-33/ST2/MAPK signalling pathway in macrophage polarisation and endometrial fibrosis.
Li G, Xu F, Luo S, Jin Y, Yuan L, Yang X, Xuan T, Liu D
International immunopharmacology 2026 Jul 1;180:116743
International immunopharmacology 2026 Jul 1;180:116743
Immunological activity of peach pectins: Insights from cells to animals.
Liu M, Liu X, Blecker C, Bi J
International journal of biological macromolecules 2026 Jan;337(Pt 2):149192
International journal of biological macromolecules 2026 Jan;337(Pt 2):149192
Effects of repetitive transcranial magnetic stimulation on apoptosis and MAPK/PI3K-AKT signaling pathways in rats with spinal cord injury.
Xu Q, Su J, Lei Q, Liu J, Wang J, Yang M, Song J, Chen H, Lu J
Brain research bulletin 2026 Jan;234:111687
Brain research bulletin 2026 Jan;234:111687
Pyraclostrobin induces brain oxidative stress, apoptosis and inflammation through mitochondrial phosphorylation-induced ROS activation of the p38 MAPK pathway.
Li Y, Chen J, Chen Y, Dong Q, Jin X, Zhao P, Dong Z
Pesticide biochemistry and physiology 2026 Jan;216(Pt 1):106787
Pesticide biochemistry and physiology 2026 Jan;216(Pt 1):106787
Curcumin induces apoptosis in osteosarcoma cells by regulating the glycolytic pathway via the MAPK axis: a mechanistic study.
Wang Y, Zhang Y, Zhang Y, Zhao J, Liao J, Luo J, Chen M, Peng P
Open life sciences 2026 Jan;21(1):20251296
Open life sciences 2026 Jan;21(1):20251296
Isomeranzin activates Gnas-AMPK signaling to drive white adipose browning and curb obesity in mice.
Shi M, Ye Y, Hu L, Yan Y, Jiang S, Wang P, Li F, Ai M, Huang J, Yang L, Huang K, Liang M
EMBO molecular medicine 2026 Jan;18(1):55-90
EMBO molecular medicine 2026 Jan;18(1):55-90
Astragalus polysaccharides inhibit arsenic trioxide-induced BMSCs damage through inhibition of Jnk and p38 signaling pathways.
Wu W, Bamba D, Zhang Z, Wu F, Li Y, Qi W, Liu Y, Zhang T, Su Y, Wang X, Wang H, Duan S, Ne J, Wang W, Liu J, Tang J, Li F, Wu Q, Li Y, Yang F, Yang L
Chinese herbal medicines 2026 Jan;18(1):178-187
Chinese herbal medicines 2026 Jan;18(1):178-187
Lobetyolin alleviates microglial inflammation by activating CK2α/Opa1-mediated mitochondrial fusion in ischemic stroke.
Qin N, Liu R, Deng R, Jia W, Yang Y, Sun J, Gao S, Zhu T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157651
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157651
Periodontitis pathogen Porphyromonas gingivalis promotes chronic obstructive pulmonary disease via affecting neutrophils chemotaxis and function.
Zhang L, Tian H, Ma Y, Xu J, Guo C, Wang Z, Ma J
International journal of oral science 2026 Jan 9;18(1):4
International journal of oral science 2026 Jan 9;18(1):4
Eleutheroside E alleviates cisplatin-induced ototoxicity by down-regulating MAPK/NF-κB/NLRP3 signaling pathway and inhibiting cochlear cell pyroptosis.
Zhang Y, Lu L, Tong B, Wang J, Liu K, Zhang J, Zhang D, Tian M, Sun W, Liu H, Wang P, Duan M, Tang Y
Communications biology 2026 Jan 8;9(1):214
Communications biology 2026 Jan 8;9(1):214
Rab43 mitigates the inflammatory response in acute lung injury via MyD88 ubiquitination.
Wang Y, Liu X, Zhu Z, Wu D, Chen Y, Gong D, Wu P, Qian H, He B, Wang G
Scientific reports 2026 Jan 7;16(1):4843
Scientific reports 2026 Jan 7;16(1):4843
Adenosine metabolic clearance maintains liver homeostasis by licensing arginine methylation of RIPK1.
Liu R, Wang G, Jiang Z, Zou T, Wang C, Wang W, Cai M, Zhang S, Wang G, Cao H, Zhang D, Wang X, Deng S, Li T, Gu J
The Journal of experimental medicine 2026 Jan 5;223(1)
The Journal of experimental medicine 2026 Jan 5;223(1)
Active components and mechanisms of Shuganning injection in lessening acetaminophen-induced acute liver injury.
Fu C, He F, Zhang L, Li Y, Yang L, Sun J, Chi M, Gong Z, Zheng L, Huang Y
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120738
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120738
Multi-Targeted Therapeutic Mechanisms of Huangqi Guizhi Wuwu Decoction Against Rheumatoid Arthritis: An Integrated Approach Combining Serum Pharmacochemistry, Network Pharmacology, Metabolomics, and Experimental Validation.
Xu Z, Li Z, Qu J, Liang C, Zhang Y, Zhao Q, Li Q
Pharmaceuticals (Basel, Switzerland) 2026 Jan 29;19(2)
Pharmaceuticals (Basel, Switzerland) 2026 Jan 29;19(2)
PDK4-driven metabolic reprogramming enhances mesothelial cell invasion in colorectal cancer peritoneal metastasis.
Han L, Zhang Q, Wu Y, Luo W, Mo S, Fang H, Li Q, Wang R, Cai G, Dai W
Acta biochimica et biophysica Sinica 2026 Jan 28;58(3):638-648
Acta biochimica et biophysica Sinica 2026 Jan 28;58(3):638-648
Cyclovirobuxine D attenuates collagen-induced arthritis by inhibiting PI3K/AKT pathway and macrophage polarization.
Sun Y, Zhang J, Wu Y, Liu Z, Li G
Arthritis research & therapy 2026 Jan 28;28(1)
Arthritis research & therapy 2026 Jan 28;28(1)
Dexmedetomidine alleviates sepsis-associated acute kidney injury by inhibiting renal tubular ferroptosis via JNK/MAPK-LCN2 pathway.
Liu B, Ao S, Luo L, Qiao L, Kuang T, Xiao H, Zhou J, Yin S, Liang H, Li F, Dai W, Zhu J
European journal of medical research 2026 Jan 26;31(1):315
European journal of medical research 2026 Jan 26;31(1):315
Bu-Shen-Tian-Jing Formula alleviates oxidative-inflammatory stress in granulosa cells of polycystic ovary syndrome through AGEs-RAGE/NOX4/NF-κB pathway.
Zhang Q, Ren J, Ye J, Chen F, Xiang F, Shi B, Zhou Z, Zhou J, Wang F, Qu F
Chinese medicine 2026 Jan 23;21(1):50
Chinese medicine 2026 Jan 23;21(1):50
Esketamine alleviates COPD-depression comorbidity in rats via MAPK/NF-κB inhibition and gut-lung-brain axis modulation.
Liu A, Zhang XQ, Guo JX, Wen QY, Dai K, Zheng WJ, Wu JH, Li CY, Chen ZY
Journal of neuroinflammation 2026 Jan 22;23(1):68
Journal of neuroinflammation 2026 Jan 22;23(1):68
Vasicine Attenuates Allergic Asthma by Suppressing Mast Cell Degranulation and Th2 Inflammation via Modulation of the FcεRI/Lyn + Syk/MAPK Pathway.
Qu L, Du W, Ren Z, Chen M, Wu X, Cao X, Rao G, Tong X, Huang F, Sun Y
Pharmaceuticals (Basel, Switzerland) 2026 Jan 22;19(1)
Pharmaceuticals (Basel, Switzerland) 2026 Jan 22;19(1)
PARP1 stabilizes FOXN3 to suppress pulmonary fibrosis through p38-related feedback regulation.
Zhu X, Huo Q, Jin L, Du J, Yu J, Wang H, Wu N, Li Y, Rui Y, Zhao C, Zhou J, Zhang Y, Li H, Lin J, Zheng C, Li W
Science advances 2026 Jan 2;12(1):eady1681
Science advances 2026 Jan 2;12(1):eady1681
The mechanism of indigo naturalis and its active ingredients against ulcerative colitis.
Ma KY, Hou BL, Fan AQ, Huang AL, Li BR, Liang YN, Wang Z
Scientific reports 2026 Jan 14;16(1):5220
Scientific reports 2026 Jan 14;16(1):5220
Therapeutic effects of the n-butanol extract of Potentilla freyniana Bornm. in hepatocellular carcinoma cells.
Wang Y, Zhang Z, Cao L, Huang S, Huang X, Zhang Z, Zhang Y, Li X
Journal of ethnopharmacology 2026 Jan 10;354:120492
Journal of ethnopharmacology 2026 Jan 10;354:120492
Structure characterization and in vitro immunomodulatory effects of a novel galactoglucomannan in cultivated Chinese cordyceps (Cordyceps sinensis).
Qian Z, Li S, Liu X, Liu J, Zhou J, Huang Y, Yang W, Liang Y, Li W, Huang W, Li W
Carbohydrate polymers 2026 Jan 1;371:124520
Carbohydrate polymers 2026 Jan 1;371:124520
Integrating UPLC-HR-MS, network pharmacology and experimental validation to reveal the potential mechanism of Fuzheng Bixie granules in treating acute lung injury.
Yang L, Wu Z, Li Y, Ren G, Spáčil R, Ren W, Xu H
Naunyn-Schmiedeberg's archives of pharmacology 2026 Feb;399(3):4589-4605
Naunyn-Schmiedeberg's archives of pharmacology 2026 Feb;399(3):4589-4605
Effects of incompletely degraded galactomannan on growth performance and immune function of cyclophosphamide-induced immunosuppressed broilers.
Zhang J, Diao X, Jiang Y, Chen Y, Lai C, Huang C, Zhu C, Yong Q
Poultry science 2026 Feb;105(2):106218
Poultry science 2026 Feb;105(2):106218
SERPINE1-Driven MAPK Activation Enhances Cuproptosis Resistance and Angiogenic Potential in Colorectal Cancer.
Gao P, Li H, Luo J, Zhang C, Wei J, Li X, Ma H
Digestive diseases and sciences 2026 Feb 9;
Digestive diseases and sciences 2026 Feb 9;
Combining network pharmacology and experimental validation to demonstrate that salidroside alleviates acute lung injury by inhibiting ferroptosis via the MAPK/GPX4 pathway.
Zhao M, Fang W, Chen M, Wang MQ, Lin W
Respiratory research 2026 Feb 4;27(1)
Respiratory research 2026 Feb 4;27(1)
Anti-inflammatory effects and mechanisms of Podophyllum hexandrum rhizomes and fruits in a chronic pelvic inflammatory disease rat model.
Zhang B, Yang AT, Wang LN, Yu Q, Tan CC, Chao WH, Geng HY, Pei TX, Zhang L, Cao SJ, Qiu F, Kang N
Journal of ethnopharmacology 2026 Feb 28;357:120954
Journal of ethnopharmacology 2026 Feb 28;357:120954
Glibenclamide attenuates osteoarthritis by suppressing NLRP3 inflammasome activation in synovial macrophages through the MAPK pathway.
Ni J, Zhou H, Shen K, Xu H, Wang J, Liu J, Liu F
Journal of translational medicine 2026 Feb 26;24(1)
Journal of translational medicine 2026 Feb 26;24(1)
MKRN2 enhances hepatocellular carcinoma proliferation through the p38 MAPK pathway.
Chen X, Yan Z, Du X, Zhang Z, Liu X, Zhang J, Hu L, He K, Wang J, Han Y
Human cell 2026 Feb 25;39(3)
Human cell 2026 Feb 25;39(3)
STING deficiency alleviates scar formation after glaucoma filtration surgery by suppressing p38 MAPK-induced inflammation in mice.
Ye H, Lu X, Chen H, Yang X, Xu H, Huang L, Zheng Q, Le R, Liang Y
Eye and vision (London, England) 2026 Feb 2;13(1):7
Eye and vision (London, England) 2026 Feb 2;13(1):7
Exploring the Effects and Mechanisms of Neohesperidin Dihydrochalcone on Acute Lung Injury in Mice with Sepsis Using Network Pharmacology and Machine Learning.
Liu M, Li T, Dai X, Liu X, Deng W
Current issues in molecular biology 2026 Feb 18;48(2)
Current issues in molecular biology 2026 Feb 18;48(2)
Sphingosine-1-phosphate drives astrocyte pyroptosis via activation of NLRC4 inflammasome in autism spectrum disorder.
Shi Y, Chen S, Zhang X, Yang Y, Chen A, Sun Y, Chen X, Zhao S, Zhu T, Qiao W, Fan L, Wu L
Brain, behavior, and immunity 2026 Feb 13;135:106482
Brain, behavior, and immunity 2026 Feb 13;135:106482
Hypoxia-preconditioned cardiomyocyte-derived extracellular vesicles alleviate myocardial ischemic injury by reprogramming macrophage polarization via the Fgl2/NF-κB pathway.
Zhang Z, Shen H, Zhang S, Zhou J, Zhang M, Wang Y, Zheng Y, Chang Y, Liang X, Hu X, Gao W
International immunopharmacology 2026 Feb 1;170:116077
International immunopharmacology 2026 Feb 1;170:116077
U0126 induces osteoclast differentiation via the p38-NFATc-1 signaling pathway.
Wang J, Liu J, Jia X, Chen G, Chen S, Huang X
Tissue & cell 2026 Apr;99:103263
Tissue & cell 2026 Apr;99:103263
The GOLM1-ACLY pathway regulates macrophage-secreted EFEMP1 via H3K27ac modifications to drive tumor progression.
Zhen L, Min M, Mo X, Zhao G, Li H, Liu M, Wan L, Yang X, Huang L, Zhang Y, Gao Q, Zhong H, Qiang G, Wu F, Xie Q, Wei C, Zhao R
Journal of advanced research 2026 Apr;82:765-783
Journal of advanced research 2026 Apr;82:765-783
Tanshinone IIA attenuates airway inflammation and airway remodeling in bronchial asthma by inhibiting p38/NF-κB and AKT/HIF-1α.
Yu W, Peng Z, Lü B, Yu Y, Chen J
The Journal of asthma : official journal of the Association for the Care of Asthma 2026 Apr;63(4):428-438
The Journal of asthma : official journal of the Association for the Care of Asthma 2026 Apr;63(4):428-438
Intestinal epithelial protection and gut microbiota modulation by Ganoderma lucidum proteoglycan are associated with its hypoglycemic potential in type 2 diabetes.
Zhang Q, Chen J, Zhang Y, Wang Y, Li J, Pan Y, Zhang Z, Yang H, He Y, Zhou P
International journal of biological macromolecules 2026 Apr;354:151441
International journal of biological macromolecules 2026 Apr;354:151441
Zinc-doped carbon dots from natural Isatis Indigotica folium and calamine: SOD/CAT-mimetic activity targets ROS-Ca²⁺-NLRP3 axis for psoriatic dermatitis therapy.
Tian X, Huang Y, He C, Dai E, Zhang X, Zou P, Liu R, Xia M, Lu Z, Jin B, Wang S, Zhang Y, Kong H, Qu H, Zhao Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:158013
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:158013
Caffeine inhibited the hyperoxia-induced A2AR-ERK/p38 MAPK-IL-8 pathway in type II alveolar epithelial cells to suppress NETs formation in bronchopulmonary dysplasia.
Wang X, Song Y, Yu L, Song K
Pediatric research 2026 Apr 29;
Pediatric research 2026 Apr 29;
Brucea Javanica Oil Attenuates Osteosarcoma Progression by Reprogramming Tumor-associated Macrophages via Inhibiting PI3K/AKT Pathway.
Guo Y, Jiang Y, Li Z, Zhou J, Yao N
Applied biochemistry and biotechnology 2026 Apr 28;
Applied biochemistry and biotechnology 2026 Apr 28;
Tuihong formula attenuates DNCB-induced atopic dermatitis in mice via suppression of MAPK/NF-κB signaling and epidermal barrier restoration.
Huang Y, Lin W, Chen X, Lin F, Li J, Liu Y, Liu Y, Luo G, Du X, Duan L, Zhan Y, Zhao T
Journal of ethnopharmacology 2026 Apr 25;368:121771
Journal of ethnopharmacology 2026 Apr 25;368:121771
USP1 dependent stabilization of LTA4H drives hepatocellular carcinoma angiogenesis.
Xu B, Wang Y, Lin Z, Chen W, Liu M, Tang Z, Ma K, Jiang L, Zheng W, Bian S
Biochimica et biophysica acta. Molecular basis of disease 2026 Apr 25;1872(6):168270
Biochimica et biophysica acta. Molecular basis of disease 2026 Apr 25;1872(6):168270
Bovine serum albumin-coated metal-phenolic nanoplatform for atherosclerosis therapy via targeted delivery and inhibition of vascular smooth muscle cells proliferation.
Li N, Huang Q, Liu Y, Ren D, Liu Y, Liu X, Zhang P, Liu R
Free radical biology & medicine 2026 Apr 23;251:372-386
Free radical biology & medicine 2026 Apr 23;251:372-386
CSRNP1 Promotes Apoptosis and Mitochondrial Dysfunction via ROS-Mediated JNK/p38 MAPK Pathway Activation in Hepatocellular Carcinoma.
Shi H, Chen L, Huang J, Lin X, Huang L, Tang M, Lu K, Wang W, Zhu M
Oncology research 2025;34(1):17
Oncology research 2025;34(1):17
FTO Alleviates Hepatic Ischemia-Reperfusion Injury by Regulating Apoptosis and Autophagy.
Wang PX, Zhu L, Xiang M, Zhang R, Zheng X, Zheng Z, Li K
Gastroenterology research and practice 2025;2025:5587859
Gastroenterology research and practice 2025;2025:5587859
Volatile Oil From Acorus Gramineus Rhizoma Synergizes with Crebanine to Alleviate Oxidative Stress and Endoplasmic Reticulum Stress in Myocardial Ischemia-Reperfusion Injury by Suppressing GRP78-PERK/ATF6-CHOP and MAPK-NF-κB-TNF-α Signaling Pathways.
Zha L, Cui L, Mei J, Pu J, Hao J, Fan X, Wang H, Fang H, Ma Y
Journal of inflammation research 2025;18:12929-12948
Journal of inflammation research 2025;18:12929-12948
VOPP1 as a Novel Susceptibility Gene in Rheumatoid Arthritis: Insights Into Its Mechanisms From Mendelian Randomization and Experimental Validation.
Wu W, Cai H, Nan Y, Tang J, Wang Y
Journal of inflammation research 2025;18:10341-10354
Journal of inflammation research 2025;18:10341-10354
Lasalocid inhibits melanoma by down-regulating FOXM1 through PI3K/AKT and JNK/P38 MAPK pathways.
Yuan Q, Jiang H, Zhu M, Chu Y, Zhang Y, Bie J, Li L
Journal of Cancer 2025;16(3):765-783
Journal of Cancer 2025;16(3):765-783
Study on the mechanism of gracillin inhibiting the proliferation of lung cancer NCI-H1299 cells based on MAPK signaling pathway.
Xiao B, Zhang M, Liu H, Cui A, Tian Y, Tang F, Liao S, Li M, Huang H, Peng W, Yang J
Journal of Cancer 2025;16(10):3048-3064
Journal of Cancer 2025;16(10):3048-3064
Identification and validation of the VEGF/p38MAPK/HSP27 pro-tumor inflammatory pathway: screening of active components from Patrinia villosa and evaluation of their drug-likeness.
Li X, Ju Y, Yang X, Li T, Wang S, Bao Y, Meng X
Frontiers in immunology 2025;16:1631031
Frontiers in immunology 2025;16:1631031
FKBP5-CCL5 interaction promotes neuroinflammation and neuronal apoptosis in ischemic stroke by regulating the MAPK pathway and enhancing NET formation.
Li Z, Yin T, Guo H, Liu Z, Wang P, Liu C, Wang Q, Zhang M, Xiao Y, Wang J, Hao J, Zhang L
Frontiers in immunology 2025;16:1609989
Frontiers in immunology 2025;16:1609989
Identification and evaluation of a pinocembrin analog as a TRPV1 inhibitor with analgesic properties in murine pain models.
Chen H, Li G, Deng L, Xu N, Lee SM, Nie X, Bian JS
Frontiers in pharmacology 2025;16:1585181
Frontiers in pharmacology 2025;16:1585181
Desulfovibrio vulgaris exacerbates sepsis by inducing inflammation and oxidative stress in multiple organs.
Wu R, Yu Z, Guo P, Xiang X, Zeng Y, Fu S, Yang M, Huang X, Wang Z, Chen A, Ge Y, Zhao X, Xiao W
Frontiers in microbiology 2025;16:1574998
Frontiers in microbiology 2025;16:1574998
Enhancing pancreatic cancer treatment: the role of H101 oncolytic virus in irreversible electroporation.
Xi P, Zeng D, Chen M, Jiang L, Zhang Y, Qin D, Yao Z, He C
Frontiers in immunology 2025;16:1546242
Frontiers in immunology 2025;16:1546242
Zirconia/dental pulp stem cell composite scaffolds repair osteogenic defect via regulating macrophages.
Wu Y, He M, Li C, Shang W, Hu J, Liu B
Frontiers in bioengineering and biotechnology 2025;13:1632000
Frontiers in bioengineering and biotechnology 2025;13:1632000
Kisspeptin Suppresses the Growth of Primary Pterygial Cells via Inhibiting Chemokine (C-X-C Motif) Ligands in Microenvironment.
Wu P, Liu S, Xu T, Zhao G
Current eye research 2025 Sep;50(9):894-902
Current eye research 2025 Sep;50(9):894-902
Ovotransferrin ameliorated intestinal barrier dysfunction in DSS-induced ulcerative colitis mice via inhibition of PI3K-Akt/MAPK signaling pathways and modulation of tissue metabolism.
Zheng D, Ma L, Xin X, Gao Y, Dong S, Huang Y, Wu J, Huo J, Li S
International journal of biological macromolecules 2025 Sep;321(Pt 1):146274
International journal of biological macromolecules 2025 Sep;321(Pt 1):146274
IFITM1 promotes proliferation, migration and macrophage-like transdifferentiation of vascular smooth muscle cells via c-Src/MAPK/GATA2/E2F2 pathway in atherosclerosis.
Huang QH, Tang XY, Huang QY, Zhi SB, Zheng XQ, Gan CY, Huang MF, Pan ZF, Zhong ZX
Biochemical pharmacology 2025 Sep;239:117014
Biochemical pharmacology 2025 Sep;239:117014
Pharmacological role of MLN4924 in cisplatin-induced acute kidney injury.
Chen F, Yusufu A, Li G, Gao X, Lu D, Wu X, Ni L
Biochimica et biophysica acta. General subjects 2025 Sep;1869(10):130842
Biochimica et biophysica acta. General subjects 2025 Sep;1869(10):130842
Xinbao pill attenuated water retention by regulating the CaSR/AQP2 pathway in LAD-induced chronic heart failure rats.
Li S, Wang Y, Cui X, Tian X, Huang Z, Zhang R, Cheng Y, Liu Z, Wang D
Journal of traditional and complementary medicine 2025 Sep;15(5):495-508
Journal of traditional and complementary medicine 2025 Sep;15(5):495-508
Deciphering functional landscapes of rumen microbiota unveils the role of Prevotella bryantii in milk fat synthesis in goats.
Lei Y, Zheng Y, Yan Y, Zhang K, Sun X, Yang B, Ge L, Meng Z, Cao X, Zhang X, Yan X, Xu Y, Zhang T, Shi J, Chen S, Qiu Q, Chen Y, Deng L, Li Z, Wang X, Zhang K
Genome biology 2025 Sep 26;26(1):311
Genome biology 2025 Sep 26;26(1):311
Comparison of Quercetin and Isoquercitrin's Anti-Heart Failure Activity via MAPK Inflammatory Pathway and Caspase Apoptosis Pathway.
Guo A, Chen X, Bai Y, Dai Y, Yue H
Pharmaceuticals (Basel, Switzerland) 2025 Sep 26;18(10)
Pharmaceuticals (Basel, Switzerland) 2025 Sep 26;18(10)
Discovery of 3g as an Orally Bioavailable, TIR Domain Selective, and Potent MyD88 Inhibitor for the Treatment of Acute Lung Injury.
Chen P, Dong K, Zhu L, Huang N, Zhang K, Lv Y, Jiang M, Chen Q, Zou Y, Chen Z, Guo M, Zheng Z, Sun C, Cho YC, Liang G, Tang Q
Journal of medicinal chemistry 2025 Sep 25;68(18):19626-19644
Journal of medicinal chemistry 2025 Sep 25;68(18):19626-19644
Systematic reevaluation on the antipyretic, analgesic effects, and uncover the mechanisms of Chaiqin Qingning capsule, a traditional Chinese medicine, via establishing lipopolysaccharide - induced fever models, physical and chemical - stimuli pain models.
Huang L, Gao H, Halihaman B, Li C, Ding X
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120432
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120432
Transcriptomic bioinformatics analysis proposes a novel BCL2-MAPK14-TXN oxidative stress diagnostic model of sepsis and identifies TXN as an oxidative stress-related signature gene in sepsis.
Zou Z, Wu M, Peng Y, Luo S
International immunopharmacology 2025 Sep 23;162:115016
International immunopharmacology 2025 Sep 23;162:115016
Colla Corii Asini regulate collagen regeneration in UV exposure-induced skin photoaging in mice.
Ma Y, Huang J, Gong J, Li L, Zhao Y, Jin Y, Gu J, Liu H, Wang Y, Sun Y
Chinese medicine 2025 Sep 22;20(1):146
Chinese medicine 2025 Sep 22;20(1):146
Chronic Waterborne Exposure to Polystyrene Microplastics Induces Kupffer Cell Polarization Imbalance and Hepatic Lipid Accumulation.
Li T, Yao Z, Huang Y, Li R, Zhang L, Chen R, Gu W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Sep 15;39(17):e70980
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Sep 15;39(17):e70980
Dapagliflozin promotes metabolic reprogramming against myocardial infarction through the MAPK-FOXO3-STC1 and HIF-1a-STC1 pathways.
Zhang X, Zhou C, Chen G, Li Y, Liu X, Luo S
Life sciences 2025 Sep 15;377:123798
Life sciences 2025 Sep 15;377:123798
Bushen Jiangu decoction alleviates osteoporosis by inhibiting MMP2 expression and activation of the MAPK pathway in vitro.
Chen P, Lin J
Tissue & cell 2025 Oct;96:103025
Tissue & cell 2025 Oct;96:103025
ZAKα Induces Pyroptosis of Colonic Epithelium Via the Caspase-11/GSDMD Pathway to Aggravate Colitis.
Li S, Chen M, Zheng S, Abudourexiti W, Zhu F, Wang Z, Guo Y, Yu Z, Yang Z, Zhang L, Ding C, Gong J
Inflammation 2025 Oct;48(5):3235-3251
Inflammation 2025 Oct;48(5):3235-3251
The SLCO4A1-Mediated Transmembrane Transport of Lysionotin Attenuates Acute Lung Injury Through Activating the AMPK/Nrf2 Signaling Pathway.
Xiong D, Lin M, Xie W, Zhang X, Huang L, Deng L, Huang X, Liu W, Tang S
Phytotherapy research : PTR 2025 Oct;39(10):4404-4427
Phytotherapy research : PTR 2025 Oct;39(10):4404-4427
Self-propelled gas nanomotor-integrated microneedles for melanoma therapy: Dual-action in situ eradication and metastatic suppression.
Lee C, Huang S, Liu H, He X, Hao Y, Zeng L, Li Y, Lv Z, Xu Y, Guo R
Materials today. Bio 2025 Oct;34:102122
Materials today. Bio 2025 Oct;34:102122
Idebenone attenuates RANKL-induced osteoclastogenesis and improves bone mass in ovariectomized mice.
Yu C, Cai L, Zhuang L, Wu Y, Wu Q, Liang H, Shi M, Miao J, Song H, Jin H, Pan Y
Free radical biology & medicine 2025 Oct;238:206-219
Free radical biology & medicine 2025 Oct;238:206-219
DUSP1-mediated suppression of p38 MAPK signaling pathway reduces ferroptosis in cerebral ischemia-reperfusion injury.
Ma S, Zhang X, Fan J, Chen M, Yao Q, Zhang N, Shi K, Duan M, Yang H, Gao T, Ma X, Wang J, Li W, Zhou C, Zhan S
Neurochemistry international 2025 Oct;189:106024
Neurochemistry international 2025 Oct;189:106024
Ganoderic acid a derivative induces apoptosis of cervical cancer cells by inhibiting JNK pathway.
Wang M, Han Q, Zhang X, Dong X, Ran J, Wei F, Luo Y, Sun X
Chinese herbal medicines 2025 Oct;17(4):756-767
Chinese herbal medicines 2025 Oct;17(4):756-767
Removal and toxic intervention of polystyrene microplastics and nanoplastics by magnetic nano-Fe(3)O(4) in spermatogonial GC-1 cells.
Cheng C, Cui Y, Wang Y, Huang J, Ma J, Luo T, Chen W
Reproductive toxicology (Elmsford, N.Y.) 2025 Oct;137:109020
Reproductive toxicology (Elmsford, N.Y.) 2025 Oct;137:109020
Eimeria tenella aspartyl protease is identified as a potential TLR15 ligand and activates macrophages and dendritic cells in chickens.
Chen C, Men Z, Pu X, Lu M, Xu L, Yan R, Li X, Song X
Poultry science 2025 Oct;104(10):105525
Poultry science 2025 Oct;104(10):105525
OTSSP167 suppresses TNBC brain metastasis via ROS-driven P38/JNK and FAK/ERK pathways.
Tang D, Xu C, Jiang Z, Meng Z, Zhang M, Fan F, Liu H
European journal of pharmacology 2025 Oct 5;1004:178017
European journal of pharmacology 2025 Oct 5;1004:178017
Multi-omics and network pharmacology approaches reveal the mechanism of action of KeKe tablet against post-infectious cough.
Su M, Zhang J, Wang S, Chen W, Lai M, Peng L, Liang Y, Feng Y, Zhou H, Qiao W, Sun P
Chinese medicine 2025 Oct 4;20(1):160
Chinese medicine 2025 Oct 4;20(1):160
Chamazulene Induces Metabolic Reprogramming and Mitigates Inflammation in Photoaged Skin: PPARα/γ as Potential Regulators.
Zhou Y, Wang W, He L, Zhang N, Zhou B, Chen Z, Ma L, Yao L
Antioxidants (Basel, Switzerland) 2025 Oct 31;14(11)
Antioxidants (Basel, Switzerland) 2025 Oct 31;14(11)
1,8-Cineole alleviates spinal cord injury by inhibiting microglial pyroptosis via the P38 MAPK and PI3K/AKT/NLRP3 signaling pathways to protects neurons.
Zhou W, Liu Z, Qiu X, Tian M, He B, Tang C, Tang Q, Ye R, Zhong D, Liao Y
International immunopharmacology 2025 Oct 30;164:115400
International immunopharmacology 2025 Oct 30;164:115400
Paeonol reduces IL-1β induced apoptosis and degeneration by regulating MAPK pathway in nucleus pulposus cells.
Yu C, Wei X, Wang J, Wang L, Wang J
Biochemical and biophysical research communications 2025 Oct 20;785:152687
Biochemical and biophysical research communications 2025 Oct 20;785:152687
Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer's disease.
Song Z, Xie X, Chen Y, Zhang B, Li X, Yang Y, Mo W, Zhang J, Xu D
Immunity 2025 Oct 14;58(10):2574-2592.e9
Immunity 2025 Oct 14;58(10):2574-2592.e9
Nano-Self-Assembled Particles Loaded with Aldehyde Dehydrogenase 2 Agonist Inhibit Ischemia-Reperfusion Injury of Transplanted Kidneys.
Hu Q, Lu Z, Yasen K, Liu A, Shi X, Ye Q, Zhong Z
ACS nano 2025 Oct 14;19(40):35853-35870
ACS nano 2025 Oct 14;19(40):35853-35870
A cell-free TLR5(high) MSC membrane nanoparticle therapy for Crohn's disease: Targeted immunomodulation via the flagellin/TLR5 axis.
Xie Y, Li Y, Xu C, Zhang W, Jiang Y, Wang L, Tang Y, Sun Q, Yang H, Mai X, Shen P, Wang B
Journal of controlled release : official journal of the Controlled Release Society 2025 Oct 10;386:114121
Journal of controlled release : official journal of the Controlled Release Society 2025 Oct 10;386:114121
Crinis Carbonisatus-Derived Carbon Dot Suspension Alleviates Temporal Lobe Epilepsy.
Huang Y, Li M, Dong L, He C, Zou P, Xia M, Jin B, Wang S, Lu Z, Qu H, Zhang Y, Kong H
Pharmaceuticals (Basel, Switzerland) 2025 Oct 1;18(10)
Pharmaceuticals (Basel, Switzerland) 2025 Oct 1;18(10)
Salvianolic Acid A Mitigates Osteoporotic Bone Loss by Repressing Reactive Oxygen Species via the Nrf2-HO-1 Pathway.
Qiu H, Cai C, Zhang Y, Yang S, Hu X, Chu T
Phytotherapy research : PTR 2025 Nov;39(11):4977-4990
Phytotherapy research : PTR 2025 Nov;39(11):4977-4990
The β-glucan from Lentinus alleviates UVB-induced dermal fibroblasts senescence and skin photoaging.
Wei K, He L, Li X, Wu M, Wang H, Hu L, Xu H, Zhang Y, Zhou L, Xu X, Guo L
International journal of biological macromolecules 2025 Nov;329(Pt 2):147834
International journal of biological macromolecules 2025 Nov;329(Pt 2):147834
Lysyl oxidase-like 2 inhibition alleviates subretinal fibrosis in neovascular age-related macular degeneration model.
Yang X, Ma A, Liu Y, He Z, Yu J, Su S, Chen J, Sang A
Experimental eye research 2025 Nov;260:110588
Experimental eye research 2025 Nov;260:110588
Intestinal taurine acts as a novel immunometabolic modulator of IBD by degrading redundant mitochondrial RNA.
Wu LX, Xie JH, Li JY, Li WP, Mao XT, Huang LJ, Chen HT, Zhong JY, Lin LM, Su S, Li YY, Cao Q, Jin J
Cellular & molecular immunology 2025 Nov;22(11):1398-1413
Cellular & molecular immunology 2025 Nov;22(11):1398-1413
Chrysin inhibits PEDV replication by antagonizing apoptosis via the ROS/JNK/p53 axis.
Zhi Y, Ren Y, Xia X, Tian Q, Meng Y, Tao S
Microbial pathogenesis 2025 Nov;208:107957
Microbial pathogenesis 2025 Nov;208:107957
BMAL1 modulates respiratory syncytial virus-induced inflammation through p38 mitogen-activated protein kinase pathway: insights into circadian regulation.
Wang L, Yao J, Zhuo X, Chen L, Jiang Z, Liu H
Microbial pathogenesis 2025 Nov;208:107954
Microbial pathogenesis 2025 Nov;208:107954
Platycodin D attenuates diabetic renal ischemia/reperfusion injury by enhancing mitophagy and suppressing MAPK/NF-κB signaling activation.
Qin X, Liu J, Zhao X, Wang L, Liu X, Chen Z
Biochimica et biophysica acta. Molecular basis of disease 2025 Nov;1871(8):168026
Biochimica et biophysica acta. Molecular basis of disease 2025 Nov;1871(8):168026
MAP30 inhibits proliferation and metastasis of bladder cancer by increasing EGR1 expression and promoting the transcriptional activation of DUSP1.
Wang K, Gu Q, Xue C, Shi J, Wang K, He X
Molecular immunology 2025 Nov;187:48-60
Molecular immunology 2025 Nov;187:48-60
Arsenic trioxide-based nanoparticles for enhanced chemotherapy by activating pyroptosis.
Wang S, Ma D, Yang M, Zhang Y, Wang S, Zhou W
Acta pharmaceutica Sinica. B 2025 Nov;15(11):6001-6018
Acta pharmaceutica Sinica. B 2025 Nov;15(11):6001-6018
iRGD-modified co-loaded curcumin piperine liposomes inhibit angiogenesis in non-small cell lung cancer through the VEGFR2/P38/MK2 signaling axis.
Huang X, Chen Y, Chen J, Lin J, Zhuang Y, Huang M, Yu H, Wang M, Wang Y, Wang Y
Discover oncology 2025 Nov 7;16(1):2056
Discover oncology 2025 Nov 7;16(1):2056
Exploration of new azole derivatives containing ethanolamine moiety as anti-UC agents by inhibiting NF-κB/MAPK pathways.
Ju MQ, Huang ZX, Mo QY, Liu S, Wang DX, Li YP, Wan CP, Mao ZW
Molecular diversity 2025 Nov 6;
Molecular diversity 2025 Nov 6;
Helicobacter pylori Lipopolysaccharide Upregulates MDM2 via the TLR4/MAPK/AP-1 Pathway to Promote Gastric Cancer Progression.
Li Y, Xu L, Lu X, Fu B, Jiang Q, Xiong W, Tang W, Wu D
Digestive diseases and sciences 2025 Nov 29;
Digestive diseases and sciences 2025 Nov 29;
Circulating FABP5 released by dying macrophages function as a DAMP to exacerbate septic inflammation.
Wu R, Zeng Y, Han J, Li L, Xiong QM, Li S, Fu S, Qin P, Wang Z, He Y, Yan Z, Xiao W, Zeng Z, Lian ZX, Zhao ZB, Xiao W, Jiang Y, Gong S
Cell reports 2025 Nov 25;44(11):116497
Cell reports 2025 Nov 25;44(11):116497
TIM3 attenuates morphine antinociceptive tolerance and microglial neuroinflammation by suppressing the TRAF6/NF-κB pathway in male mice.
Yang H, Shen T, Qi Z, Yang Z, Zhang M, Jiang J, Sun Z, Lu C
Neuropharmacology 2025 Nov 15;279:110638
Neuropharmacology 2025 Nov 15;279:110638
A glucose kinase-independent HK2 activity prevents TNF-induced cell death by phosphorylating RIPK1.
Zou T, Liu R, Wang G, Wang G, Jiang Z, Wang C, Wang W, Cai M, Zhang S, Cao H, Zhang D, Wang X, Deng S, Li T, Gu J
Nature communications 2025 Nov 13;16(1):9979
Nature communications 2025 Nov 13;16(1):9979
CpG ODN Activates TLR9 and Upregulates TLR3 via the p38 MAPK-ATF3 Signaling Axis to Synergistically Enhance Dendritic Cell Vaccine Efficacy.
Zhou L, Lei Z, Jiang Q, Xu L, Wang Q, Huang Y, Lei T
Cells 2025 Nov 13;14(22)
Cells 2025 Nov 13;14(22)
Targeting the p38/MAPK pathway to induce apoptosis: a multidimensional mechanistic exploration of Mentha and its active compound diosmetin against liver cancer.
Song Y, Du Y, Li W, Fan Y, Zhang Y, Shen H, Cheng L, Wang J, Deng F, Tang B
Scientific reports 2025 Nov 11;15(1):39432
Scientific reports 2025 Nov 11;15(1):39432
Harnessing engineered adaptive nanoparticles to modulate macrophages for treating corneal alkali burns.
Qin X, Zhang L, Wang X, Meng J, Miao YB, Wang Q, Zou L, Yang Q, Jiang L, Shi Y
Journal of controlled release : official journal of the Controlled Release Society 2025 Nov 10;387:114253
Journal of controlled release : official journal of the Controlled Release Society 2025 Nov 10;387:114253
Aregs-IGFBP3-mediated SMC-like cells apoptosis impairs beige adipocytes formation in aged mice.
Wang S, Cui Y, Wang L, Feng C, Sun Y, Huo B, Jiang H, Zhao M, Tu Y, Wang Q, Yang Y, Zhang Q
Molecular metabolism 2025 May;95:102125
Molecular metabolism 2025 May;95:102125
Flammulina velutipes polysaccharide exerts immunomodulatory function involving RSAD2 to regulate the NF-κB/MAPK signaling pathway in RAW264.7 macrophage cells and in mouse spleen cells.
Wang Q, Wang S, Cui L, Zhang Y, Waterhouse GIN, Sun-Waterhouse D, Ma C, Kang W
International journal of biological macromolecules 2025 May;309(Pt 3):142985
International journal of biological macromolecules 2025 May;309(Pt 3):142985
METTL3-mediated m6A modification of PAK6 drives cervical cancer progression through activating MAPK14.
Zhu ZM, Huo FC, Shi C, Li MT, Zhou Y, Zhang LS, Pei DS
International journal of biological macromolecules 2025 May;309(Pt 2):142880
International journal of biological macromolecules 2025 May;309(Pt 2):142880
Cyclic RGD modified dextran-quercetin polymer micelles for targeted therapy of breast cancer.
Yang C, Ma H, Liang Z, Zhuang Y, Hu L, Zhang K, Huang L, Li M, Zhang S, Zhen Y
International journal of biological macromolecules 2025 May;308(Pt 1):142272
International journal of biological macromolecules 2025 May;308(Pt 1):142272
The Potential Hepatocyte Differentiation Targets and MSC Proliferation by FH1.
Luo S, Wu F, Jin Y, Liu D
Journal of cellular and molecular medicine 2025 May;29(9):e70601
Journal of cellular and molecular medicine 2025 May;29(9):e70601
Targeting HPK1 inhibits neutrophil responses to mitigate post-stroke lung and cerebral injuries.
Zhang T, Sun Y, Xia J, Fan H, Shi D, Wu Q, Huang M, Hou XY
EMBO molecular medicine 2025 May;17(5):1018-1040
EMBO molecular medicine 2025 May;17(5):1018-1040
Melatonin Promotes Osteogenic Differentiation of Rat Adipose-Derived Stem Cells via the p38/MAPK Signaling Pathway.
Meng S, Han S, Kong M, Liu Z, Lin A, Qu C, Li L, Ma X, Wang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 May 31;39(10):e70647
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 May 31;39(10):e70647
Targeting BATF2-RGS2 axis reduces T-cell exhaustion and restores anti-tumor immunity.
Gu X, Gao C, Su X, Zhu Y, Fang Q, Yu J, Wang Z, Zhao D, Zhang W
Molecular cancer 2025 May 30;24(1):157
Molecular cancer 2025 May 30;24(1):157
Ethanol extract of Moschus attenuates glutamate-induced cytotoxicity in HT22 cells by regulating the Nrf2 and MAPK pathways.
Chu Z, Chen Y, Xie D, Song C, Yang L, Qin T, Zhai Z, Cao Z, Xu Y, Sun T
Journal of ethnopharmacology 2025 May 28;348:119879
Journal of ethnopharmacology 2025 May 28;348:119879
Aqueous Polygalae Radix extract (PRE) prolongs the lifespan of C. elegans and alleviates D-galactose-induced oxidative stress in the mouse liver and brain by modulating PPARγ/MAPK.
Zhang J, Zheng W, Zhou Z, An Y, Zheng H, Zhang Y, Wei Y, Zhang Q, Zheng J, Wang F
Journal of ethnopharmacology 2025 May 28;348:119878
Journal of ethnopharmacology 2025 May 28;348:119878
Inflammation-responsive biomimetic nanoparticles with epigallocatechin-3-gallate for acute lung injury therapy via autophagy enhancement.
Han Y, Liu T, Wei R, Dai C, Huang X, Hu D
iScience 2025 May 16;28(5):112318
iScience 2025 May 16;28(5):112318
Multi-Omics Unveils Inflammatory Regulation of Fermented Sini Decoction Dregs in Broilers Infected with Avian Pathogenic Escherichia coli.
Mo S, Fang X, Xiao W, Huang B, Li C, Yang H, Wu Y, Wang Y, Ma H
Veterinary sciences 2025 May 15;12(5)
Veterinary sciences 2025 May 15;12(5)
Dendrobium nobile lindl extract modulates integrin αIIbβ3-mediated signaling pathways to inhibit platelet activation and thrombosis.
Hua C, Wu M, Xiao Y, Zhang R, Yuan Y, Zhang L, Guo F, Liu J, Yang Z, Liu G
Journal of ethnopharmacology 2025 May 12;347:119728
Journal of ethnopharmacology 2025 May 12;347:119728
Allocryptopine Attenuates Inflammatory Responses in Microglial Cells Via TLR4-Dependent NF-κB and p38 MAPK Pathways.
Nigdelioglu Dolanbay S, Şirin S, Aslim B
Molecular neurobiology 2025 Mar;62(3):3833-3847
Molecular neurobiology 2025 Mar;62(3):3833-3847
Protective Effects of Lactoferrin Treatment Against Sodium Arsenite Exposure-Induced Nephrotoxicity.
Li S, Yin Y, Dong X, Xu L, Yang Z, Li H, Zou Y, Wu Z
Biological trace element research 2025 Mar;203(3):1539-1554
Biological trace element research 2025 Mar;203(3):1539-1554
Egln3 expression in microglia enhances the neuroinflammatory responses in Alzheimer's disease.
Guan J, Wu P, Liu M, Jiang C, Meng X, Wu X, Lu M, Fan Y, Gan L
Brain, behavior, and immunity 2025 Mar;125:21-32
Brain, behavior, and immunity 2025 Mar;125:21-32
4-Octyl Itaconate Alleviates Myocardial Ischemia-Reperfusion Injury Through Promoting Angiogenesis via ERK Signaling Activation.
Yang J, Duan C, Wang P, Zhang S, Gao Y, Lu S, Ji Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(10):e2411554
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(10):e2411554
Network pharmacology and in vivo study: Unraveling the therapeutic mechanisms of Panax ginseng in potentially treating ulcerative colitis.
Qin Y, Zhang RY, Zhang Y, Zhao YQ, Hao HF, Wang JP
World journal of gastroenterology 2025 Mar 7;31(9):100271
World journal of gastroenterology 2025 Mar 7;31(9):100271
Integrative network pharmacology, transcriptomics, and proteomics reveal the material basis and mechanism of the Shen Qing Weichang Formula against gastric cancer.
Wang Y, Sun X, Ren M, Ma F, Zhao R, Zhu X, Xu Y, Cao N, Chen Y, Pan Y, Zhao A
Chinese medicine 2025 Mar 29;20(1):42
Chinese medicine 2025 Mar 29;20(1):42
N-Acetylcysteine as a Host-Directed Therapy Against Clarithromycin-Resistant Mycobacterium abscessus.
Yang S, Zhang Y, Xu J, Chen Z, Ren Y, Long Y, Huang X, Liu J, Huang H, Xie S, Ma R, Dong Y, Fan X, Hu Z, Li F
Pathogens (Basel, Switzerland) 2025 Mar 21;14(4)
Pathogens (Basel, Switzerland) 2025 Mar 21;14(4)
Discovery of Novel Oxazolo[4,3-f]purine Derivatives as Antitumor Agents through PPIA Interaction.
Li XJ, Zhang MC, Li X, Guan LL, Liang YR, Hao EJ, Wang Y, Guo HM
Journal of medicinal chemistry 2025 Mar 13;68(5):5573-5596
Journal of medicinal chemistry 2025 Mar 13;68(5):5573-5596
H3K18 lactylation-mediated nucleotide-binding oligomerization domain-2 (NOD2) expression promotes bilirubin-induced pyroptosis of astrocytes.
Li J, Li S, Sun Q, Li L, Zhang Y, Hua Z
Journal of neuroinflammation 2025 Mar 12;22(1):76
Journal of neuroinflammation 2025 Mar 12;22(1):76
Harnessing Anti-Inflammatory and Regenerative Potential: GelMA Hydrogel Loaded with IL-10 and Kartogenin for Intervertebral Disc Degeneration Therapy.
Yang S, Shi J, Qiao Y, Teng Y, Zhong X, Wu T, Liu C, Ge J, Yang H, Zou J
ACS biomaterials science & engineering 2025 Mar 10;11(3):1486-1497
ACS biomaterials science & engineering 2025 Mar 10;11(3):1486-1497
Hamayou () protein hydrolysate ameliorates depression by regulating the mitogen-activated protein kinase pathway.
Weijia LI, Jing LU, Chao MA, Mengmeng L, Ke P, Hongyan C, Zhe L, Guangfu L
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2025 Jun;45(3):493-507
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2025 Jun;45(3):493-507
Negative Effect of Gst-35 on the Health Span of Caenorhabditis elegans Through Lysosomal Dysfunction via the Pmk-1 and Skr Genes.
Gao Y, Zhang X, Wei C, Lin H, Wu M, Ma B, Jiang J, Li S, Wang H
Aging cell 2025 Jun;24(6):e70016
Aging cell 2025 Jun;24(6):e70016
ULBP2 promotes progression of head and neck squamous cell carcinoma by modulating MAPK signaling pathway.
Xu W, Liu S, Yang W
Journal of stomatology, oral and maxillofacial surgery 2025 Jun;126(3S):102204
Journal of stomatology, oral and maxillofacial surgery 2025 Jun;126(3S):102204
Luteolin ameliorates kainic acid-induced seizure by modulating GADD45B and reducing oxidative stress in hippocampal neurons.
Luo C, Wang Z, Liao J, Fu C, Zhang F, Zhao J
Neuropeptides 2025 Jun;111:102524
Neuropeptides 2025 Jun;111:102524
Rhein induces apoptosis of AGS and MGC803 cells by regulating the Ras/PI3K/AKT and p38/MAPK signaling pathway.
Wan M, Gan A, Dai J, Lin F, Wang R, Wu B, Yan T, Jia Y
The Journal of pharmacy and pharmacology 2025 Jun 9;77(6):783-793
The Journal of pharmacy and pharmacology 2025 Jun 9;77(6):783-793
Neutrophil-derived exosomes promote sepsis-related multiple organ dysfunction through the induction of neutrophil extracellular trap formation.
Xie X, Pi M, Zhang H, Zhou L, Liu M, Zhu W, Jiao Y, Gu X, Ma Z
International immunopharmacology 2025 Jun 26;159:114892
International immunopharmacology 2025 Jun 26;159:114892
Sea Cucumber Fucoidan Inhibits Helicobacter pylori Gastritis via MAPK/NF-κB Signaling and Gut Microbiota Modulation.
Cao J, Yao M, Wang K, Qin L, Zhang Q, Zhang H, Wei J, Qu C, Xue C, Miao J
Journal of agricultural and food chemistry 2025 Jun 11;73(23):14333-14352
Journal of agricultural and food chemistry 2025 Jun 11;73(23):14333-14352
GDF11 Regulates M1 and M2 Polarization of BV2 Microglial Cells via p38 MAPK Signaling Pathway.
Zhao X, Qin R, Li G, Lv G, Zhao D, Kong L, Qi M, Li P
Molecular neurobiology 2025 Jul;62(7):9290-9305
Molecular neurobiology 2025 Jul;62(7):9290-9305
Formononetin Alleviates the Inflammatory Response Induced by Carotid Balloon Injury in Rats via the PP2A/MAPK Axis.
Zhao H, Wu X, Yang S, Jiang L, Yu H, Li Y
Immunological investigations 2025 Jul;54(5):729-742
Immunological investigations 2025 Jul;54(5):729-742
Senescent macrophages induce ferroptosis in skeletal muscle and accelerate osteoarthritis-related muscle atrophy.
Xiang W, Zhang T, Li B, Li S, Zhang B, Fang S, Chen L, Gong Y, Huang B, Feng D, Wu J, Yuan J, Wu Y, Yan X, Jin R, Zhang X, Fang X, Lian J, Chen L, Zhou S, Ni Z
Nature aging 2025 Jul;5(7):1295-1316
Nature aging 2025 Jul;5(7):1295-1316
The Polarization of Macrophages Regulated by KCNG3 via the Activation of ASK1 Mediated by Potassium Ion Efflux.
Zhang S, Xin Y, Yang Y, Zhang Y, Geng J
Cell biology international 2025 Jul;49(7):810-823
Cell biology international 2025 Jul;49(7):810-823
Andrographolide and its sulfated metabolite alleviated DSS-induced inflammatory bowel disease through regulating inflammation and immune via MAPK/NLRP3 pathways and the balance of Th17/Treg cells.
Zhang HL, Chang J, Sun CP, Huo ZP, Feng YL, Li PY, Jia YX, Hui SW, Zhu QM, Cai JY, He Y, Qiu F, Zhang J
Molecular immunology 2025 Jul;183:313-320
Molecular immunology 2025 Jul;183:313-320
MiR-100-5p as a biomarker in hand-arm vibration disease: Mediating pathogenesis through angiogenesis suppression.
Zheng H, Lang L, Li W, Wang Q, Xiao B, Jia Y, Pan S, Yan M
Genomics 2025 Jul;117(4):111067
Genomics 2025 Jul;117(4):111067
CD8a + GZMK + T Cells Inhibit Osteoclastogenesis in Postmenopausal Osteoporosis via the p38-MAPK Pathway.
He X, Wang J, Liu M, Jiang Z, Yuan H
Calcified tissue international 2025 Jul 7;116(1):95
Calcified tissue international 2025 Jul 7;116(1):95
Colchicine alleviates ischemic white matter lesions and cognitive deficits by inhibiting microglia inflammation via the TAK1/MAPK/NF-κB signaling pathway.
Liu Y, Zhai Y, Ma L, Wang Z, Wang J, Hu B, Tang Y
Behavioural brain research 2025 Jul 26;490:115619
Behavioural brain research 2025 Jul 26;490:115619
Dibutyl phthalate promotes central precocious puberty through primordial follicle activation by downregulating BMP15.
Yao Y, Liu W, Tang M, Wang Z, Zhang X, Li Y, Xiao X, Liu F
Ecotoxicology and environmental safety 2025 Jul 15;300:118460
Ecotoxicology and environmental safety 2025 Jul 15;300:118460
Kushenol I combats ulcerative colitis via intestinal barrier preservation and gut microbiota optimization.
He XD, Li M, Zuo XD, Ni HY, Han YX, Hu YK, Yu J, Yang XX
World journal of gastroenterology 2025 Jul 14;31(26):105656
World journal of gastroenterology 2025 Jul 14;31(26):105656
Negative Air Ions Attenuate Nicotine-Induced Vascular Endothelial Dysfunction by Suppressing AP1-Mediated FN1 and SPP1.
Xiao S, Wei T, Xiao M, Shan M, An Z, Li N, Zhou J, Zhao S, Lu X
Antioxidants (Basel, Switzerland) 2025 Jul 14;14(7)
Antioxidants (Basel, Switzerland) 2025 Jul 14;14(7)
Pharmacological evaluation of physcion as a TRPV1 inhibitor with multimodal analgesic efficacy in experimental pain models.
Chen H, Li G, Deng L, Li S, Huang S, Lee SM, Nie X, Bian JS
Biological research 2025 Jul 10;58(1):48
Biological research 2025 Jul 10;58(1):48
TEAD4-mediated upregulation of LPAR3 augments hepatic stellate cell activation in portal hypertension.
Qi R, Chang Z, Zhao W, Qiu Y, Chang W, Zhang Y, Hu X, Li Z
Cell biology and toxicology 2025 Jul 1;41(1):110
Cell biology and toxicology 2025 Jul 1;41(1):110
Poly (β-amino esters)/Mobil Composition of Matter 41-mediated delivery of siIL-1β alleviates deep vein thrombosis in rat hind limbs.
Zheng B, Chen J, Xu Y, Wu W, Zhu Y, Cai W, Lin W, Shi C
Journal of biomaterials applications 2025 Jan;39(6):648-660
Journal of biomaterials applications 2025 Jan;39(6):648-660
Cortisol suppresses lipopolysaccharide-induced in vitro inflammatory response of large yellow croaker (Larimichthys crocea) via the glucocorticoid receptor and p38 mitogen-activated protein kinase pathways.
Wang J, Wu C, Ye Z, Yin X, Li W, Zhang G, Jiang Z, Liang X, Wei Y, Ge L, Xu X, Wang T, Yang J
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2025 Jan;275:111046
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2025 Jan;275:111046
Role of semaphorin7A in epithelial-mesenchymal transition and proliferative vitreoretinopathy.
Song S, Yang R, Su Y, Wang F
Experimental eye research 2025 Jan;250:110153
Experimental eye research 2025 Jan;250:110153
PINK1 modulates Prdx2 to reduce lipotoxicity-induced apoptosis and attenuate cardiac dysfunction in heart failure mice with a preserved ejection fraction.
Zhang H, Xu T, Mei X, Zhao Q, Yang Q, Zeng X, Ma Z, Zhou H, Zeng Q, Xu D, Ren H
Clinical and translational medicine 2025 Jan;15(1):e70166
Clinical and translational medicine 2025 Jan;15(1):e70166
Trans-cinnamic acid alleviates high-fat diet-induced renal injury via JNK/ERK/P38 MAPK pathway.
Jia K, Shi P, Zhang L, Yan X, Xu J, Liao K
The Journal of nutritional biochemistry 2025 Jan;135:109769
The Journal of nutritional biochemistry 2025 Jan;135:109769
Hyperlipidemia exacerbates acute pancreatitis via interactions between P38MAPK and oxidative stress.
Qiu M, Huang Y, Zhou X, Yu J, Li J, Wang W, Zippi M, Fiorino S, Hong W
Cellular signalling 2025 Jan;125:111504
Cellular signalling 2025 Jan;125:111504
Pharmacodynamics of huaier aqueous extract against papillary thyroid carcinoma in vivo and in vitro.
Xu FZ, Zheng LL, Qin JB, Li YX, Chen KH, Dai LH, Zhu QL, Sang JF
Integrative cancer therapies 2025 Jan-Dec;24:15347354251339073
Integrative cancer therapies 2025 Jan-Dec;24:15347354251339073
G(1-5)-EM2, a multi-targeted agonist to opioid and growth hormone secretagogue receptors exhibited nontolerance forming antinociceptive effects in a mouse model of burn pain.
Cheng S, Ding J, Xu B, Wang Y, Shen X, Xia Y, Wu L, Wei J
European journal of pharmacology 2025 Jan 5;986:177148
European journal of pharmacology 2025 Jan 5;986:177148
Ferrostatin-1 inhibits osteoclast differentiation and prevents osteoporosis by suppressing lipid peroxidation.
Xu W, Lv S, Wang X, Song C, Xi C, Yan J
Journal of orthopaedic surgery and research 2025 Jan 30;20(1):117
Journal of orthopaedic surgery and research 2025 Jan 30;20(1):117
Galactin-8 DNA methylation mediates macrophage autophagy through the MAPK/mTOR pathway to alleviate atherosclerosis.
Xia B, Lu YL, Peng J, Liang JW, Li FQ, Ding JY, Wan CW, Le CY, Dai JL, Jie-Wang, Guo B, Huang J
Scientific reports 2025 Jan 2;15(1):603
Scientific reports 2025 Jan 2;15(1):603
Cardiotoxicity of polystyrene nanoplastics and associated mechanism of myocardial cell injury in mice.
Xiong Z, Kong Q, Hua J, Chen Q, Wang D
Ecotoxicology and environmental safety 2025 Jan 15;290:117712
Ecotoxicology and environmental safety 2025 Jan 15;290:117712
Mechanism of dihydroartemisinin in the treatment of ischaemia/reperfusion-induced acute kidney injury via network pharmacology, molecular dynamics simulation and experiments.
Jiang B, Liu J, Qu Z, Wang Y, Wang Y, Li Z, Jin X, Lao Y, He R, Yang S
International immunopharmacology 2025 Jan 10;144:113705
International immunopharmacology 2025 Jan 10;144:113705
The Shh-p38-NFATc1 signaling pathway is essential for osteoclastogenesis during tooth eruption.
Liu J, Wang J, Huang R, Jia X, Huang X
Tissue & cell 2025 Feb;92:102643
Tissue & cell 2025 Feb;92:102643
Reciprocal tumor-platelet interaction through the EPHB1-EFNB1 axis in the liver metastatic niche promotes metastatic tumor outgrowth in pancreatic ductal adenocarcinoma.
Yao LL, Qin WT, Hu LP, Shi TZ, Yu Yang J, Li Q, Nie HZ, Li J, Wang X, Zhu L, Liu DJ, Zhang YL, Jiang SH, Zhang ZG, Yang XM, Li DX, Zhang XL
Cancer communications (London, England) 2025 Feb;45(2):143-166
Cancer communications (London, England) 2025 Feb;45(2):143-166
MAPK14/AIFM2 pathway regulates mitophagy-dependent apoptosis to improve atrial fibrillation.
Wang L, Sang W, Jian Y, Han Y, Wang F, Wubulikasimu S, Yang L, Tang B, Li Y
Journal of molecular and cellular cardiology 2025 Feb;199:1-11
Journal of molecular and cellular cardiology 2025 Feb;199:1-11
HSPA1A inhibits pyroptosis and neuroinflammation after spinal cord injury via DUSP1 inhibition of the MAPK signaling pathway.
He X, Deng B, Zhang C, Zhang G, Yang F, Zhu D, Yang Y, Ma B, Hu X, Wang Y, Kang X
Molecular medicine (Cambridge, Mass.) 2025 Feb 9;31(1):53
Molecular medicine (Cambridge, Mass.) 2025 Feb 9;31(1):53
Ginkgetin delays the progression of osteoarthritis by inhibiting the NF-κB and MAPK signaling pathways.
Zhu L, Bi Y, Liang T, Zhang P, Xiao X, Yu T
Journal of orthopaedic surgery and research 2025 Feb 5;20(1):139
Journal of orthopaedic surgery and research 2025 Feb 5;20(1):139
Exploring macrophage and nerve interaction in endometriosis-associated pain: the inductive role of IL-33.
Li J, Wu Z, Li N, Wang J, Huang M, Zhu L, Wan G, Zhang Z
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Feb 19;74(1):42
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Feb 19;74(1):42
ADCY5 Gene Affects Seasonal Reproduction in Dairy Goats by Regulating Ovarian Granulosa Cells Steroid Hormone Synthesis.
Shi C, Zhang F, He Q, Man J, Mu Y, Zhao J, Zhu L, Loor JJ, Luo J
International journal of molecular sciences 2025 Feb 14;26(4)
International journal of molecular sciences 2025 Feb 14;26(4)
Liuwei Anshen Capsule alleviates cognitive impairment induced by sleep deprivation by reducing neuroapoptosis and inflammation.
Li LY, Liu SZ, Yu X, Shi X, You H, Liu P, Wang F, Wang P, Chen LL
Journal of ethnopharmacology 2025 Feb 11;341:119311
Journal of ethnopharmacology 2025 Feb 11;341:119311
Integrative network pharmacology and multi-omics to study the potential mechanism of Niuhuang Shangqing Pill on acute pharyngitis.
Gu Y, Liu M, Niu N, Jia J, Gao F, Sun Y, Zhang Z, Dai Z, Jiao J, Zhu Z, Jia S, Xu J, Zhang Z, Xu B, Lei HM
Journal of ethnopharmacology 2025 Feb 10;338(Pt 3):119100
Journal of ethnopharmacology 2025 Feb 10;338(Pt 3):119100
MAP6D1 Silencing alleviates high glucose-induced injury of trophoblast cells during gestational diabetes mellitus.
Li X, Zhu Y, Jiang X, Liu S, Hu J, Zhang M, Bai M, Xu X, Yao H
Cytotechnology 2025 Dec;77(6):193
Cytotechnology 2025 Dec;77(6):193
Sophoridine inhibits proliferation and migration by targeting PIM1 in breast cancer.
Chen L, Xia Y, Min L, Zhang Y, Huang D, Zhang Y, You A, Li Z
Pharmaceutical biology 2025 Dec;63(1):503-523
Pharmaceutical biology 2025 Dec;63(1):503-523
PINK1 overexpression suppresses p38 MAPK/NF‑κB signaling to attenuate chondrocyte senescence in osteoarthritis.
Jie L, Zhang Y, Liu J, Fu H, Zhu Z, Huang Z, Shi X, Wang P, Yin S
International journal of molecular medicine 2025 Dec;56(6)
International journal of molecular medicine 2025 Dec;56(6)
Xuebijing injection alleviates septic acute kidney injury by modulating inflammation, mitochondrial dysfunction, and endoplasmic reticulum stress.
Zhang L, Zhang G, Mao W, Sun S, Tao S, Gao Y, Zhang N, Jiang G, Chen M, Lu X, Chen S
Renal failure 2025 Dec;47(1):2483986
Renal failure 2025 Dec;47(1):2483986
Vitexin enhances mitophagy and improves renal ischemia-reperfusion injury by regulating the p38/MAPK pathway.
Chen J, Chen C, Lv C, Feng R, Zhong W, Liu Y, Zhou S, Zhao M
Renal failure 2025 Dec;47(1):2463572
Renal failure 2025 Dec;47(1):2463572
RAB3GAP2 silencing alleviates oxidative stress in cataracts by enhancing Mfn2-mediated mitochondrial autophagy by activating JNK/STAT3.
Huang Y, Liu Q, Chen L, Tan X, Zeng D, Zhang Y, Qin J, Zeng F, Wei X, Zhong Q, Zhang J, Yuan D
International journal of biological macromolecules 2025 Dec;334(Pt 2):149102
International journal of biological macromolecules 2025 Dec;334(Pt 2):149102
Co-fermentation of honeysuckle-Cassia seeds by Lactobacillus acidophilus and Bacillus subtilis: A new approach to attenuate alcohol-induced acute gastric mucosal damage and modulate immune response.
Zhou M, Cao X, Ji H, Liu Z, Guo H, Zhang Y, Huang Y, Wang F, Pang M, Wei Y
Food research international (Ottawa, Ont.) 2025 Dec;222(Pt 1):117639
Food research international (Ottawa, Ont.) 2025 Dec;222(Pt 1):117639
Modulation of lipid droplet biogenesis by p38 MAPK and caspase-1 in docosahexaenoic acid-induced EA.hy926 endothelial cell apoptosis.
Du Y, Lv X, Shen Y, Ren X, Ye S
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Dec;1870(8):159683
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Dec;1870(8):159683
UBE2M inhibits neoplastic cell proliferation via MKK7-JNK-EGR1 axis in melanoma.
Xu L, Pan C, Wang Y, Ni L, Zeng P, Lin X, Lyu X, Huang S, Dang N
Journal of translational medicine 2025 Dec 8;24(1):52
Journal of translational medicine 2025 Dec 8;24(1):52
The mechanism of S100A8/A9 heterodimer promoting atherosclerotic thrombosis.
Feng J, Qin Y, Zhao H, Liu Y
Clinical and experimental medicine 2025 Dec 31;26(1):70
Clinical and experimental medicine 2025 Dec 31;26(1):70
Sestrin2 Knockdown Impairs Proliferation, Migration, Invasion, and Apoptosis in OSCC Cells via PI3K/AKT/mTOR and MAPK Pathways.
Yang W, Wang W, Zhang Z, Zhao Z, Li K, Liu Z, Xu L, Shi M, Li Y, Wang H
Current issues in molecular biology 2025 Dec 26;48(1)
Current issues in molecular biology 2025 Dec 26;48(1)
Liensinine can improve vascular remodeling in hypertension through the ferroptosis-related TLR4 inflammatory pathway.
Chen D, Jia P, Wang M, Du B, Du H, Huang X, Zeng J, Cai Q, Zhang L, Zhu Y, Lin S, Lian D, Peng J
Journal of molecular medicine (Berlin, Germany) 2025 Dec 26;104(1):13
Journal of molecular medicine (Berlin, Germany) 2025 Dec 26;104(1):13
Melatonin attenuates glandular cystitis via modulation of THBS1 and TLR4/p38 MAPK/STAT3 signaling.
Chen B, Gong S, Zhang J, Zhang Y, Wang H
Scientific reports 2025 Dec 24;15(1):44497
Scientific reports 2025 Dec 24;15(1):44497
Hsa_circ_0000437 promotes the progression of rheumatic valvular heart disease by activating the mitogen-activated protein kinase signaling pathways after sponging let-7f-5p and targeting RAS-like proto-oncogene B.
Zhu L, Li N, Shi H, Song J, Fang Z, Shen Q, Zhu X, Dan Y, Shao G, Sun L
Human cell 2025 Dec 15;39(1):19
Human cell 2025 Dec 15;39(1):19
Anti-Inflammatory Effect of a Polysaccharide Derived from Artocarpus heterophyllus Lam. Pulp on Lipopolysaccharide-Stimulated RAW264.7 Macrophages Through Inhibiting MAPK/ERK Signaling Pathway.
Bai B, Liu M, Xu P, Zhang Y, Xu F, Wu G, Zhou Y, Zhu K
Nutrients 2025 Dec 12;17(24)
Nutrients 2025 Dec 12;17(24)
Pla2g7 regulates bone homeostasis via Alox12/12-HETE/Gpr31 signaling axis.
Jin J, Zheng Z, Gu J, Zhang Q, Xu Z, Feng Z, Tao S, He S, Cheng J, Wang J, Zheng HF, Li S, Zhao F, Chen J
Nature communications 2025 Dec 10;16(1):11449
Nature communications 2025 Dec 10;16(1):11449
Resolvin D1 Modulates the Inflammatory Processes of Human Periodontal Ligament Cells via NF-κB and MAPK Signaling Pathways.
Yan J, Cai J, Pan X, Li S, Fenton CG, Fenton KA, Kantarci A, Xue Y, Xue Y, Xing Z
Biomedicines 2025 Dec 10;13(12)
Biomedicines 2025 Dec 10;13(12)
Taxifolin Inhibits Platelet Activation and Thrombosis by Regulating the PI3K/Akt and MAPK Signaling Pathways.
Guo F, Yang R, Xiong X, Yuan Y, Zhang L, Hua C, Wu M, Xiao Y, Zhang R, Liu J, Yang Z, Liu G
Molecular nutrition & food research 2025 Aug;69(16):e70129
Molecular nutrition & food research 2025 Aug;69(16):e70129
Analgesic Mechanism of Emodin in Neuropathic Pain Through Inhibiting P2X4 Purinoceptor Signaling.
Chen P, Gong Q, Wang H, Wang C, Wang W, Wu J, Wu Z, Wang L
Molecular neurobiology 2025 Aug;62(8):10210-10227
Molecular neurobiology 2025 Aug;62(8):10210-10227
A novel variant in the MAP3K1 genomic locus reveals abnormal cell apoptosis as a potential pathogenic mechanism in 46, XY disorders of sex development.
Lu Y, Wei S, Wang S, Zhang J, Xu Y, Huang C, Pan W, Wang Z
Molecular medicine reports 2025 Aug;32(2)
Molecular medicine reports 2025 Aug;32(2)
Macrocyclic diterpenoids from Stellera chamaejasme roots alleviate imiquimod-induced psoriasiform inflammation via STAT1/S100A9 signalling pathway.
Nie YW, Liu X, Peng Y, Zhang CY, Xi RF, Jiang XX, Wang Y, Lu HZ, Guo DJ, Guo WJ, Duan YJ, Nian H, Wang K, Chen JY, Li FL, Zhu JY
British journal of pharmacology 2025 Aug;182(16):3884-3902
British journal of pharmacology 2025 Aug;182(16):3884-3902
Chemical discovery of a novel MD2/ADAM17 dual-target inhibitor as a potential therapeutic candidate for saturated fatty acid-induced myocardial inflammatory injury.
Zhang XD, Zhong YS, Yan H, Jin LH, Chen J, Chen ZX, Zhang ZY, Zhao YJ, Qian JC
Metabolism: clinical and experimental 2025 Aug;169:156298
Metabolism: clinical and experimental 2025 Aug;169:156298
METTL11A serves as a novel therapeutic target for acute myeloid leukemia through regulation of the p38-MAPK pathway.
Li J, Zhang J, Zhang P
Translational cancer research 2025 Aug 31;14(8):4561-4573
Translational cancer research 2025 Aug 31;14(8):4561-4573
Pyrazolamide derivative T1 inhibits hepatocellular carcinoma cell proliferation through MAPK pathway modulation.
Zhang Y, Chen Y, Lv H, Wang H, Wang J, Lv X, Zhang M
International immunopharmacology 2025 Aug 28;161:115044
International immunopharmacology 2025 Aug 28;161:115044
Membrane protein CRISPR screen identifies RPSA as an essential host factor for porcine epidemic diarrhea virus replication.
Zhao Y, Guo G, Sun Y, Zhang M, Yang G, Liu Z, Song Y, Ghonaim AH, Ma N, Zhang M, Jongkaewwattana A, He Q, Li W
Journal of virology 2025 Aug 19;99(8):e0064925
Journal of virology 2025 Aug 19;99(8):e0064925
Per2 deficiency in microglia alleviates motor dysfunction by inhibiting ferroptosis in spinal cord injury.
Bie P, Su D, Gao Y, Wu L, Niu Z, Zhao Y, He H, Jiang Z, Zeng Z, Zhang Y, Fan H, Xia H
Communications biology 2025 Aug 16;8(1):1234
Communications biology 2025 Aug 16;8(1):1234
Selenoprotein K-dependent MyD88 palmitoylation promotes hepatic metaflammation in high-fat diet fed mice.
You M, Zhang Y, Gao M, Zhao W, Wei L, Ruan XZ, Chen Y
Free radical biology & medicine 2025 Aug 16;236:144-159
Free radical biology & medicine 2025 Aug 16;236:144-159
The chemokine receptor type 5 inhibitor maraviroc alleviates sepsis-associated liver injury by regulating MAPK/NF-κB signaling.
Shao J, Wang T, Tang C, Yu J, Chen Y, Guo X, Wang H, Zhou L, Zhang G, Li Y, Yu H, Zheng R
Naunyn-Schmiedeberg's archives of pharmacology 2025 Apr;398(4):3655-3666
Naunyn-Schmiedeberg's archives of pharmacology 2025 Apr;398(4):3655-3666
Crucial role of low molecular weight chondroitin sulfate from hybrid sturgeon cartilage in osteoarthritis improvement: Focusing on apoptosis, systemic inflammation, and intestinal flora.
Jing Y, Wang K, Pi T, Chen Z, Liu T, Liu X, Ye H, Xu X, Zhao Y
International journal of biological macromolecules 2025 Apr;298:139850
International journal of biological macromolecules 2025 Apr;298:139850
Pinocembrin alleviates renal ischemia-reperfusion injury/unilateral ureteral obstruction (UUO)-generated renal fibrosis by targeting the CYP1B1/ROS/MAPK axis.
Zhang BH, Chen H, Yang R, Jiang Z, Huang S, Chen Z, Liu C, Wang L, Liu XH
The FEBS journal 2025 Apr;292(8):2119-2144
The FEBS journal 2025 Apr;292(8):2119-2144
Carfilzomib inhibits the progression of hepatocellular cancer by upregulating GADD45α expression.
Chen M, Chen X, Shui Y, Ji C, Guo W
Oncology letters 2025 Apr;29(4):208
Oncology letters 2025 Apr;29(4):208
TGR5 attenuates DOCA-salt hypertension through regulating histone H3K4 methylation of ENaC in the kidney.
Xu L, Wu X, Long L, Li S, Huang M, Li M, Feng P, Levi M, Chen W, Wang L, Li C, Wang W
Metabolism: clinical and experimental 2025 Apr;165:156133
Metabolism: clinical and experimental 2025 Apr;165:156133
Berberine Alleviates 1-Methyl-3-Nitro-1-Nitrosoguanidine- Induced Chronic Atrophic Gastritis in Rats.
Wang L, Xie L
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2025 Apr 7;36(11):723-731
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2025 Apr 7;36(11):723-731
Febrile temperature-regulated TRPV1 in CD4(+) T cells mediates neuroinflammation in complex febrile seizures.
Kong S, Jia X, Liang X, Chen Y, Liang J, Zhang Y, Wu N, Su S, Chen T, He X, Yin J, Han S, Liu W, Fan Y, Xu J, Peng B
Journal of neuroinflammation 2025 Apr 7;22(1):103
Journal of neuroinflammation 2025 Apr 7;22(1):103
Deletion of HIF-2α in Dendritic Cells Attenuates Anti-Glomerular Basement Membrane Nephritis.
Miao J, Qu J, Li D, Zhang M
Biomedicines 2025 Apr 7;13(4)
Biomedicines 2025 Apr 7;13(4)
Xifeng Jiannao pill mitigates MPTP-induced neuronal apoptosis by reducing inflammation and oxidative stress via MAPK signaling.
Han X, He G, Wang J, Lou H, Chen L, Zhang L, Liu B, Wu D, Liu X, Wang S, Zhang C, Guo L
Metabolic brain disease 2025 Apr 4;40(4):170
Metabolic brain disease 2025 Apr 4;40(4):170
Alleviation of obesity cardiomyopathy by Fisetin through the inhibition of NF-κB/MAPK signaling.
Liu X, Zhu J, Li C, Tong C, Zhao C, Lin X, Wang Y, Alinejad T, Wu H, Chen G, Li L
International immunopharmacology 2025 Apr 4;151:114319
International immunopharmacology 2025 Apr 4;151:114319
Luteolin 7-Glucuronide in Artemisia rupestris L. Extract Attenuates Pulmonary Fibrosis by Inhibiting Fibroblast Activation and FMT via Targeting of TGF-β1.
Peng L, Fan Y, Wang L, Han C, Hao Z
Antioxidants (Basel, Switzerland) 2025 Apr 29;14(5)
Antioxidants (Basel, Switzerland) 2025 Apr 29;14(5)
Tanshinone IIA alleviates tri-ortho-cresyl phosphate-induced ovarian damage through Hippo signaling pathway activation in mice.
Ma Z, Hu N, Zheng L, Xue Y, Zhou C, Wang W, Cheng X, Luo T, Yu J, Hu L
Journal of ovarian research 2025 Apr 26;18(1):85
Journal of ovarian research 2025 Apr 26;18(1):85
Impact of Escherichia coli and Lipopolysaccharide on the MAPK Signaling Pathway, MMPs, TIMPs, and the uPA System in Bovine Mammary Epithelial Cells.
Zhang Y, Ding Y, Liang J, Zhang K, Su H, Wang D, Zhang M, Zhao F, Sun Z, Wu Z, Wang F, Cao G, Zhang Y
International journal of molecular sciences 2025 Apr 20;26(8)
International journal of molecular sciences 2025 Apr 20;26(8)
Canolol Alleviates Ethanol-Induced Gastric Ulcer by Inhibiting p38 MAPK/NF-κB/NLRP3 Pathway.
Ma C, Zhang L, Huang Q, Deng Q, Huang F, Xu J
Journal of agricultural and food chemistry 2025 Apr 16;73(15):9103-9111
Journal of agricultural and food chemistry 2025 Apr 16;73(15):9103-9111
Asparagine transporter supports macrophage inflammation via histone phosphorylation.
Wang C, Ye Y, Zhao M, Chen Q, Liu B, Ren W
Science advances 2025 Apr 11;11(15):eads3506
Science advances 2025 Apr 11;11(15):eads3506
Sodium Tanshinone IIA Sulfonate Protects Primary Cardiomyocytes Against Radiation-Induced Myocardial Injury via the p38 Pathway.
Ma L, Zhang T, Wang R, Li C, Yu J, Wang G, Cai H, Li T, Zhang Y, Li Y, Xie P
International heart journal 2024;65(4):730-737
International heart journal 2024;65(4):730-737
Quercetin of huoxuehuayu tongluo decoction and azithromycin combination therapy effectively improves rat tubal factor infertility by inhibiting inflammation.
Shao L, Wang N, Yan Y, Tan Y, Wu Q, Lei L, Wang M, Liu L
Iranian journal of basic medical sciences 2024;27(6):685-694
Iranian journal of basic medical sciences 2024;27(6):685-694
FBLN5 was Regulated by PRDM9, and Promoted Senescence and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells.
Zhao M, Rong R, Zhang C, Yang H, Han X, Fan Z, Zheng Y, Zhang J
Current stem cell research & therapy 2024;19(3):417-425
Current stem cell research & therapy 2024;19(3):417-425
Modified Zuo Gui Wan Ameliorates Ovariectomy-Induced Osteoporosis in Rats by Regulating the SCFA-GPR41-p38MAPK Signaling Pathway.
Song C, Yan Q, Ma Y, Li P, Yang Y, Wang Y, Li W, Wan X, Li Y, Zhu R, Liu H, Zhang Z
Drug design, development and therapy 2024;18:6359-6377
Drug design, development and therapy 2024;18:6359-6377
Rhein alleviates MPTP-induced Parkinson's disease by suppressing neuroinflammation via MAPK/IκB pathway.
Qin X, Wang S, Huang J, Hu B, Yang X, Liang L, Zhou R, Huang W
Frontiers in neuroscience 2024;18:1396345
Frontiers in neuroscience 2024;18:1396345
Downregulation of Circular RNA Gla Reduced Astrocyte Inflammatory Status by Regulating miR-488/MEKK1 Levels and Promoted Functional Recovery After Spinal Cord Injury.
Shao Q, Zhang Y, Zhang Z, Jiang W, Yin Y, Fang Y, Zhang C, Chen Q, Ning B
Journal of inflammation research 2024;17:7123-7139
Journal of inflammation research 2024;17:7123-7139
Cross-border regulation of the STK39/MAPK14 pathway by Lycium barbarum miR166a to inhibit triple-negative breast cancer.
Hou Y, Li J, Li X, Lv Y, Yuan C, Tian J, Liu X
American journal of translational research 2024;16(6):2683-2698
American journal of translational research 2024;16(6):2683-2698
Cistanche deserticola polysaccharide alleviates constipation by regulating intestinal barrier function and intestinal microbiota and their metabolites.
Yu Z, Zhang Z, Hu C, Xie L, Zhang R, Gao R, Zhang Z, Wei X, Li T, Guo J
American journal of translational research 2024;16(11):7036-7053
American journal of translational research 2024;16(11):7036-7053
PSAT1 mediated EMT of colorectal cancer cells by regulating Pl3K/AKT signaling pathway.
Wang M, Zhang H, Lu Z, Su W, Tan Y, Wang J, Jia X
Journal of Cancer 2024;15(10):3183-3198
Journal of Cancer 2024;15(10):3183-3198
Gut microbiota derived metabolite trimethylamine N-oxide influences prostate cancer progression via the p38/HMOX1 pathway.
Zhou Y, Lv J, Jin S, Fu C, Liu B, Shen Y, Li M, Zhang Y, Feng N
Frontiers in pharmacology 2024;15:1526051
Frontiers in pharmacology 2024;15:1526051
Anillin contributes to prostate cancer progression through the regulation of IGF2BP1 to promote c-Myc and MAPK signaling.
Liu J, Wang S, Zhang C, Wei Z, Han D, Song Y, Song X, Chao F, Wu Z, Xu G, Chen G
American journal of cancer research 2024;14(2):490-506
American journal of cancer research 2024;14(2):490-506
Jianpi Huayu Prescription Prevents Atherosclerosis by Improving Inflammation and Reshaping the Intestinal Microbiota in ApoE(-/-) Mice.
Zhao HR, Xian QC, Zhang XM, Ma XY, Wang FQ, Wang RS, Liu ZJ, Zhang ZG
Cell biochemistry and biophysics 2024 Sep;82(3):2297-2319
Cell biochemistry and biophysics 2024 Sep;82(3):2297-2319
ABT‑737 increases cisplatin sensitivity through the ROS‑ASK1‑JNK MAPK signaling axis in human ovarian cancer cisplatin‑resistant A2780/DDP cells.
Li X, Guo Y, Xing Z, Gong T, Yang L, Yang T, Chang B, Wang X, Yu B, Guo R
Oncology reports 2024 Sep;52(3)
Oncology reports 2024 Sep;52(3)
WIP1-mediated regulation of p38 MAPK signaling attenuates pyroptosis in sepsis-associated acute kidney injury.
Wang Y, Cui C, Zhao W, Tian X, Liu P, Wei L, Zhu Z, Liu M, Fu R, Jia L
Immunobiology 2024 Sep;229(5):152832
Immunobiology 2024 Sep;229(5):152832
The effects and mechanisms of AM1241 in alleviating cerebral ischemia-reperfusion injury.
Li S, Yang P, Wu Z, Huang W, Zhu X, Zhong L
Brain research bulletin 2024 Sep;215:111025
Brain research bulletin 2024 Sep;215:111025
Tumoral EIF4EBP1 regulates the crosstalk between tumor-associated macrophages and tumor cells in MRTK.
Wu X, Mi T, Jin L, Ren C, Wang J, Zhang Z, Liu J, Wang Z, Guo P, He D
European journal of pharmacology 2024 Sep 5;978:176787
European journal of pharmacology 2024 Sep 5;978:176787
Spinster homolog 2/S1P signaling ameliorates macrophage inflammatory response to bacterial infections by balancing PGE(2) production.
Fang C, Ren P, He Y, Wang Y, Yao S, Zhao C, Li X, Zhang X, Li J, Li M
Cell communication and signaling : CCS 2024 Sep 30;22(1):463
Cell communication and signaling : CCS 2024 Sep 30;22(1):463
Esketamine mitigates mechanical ventilation-induced lung injury in chronic obstructive pulmonary disease rats via inhibition of the MAPK/NF-κB signaling pathway and reduction of oxidative stress.
Cai SY, Liu A, Xie WX, Zhang XQ, Su B, Mao Y, Weng DG, Chen ZY
International immunopharmacology 2024 Sep 30;139:112725
International immunopharmacology 2024 Sep 30;139:112725
β-chitosan attenuates hepatic macrophage-driven inflammation and reverses aging-related cognitive impairment.
Zou C, Cai R, Li Y, Xue Y, Zhang G, Alitongbieke G, Pan Y, Zhang S
iScience 2024 Sep 20;27(9):110766
iScience 2024 Sep 20;27(9):110766
Chemical Composition, Antioxidant Capacity, and Anticancerous Effects against Human Lung Cancer Cells of a Terpenoid-Rich Fraction of Inula viscosa.
Seglab F, Abou Assali M, AlYafei T, Hassan H, Pinto DCGA, Baydoun S, Al Thani AA, Shaito AA
Biology 2024 Sep 2;13(9)
Biology 2024 Sep 2;13(9)
Neohesperidin Attenuates DSS-Induced Ulcerative Colitis by Inhibiting Inflammation, Reducing Intestinal Barrier Damage, and Modulating Intestinal Flora Composition.
Ju T, Song Z, Qin D, Cheng J, Li T, Hu G, Fu S
Journal of agricultural and food chemistry 2024 Sep 18;72(37):20419-20431
Journal of agricultural and food chemistry 2024 Sep 18;72(37):20419-20431
CREB1 promotes cholangiocarcinoma metastasis through transcriptional regulation of the LAYN-mediated TLN1/β1 integrin axis: CREB1 promotes cholangiocarcinoma metastasis through regulating LAYN/TLN1/β1 integrin axis.
Liang S, Zhou S, Tang Y, Xiao M, Ye K
Heliyon 2024 Sep 15;10(17):e36595
Heliyon 2024 Sep 15;10(17):e36595
Umbilical cord blood-derived exosomes attenuate dopaminergic neuron damage of Parkinson's disease mouse model.
Ye J, Sun X, Jiang Q, Gui J, Feng S, Qin B, Xie L, Guo A, Dong J, Sang M
Journal of nanobiotechnology 2024 Sep 14;22(1):567
Journal of nanobiotechnology 2024 Sep 14;22(1):567
Structure characterization and immunological activity of capsular polysaccharide from live and heat-killed Lacticaseibacillus paracasei 6235.
Wang Y, Liu R, Xie Z, Du L, Wang Y, Han J, Zhang L
International journal of biological macromolecules 2024 Oct;277(Pt 1):134010
International journal of biological macromolecules 2024 Oct;277(Pt 1):134010
EREG silencing inhibits tumorigenesis via inactivating ERK/p38 MAPK pathway in pancreatic ductal adenocarcinoma.
Liu F, Wu W, Cao W, Feng L, Yuan J, Ren Z, Dai N, Wang X, Li X, Yue S
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167336
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167336
Schisandra chinensis lignans regulate and cooperate with endogenous cannabinoid systems to ameliorate intestinal barrier injury associated with depression.
Wang J, Zheng A, Lin F, Zhang X, Shi K, Yan T, Jia Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Oct;133:155929
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Oct;133:155929
MAPK signaling pathway participates in the regulation of intestinal phosphorus and calcium absorption in broiler chickens via 1,25-dihydroxyvitamin D(3).
Han J, Lv X, He L, Liu M, Qu H, Xi L, Zhang L, Ma B, Shi C, Yang G, Wang Z
Poultry science 2024 Oct;103(10):104052
Poultry science 2024 Oct;103(10):104052
Orally Administered Ginkgolide C Alleviates MPTP-Induced Neurodegeneration by Suppressing Neuroinflammation and Oxidative Stress through Microbiota-Gut-Brain Axis in Mice.
Gao X, Fu S, Wen J, Yan A, Yang S, Zhang Y, Liu D, He D
Journal of agricultural and food chemistry 2024 Oct 9;72(40):22115-22131
Journal of agricultural and food chemistry 2024 Oct 9;72(40):22115-22131
Exploring the Effect of Fidgetin-Like 1 on Colorectal Cancer Through Tissue Chip and In Vitro Experiments.
Xu Y, Shen Y, Zhang C, Zheng L, Ji F, Chen J, Cheng S, Zheng Y
Balkan medical journal 2024 Oct 31;41(6):491-498
Balkan medical journal 2024 Oct 31;41(6):491-498
Lactobacillus paracasei subsp. paracasei NTU 101 prevents obesity by regulating AMPK pathways and gut microbiota in obese rat.
Kim S, Na GH, Yim DJ, Liu CF, Lin TH, Shih TW, Pan TM, Lee CL, Koo YK
Biochemical and biophysical research communications 2024 Oct 30;731:150279
Biochemical and biophysical research communications 2024 Oct 30;731:150279
Exploring the anti-inflammatory and immune regulatory effects of Taohe Chengqi decoction in sepsis-induced lung injury.
Deng M, Chen S, Wu J, Su L, Xu Z, Jiang C, Sheng L, Yang X, Zeng L, Wang J, Dai W
Journal of ethnopharmacology 2024 Oct 28;333:118404
Journal of ethnopharmacology 2024 Oct 28;333:118404
Erianin inhibits the progression of pancreatic cancer by directly targeting AKT and ASK1.
Liu R, Qiu M, Deng X, Zhang M, Gao Z, Wang Y, Mei H, Zhai M, Zhang Q, Hao J, Yang Z, Wang H
Cancer cell international 2024 Oct 25;24(1):348
Cancer cell international 2024 Oct 25;24(1):348
p38 MAPK inhibitor SB202190 suppresses ferroptosis in the glutamate-induced retinal excitotoxicity glaucoma model.
Feng L, Wang C, Zhang C, Zhang W, Zhu W, He Y, Xia Z, Song W
Neural regeneration research 2024 Oct 1;19(10):2299-2309
Neural regeneration research 2024 Oct 1;19(10):2299-2309
Exosomal miR-552-3p isolated from BALF of patients with silicosis induces fibroblast activation.
Li M, Li Y, Liu Q, Jiang M, He Y, Liao X, Tao L, Meng J
Toxicology letters 2024 Nov;401:55-70
Toxicology letters 2024 Nov;401:55-70
Enhancing DOX efficacy against NSCLC through UDCA-mediated modulation of the TGF-β/MAPK autophagy pathways.
Li Y, Zhao H, Shen Z, Zheng Y, Jiang Y, Song Y, Cai Y
Scientific reports 2024 Nov 8;14(1):27169
Scientific reports 2024 Nov 8;14(1):27169
Hypoxanthine Produces Rapid Antidepressant Effects by Suppressing Inflammation in Serum and Hippocampus.
Wu L, Chen J, Yu Q, Lu C, Shu Y
ACS chemical neuroscience 2024 Nov 6;15(21):3970-3980
ACS chemical neuroscience 2024 Nov 6;15(21):3970-3980
Low-Medium Polarity Ginsenosides from Wild Ginseng Improves Immunity by Activating the AhR/MAPK Pathway through Tryptophan Metabolism Driven by Gut Microbiota.
Zhang M, Ma L, Luo J, Ren T, Liu S, Pan L, Bao Y, Li F, Dai Y, Pi Z, Yue H, Zheng F
Journal of agricultural and food chemistry 2024 Nov 27;72(47):26142-26154
Journal of agricultural and food chemistry 2024 Nov 27;72(47):26142-26154
Palmitoylation licenses RIPK1 kinase activity and cytotoxicity in the TNF pathway.
Zhang N, Liu J, Guo R, Yan L, Yang Y, Shi C, Zhang M, Shan B, Li W, Gu J, Xu D
Molecular cell 2024 Nov 21;84(22):4419-4435.e10
Molecular cell 2024 Nov 21;84(22):4419-4435.e10
Programmed cell death-related ABI1 is a critical mediator of abdominal aortic aneurysm.
Wang H, Xu Z, Guo J, Li L, Tian Y, Fu S
European journal of medical research 2024 Nov 21;29(1):557
European journal of medical research 2024 Nov 21;29(1):557
Non-Sugar Sweetener Rubusoside Alleviates Lipid Metabolism Disorder In Vivo and In Vitro by Targeting PPARγ/α, Lgals3, and Mknk2.
Huang W, Jiang M, Wang X, Pan D, Chen W, Fan L
Journal of agricultural and food chemistry 2024 Nov 20;72(46):25601-25619
Journal of agricultural and food chemistry 2024 Nov 20;72(46):25601-25619
Carthamin yellow alleviates dextran sodium sulfate-induced ulcerative colitis by repairing the intestinal barrier and activating the Nrf2/GPX4 axis.
Bian W, Wei L, Wang K
International immunopharmacology 2024 Nov 15;141:113020
International immunopharmacology 2024 Nov 15;141:113020
7-hydroxycoumarin ameliorates ulcerative colitis in mice by inhibiting the MAPK pathway and alleviating gut microbiota dysbiosis.
Liu M, Sun H, Fu H, Fu L, Zheng X, Chen Y
BMC gastroenterology 2024 Nov 12;24(1):405
BMC gastroenterology 2024 Nov 12;24(1):405
IL1RAP Exacerbates Sepsis-Induced Pulmonary and Spleen Injury Through Regulating CD4(+) T Lymphocyte Differentiation.
Huang L, Wu C, Xu D, Cui Y, Tang J
Immunological investigations 2024 May;53(4):574-585
Immunological investigations 2024 May;53(4):574-585
circUSP13 facilitates the fast-to-slow myofiber shift via the MAPK/ERK signaling pathway in goat skeletal muscles.
Zhang Z, Kang Z, Deng K, Li J, Liu Z, Huang X, Wang F, Fan Y
Journal of cellular physiology 2024 May;239(5):e31226
Journal of cellular physiology 2024 May;239(5):e31226
Alcohol extract of Rubia yunnanensis: Metabolic alterations and preventive effects against OGD/R‑induced oxidative damage in HT22 cells.
Cheng J, Li G, Yang L, Chen P, Duan X
Biomedical reports 2024 May;20(5):75
Biomedical reports 2024 May;20(5):75
The prognostic significance and potential mechanism of DBF4 zinc finger in hepatocellular carcinoma.
Wu Z, Zhang L, Li X, Liu L, Kuang T, Qiu Z, Deng W, Wang W
Scientific reports 2024 May 9;14(1):10662
Scientific reports 2024 May 9;14(1):10662
D-mannose alleviates intervertebral disc degeneration through glutamine metabolism.
Dong ZL, Jiao X, Wang ZG, Yuan K, Yang YQ, Wang Y, Li YT, Wang TC, Kan TY, Wang J, Tao HR
Military Medical Research 2024 May 6;11(1):28
Military Medical Research 2024 May 6;11(1):28
Inhibition of macrophage MAPK/NF-κB pathway and Th2 axis by mangiferin ameliorates MC903-induced atopic dermatitis.
Lu C, Deng S, Liu Y, Yang S, Qin D, Zhang L, Wang RR, Zhang Y
International immunopharmacology 2024 May 30;133:112038
International immunopharmacology 2024 May 30;133:112038
Readily Available Oral Prebiotic Protein Reactive Oxygen Species Nanoscavengers for Synergistic Therapy of Inflammation and Fibrosis in Inflammatory Bowel Disease.
Yu Y, Yang D, Lin B, Zhu L, Li C, Li X
ACS nano 2024 May 28;18(21):13583-13598
ACS nano 2024 May 28;18(21):13583-13598
ECHDC2 inhibits the proliferation of gastric cancer cells by binding with NEDD4 to degrade MCCC2 and reduce aerobic glycolysis.
He J, Yi J, Ji L, Dai L, Chen Y, Xue W
Molecular medicine (Cambridge, Mass.) 2024 May 23;30(1):69
Molecular medicine (Cambridge, Mass.) 2024 May 23;30(1):69
Glycyrrhizic Acid Alleviates Semen Strychni-Induced Neurotoxicity Through the Inhibition of HMGB1 Phosphorylation and Inflammatory Responses.
Yu C, Xiang Y, Zhang M, Wen J, Duan X, Wang L, Deng G, Fang P
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2024 May 21;19(1):21
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2024 May 21;19(1):21
Oral Administration of Deer Bone Collagen Peptide Can Enhance the Skin Hydration Ability and Antioxidant Ability of Aging Mice Induced by D-Gal, and Regulate the Synthesis and Degradation of Collagen.
Zhang K, Zhao C, Liu K, Feng R, Zhao Y, Zong Y, Du R
Nutrients 2024 May 21;16(11)
Nutrients 2024 May 21;16(11)
Naringin attenuates Actinobacillus pleuropneumoniae-induced acute lung injury via MAPK/NF-κB and Keap1/Nrf2/HO-1 pathway.
Huang QL, Huang LN, Zhao GY, Liu C, Pan XY, Li ZR, Jing XH, Qiu ZY, Xin RH
BMC veterinary research 2024 May 17;20(1):204
BMC veterinary research 2024 May 17;20(1):204
The Effects of Resveratrol and Apigenin on Jejunal Oxidative Injury in Ducks and on Immortalized Duck Intestinal Epithelial Cells Exposed to H(2)O(2).
Zhou N, Cao Y, Luo Y, Wang L, Li R, Di H, Gu T, Cao Y, Zeng T, Zhu J, Chen L, An D, Ma Y, Xu W, Tian Y, Lu L
Antioxidants (Basel, Switzerland) 2024 May 17;13(5)
Antioxidants (Basel, Switzerland) 2024 May 17;13(5)
Overexpressing of the GIPC1 protects against pathological cardiac remodelling.
Sun X, Han Y, Yu Y, Chen Y, Dong C, Lv Y, Qu H, Fan Z, Yu Y, Sang Y, Tang W, Liu Y, Ju J, Zhao D, Bai Y
European journal of pharmacology 2024 May 15;971:176488
European journal of pharmacology 2024 May 15;971:176488
Helicobacter pylori disrupts gastric mucosal homeostasis by stimulating macrophages to secrete CCL3.
Wei YF, Li X, Zhao MR, Liu S, Min L, Zhu ST, Zhang ST, Xie SA
Cell communication and signaling : CCS 2024 May 10;22(1):263
Cell communication and signaling : CCS 2024 May 10;22(1):263
Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop.
Yang S, Xie J, Pan Z, Guan H, Tu Y, Ye Y, Huang S, Fu S, Li K, Huang Z, Li X, Shi Z, Li L, Zhang Y
Experimental & molecular medicine 2024 Mar;56(3):630-645
Experimental & molecular medicine 2024 Mar;56(3):630-645
VSIG4 inhibits RANKL-induced osteoclastogenesis by enhancing Nrf2-dependent antioxidant response against reactive oxygen species production.
Miao J, Tu Y, Jiang J, Ren R, Wu Q, Liang H, Wang T, Lin B, Wu J, Pan Y, Wang X, Jin H
International journal of biological macromolecules 2024 Mar;260(Pt 2):129357
International journal of biological macromolecules 2024 Mar;260(Pt 2):129357
Caffeic acid-grafted chitooligosaccharides downregulate MAPK and NF-kB in RAW264.7 cells.
Bui VH, Vo HN, Kim SK, Ngo DN
Chemical biology & drug design 2024 Mar;103(3):e14496
Chemical biology & drug design 2024 Mar;103(3):e14496
PARP5A and RNF146 phase separation restrains RIPK1-dependent necroptosis.
Hou S, Zhang J, Jiang X, Yang Y, Shan B, Zhang M, Liu C, Yuan J, Xu D
Molecular cell 2024 Mar 7;84(5):938-954.e8
Molecular cell 2024 Mar 7;84(5):938-954.e8
Spinosin inhibits activated hepatic stellate cell to attenuate liver fibrosis by targeting Nur77/ASK1/p38 MAPK signaling pathway.
Lin G, Li W, Hong W, Zhu D, Hu H, Fu J, Gao Y, Chen S, Chai D, Zeng JZ
European journal of pharmacology 2024 Mar 5;966:176270
European journal of pharmacology 2024 Mar 5;966:176270
Protective Effects of Carbonated Chitosan Montmorillonite on Vomitoxin-Induced Intestinal Inflammation.
Tang R, Ju X, Niu X, Liu X, Li Y, Yu Z, Ma X, Gao Y, Li Y, Xie H, Zhou Q, Yong Y
Polymers 2024 Mar 5;16(5)
Polymers 2024 Mar 5;16(5)
Soybean-derived antihypertensive hydrolysates attenuate Ang II-induced renal damage by modulating MAPK and NF-κB signaling pathways.
Song T, Ding YY, Zhang T, Cai Q, Hu Y, Gu Q, Gu Z
Food & function 2024 Mar 4;15(5):2485-2496
Food & function 2024 Mar 4;15(5):2485-2496
Association of TRAIL receptor with phosphatase SHP-1 enables repressing T cell receptor signaling and T cell activation through inactivating Lck.
Chyuan IT, Liao HJ, Tan TH, Chuang HC, Chu YC, Pan MH, Wu CS, Chu CL, Sheu BC, Hsu PN
Journal of biomedical science 2024 Mar 27;31(1):33
Journal of biomedical science 2024 Mar 27;31(1):33
L-Theanine alleviates heat stress through modulation of gut microbiota and immunity.
Liu S, Wang B, Lin L, Xu W, Gong ZH, Xiao WJ
Journal of the science of food and agriculture 2024 Mar 15;104(4):2059-2072
Journal of the science of food and agriculture 2024 Mar 15;104(4):2059-2072
Study on the effect and mechanism of Zhenzhu Tongluo pills in treating diabetic peripheral neuropathy injury.
Dong P, Zhou L, Wang X, Xue L, Du Y, Cui R
European journal of medical research 2024 Mar 1;29(1):149
European journal of medical research 2024 Mar 1;29(1):149
Myricanol attenuates sepsis-induced inflammatory responses by nuclear factor erythroid 2-related factor 2 signaling and nuclear factor kappa B/mitogen-activated protein kinase pathway via upregulating Sirtuin 1.
Liu K, Yang L, Wang P, Zhu J, Li F, Peng J, Huang K, Liang M
Inflammopharmacology 2024 Jun;32(3):1887-1901
Inflammopharmacology 2024 Jun;32(3):1887-1901
Prednisone combined with Dihydroartemisinin attenuates systemic lupus erythematosus by regulating M1/M2 balance through the MAPK signaling pathway.
Chen Y, Tao T, Liang Z, Chen X, Xu Y, Zhang T, Zhou D
Molecular immunology 2024 Jun;170:144-155
Molecular immunology 2024 Jun;170:144-155
Tris (2-chloroisopropyl) phosphate and Tris (nonylphenyl) phosphite Promote Human Renal Cell Apoptosis through the ERK/CEPBA/Long Non-Coding RNA Cytoskeleton Regulator Axis.
Zhao H, Yan Y, Gao Y, Wang J, Li S
Toxics 2024 Jun 22;12(7)
Toxics 2024 Jun 22;12(7)
Network pharmacology and biochemical experiments reveal the antiapoptotic mechanism of huperzine A for treating diabetic retinopathy.
Zhang Y, Huang W, Tian Q, Bai G, Wu W, Yin H, Hu L, Chen X
The British journal of ophthalmology 2024 Jun 20;108(7):989-998
The British journal of ophthalmology 2024 Jun 20;108(7):989-998
Daphnetin Ameliorates Neuropathic Pain via Regulation of Microglial Responses and Glycerophospholipid Metabolism in the Spinal Cord.
Liang W, Zhang T, Zhang M, Gao J, Huang R, Huang X, Chen J, Cheng L, Zhang L, Huang Z, Tan Q, Jia Z, Zhang S
Pharmaceuticals (Basel, Switzerland) 2024 Jun 16;17(6)
Pharmaceuticals (Basel, Switzerland) 2024 Jun 16;17(6)
Orientin alleviates the inflammatory response in psoriasis like dermatitis in BALB/c mice by inhibiting the MAPK signaling pathway.
Long Q, Ma T, Wang Y, Chen S, Tang S, Wang T, Zhou Y, Xu K, Wan P, Cao Y
International immunopharmacology 2024 Jun 15;134:112261
International immunopharmacology 2024 Jun 15;134:112261
Structural elucidation and anti-psoriasis activity of a novel polysaccharide from Saussurea Costus.
Gong X, Zhang Z, Shi X, Zhu Y, Ali F, Dong Y, Zhang F, Zhang B
Carbohydrate polymers 2024 Jun 1;333:121963
Carbohydrate polymers 2024 Jun 1;333:121963
STAU1 exhibits a dual function by promoting amyloidogenesis and tau phosphorylation in cultured cells.
Li CL, Zhou GF, Xie XY, Wang L, Chen X, Pan QL, Pu YL, Yang J, Song L, Chen GJ
Experimental neurology 2024 Jul;377:114805
Experimental neurology 2024 Jul;377:114805
Microglial uptake of hADSCs-Exo mitigates neuroinflammation in ICH.
Zhao L, Li J
Cellular signalling 2024 Jul;119:111146
Cellular signalling 2024 Jul;119:111146
Myeloid-derived growth factor ameliorates dextran sodium sulfate-induced colitis by regulating macrophage polarization.
Yang Y, Zhao C, Yang Z, Du C, Chang Z, Wen X, Zhang X, Liu Y, Hu L, Gao Z
Journal of molecular medicine (Berlin, Germany) 2024 Jul;102(7):875-886
Journal of molecular medicine (Berlin, Germany) 2024 Jul;102(7):875-886
CDK5-USP30 signaling pathway regulates MAVS-mediated inflammation via suppressing mitophagy in MPTP/MPP(+) PD model.
Ren Y, Wu X, Bai T, Yang N, Yuan Y, Xu L, Wen Y, Wen Y, Wang Z, Zhou L, Zou F, Li W
Ecotoxicology and environmental safety 2024 Jul 1;279:116446
Ecotoxicology and environmental safety 2024 Jul 1;279:116446
Exposure to volatile organic compounds induces cardiovascular toxicity that may involve DNA methylation.
Li Z, Lu J, Ruan X, Wu Y, Zhao J, Jiao X, Sun J, Sun K
Toxicology 2024 Jan;501:153705
Toxicology 2024 Jan;501:153705
Study on the molecular mechanism of dihydromyricetin in alleviating liver cirrhosis based on network pharmacology.
Wei L, Li X, Yao Y, Wang S, Ai X, Liu S
Chemical biology & drug design 2024 Jan;103(1):e14421
Chemical biology & drug design 2024 Jan;103(1):e14421
Trimethylamine-N oxide enhances post-stroke depression progression via ROS-p38/MAPK signaling.
Hu Y, Liu Y, Wang H, Wang X
Human & experimental toxicology 2024 Jan-Dec;43:9603271241306396
Human & experimental toxicology 2024 Jan-Dec;43:9603271241306396
Corilagin relieves atherosclerosis via the toll-like receptor 4 signaling pathway in vascular smooth muscle cells.
Wang Y, Li Y, Chen Y, Mao J, Ji J, Zhang S, Liu P, Pronyuk K, Fisher D, Dang Y, Zhao L
International journal of immunopathology and pharmacology 2024 Jan-Dec;38:3946320241254083
International journal of immunopathology and pharmacology 2024 Jan-Dec;38:3946320241254083
Gestational exposure to 1-NP induces ferroptosis in placental trophoblasts via CYP1B1/ERK signaling pathway leading to fetal growth restriction.
Yu S, Mu Y, Wang K, Wang L, Wang C, Yang Z, Liu Y, Li S, Zhang M
Chemico-biological interactions 2024 Jan 5;387:110812
Chemico-biological interactions 2024 Jan 5;387:110812
Protective Effect of Artocarpus heterophyllus Lam. (Jackfruit) Polysaccharides on Liver Injury Induced by Cyclophosphamide in Mice.
Cheng M, Zheng Y, Wu G, Tan L, Xu F, Zhang Y, Chen X, Zhu K
Nutrients 2024 Jan 4;16(1)
Nutrients 2024 Jan 4;16(1)
Cholinergic signaling of muscarinic receptors directly involves in the neuroprotection of muscone by inducing Ca(2+) antagonism and maintaining mitochondrial function.
Shen G, Zhou Z, Guo Y, Li L, Zeng J, Wang J, Zhao J
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117192
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117192
Prepared Radix Polygoni Multiflori and emodin alleviate lipid droplet accumulation in nonalcoholic fatty liver disease through MAPK signaling pathway inhibition.
Huang C, Zhang Y, Xu Y, Wei S, Yang T, Wang S, Li C, Lin H, Li X, Zhao S, Zhu L, Pan W
Aging 2024 Jan 26;16(3):2362-2384
Aging 2024 Jan 26;16(3):2362-2384
The protective effect of Ergolide in osteoarthritis: In vitro and in vivo studies.
Meng X, Sun L, Meng X, Bi Q
International immunopharmacology 2024 Jan 25;127:111355
International immunopharmacology 2024 Jan 25;127:111355
Bioinformatics and experimental studies jointly reveal that Sacubitril Valsartan improves myocardial oxidative stress and inflammation by regulating the MAPK signaling pathway to treat chemotherapy related cardiotoxicity.
Shi H, Lu H, Zheng Y, Pu P, Wei L, Hu D, Tang H, Wang L
Biochemical and biophysical research communications 2024 Jan 1;690:149244
Biochemical and biophysical research communications 2024 Jan 1;690:149244
Icariin decreases cell proliferation and inflammation of rheumatoid arthritis-fibroblast like synoviocytes via GAREM1/MAPK signaling pathway.
Wu Z, Liu Q, Cao Z, Li H, Zhou Y, Zhang P
Immunopharmacology and immunotoxicology 2024 Feb;46(1):86-92
Immunopharmacology and immunotoxicology 2024 Feb;46(1):86-92
Tobacco introduced Perilla frutescens and Ocimum basilicum genes attenuates neutrophilic inflammation in lung tissues of COPD rats.
Wei K, Zhang X, Yang J, Chen J
Ecotoxicology and environmental safety 2024 Feb;271:115956
Ecotoxicology and environmental safety 2024 Feb;271:115956
Targeting ROCK1 in diabetic kidney disease: Unraveling mesangial fibrosis mechanisms and introducing myricetin as a novel antagonist.
Yuan N, Diao J, Dong J, Yan Y, Chen Y, Yan S, Liu C, He Z, He J, Zhang C, Wang H, Wang M, He F, Xiao W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Feb;171:116208
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Feb;171:116208
Exploration of costunolide derivatives as potential anti-inflammatory agents for topical treatment of atopic dermatitis by inhibiting MAPK/NF-κB pathways.
Lu C, Li X, Du W, Zhang X, Li Y, Hu C, Mao Z, Zhang Y, Wang R
Bioorganic chemistry 2024 Feb;143:107054
Bioorganic chemistry 2024 Feb;143:107054
Orally administered neohesperidin attenuates MPTP-induced neurodegeneration by inhibiting inflammatory responses and regulating intestinal flora in mice.
He D, Gao X, Wen J, Zhang Y, Yang S, Sun X, Cui M, Li Z, Fu S, Liu J, Liu D
Food & function 2024 Feb 5;15(3):1460-1475
Food & function 2024 Feb 5;15(3):1460-1475
Warm Acupuncture Reduces Pain and Inflammation in Rats with Lumbar Disc Herniation Induced by Autologous Nucleus Pulposus Transplantation via Regulating p38MAPK/NF-κB Pathway.
Pan F, Zeng F, Chen Y, Zheng Y, Chen Z, Zhu X, Yin MF, Huang Y, Liu Z
Journal of acupuncture and meridian studies 2024 Feb 29;17(1):28-37
Journal of acupuncture and meridian studies 2024 Feb 29;17(1):28-37
Resveratrol-laden mesoporous silica nanoparticles regulate the autophagy and apoptosis via ROS-mediated p38-MAPK/HIF-1a /p53 signaling in hypertrophic scar fibroblasts.
Zuo J, Ma S
Heliyon 2024 Feb 29;10(4):e24985
Heliyon 2024 Feb 29;10(4):e24985
Aggresome formation promotes ASK1/JNK signaling activation and stemness maintenance in ovarian cancer.
Chen Y, Qiang Y, Fan J, Zheng Q, Yan L, Fan G, Song X, Zhang N, Lv Q, Xiong J, Wang J, Cao J, Liu Y, Xiong J, Zhang W, Li F
Nature communications 2024 Feb 13;15(1):1321
Nature communications 2024 Feb 13;15(1):1321
Sasanquasaponin from Camellia oleifera Abel Exerts an Anti-Inflammatory Effect in RAW 264.7 Cells via Inhibition of the NF-κB/MAPK Signaling Pathways.
Zhao Y, Zhao N, Kollie L, Yang D, Zhang X, Zhang H, Liang Z
International journal of molecular sciences 2024 Feb 10;25(4)
International journal of molecular sciences 2024 Feb 10;25(4)
Therapeutic potential of Lacticaseibacillus rhamnosus grx10 and its derived postbiotic through gut microbiota and MAPK/MLCK/MLC pathway-mediated intestinal barrier repairment in ulcerative colitis.
Ye H, Liu X, Guan K, Ma Y, Liu R, Liu Y, Lv X, Wang R, Li Q
Journal of food science 2024 Dec;89(12):10035-10052
Journal of food science 2024 Dec;89(12):10035-10052
Active Targets and Potential Mechanisms of Erhuang Quzhi Formula in Treating NAFLD: Network Analysis and Experimental Assessment.
Pan P, Chen W, Wu X, Li C, Gao Y, Qin D
Cell biochemistry and biophysics 2024 Dec;82(4):3297-3315
Cell biochemistry and biophysics 2024 Dec;82(4):3297-3315
Pseudorabies virus UL13 primes inflammatory response through downregulating heat shock factor 1.
Zhang WJ, Feng H, Zhang MM, Liu JS, Li LT, Chen HC, Liu ZF
Virology 2024 Dec;600:110214
Virology 2024 Dec;600:110214
Folic acid mitigates the developmental and neurotoxic effects of bisphenol A in zebrafish by inhibiting the oxidative stress/JNK signaling pathway.
Li R, Yang W, Yan X, Zhou X, Song X, Liu C, Zhang Y, Li J
Ecotoxicology and environmental safety 2024 Dec;288:117363
Ecotoxicology and environmental safety 2024 Dec;288:117363
Pharmacological Network Analysis of the Functions and Mechanism of Quercetin From Jisuikang (JSK) in Spinal Cord Injury (SCI).
Dong L, He H, Chen Z, Wang X, Li Y, Lü G, Wang B, Kuang L
Journal of cellular and molecular medicine 2024 Dec;28(24):e70269
Journal of cellular and molecular medicine 2024 Dec;28(24):e70269
Protocatechuic acid attenuates intestinal inflammation through TLR4/p38 and NF-κB pathways in heat-stressed broilers.
Wang S, Wang X, Gao Y, Fu Y, Han Z, Xu P, Tang J
Poultry science 2024 Dec;103(12):104424
Poultry science 2024 Dec;103(12):104424
The ellagitannin metabolite urolithin C attenuated cognitive impairment by inhibiting neuroinflammation via downregulation of MAPK/NF-kB signaling pathways in aging mice.
Chen P, Wu L, Lei J, Chen F, Feng L, Liu G, Zhou B
International immunopharmacology 2024 Dec 5;142(Pt B):113151
International immunopharmacology 2024 Dec 5;142(Pt B):113151
Engineered Magneto-Piezoelectric Nanoparticles-Enhanced Scaffolds Disrupt Biofilms and Activate Oxidative Phosphorylation in Icam1(+) Macrophages for Infectious Bone Defect Regeneration.
Wu H, Chen C, Li J, Yu D, Wu X, Huang H, Tang Z, Wu Q, Yan S, Wang N, Wang M, Wei F, Yu Y, Wang D, Shi M, Yue X, Cao P, Zheng Z, Li X, Guo B, Shi L, Guo Z
ACS nano 2024 Dec 31;18(52):35575-35594
ACS nano 2024 Dec 31;18(52):35575-35594
NLRP12 c.1382dup promotes the development of Crohn's disease through the ERK/NLRP3/ IL-1β pathway.
Huang Y, Xu L, Yang Q, Xiao X, Ye Z, Li R, Guan Y, Wu X
Gene 2024 Dec 30;931:148855
Gene 2024 Dec 30;931:148855
Discovery of Novel MyD88 Inhibitor A5S to Alleviate Acute Lung Injury with Favorable Drug-like Properties.
Chen P, Zou Y, Wang X, Chen Z, Dong K, Yang J, Cui Y, Gu J, Wu X, Li X, Zhou Y, Guo M, Zheng Z, Chen Q, Zhu W, Wu D, Yin L, Chen L, Ouyang Q, Liang G, Tang Q
Journal of medicinal chemistry 2024 Dec 26;67(24):22263-22281
Journal of medicinal chemistry 2024 Dec 26;67(24):22263-22281
MS4A3 regulates hematopoietic myeloid differentiation through ROS/TGF-β/p38MAPK pathway.
Dong Y, Yue T, Wang X, Huo Q, Li W, Zhang S, Zhao Y, Li D
International immunopharmacology 2024 Dec 25;143(Pt 3):113578
International immunopharmacology 2024 Dec 25;143(Pt 3):113578
Contribution of inwardly rectifying potassium channel 4.1 in orofacial neuropathic pain: Regulation of pannexin 3 via the reactive oxygen species-activated P38 MAPK signal pathway.
Feng YH, Tang RJ, Zhang YY, Lin J, Liu YJ, Li YK, Li CJ, Zhou C, Liu F, Shen JF
The European journal of neuroscience 2024 Aug;60(4):4569-4585
The European journal of neuroscience 2024 Aug;60(4):4569-4585
High Dose of Estrogen Protects the Lungs from Ischemia-Reperfusion Injury by Downregulating the Angiotensin II Signaling Pathway.
Dai P, He J, Wei Y, Xu M, Zhao J, Zhou X, Tang H
Inflammation 2024 Aug;47(4):1248-1261
Inflammation 2024 Aug;47(4):1248-1261
Can thymosin beta 10 function both as a non-invasive biomarker and chemotherapeutic target in human colorectal cancer?
Yang J, Yang X, Guo T, Wang L, Zhao Z, Hu Z, Li Y
Translational oncology 2024 Aug;46:102026
Translational oncology 2024 Aug;46:102026
The Role of KDM2A and H3K36me2 Demethylation in Modulating MAPK Signaling During Neurodevelopment.
Ren Z, Tang H, Zhang W, Guo M, Cui J, Wang H, Xie B, Yu J, Chen Y, Zhang M, Han C, Chu T, Liang Q, Zhao S, Huang Y, He X, Liu K, Liu C, Chen C
Neuroscience bulletin 2024 Aug;40(8):1076-1092
Neuroscience bulletin 2024 Aug;40(8):1076-1092
Fungal metabolite altersolanol a exhibits potent cytotoxicity against human placental trophoblasts in vitro via mitochondria-mediated apoptosis.
Gu T, Wen Y, Zhou Q, Yuan W, Guo H, Chang WL, Yang Q
Mycotoxin research 2024 Aug;40(3):419-432
Mycotoxin research 2024 Aug;40(3):419-432
GPR124 promotes trophoblast proliferation, migration, and invasion and inhibits trophoblast cell apoptosis and inflammation via JNK and P38 MAPK pathways.
Shen Y, Lian Y, Xiao L, Miu Y, Niu J, Cui Q
Journal of cellular physiology 2024 Aug;239(8):e31298
Journal of cellular physiology 2024 Aug;239(8):e31298
Mannan-binding lectin inhibits oxidative stress-induced senescence via the NAD+/Sirt1 pathway.
Lei Y, Meng J, Shi H, Shi C, Li C, Yang Z, Zhang W, Zuo D, Wang F, Wang M
International immunopharmacology 2024 Aug 20;137:112468
International immunopharmacology 2024 Aug 20;137:112468
Extract of Phyllanthus emblica L. fruit stimulates basal glucose uptake and ameliorates palmitate-induced insulin resistance through AMPK activation in C2C12 myotubes.
Li HY, Li CF, Liu CH, Chen SC, Liu YF, Lv QH, Zhang W
BMC complementary medicine and therapies 2024 Aug 2;24(1):296
BMC complementary medicine and therapies 2024 Aug 2;24(1):296
Emodin suppresses alkali burn-induced corneal inflammation and neovascularization by the vascular endothelial growth factor receptor 2 signaling pathway.
Xueying Z, Liang G, Siyi L, Fengyue LI, Mingli L, Wanting L, Chun M, Guanghui L
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2024 Apr;44(2):268-276
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2024 Apr;44(2):268-276
Pimpinellin ameliorates macrophage inflammation by promoting RNF146-mediated PARP1 ubiquitination.
Yang L, Du M, Liu K, Wang P, Zhu J, Li F, Wang Z, Huang K, Liang M
Phytotherapy research : PTR 2024 Apr;38(4):1783-1798
Phytotherapy research : PTR 2024 Apr;38(4):1783-1798
HBI-8000 improves heart failure with preserved ejection fraction via the TGF-β1/MAPK signalling pathway.
Tian J, Li W, Zeng L, Li Y, Du J, Li Y, Li B, Su G
Journal of cellular and molecular medicine 2024 Apr;28(7):e18238
Journal of cellular and molecular medicine 2024 Apr;28(7):e18238
Defective prelamin A processing promotes unconventional necroptosis driven by nuclear RIPK1.
Yang Y, Zhang J, Lv M, Cui N, Shan B, Sun Q, Yan L, Zhang M, Zou C, Yuan J, Xu D
Nature cell biology 2024 Apr;26(4):567-580
Nature cell biology 2024 Apr;26(4):567-580
TuBG1 promotes hepatocellular carcinoma via ATR/P53-apoptosis and cycling pathways.
Zhang Y, Wang ZZ, Han AQ, Yang MY, Zhu LX, Pan FM, Wang Y
Hepatobiliary & pancreatic diseases international : HBPD INT 2024 Apr;23(2):195-209
Hepatobiliary & pancreatic diseases international : HBPD INT 2024 Apr;23(2):195-209
Osthole Activates the Cholinergic Anti-Inflammatory Pathway via α7nAChR Upregulation to Alleviate Inflammatory Responses.
Li SH, Li MY, Yuan TT, Wang GW, Zeng JB, Shi Z, Liu JH, Su JC
Chemistry & biodiversity 2024 Apr;21(4):e202400290
Chemistry & biodiversity 2024 Apr;21(4):e202400290
Hesperidin ameliorates H(2)O(2)-induced bovine mammary epithelial cell oxidative stress via the Nrf2 signaling pathway.
Huang Q, Liu J, Peng C, Han X, Tan Z
Journal of animal science and biotechnology 2024 Apr 9;15(1):57
Journal of animal science and biotechnology 2024 Apr 9;15(1):57
Differences in Airway Remodeling and Emphysematous Lesions between Rats Exposed to Smoke from New-Type and Conventional Tobacco Varieties.
Wei K, Li Y, Du B, Wu J
Antioxidants (Basel, Switzerland) 2024 Apr 24;13(5)
Antioxidants (Basel, Switzerland) 2024 Apr 24;13(5)
The role of FPR2-mediated ferroptosis in formyl peptide-induced acute lung injury against endothelial barrier damage and protective effect of the mitochondria-derived peptide MOTS-c.
Wen Z, Fan J, Zhan F, Li X, Li B, Lu P, Yao X, Shen Z, Liu Z, Wang C, Li X, Jin W, Zhang X, Qi Y, Wang X, Song M
International immunopharmacology 2024 Apr 20;131:111911
International immunopharmacology 2024 Apr 20;131:111911
Verapamil Attenuates the Severity of Tendinopathy by Mitigating Mitochondrial Dysfunction through the Activation of the Nrf2/HO-1 Pathway.
Wang Z, Dong Z, Li Y, Jiao X, Liu Y, Chang H, Gan Y
Biomedicines 2024 Apr 18;12(4)
Biomedicines 2024 Apr 18;12(4)
Study on the Mechanism of Jiaotai Pill Intervention on Insomnia Animal Model Based on Gut Microbiome and Metabolomics.
Yang Y, Liu J, Ou H, Ma X, Li J, Shao B, Jin R, Zhao J
Evidence-based complementary and alternative medicine : eCAM 2023;2023:2442505
Evidence-based complementary and alternative medicine : eCAM 2023;2023:2442505
Vitamin K2 (MK-7) attenuates LPS-induced acute lung injury via inhibiting inflammation, apoptosis, and ferroptosis.
Wang Y, Yang W, Liu L, Liu L, Chen J, Duan L, Li Y, Li S
PloS one 2023;18(11):e0294763
PloS one 2023;18(11):e0294763
Adiponectin inhibits TGF-β1-induced skin fibroblast proliferation and phenotype transformation via the p38 MAPK signaling pathway.
Wang X, Yan X, Huang F, Wu L
Open life sciences 2023;18(1):20220679
Open life sciences 2023;18(1):20220679
The Protective Effect of Selenium Nanoparticles in Osteoarthritis: In vitro and in vivo Studies.
Li Y, Zhu S, Luo J, Tong Y, Zheng Y, Ji L, He Z, Jing Q, Huang J, Zhang Y, Bi Q
Drug design, development and therapy 2023;17:1515-1529
Drug design, development and therapy 2023;17:1515-1529
Acupuncture Relieves Cervical Spondylosis Radiculopathy by Regulating Spinal Microglia Activation Through MAPK Signaling Pathway in Rats.
Shi T, Liu Y, Ji B, Wang J, Ge Y, Fang Y, Xie Y, Xiao H, Wu L, Wang Y
Journal of pain research 2023;16:3945-3960
Journal of pain research 2023;16:3945-3960
Establishment of Risk Model and Analysis of Immunoinfiltration Based on Mitophagy-Related Associated Genes in Atrial Fibrillation.
Sang W, Wang L, Yan X, Sun H, Han Y, Wang F, Tang B, Li Y
Journal of inflammation research 2023;16:2561-2583
Journal of inflammation research 2023;16:2561-2583
Exploration of the mechanism of aloin ameliorates of combined allergic rhinitis and asthma syndrome based on network pharmacology and experimental validation.
Feng Y, Qiao H, Liu H, Wang J, Tang H
Frontiers in pharmacology 2023;14:1218030
Frontiers in pharmacology 2023;14:1218030
Levetiracetam attenuates diabetes-associated cognitive impairment and microglia polarization by suppressing neuroinflammation.
Zhang YY, Wang L, Guo H, Han TT, Chang YH, Cui XC
Frontiers in pharmacology 2023;14:1145819
Frontiers in pharmacology 2023;14:1145819
Fibroblast growth factor 1 ameliorates thin endometrium in rats through activation of the autophagic pathway.
Zhu J, Li Z, Yin F, Yu X, Lu Y, Zhou T, Gong F, Xu Z
Frontiers in pharmacology 2023;14:1143096
Frontiers in pharmacology 2023;14:1143096
Arctiin-encapsulated DSPE-PEG bubble-like nanoparticles inhibit alveolar epithelial type 2 cell senescence to alleviate pulmonary fibrosis via the p38/p53/p21 pathway.
Xiong D, Gao F, Shao J, Pan Y, Wang S, Wei D, Ye S, Chen Y, Chen R, Yue B, Li J, Chen J
Frontiers in pharmacology 2023;14:1141800
Frontiers in pharmacology 2023;14:1141800
The anti-photoaging effect of C-phycocyanin on ultraviolet B-irradiated BALB/c-nu mouse skin.
Zhou Y, Bai R, Huang Y, Li W, Chen J, Cheng Z, Wu X, Diao Y
Frontiers in bioengineering and biotechnology 2023;11:1229387
Frontiers in bioengineering and biotechnology 2023;11:1229387
Apelin-Overexpressing Neural Stem Cells in Conjunction with a Silk Fibroin Nanofiber Scaffold for the Treatment of Traumatic Brain Injury.
Li T, Tang Q, Xu J, Ye X, Chen K, Zhong J, Zhu J, Lu S, Zhu T
Stem cells and development 2023 Sep;32(17-18):539-553
Stem cells and development 2023 Sep;32(17-18):539-553
Exogenous spermidine alleviates diabetic cardiomyopathy via suppressing reactive oxygen species, endoplasmic reticulum stress, and Pannexin-1-mediated ferroptosis.
Sun J, Xu J, Liu Y, Lin Y, Wang F, Han Y, Zhang S, Gao X, Xu C, Yuan H
Biomolecules & biomedicine 2023 Sep 4;23(5):825-837
Biomolecules & biomedicine 2023 Sep 4;23(5):825-837
3,5,6-Trichloro-2-pyridinol confirms ototoxicity in mouse cochlear organotypic cultures and induces cytotoxicity in HEI-OC1 cells.
Huang M, Zou M, Mao S, Xu W, Hong Y, Wang H, Gui F, Yang L, Lian F, Chen R
Toxicology and applied pharmacology 2023 Sep 15;475:116612
Toxicology and applied pharmacology 2023 Sep 15;475:116612
Nephroprotective Effects of Cardamonin on Renal Ischemia Reperfusion Injury/UUO-Induced Renal Fibrosis.
Zhang B, Chen ZY, Jiang Z, Huang S, Liu XH, Wang L
Journal of agricultural and food chemistry 2023 Sep 13;71(36):13284-13303
Journal of agricultural and food chemistry 2023 Sep 13;71(36):13284-13303
DHX9 Strengthens Atherosclerosis Progression By Promoting Inflammation in Macrophages.
Huangfu N, Ma H, Tian M, Zhang J, Wang Y, Li Z, Chen X, Cui H
Inflammation 2023 Oct;46(5):1725-1738
Inflammation 2023 Oct;46(5):1725-1738
Treatment with S-adenosylmethionine ameliorates irinotecan-induced intestinal barrier dysfunction and intestinal microbial disorder in mice.
Xiao L, Dou W, Wang Y, Deng H, Xu H, Pan Y
Biochemical pharmacology 2023 Oct;216:115752
Biochemical pharmacology 2023 Oct;216:115752
Cocktail of three isoquinoline alkaloids derived from Glaucium grandiflorum Boiss. & A. Huet subsp. refractum (Nábelek) Mory inhibits the production of LPS-induced ROS, pro-inflammatory cytokines, and mediators through the down-regulation of p38 MAPK in BV-2 cells.
Nigdelioglu Dolanbay S, Şirin S, Aslim B
Fitoterapia 2023 Oct;170:105652
Fitoterapia 2023 Oct;170:105652
Anti-rheumatoid arthritis effects of total saponins from Rhizoma Panacis Majoris on adjuvant-induced arthritis in rats and rheumatoid arthritis fibroblast-like synoviocytes.
Ren M, Ma K, Pang X, Liu Y, Song Z, Zhou R, Tang Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155021
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155021
A network pharmacology approach to investigate dehydrocostus lactone inhibits the proliferation and epithelial-mesenchymal transition of human gastric cancer cells via regulating the PI3K/Akt and extracellular signal-regulated kinases/mitogen-activated protein kinase signalling pathways.
Wan M, Dai J, Gan A, Wang J, Lin F, Zhang X, Lv X, Wu B, Yan T, Jia Y
The Journal of pharmacy and pharmacology 2023 Oct 5;75(10):1344-1356
The Journal of pharmacy and pharmacology 2023 Oct 5;75(10):1344-1356
Lycium barbarum glycopeptide alleviates neuroinflammation in spinal cord injury via modulating docosahexaenoic acid to inhibiting MAPKs/NF-kB and pyroptosis pathways.
Jiang Z, Zeng Z, He H, Li M, Lan Y, Hui J, Bie P, Chen Y, Liu H, Fan H, Xia H
Journal of translational medicine 2023 Oct 31;21(1):770
Journal of translational medicine 2023 Oct 31;21(1):770
Sirtuin1 Mediates the Protective Effects of Echinacoside against Sepsis-Induced Acute Lung Injury via Regulating the NOX4-Nrf2 Axis.
Xie W, Deng L, Lin M, Huang X, Qian R, Xiong D, Liu W, Tang S
Antioxidants (Basel, Switzerland) 2023 Oct 29;12(11)
Antioxidants (Basel, Switzerland) 2023 Oct 29;12(11)
Macrophages originated IL-33/ST2 inhibits ferroptosis in endometriosis via the ATF3/SLC7A11 axis.
Wu Q, Liang Z, Jiang J, Feng X, Liu J, Zhang Z, Wang H, Wang N, Gou Y, Li Z, Cao Y
Cell death & disease 2023 Oct 11;14(10):668
Cell death & disease 2023 Oct 11;14(10):668
Ulinastatin inhibits the metastasis of nasopharyngeal carcinoma by involving uPA/uPAR signaling.
Li CZ, Qiang YY, Liu ZJ, Zheng LS, Peng LX, Mei Y, Meng DF, Wei WW, Chen DW, Xu L, Lang YH, Xie P, Peng XS, Wang MD, Guo LL, Shu DT, Ding LY, Lin ST, Luo FF, Wang J, Li SS, Huang BJ, Chen JD, Qian CN
Drug development research 2023 Nov;84(7):1468-1481
Drug development research 2023 Nov;84(7):1468-1481
Polydatin inhibited TNF-α-induced apoptosis of skeletal muscle cells through AKT-mediated p38 MAPK and NF-κB pathways.
Liu Y, Xie F, Lu C, Zhou Z, Li S, Zhong J, Li Q, Shao X
General physiology and biophysics 2023 Nov;42(6):521-529
General physiology and biophysics 2023 Nov;42(6):521-529
Linderalactone mitigates diabetic cardiomyopathy in mice via suppressing the MAPK/ATF6 pathway.
Han X, Zhou W, Zhang J, Tu Y, Wei J, Zheng R, Zhu J, Xu D, Ying H, Wu G, Shi Q, Liang G
International immunopharmacology 2023 Nov;124(Pt B):110984
International immunopharmacology 2023 Nov;124(Pt B):110984
Tanshinone I attenuates gastric precancerous lesions by inhibiting epithelial mesenchymal transition through the p38/STAT3 pathway.
Liang D, Tang S, Liu L, Zhao M, Ma X, Zhao Y, Shen C, Liu Q, Tang J, Zeng J, Chen N
International immunopharmacology 2023 Nov;124(Pt A):110902
International immunopharmacology 2023 Nov;124(Pt A):110902
Deficiency of S100A8/A9 attenuates pulmonary microvascular leakage in septic mice.
Yu J, Zhao B, Pi Q, Zhou G, Cheng Z, Qu C, Wang X, Kong L, Luo S, Du D, Guo Y
Respiratory research 2023 Nov 17;24(1):288
Respiratory research 2023 Nov 17;24(1):288
Extracts of Oldenlandia diffusa protects chondrocytes via inhibiting apoptosis and associated inflammatory response in osteoarthritis.
Lou C, Lin C, Wang W, Jiang H, Cai T, Lin S, Xue X, Lin J, Pan X
Journal of ethnopharmacology 2023 Nov 15;316:116744
Journal of ethnopharmacology 2023 Nov 15;316:116744
Prognosis-related VDAC1 regulates the proliferation and apoptosis of osteosarcoma cells via the MAPK signaling pathway.
Cai X, Zhu S
Genomics 2023 May;115(3):110595
Genomics 2023 May;115(3):110595
Boris knockout eliminates AOM/DSS-induced in situ colorectal cancer by suppressing DNA damage repair and inflammation.
Zuo BW, Yao WX, Fang MD, Ren J, Tu LL, Fan RJ, Zhang YM
Cancer science 2023 May;114(5):1972-1985
Cancer science 2023 May;114(5):1972-1985
Multi-omics analysis of a drug-induced model of bipolar disorder in zebrafish.
Li Y, Zhang L, Mao M, He L, Wang T, Pan Y, Zhao X, Li Z, Mu X, Qian Y, Qiu J
iScience 2023 May 19;26(5):106744
iScience 2023 May 19;26(5):106744
Methionine sulfoxide suppresses adipogenic differentiation by regulating the mitogen-activated protein kinase signaling pathway.
Qin D, Lei Y, Xie W, Zheng Q, Peng Z, Liu Y, Dai B, Ma T, Wei P, Gao C, Guo X, Gao J, Zhao J, Du J, Zeng Q, Zhang Z, Dong X, Shen H
Cell biology international 2023 Mar;47(3):648-659
Cell biology international 2023 Mar;47(3):648-659
Pharmacological network analysis of the functions and mechanism of kaempferol from Du Zhong in intervertebral disc degeneration (IDD).
Wang X, Tan Y, Liu F, Wang J, Liu F, Zhang Q, Li J
Journal of orthopaedic translation 2023 Mar;39:135-146
Journal of orthopaedic translation 2023 Mar;39:135-146
11β-Hydroxysteroid dehydrogenase type 1 amplifies inflammation in LPS-induced THP-1 cells.
Luo L, Zhu D, Zhang Z, Zeng H, Huang M, Zhou S
Iranian journal of basic medical sciences 2023 Mar;26(3):374-379
Iranian journal of basic medical sciences 2023 Mar;26(3):374-379
Antiangiogenic potential of Lepista nuda extract suppressing MAPK/p38 signaling-mediated developmental angiogenesis in zebrafish and HUVECs.
Deshmukh D, Hsu YF, Chiu CC, Jadhao M, Hsu SCN, Hu SY, Yang SH, Liu W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Mar;159:114219
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Mar;159:114219
The antimicrobial peptide LK2(6)A(L) exhibits anti-inflammatory activity by binding to the myeloid differentiation 2 domain and protects against LPS-induced acute lung injury in mice.
Zhang J, Sun Y, Sun C, Shang D
Bioorganic chemistry 2023 Mar;132:106376
Bioorganic chemistry 2023 Mar;132:106376
ROS-activated MAPK/ERK pathway regulates crosstalk between Nrf2 and Hif-1α to promote IL-17D expression protecting the intestinal epithelial barrier under hyperoxia.
Wang P, Li T, Niu C, Sun S, Liu D
International immunopharmacology 2023 Mar;116:109763
International immunopharmacology 2023 Mar;116:109763
Calcitonin gene-related peptide ameliorates sepsis-induced intestinal injury by suppressing NLRP3 inflammasome activation.
Ning W, Gao G, Zhou Y, Li WQ, Yang HH, Duan XB, Li X, Gong YB, Li D, Guo R
International immunopharmacology 2023 Mar;116:109747
International immunopharmacology 2023 Mar;116:109747
Naringenin Attenuates Isoprenaline-Induced Cardiac Hypertrophy by Suppressing Oxidative Stress through the AMPK/NOX2/MAPK Signaling Pathway.
Li Y, He B, Zhang C, He Y, Xia T, Zeng C
Nutrients 2023 Mar 9;15(6)
Nutrients 2023 Mar 9;15(6)
Erxian decoction alleviates cisplatin-induced premature ovarian failure in rats by reducing oxidation levels in ovarian granulosa cells.
Liu J, Yang Y, He Y, Feng C, Ou H, Yang J, Chen Y, You F, Shao B, Bao J, Guan X, Chen F, Zhao P
Journal of ethnopharmacology 2023 Mar 25;304:116046
Journal of ethnopharmacology 2023 Mar 25;304:116046
Inhibition of fatty acid synthase protects obese mice from acute lung injury via ameliorating lung endothelial dysfunction.
Wu Z, Zhu L, Nie X, Liu Y, Zhang X, Qi Y
Respiratory research 2023 Mar 15;24(1):81
Respiratory research 2023 Mar 15;24(1):81
Corilagin ameliorates macrophages inflammation in atherosclerosis through TLR4-NFκB/MAPK pathway.
Meng D, Deng X, Wu Y, Wu J, Zhang Y, Zhang J, Zhao Y, Che Y
Heliyon 2023 Jun;9(6):e16960
Heliyon 2023 Jun;9(6):e16960
RNA aptamers with specific binding affinity to CD40 (CD40Apt) represents a promising antagonist of the CD40-CD40L signaling for thyroid-associated ophthalmopathy (TAO) treatment in mouse.
Chen Y, Tang R, Xiong W, Zhang F, Wang N, Xie B, Cao J, Chen Z, Ma C
Journal of translational medicine 2023 Jun 18;21(1):396
Journal of translational medicine 2023 Jun 18;21(1):396
Arsenic interferes with spermatogenesis involving Rictor/mTORC2-mediated blood-testis barrier disruption in mice.
Li X, Wang W, Hou Y, Li G, Yi H, Cui S, Zhang J, He X, Zhao H, Yang Z, Qiu Y, Liu Z, Xie J
Ecotoxicology and environmental safety 2023 Jun 1;257:114914
Ecotoxicology and environmental safety 2023 Jun 1;257:114914
Deficiency of S100 calcium binding protein A9 attenuates vascular dysfunction in aged mice.
Zhao B, Yu J, Luo Y, Xie M, Qu C, Shi Q, Wang X, Zhao X, Kong L, Zhao Y, Guo Y
Redox biology 2023 Jul;63:102721
Redox biology 2023 Jul;63:102721
The role of calcium-sensing receptor in ginsenoside Rg1 promoting reendothelialization to inhibit intimal hyperplasia after balloon injury.
Xu S, Hu A, Chen J, Shuai Z, Liu T, Deng J, Li L, Gong Q, He Z, Yu L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jul;163:114843
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jul;163:114843
Suramin ameliorates osteoarthritis by acting on the Nrf2/HO-1 and NF-κB signaling pathways in chondrocytes and promoting M2 polarization in macrophages.
Shen PC, Huang SH, Liu ZM, Lu CC, Chou SH, Tien YC
International immunopharmacology 2023 Jul;120:110295
International immunopharmacology 2023 Jul;120:110295
Cangfu Daotan Wan alleviates polycystic ovary syndrome with phlegm-dampness syndrome via disruption of the PKP3/ERCC1/MAPK axis.
Li Y, Wu H, Guo Y, Wei C, Guan L, Ju W, Lian F
Journal of ovarian research 2023 Jul 7;16(1):134
Journal of ovarian research 2023 Jul 7;16(1):134
Embryonic Exposure to UV-328 Impairs the Cell Cycle in Zebrafish (Danio rerio) by Inhibiting the p38 MAPK/p53/Gadd45a Signaling Pathway.
Zhang L, Shen L, Huang Y, Cui S, Zhao Q, Zhang C, Zhuang S, Jiang G
Environmental science & technology 2023 Jul 11;57(27):9965-9974
Environmental science & technology 2023 Jul 11;57(27):9965-9974
MicroRNA profiling reveals the role of miR-133b-3p in promoting apoptosis and inhibiting cell proliferation and testosterone synthesis in mouse TM3 cells.
Pan C, Fei Q, Jin J, Zheng J, Wu D, Li H, Huang X, Kong X
In vitro cellular & developmental biology. Animal 2023 Jan;59(1):63-75
In vitro cellular & developmental biology. Animal 2023 Jan;59(1):63-75
Blocking circadian clock factor Rev-erbα inhibits growth plate chondrogenesis via up-regulating MAPK-ERK1/2 pathway.
Qian Z, Liu Z, Feng Z, Cai Z, Qiu Y, Zhu Z
Cell cycle (Georgetown, Tex.) 2023 Jan;22(1):73-84
Cell cycle (Georgetown, Tex.) 2023 Jan;22(1):73-84
Metastatic effects of environmental carcinogens mediated by MAPK and UPR pathways with an in vivo Drosophila Model.
Fangninou FF, Yu Z, Li Z, Guadie A, Li W, Xue L, Yin D
Journal of hazardous materials 2023 Jan 5;441:129826
Journal of hazardous materials 2023 Jan 5;441:129826
Angiotensin-(1-7) ameliorates sepsis-induced cardiomyopathy by alleviating inflammatory response and mitochondrial damage through the NF-κB and MAPK pathways.
Chen XS, Cui JR, Meng XL, Wang SH, Wei W, Gao YL, Shou ST, Liu YC, Chai YF
Journal of translational medicine 2023 Jan 2;21(1):2
Journal of translational medicine 2023 Jan 2;21(1):2
Enhanced De Novo Lipid Synthesis Mediated by FASN Induces Chemoresistance in Colorectal Cancer.
Han L, Dai W, Luo W, Ye L, Fang H, Mo S, Li Q, Xu Y, Wang R, Cai G
Cancers 2023 Jan 17;15(3)
Cancers 2023 Jan 17;15(3)
Recombinant human angiotensin-converting enzyme 2 plays a protective role in mice with sepsis-induced cardiac dysfunction through multiple signaling pathways dependent on converting angiotensin II to angiotensin 1-7.
Wu C, Chen Y, Zhou P, Hu Z
Annals of translational medicine 2023 Jan 15;11(1):13
Annals of translational medicine 2023 Jan 15;11(1):13
Pharmacological vitamin C inhibits mTOR signaling and tumor growth by degrading Rictor and inducing HMOX1 expression.
Qin S, Wang G, Chen L, Geng H, Zheng Y, Xia C, Wu S, Yao J, Deng L
PLoS genetics 2023 Feb;19(2):e1010629
PLoS genetics 2023 Feb;19(2):e1010629
Oxymatrine attenuated isoproterenol-induced heart failure via the TLR4/NF-κB and MAPK pathways in vivo and in vitro.
Sun H, Bai J, Sun Y, Zhen D, Fu D, Wang Y, Wei C
European journal of pharmacology 2023 Feb 15;941:175500
European journal of pharmacology 2023 Feb 15;941:175500
Luteoloside Induces G0/G1 Phase Arrest of Neuroblastoma Cells by Targeting p38 MAPK.
He Y, Luo M, Lei S, Zeng Z, Chen T, Wu Y, Wang D, Wang L, Wang L
Molecules (Basel, Switzerland) 2023 Feb 12;28(4)
Molecules (Basel, Switzerland) 2023 Feb 12;28(4)
Deciphering the underlying wound healing mechanisms of Streptocaulon juventas (Lour.) Merr. by integrating network pharmacology, transcriptomics, and experimental validation.
Li Y, Zang J, Wang X, Feng X, Qiu F
Journal of ethnopharmacology 2023 Feb 10;302(Pt A):115890
Journal of ethnopharmacology 2023 Feb 10;302(Pt A):115890
Metformin exhibits antineoplastic effects on Pten-deficient endometrial cancer by interfering with TGF-β and p38/ERK MAPK signalling.
Ruiz-Mitjana A, Vidal-Sabanés M, Navaridas R, Perramon-Güell A, Yeramian A, Nicholson-Sabaté N, Egea J, Encinas M, Matias-Guiu X, Dolcet X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115817
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115817
Antinociceptive and neuroprotective effect of echinacoside on peripheral neuropathic pain in mice through inhibiting P2X7R/FKN/CX3CR1 pathway.
Liu N, Zhang GX, Zhu CH, Lan XB, Tian MM, Zheng P, Peng XD, Li YX, Yu JQ
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115675
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115675
Liensinine improves AngII-induced vascular remodeling via MAPK/TGF-β1/Smad2/3 signaling.
Jia P, Chen D, Zhu Y, Wang M, Zeng J, Zhang L, Cai Q, Lian D, Zhao C, Xu Y, Chu J, Lin S, Peng J, Lin W
Journal of ethnopharmacology 2023 Dec 5;317:116768
Journal of ethnopharmacology 2023 Dec 5;317:116768
Studies of the Immunomodulatory Activity of Polysaccharides from the Stem of Cynomorium songaricum Based on Intestinal Microbial Analysis.
Lv T, Chen J, He Z, Chen W, Zong Y, Du R
Molecules (Basel, Switzerland) 2023 Dec 26;29(1)
Molecules (Basel, Switzerland) 2023 Dec 26;29(1)
Mitochondrion-targeted carboxymethyl chitosan hybrid nanoparticles loaded with Coenzyme Q10 protect cardiac grafts against cold ischaemia‒reperfusion injury in heart transplantation.
Yuan S, Che Y, Wang Z, Xing K, Xie X, Chen Y
Journal of translational medicine 2023 Dec 20;21(1):925
Journal of translational medicine 2023 Dec 20;21(1):925
Cell and rat serum, urine and tissue metabolomics analysis elucidates the key pathway changes associated with chronic nephropathy and reveals the mechanism of action of rhein.
Wang L, Yu X, Li H, He D, Zeng S, Xiang Z
Chinese medicine 2023 Dec 1;18(1):158
Chinese medicine 2023 Dec 1;18(1):158
Thymosin β4 Exerts a Cytoprotective Function and Attenuates Liver Injury in Murine Hepatic Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation.
Wang X, Zhou Y, Sun Q, Zhang Q, Zhou H, Zhang J, Du Y, Wang Y, Yuan K, Xu L, Zhang M, Yan D, Zeng L, Xu K, Sang W
Transplantation and cellular therapy 2023 Aug;29(8):492.e1-492.e10
Transplantation and cellular therapy 2023 Aug;29(8):492.e1-492.e10
The role of ROS/p38 MAPK/NLRP3 inflammasome cascade in arsenic-induced depression-/anxiety-like behaviors of mice.
Liu X, Zhang R, Fan J, Chen Y, Wang H, Ge Y, Liang H, Li W, Liu H, Lv Z, Dou W, Jiang H, Li X
Ecotoxicology and environmental safety 2023 Aug;261:115111
Ecotoxicology and environmental safety 2023 Aug;261:115111
CHMP4A stimulates CD8+ T-lymphocyte infiltration and inhibits breast tumor growth via the LSD1/IFNβ axis.
Song S, Zhang D, Chen J, Qi L, Zhang M, Yang X, Ye T, Ye Q, Lin J
Cancer science 2023 Aug;114(8):3162-3175
Cancer science 2023 Aug;114(8):3162-3175
Oxidative Stress-mediated Sprouty-related Protein with an EVH1 Domain 1 Down-regulation Contributes to Resisting Oxidative Injury in Microglia.
Wei L, Li X, Wei Q, Chen L, Xu L, Zhou P
Neuroscience 2023 Aug 21;526:13-20
Neuroscience 2023 Aug 21;526:13-20
WITHDRAWN: Expression of Tmem41b and MMP13 associated with poor outcome in osteosarcomas.
Li GH, Liu X, Feng LJ, Zhang L
Neoplasma 2023 Aug 20;
Neoplasma 2023 Aug 20;
Neuroprotection of β-caryophyllene against cerebral ischemia/reperfusion injury by inhibiting P38 MAPK/NLRP3 signaling pathway.
Zhao H, Deng L, Chen S, Wang X, Dong Z
Neuroreport 2023 Aug 2;34(12):617-623
Neuroreport 2023 Aug 2;34(12):617-623
Mucin2 regulated by Ho1/p38/IL-10 axis plays a protective role in polystyrene nanoplastics-mediated intestinal toxicity.
Cui M, He Q, Wang Z, Yu Y, Gao H, Liu Z, Peng H, Wang H, Zhang X, Li D, Chen L, Xing X, Xiao Y, Chen W, Wang Q
Environmental pollution (Barking, Essex : 1987) 2023 Aug 1;330:121808
Environmental pollution (Barking, Essex : 1987) 2023 Aug 1;330:121808
SARS-CoV-2 E protein-induced THP-1 pyroptosis is reversed by Ruscogenin.
Huang H, Li X, Zha D, Lin H, Yang L, Wang Y, Xu L, Wang L, Lei T, Zhou Z, Xiao YF, Xin HB, Fu M, Qian Y
Biochemistry and cell biology = Biochimie et biologie cellulaire 2023 Aug 1;101(4):303-312
Biochemistry and cell biology = Biochimie et biologie cellulaire 2023 Aug 1;101(4):303-312
Perilla frutescens L. alleviates trimethylamine N-oxide-induced apoptosis in the renal tubule by regulating ASK1-JNK phosphorylation.
Yong C, Huang G, Ge H, Zhu Y, Yang Y, Yu Y, Tian F, Gao K, Zhou E
Phytotherapy research : PTR 2023 Apr;37(4):1274-1292
Phytotherapy research : PTR 2023 Apr;37(4):1274-1292
Parecoxib attenuates inflammation injury in septic H9c2 cells by regulating the MAPK signaling pathway.
Qian X, Xiong S, Chen Q, Zhang J, Xie J
Experimental and therapeutic medicine 2023 Apr;25(4):150
Experimental and therapeutic medicine 2023 Apr;25(4):150
Inhibition effect of 1-acetoxy-6α-(2-methylbutyryl)eriolanolide toward soluble epoxide hydrolase: Multispectral analysis, molecular dynamics simulation, biochemical, and in vitro cell-based studies.
Zhang J, Yang FY, Zhu QM, Zhang WH, Zhang M, Yi J, Wang Y, Zhang HL, Liang GB, Yan JK, Sun CP
International journal of biological macromolecules 2023 Apr 30;235:123911
International journal of biological macromolecules 2023 Apr 30;235:123911
AKR1B1 Represses Glioma Cell Proliferation through p38 MAPK-Mediated Bcl-2/BAX/Caspase-3 Apoptotic Signaling Pathways.
Huang YK, Chang KC, Li CY, Lieu AS, Lin CL
Current issues in molecular biology 2023 Apr 13;45(4):3391-3405
Current issues in molecular biology 2023 Apr 13;45(4):3391-3405
Docosahexaenoic Acid Attenuates Radiation-Induced Myocardial Fibrosis by Inhibiting the p38/ET-1 Pathway in Cardiomyocytes.
Liu Y, Chen P, Liu T, Cheng B, Sun C, Xin H, Wen Z, Cheng Y
International journal of radiation oncology, biology, physics 2023 Apr 1;115(5):1229-1243
International journal of radiation oncology, biology, physics 2023 Apr 1;115(5):1229-1243
CMTM6 as a candidate risk gene for cervical cancer: Comprehensive bioinformatics study.
Huang X, Liu W, Liu C, Hu J, Wang B, Ren A, Huang X, Yuan Y, Liu J, Li M
Frontiers in molecular biosciences 2022;9:983410
Frontiers in molecular biosciences 2022;9:983410
Suppression of SMOC2 alleviates myocardial fibrosis via the ILK/p38 pathway.
Rui H, Zhao F, Yuhua L, Hong J
Frontiers in cardiovascular medicine 2022;9:951704
Frontiers in cardiovascular medicine 2022;9:951704
Mechanism of HSP90 Inhibitor in the Treatment of DSS-induced Colitis in Mice by Inhibiting MAPK Pathway and Synergistic Effect of Compound Sophorae Decoction.
Yuan Y, Wu H, Shuai B, Liu C, Zhu F, Gao F, Wei C, Fan H
Current pharmaceutical design 2022;28(42):3456-3468
Current pharmaceutical design 2022;28(42):3456-3468
Protective Effects of Herba Houttuyniae Aqueous Extract against OVA-Induced Airway Hyperresponsiveness and Inflammation in Asthmatic Mice.
Yang Y, Lai Q, Wang C, Zhou G
Evidence-based complementary and alternative medicine : eCAM 2022;2022:7609785
Evidence-based complementary and alternative medicine : eCAM 2022;2022:7609785
Cholecystokinin Octapeptide Promotes ANP Secretion through Activation of NOX4-PGC-1α-PPARα/PPARγ Signaling in Isolated Beating Rat Atria.
Han ZN, Lin XX, Wang YY, Ding R, Hong L, Cui X
Oxidative medicine and cellular longevity 2022;2022:5905374
Oxidative medicine and cellular longevity 2022;2022:5905374
Study on the Potential Mechanism of Semen Strychni against Myasthenia Gravis Based on Network Pharmacology and Molecular Docking with Experimental Verification.
Fang P, Yu C, Liu J, Deng G, Zhang M
Evidence-based complementary and alternative medicine : eCAM 2022;2022:3056802
Evidence-based complementary and alternative medicine : eCAM 2022;2022:3056802
Tanshinone IIA Accomplished Protection against Radiation-Induced Cardiomyocyte Injury by Regulating the p38/p53 Pathway.
Wang G, Ma L, Wang B, Gao F, Li J, Cai H, Wang J, Zhang T, Guo H, Xie P, Li Y
Mediators of inflammation 2022;2022:1478181
Mediators of inflammation 2022;2022:1478181
PCNP is a novel regulator of proliferation, migration, and invasion in human thyroid cancer.
Chen YG, Liu HX, Hong Y, Dong PZ, Liu SY, Gao YR, Lu D, Li T, Wang DY, Wu DD, Ji XY
International journal of biological sciences 2022;18(9):3605-3620
International journal of biological sciences 2022;18(9):3605-3620
Gamma synuclein promotes cancer metastasis through the MKK3/6-p38MAPK cascade.
Liu J, Shao T, Zhang J, Liu Q, Hua H, Zhang H, Wang J, Luo T, Shi YE, Jiang Y
International journal of biological sciences 2022;18(8):3167-3177
International journal of biological sciences 2022;18(8):3167-3177
The Immune-Enhancing Properties of Hwanglyeonhaedok-Tang-Mediated Biosynthesized Gold Nanoparticles in Macrophages and Splenocytes.
Mi XJ, Xu XY, Choi HS, Kim H, Cho IH, Yi TH, Kim YJ
International journal of nanomedicine 2022;17:477-494
International journal of nanomedicine 2022;17:477-494
Effects of Uremic Clearance Granules on p38 MAPK/NF-κB Signaling Pathway, Microbial and Metabolic Profiles in End-Stage Renal Disease Rats Receiving Peritoneal Dialysis.
Li X, Zheng J, Wang J, Tang X, Zhang F, Liu S, Liao Y, Chen X, Xie W, Tang Y
Drug design, development and therapy 2022;16:2529-2544
Drug design, development and therapy 2022;16:2529-2544
Therapeutic effects of shaogan fuzi decoction in rheumatoid arthritis: Network pharmacology and experimental validation.
Shi L, Zhao Y, Feng C, Miao F, Dong L, Wang T, Stalin A, Zhang J, Tu J, Liu K, Sun W, Wu J
Frontiers in pharmacology 2022;13:967164
Frontiers in pharmacology 2022;13:967164
Theaflavin-3,3'-Digallate from Black Tea Inhibits Neointima Formation Through Suppression of the PDGFRβ Pathway in Vascular Smooth Muscle Cells.
Wu Y, Chen M, Chen Z, Shu J, Zhang L, Hu J, Yu H, Huang K, Liang M
Frontiers in pharmacology 2022;13:861319
Frontiers in pharmacology 2022;13:861319
Mapk14 is a Prognostic Biomarker and Correlates with the Clinicopathological Features and Immune Infiltration of Colorectal Cancer.
Wang D, Peng L, Hua L, Li J, Liu Y, Zhou Y
Frontiers in cell and developmental biology 2022;10:817800
Frontiers in cell and developmental biology 2022;10:817800
Kukoamine A inhibits C-C motif chemokine receptor 5 to attenuate lipopolysaccharide-induced lung injury.
Liu X, Wang M, Song Y, Zhang C, Jiang Y, Li W, Xu B, Jiang Z
Drug development research 2022 Sep;83(6):1455-1466
Drug development research 2022 Sep;83(6):1455-1466
The caspase-1 inhibitor VX765 upregulates connexin 43 expression and improves cell-cell communication after myocardial infarction via suppressing the IL-1β/p38 MAPK pathway.
Su XL, Wang SH, Komal S, Cui LG, Ni RC, Zhang LR, Han SN
Acta pharmacologica Sinica 2022 Sep;43(9):2289-2301
Acta pharmacologica Sinica 2022 Sep;43(9):2289-2301
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.
Dai W, Xiang W, Han L, Yuan Z, Wang R, Ma Y, Yang Y, Cai S, Xu Y, Mo S, Li Q, Cai G
Cancer communications (London, England) 2022 Sep;42(9):848-867
Cancer communications (London, England) 2022 Sep;42(9):848-867
HIV-1 Tat Protein-Mediated Inflammatory Response Inhibits the Erythroid Hematopoietic Support Function of Bone Marrow Mesenchymal Stem Cells.
Wang X, Chen M, Ma S, Ding Y, Zhou C, Yuan Y
AIDS research and human retroviruses 2022 Sep;38(9):753-763
AIDS research and human retroviruses 2022 Sep;38(9):753-763
Analgesic effect of nobiletin against neuropathic pain induced by the chronic constriction injury of the sciatic nerve in mice.
Zhu C, Tian M, Liu N, Ma L, Lan X, Yang J, Du J, Ma H, Li Y, Zheng P, Yu J, Peng X
Phytotherapy research : PTR 2022 Sep;36(9):3644-3661
Phytotherapy research : PTR 2022 Sep;36(9):3644-3661
Hylocereus undatus flower extract suppresses OVA-induced allergic asthma in BALb/c mice by reducing airway inflammation and modulating gut microbiota.
Liao W, Liu W, Yan Y, Li L, Tong J, Huang Y, Guo S, Jiang W, Fu S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113476
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113476
Neobavaisoflavone inhibits allergic inflammatory responses by suppressing mast cell activation.
Liang R, Yuan Y, Bai Y, Liu X, Chen J, Jiang D, Meng D, Chen G, Li B, Zhou L, Guo W
International immunopharmacology 2022 Sep;110:108953
International immunopharmacology 2022 Sep;110:108953
Effects of growth hormone/estrogen/androgen on COVID-19-type proinflammatory responses in normal human lung epithelial BEAS-2B cells.
Zhu Z, Zhao Z, Chen X, Chu Z, He Y, Tan Y, Zhou J, Tang C
BMC molecular and cell biology 2022 Sep 29;23(1):42
BMC molecular and cell biology 2022 Sep 29;23(1):42
Oleuropein ameliorated lung ischemia-reperfusion injury by inhibiting TLR4 signaling cascade in alveolar macrophages.
Xu Z, Sun X, Ding B, Zi M, Ma Y
Transplant immunology 2022 Oct;74:101664
Transplant immunology 2022 Oct;74:101664
Electroacupuncture attenuates chronic salpingitis transforming growth factor-β1/p38 mitogen-activated protein kinase signaling pathway.
Xijiao HU, Yinglong C, Huanan K, Shuoxi LI, Yawen W, Jinzhe L, Yiming S, Li L
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2022 Oct;42(5):781-787
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2022 Oct;42(5):781-787
Effect of propiconazole on neutrophil extracellular traps formation: Assessing the role of autophagy.
Ma Y, Li S, Ye S, Hu D, Luo S, Wei L, Xiao F
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Oct;168:113354
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Oct;168:113354
LncRNA LINC00281/Annexin A2 Regulates Vascular Smooth Muscle Cell Phenotype Switching via the Nuclear Factor-Kappa B Signaling Pathway.
Cheng L, Wang H, Maboh R, Mao G, Wu X, Chen H
Journal of cardiovascular translational research 2022 Oct;15(5):971-984
Journal of cardiovascular translational research 2022 Oct;15(5):971-984
Triclocarban evoked neutrophil extracellular trap formation in common carp (Cyprinus carpio L.) by modulating SIRT3-mediated ROS crosstalk with ERK1/2/p38 signaling.
Li S, Wang Y, Yu D, Zhang Y, Wang X, Shi M, Xiao Y, Li X, Xiao H, Chen L, Xiong X
Fish & shellfish immunology 2022 Oct;129:85-95
Fish & shellfish immunology 2022 Oct;129:85-95
Synthesis and anti-inflammatory activity of paeonol derivatives with etherized aryl urea by regulating TLR4/MyD88 signaling pathway in RAW264.7 cell.
Gong X, He Y, Yang D, Yang S, Li J, Zhao H, Chen Q, Ren Q, Zhang B
Bioorganic chemistry 2022 Oct;127:105939
Bioorganic chemistry 2022 Oct;127:105939
7-Methoxyisoflavone suppresses vascular endothelial inflammation by inhibiting the expression of endothelial adhesion molecules.
Zhu X, Peng J, Yang L, Guo Y, Wang P, Liu K, Zhu J, Deng S, Liang M
European journal of pharmacology 2022 Oct 15;933:175268
European journal of pharmacology 2022 Oct 15;933:175268
RNA m6A reader IGF2BP3 promotes metastasis of triple-negative breast cancer via SLIT2 repression.
Jiang T, He X, Zhao Z, Zhang X, Wang T, Jia L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22618
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22618
Losartan attenuates sepsis-induced cardiomyopathy by regulating macrophage polarization via TLR4-mediated NF-κB and MAPK signaling.
Chen XS, Wang SH, Liu CY, Gao YL, Meng XL, Wei W, Shou ST, Liu YC, Chai YF
Pharmacological research 2022 Nov;185:106473
Pharmacological research 2022 Nov;185:106473
SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation.
Yan L, Zhang T, Wang K, Chen Z, Yang Y, Shan B, Sun Q, Zhang M, Zhang Y, Zhong Y, Liu N, Gu J, Xu D
Nature communications 2022 Nov 22;13(1):7153
Nature communications 2022 Nov 22;13(1):7153
CircRNA DDX21 acts as a prognostic factor and sponge of miR-1264/QKI axis to weaken the progression of triple-negative breast cancer.
Huang R, Yang Z, Liu Q, Liu B, Ding X, Wang Z
Clinical and translational medicine 2022 May;12(5):e768
Clinical and translational medicine 2022 May;12(5):e768
Forkhead Box q1 promotes invasion and metastasis in colorectal cancer by activating the epidermal growth factor receptor pathway.
Zhang JJ, Cao CX, Wan LL, Zhang W, Liu ZJ, Wang JL, Guo Q, Tang H
World journal of gastroenterology 2022 May 7;28(17):1781-1797
World journal of gastroenterology 2022 May 7;28(17):1781-1797
Estrogen-related Receptor α (ERRα) Functions in The Hypoxic Injury of Microglial Cells.
Deng CY, Zhu TT, Lian S, Wang JF, Wu R, Zheng JS
Journal of veterinary research 2022 Mar;66(1):131-140
Journal of veterinary research 2022 Mar;66(1):131-140
Effects of runt-related transcription factor 2 (RUNX2) on the autophagy of rapamycin-treated osteoblasts.
Ren C, Xu Y, Liu H, Wang Z, Ma T, Li Z, Sun L, Huang Q, Zhang K, Zhang C, Cui Y, Wang Q, Lu Y
Bioengineered 2022 Mar;13(3):5262-5276
Bioengineered 2022 Mar;13(3):5262-5276
Daidzein suppresses TGF-β1-induced cardiac fibroblast activation via the TGF-β1/SMAD2/3 signaling pathway.
Shu J, Hu L, Wu Y, Chen L, Huang K, Wang Z, Liang M
European journal of pharmacology 2022 Mar 15;919:174805
European journal of pharmacology 2022 Mar 15;919:174805
Sclareol ameliorates hyperglycemia-induced renal injury through inhibiting the MAPK/NF-κB signaling pathway.
Han X, Zhang J, Zhou L, Wei J, Tu Y, Shi Q, Zhang Y, Ren J, Wang Y, Ying H, Liang G
Phytotherapy research : PTR 2022 Jun;36(6):2511-2523
Phytotherapy research : PTR 2022 Jun;36(6):2511-2523
CPSF1 mediates retinal vascular dysfunction in diabetes mellitus via the MAPK/ERK pathway.
Zhang J, Zhang X, Zou Y, Han F
Archives of physiology and biochemistry 2022 Jun;128(3):708-715
Archives of physiology and biochemistry 2022 Jun;128(3):708-715
6-Gingerol exerts a protective effect against hypoxic injury through the p38/Nrf2/HO-1 and p38/NF-κB pathway in H9c2 cells.
Han X, Liu P, Zheng B, Zhang M, Zhang Y, Xue Y, Liu C, Chu X, Wang X, Sun S, Chu L
The Journal of nutritional biochemistry 2022 Jun;104:108975
The Journal of nutritional biochemistry 2022 Jun;104:108975
Synthesis and structure-activity relationship study of a potent MHO7 analogue as potential anti-triple negative breast cancer agent.
Liang JJ, Yu WL, Yang L, Qin KM, Yin YP, Li D, Ni YH, Yan JJ, Zhong YX, Deng ZX, Hong K
European journal of medicinal chemistry 2022 Jun 5;236:114313
European journal of medicinal chemistry 2022 Jun 5;236:114313
A long-term anti-inflammation markedly alleviated high-fat diet-induced obesity by repeated administrations of overexpressing IL10 human umbilical cord-derived mesenchymal stromal cells.
Wang L, Gao T, Li Y, Xie Y, Zeng S, Tai C, Feng Y, Shen P, Wang B
Stem cell research & therapy 2022 Jun 17;13(1):259
Stem cell research & therapy 2022 Jun 17;13(1):259
Neurotoxicity and gene expression alterations in zebrafish larvae in response to manganese exposure.
Xu Y, Peng T, Xiang Y, Liao G, Zou F, Meng X
The Science of the total environment 2022 Jun 15;825:153778
The Science of the total environment 2022 Jun 15;825:153778
KGF-2 Regulates STAP-2-Mediated Signal Transducer and Activator of Transcription 3 Signaling and Reduces Skin Scar Formation.
Zhou Q, Gong J, Bi J, Yang X, Zhang L, Lu C, Li L, Chen M, Cai J, Yang R, Li X, Li Z, Wang X
The Journal of investigative dermatology 2022 Jul;142(7):2003-2013.e5
The Journal of investigative dermatology 2022 Jul;142(7):2003-2013.e5
GCN5 participates in KLF4-VEGFA feedback to promote endometrial angiogenesis.
Cao C, Zhou Y, Zhang Y, Ma Y, Du S, Fan L, Niu R, Zhang Y, He M
iScience 2022 Jul 15;25(7):104509
iScience 2022 Jul 15;25(7):104509
Study on the new anti-atherosclerosis activity of different Herba patriniae through down-regulating lysophosphatidylcholine of the glycerophospholipid metabolism pathway.
Su D, Liao L, Zeng Q, Liao Z, Liu Y, Jin C, Zhu G, Chen C, Yang M, Ai Z, Song Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;94:153833
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;94:153833
Fine particulate matter induces endoplasmic reticulum stress-mediated apoptosis in human SH-SY5Y cells.
Zhang M, Wang Y, Wong RMS, Yung KKL, Li R
Neurotoxicology 2022 Jan;88:187-195
Neurotoxicology 2022 Jan;88:187-195
Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.
Li Z, Xu Q, Huangfu N, Chen X, Zhu J
Journal of clinical laboratory analysis 2022 Jan;36(1):e24019
Journal of clinical laboratory analysis 2022 Jan;36(1):e24019
Acacetin attenuates Streptococcus suis virulence by simultaneously targeting suilysin and inflammation.
Xie S, Zhang Y, Xu L, Li S, Shen X, Li L, Deng X, Zhou Y
Microbial pathogenesis 2022 Jan;162:105354
Microbial pathogenesis 2022 Jan;162:105354
TSH-TSHR axis promotes tumor immune evasion.
Wu Z, Xi Z, Xiao Y, Zhao X, Li J, Feng N, Hu L, Zheng R, Zhang N, Wang S, Huang T
Journal for immunotherapy of cancer 2022 Jan;10(1)
Journal for immunotherapy of cancer 2022 Jan;10(1)
Salidroside alleviates oxidative stress and apoptosis via AMPK/Nrf2 pathway in DHT-induced human granulosa cell line KGN.
Ji R, Jia FY, Chen X, Wang ZH, Jin WY, Yang J
Archives of biochemistry and biophysics 2022 Jan 15;715:109094
Archives of biochemistry and biophysics 2022 Jan 15;715:109094
Xiaoyao powder improves endometrial receptivity via VEGFR-2-mediated angiogenesis through the activation of the JNK and P38 signaling pathways.
He M, Li L, Wei X, Geng D, Jiang H, Xiangxiang G, Zhang Y, Du H
Journal of ethnopharmacology 2022 Jan 10;282:114580
Journal of ethnopharmacology 2022 Jan 10;282:114580
Immune-enhancing effects of postbiotic produced by Bacillus velezensis Kh2-2 isolated from Korea Foods.
Mi XJ, Tran THM, Park HR, Xu XY, Subramaniyam S, Choi HS, Kim J, Koh SC, Kim YJ
Food research international (Ottawa, Ont.) 2022 Feb;152:110911
Food research international (Ottawa, Ont.) 2022 Feb;152:110911
Phycocyanin inhibits Helicobacter pylori-induced hyper-proliferation in AGS cells via activation of the ROS/MAPK signaling pathway.
Bi Y, Wu D, Wu X, Wang F, Yu H, Liu P, Cui G, Chen Z
Annals of translational medicine 2022 Feb;10(4):176
Annals of translational medicine 2022 Feb;10(4):176
Berberine ameliorates erectile dysfunction in rats with streptozotocin-induced diabetes mellitus through the attenuation of apoptosis by inhibiting the SPHK1/S1P/S1PR2 and MAPK pathways.
Liu K, Sun T, Luan Y, Chen Y, Song J, Ling L, Yuan P, Li R, Cui K, Ruan Y, Lan R, Wang T, Wang S, Liu J, Rao K
Andrology 2022 Feb;10(2):404-418
Andrology 2022 Feb;10(2):404-418
L-Theanine mediates the p38MAPK signaling pathway to alleviate heat-induced oxidative stress and inflammation in mice.
Liu K, Liu E, Lin L, Hu Y, Yuan Y, Xiao W
Food & function 2022 Feb 21;13(4):2120-2130
Food & function 2022 Feb 21;13(4):2120-2130
Prenatal exposure to environmentally relevant levels of PBDE-99 leads to testicular dysgenesis with steroidogenesis disorders.
Zhao T, Tang X, Li D, Zhao J, Zhou R, Shu F, Jia W, Fu W, Xia H, Liu G
Journal of hazardous materials 2022 Feb 15;424(Pt B):127547
Journal of hazardous materials 2022 Feb 15;424(Pt B):127547
Endoglin Modulates TGFβR2 Induced VEGF and Proinflammatory Cytokine Axis Mediated Angiogenesis in Prolonged DEHP-Exposed Breast Cancer Cells.
Jadhao M, Chen CL, Liu W, Deshmukh D, Liao WT, Chen JY, Urade R, Tsai EM, Hsu SK, Wang LF, Chiu CC
Biomedicines 2022 Feb 10;10(2)
Biomedicines 2022 Feb 10;10(2)
Injection of YiQiFuMai powder protects against heart failure via inhibiting p38 and ERK1/2 MAPKs activation.
Nie Y, Zhang Y, Li Z, Wan M, Li D
Pharmaceutical biology 2022 Dec;60(1):570-578
Pharmaceutical biology 2022 Dec;60(1):570-578
Mild hypothermia ameliorates hepatic ischemia reperfusion injury by inducing RBM3 expression.
Xiao Q, Liu Y, Zhang X, Liu Z, Xiao J, Ye Q, Fu B
Apoptosis : an international journal on programmed cell death 2022 Dec;27(11-12):899-912
Apoptosis : an international journal on programmed cell death 2022 Dec;27(11-12):899-912
Biotransformation of 18β-Glycyrrhetinic Acid by Human Intestinal Fungus Aspergillus niger RG13B1 and the Potential Anti-Inflammatory Mechanism of Its Metabolites.
Zhang M, Zhang J, Wang C, Yan JK, Yi J, Ning J, Huo XK, Yu ZL, Zhang BJ, Sun CP, Ma XC
Journal of agricultural and food chemistry 2022 Dec 7;70(48):15104-15115
Journal of agricultural and food chemistry 2022 Dec 7;70(48):15104-15115
microRNA-338-3p suppresses lipopolysaccharide-induced inflammatory response in HK-2 cells.
Wang J, Li G, Lin M, Lin S, Wu L
BMC molecular and cell biology 2022 Dec 23;23(1):60
BMC molecular and cell biology 2022 Dec 23;23(1):60
Resveratrol reduces p38 mitogen-activated protein kinase phosphorylation by activating Sirtuin 1 to alleviate cognitive dysfunction after traumatic brain injury in mice.
Zhao XY, Yu D, Shi X, Hou S, Teng D
Neuroreport 2022 Aug 3;33(11):463-469
Neuroreport 2022 Aug 3;33(11):463-469
Rhodococcus equi-Derived Extracellular Vesicles Promoting Inflammatory Response in Macrophage through TLR2-NF-κB/MAPK Pathways.
Xu Z, Hao X, Li M, Luo H
International journal of molecular sciences 2022 Aug 28;23(17)
International journal of molecular sciences 2022 Aug 28;23(17)
Overexpression of NCAPG in ovarian cancer is associated with ovarian cancer proliferation and apoptosis via p38 MAPK signaling pathway.
Yu H, Zou D, Ni N, Zhang S, Zhang Q, Yang L
Journal of ovarian research 2022 Aug 19;15(1):98
Journal of ovarian research 2022 Aug 19;15(1):98
Hypothermic oxygenated perfusion combined with TJ-M2010-5 alleviates hepatic ischemia-reperfusion injury in donation after circulatory death.
Zhou W, Peng S, Du P, Zhou P, Xue C, Ye Q
International immunopharmacology 2022 Apr;105:108541
International immunopharmacology 2022 Apr;105:108541
Mechanism exploration of ancient pharmaceutic processing (Paozhi) improving the gastroprotective efficacy of Aucklandiae Radix.
Song S, Qiu R, Jin X, Zhou Z, Yan J, Ou Q, Liu X, Li W, Mao Y, Yao W, Lu T
Journal of ethnopharmacology 2022 Apr 6;287:114911
Journal of ethnopharmacology 2022 Apr 6;287:114911
Gentiopicroside Inhibits Cell Growth and Migration on Cervical Cancer via the Reciprocal MAPK/Akt Signaling Pathways.
Hu Z, Wang H, Fu Y, Ma K, Ma X, Wang J
Nutrition and cancer 2021;73(8):1459-1470
Nutrition and cancer 2021;73(8):1459-1470
PICK1 Deficiency Exacerbates Sepsis-Associated Acute Kidney Injury.
Dou Q, Tong H, Yang Y, Zhang H, Gan H
BioMed research international 2021;2021:9884297
BioMed research international 2021;2021:9884297
BMSCs Regulate Astrocytes through TSG-6 to Protect the Blood-Brain Barrier after Subarachnoid Hemorrhage.
Wan Y, Song M, Xie X, Chen Z, Gao Z, Wu X, Huang R, Chen M
Mediators of inflammation 2021;2021:5522291
Mediators of inflammation 2021;2021:5522291
Baicalin Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy via Nrf2 and MAPK Signaling Pathway.
Ma L, Wu F, Shao Q, Chen G, Xu L, Lu F
Drug design, development and therapy 2021;15:3207-3221
Drug design, development and therapy 2021;15:3207-3221
Punicalin Attenuates Breast Cancer-Associated Osteolysis by Inhibiting the NF-κB Signaling Pathway of Osteoclasts.
Li T, Jiang G, Hu X, Yang D, Tan T, Gao Z, Chen Z, Xiang C, Li S, Ouyang Z, Guo X
Frontiers in pharmacology 2021;12:789552
Frontiers in pharmacology 2021;12:789552
BCI Suppresses RANKL-Mediated Osteoclastogenesis and Alleviates Ovariectomy-Induced Bone Loss.
Cai C, Hu W, Zhang Y, Hu X, Yang S, Qiu H, Wang R, Ma M, Qiu Y, Chu T
Frontiers in pharmacology 2021;12:772540
Frontiers in pharmacology 2021;12:772540
Exploring the Critical Components and Therapeutic Mechanisms of Perilla frutescens L. in the Treatment of Chronic Kidney Disease via Network Pharmacology.
Yong C, Zhang Z, Huang G, Yang Y, Zhu Y, Qian L, Tian F, Liu L, Wu Q, Xu Z, Chen C, Zhao J, Gao K, Zhou E
Frontiers in pharmacology 2021;12:717744
Frontiers in pharmacology 2021;12:717744
Isovitexin Inhibits Ginkgolic Acids-Induced Inflammation Through Downregulating SHP2 Activation.
Zhang Y, Qi Z, Wang W, Wang L, Cao F, Zhao L, Fang X
Frontiers in pharmacology 2021;12:630320
Frontiers in pharmacology 2021;12:630320
The EIF4A3/CASC2/RORA Feedback Loop Regulates the Aggressive Phenotype in Glioblastomas.
Zhao J, Jiang Y, Chen L, Ma Y, Zhang H, Zhou J, Li H, Jing Z
Frontiers in oncology 2021;11:699933
Frontiers in oncology 2021;11:699933
IL-1β Promotes Vasculogenic Mimicry of Breast Cancer Cells Through p38/MAPK and PI3K/Akt Signaling Pathways.
Nisar MA, Zheng Q, Saleem MZ, Ahmmed B, Ramzan MN, Ud Din SR, Tahir N, Liu S, Yan Q
Frontiers in oncology 2021;11:618839
Frontiers in oncology 2021;11:618839
The effects of mTOR or Vps34-mediated autophagy on methylmercury-induced neuronal apoptosis in rat cerebral cortex.
Ni L, Wei Y, Pan J, Li X, Xu B, Deng Y, Yang T, Liu W
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Sep;155:112386
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Sep;155:112386
Diurnal regulation of oxidative phosphorylation restricts hepatocyte proliferation and inflammation.
Bai X, Liao Y, Sun F, Xiao X, Fu S
Cell reports 2021 Sep 7;36(10):109659
Cell reports 2021 Sep 7;36(10):109659
Sympathetic activity is correlated with satellite cell aging and myogenesis via β2-adrenoceptor.
Yuan S, Zheng S, Zheng K, Gao Y, Chen M, Li Y, Bai X
Stem cell research & therapy 2021 Sep 16;12(1):505
Stem cell research & therapy 2021 Sep 16;12(1):505
Quercitrin Rapidly Alleviated Depression-like Behaviors in Lipopolysaccharide-Treated Mice: The Involvement of PI3K/AKT/NF-κB Signaling Suppression and CREB/BDNF Signaling Restoration in the Hippocampus.
Sun Y, Zhang H, Wu Z, Yu X, Yin Y, Qian S, Wang Z, Huang J, Wang W, Liu T, Xue W, Chen G
ACS chemical neuroscience 2021 Sep 15;12(18):3387-3396
ACS chemical neuroscience 2021 Sep 15;12(18):3387-3396
Paternal exposure to microcystin-LR triggers developmental neurotoxicity in zebrafish offspring via an epigenetic mechanism involving MAPK pathway.
Zhao S, Xu J, Zhang W, Yan W, Li G
The Science of the total environment 2021 Oct 20;792:148437
The Science of the total environment 2021 Oct 20;792:148437
miR-128 participates in the pathogenesis of chronic constipation by regulating the p38α/M-CSF inflammatory signaling pathway.
Hong Y, Ren X, Liu W, Sun K, Chen B, Liu B, Yu X, Chen Q, Qian Q, Xie X, Jiang C
American journal of physiology. Gastrointestinal and liver physiology 2021 Oct 1;321(4):G436-G447
American journal of physiology. Gastrointestinal and liver physiology 2021 Oct 1;321(4):G436-G447
Knockdown of ST6Gal-I expression in human hepatocellular carcinoma cells inhibits their exosome-mediated proliferation- and migration-promoting effects.
Wang L, Chen X, Wang L, Wang S, Li W, Liu Y, Zhang J
IUBMB life 2021 Nov;73(11):1378-1391
IUBMB life 2021 Nov;73(11):1378-1391
RABL2A-CCDC34 Axis Promotes Sorafenib Resistance in Hepatocellular Carcinoma.
Zhou M, Chen X, Bai H, Sun Y, Zhang Z, Li S, Wang X, Zeng M
DNA and cell biology 2021 Nov;40(11):1418-1427
DNA and cell biology 2021 Nov;40(11):1418-1427
The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist-resistant prolactinomas.
Wang S, Wang A, Zhang Y, Zhu K, Wang X, Chen Y, Wu J
BMC endocrine disorders 2021 Nov 23;21(1):235
BMC endocrine disorders 2021 Nov 23;21(1):235
Drug-containing serum of rhubarb-astragalus capsule inhibits the epithelial-mesenchymal transformation of HK-2 by downregulating TGF-β1/p38MAPK/Smad2/3 pathway.
Qin MY, Huang SQ, Zou XQ, Zhong XB, Yang YF, Zhang YT, Mi ZC, Zhang YS, Huang ZG
Journal of ethnopharmacology 2021 Nov 15;280:114414
Journal of ethnopharmacology 2021 Nov 15;280:114414
1,10-Seco-Eudesmane sesquiterpenoids as a new type of anti-neuroinflammatory agents by suppressing TLR4/NF-κB/MAPK pathways.
Tang JJ, Wang MR, Dong S, Huang LF, He QR, Gao JM
European journal of medicinal chemistry 2021 Nov 15;224:113713
European journal of medicinal chemistry 2021 Nov 15;224:113713
The synthesis and bioactivity of pyrrolo[2,3-d]pyrimidine derivatives as tyrosine kinase inhibitors for NSCLC cells with EGFR mutations.
Xia Z, Huang R, Zhou X, Chai Y, Chen H, Ma L, Yu Q, Li Y, Li W, He Y
European journal of medicinal chemistry 2021 Nov 15;224:113711
European journal of medicinal chemistry 2021 Nov 15;224:113711
Overexpression of FOXA2 attenuates cigarette smoke-induced cellular senescence and lung inflammation through inhibition of the p38 and Erk1/2 MAPK pathways.
Tao Y, Sun Y, Wu B, Xu D, Yang J, Gu L, Du C
International immunopharmacology 2021 May;94:107427
International immunopharmacology 2021 May;94:107427
Anti-osteoporotic effects of alisol C 23-acetate via osteoclastogenesis inhibition.
Jia X, Zhu H, Li G, Lan M, Li X, Huang M, Xu W, Wu S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 May;137:111321
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 May;137:111321
Downregulation of CD151 restricts VCAM-1 mediated leukocyte infiltration to reduce neurobiological injuries after experimental stroke.
Gao C, Jia W, Xu W, Wu Q, Wu J
Journal of neuroinflammation 2021 May 22;18(1):118
Journal of neuroinflammation 2021 May 22;18(1):118
Simvastatin Enhances the Chondrogenesis But Not the Osteogenesis of Adipose-Derived Stem Cells in a Hyaluronan Microenvironment.
Wu SC, Chang CH, Chang LH, Wu CW, Chen JW, Chen CH, Lin YS, Chang JK, Ho ML
Biomedicines 2021 May 17;9(5)
Biomedicines 2021 May 17;9(5)
ZnO NPs delay the recovery of psoriasis-like skin lesions through promoting nuclear translocation of p-NFκB p65 and cysteine deficiency in keratinocytes.
Lai X, Wang M, Zhu Y, Feng X, Liang H, Wu J, Nie L, Li L, Shao L
Journal of hazardous materials 2021 May 15;410:124566
Journal of hazardous materials 2021 May 15;410:124566
Asenapine maleate inhibits angiotensin II-induced proliferation and activation of cardiac fibroblasts via the ROS/TGFβ1/MAPK signaling pathway.
Wu HH, Meng TT, Chen JM, Meng FL, Wang SY, Liu RH, Chen JN, Ning B, Li Y, Su GH
Biochemical and biophysical research communications 2021 May 14;553:172-179
Biochemical and biophysical research communications 2021 May 14;553:172-179
A human β-casein-derived peptide BCCY-1 modulates the innate immune response.
Cai J, Li X, Wang X, Jiang C, Shen D, Cui X, Xie K, Ji C, Cao Y
Food chemistry 2021 Jun 30;348:129111
Food chemistry 2021 Jun 30;348:129111
Long noncoding RNA AFAP1-AS1 promotes tumor progression and invasion by regulating the miR-2110/Sp1 axis in triple-negative breast cancer.
Zhang X, Li F, Zhou Y, Mao F, Lin Y, Shen S, Li Y, Zhang S, Sun Q
Cell death & disease 2021 Jun 18;12(7):627
Cell death & disease 2021 Jun 18;12(7):627
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
Zhou Z, Li Y, Ma X, Cao B, Peng T, Sheng Y, Peng H, Li R, Cao Y, Xi R, Li F, Wang M, Sun H, Zhang G, Zhang H, Hu K, Xiao W, Wang F
Journal of medicinal chemistry 2021 Jun 10;64(11):7404-7421
Journal of medicinal chemistry 2021 Jun 10;64(11):7404-7421
Cytotoxicity of apigenin toward multiple myeloma cell lines and suppression of iNOS and COX-2 expression in STAT1-transfected HEK293 cells.
Adham AN, Abdelfatah S, Naqishbandi AM, Mahmoud N, Efferth T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jan;80:153371
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jan;80:153371
MCLR induces dysregulation of calcium homeostasis and endoplasmic reticulum stress resulting in apoptosis in Sertoli cells.
Zhao S, Yuan C, Tuo X, Zhou C, Zhao Q, Shen T
Chemosphere 2021 Jan;263:127868
Chemosphere 2021 Jan;263:127868
NDUFA4L2 in smooth muscle promotes vascular remodeling in hypoxic pulmonary arterial hypertension.
Liu Y, Nie X, Zhu J, Wang T, Li Y, Wang Q, Sun Z
Journal of cellular and molecular medicine 2021 Jan;25(2):1221-1237
Journal of cellular and molecular medicine 2021 Jan;25(2):1221-1237
Pro-protein convertase subtilisin/kexin type 9 promotes intestinal tumor development by activating Janus kinase 2/signal transducer and activator of transcription 3/SOCS3 signaling in Apc(Min/+) mice.
Yang K, Zhu J, Luo HH, Yu SW, Wang L
International journal of immunopathology and pharmacology 2021 Jan-Dec;35:20587384211038345
International journal of immunopathology and pharmacology 2021 Jan-Dec;35:20587384211038345
Critical roles of sphingosine kinase 1 in the regulation of neuroinflammation and neuronal injury after spinal cord injury.
Wang C, Xu T, Lachance BB, Zhong X, Shen G, Xu T, Tang C, Jia X
Journal of neuroinflammation 2021 Feb 18;18(1):50
Journal of neuroinflammation 2021 Feb 18;18(1):50
Bioactive constituents of Mosla chinensis-cv. Jiangxiangru ameliorate inflammation through MAPK signaling pathways and modify intestinal microbiota in DSS-induced colitis mice.
Wang X, Cheng K, Liu Z, Sun Y, Zhou L, Xu M, Dai X, Xiong Y, Zhang H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Dec;93:153804
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Dec;93:153804
Diterpenoid alkaloids from Delphinium forrestii var. viride and their anti-inflammation activity.
Song Z, Gao C, Jiang Q, Xu J, Xiong L, Liu K, Sun D, Li H, Chen L
Phytochemistry 2021 Dec;192:112971
Phytochemistry 2021 Dec;192:112971
Shockwave Treatment Enhanced Extracellular Matrix Production in Articular Chondrocytes Through Activation of the ROS/MAPK/Nrf2 Signaling Pathway.
Shen PC, Chou SH, Lu CC, Huang HT, Chien SH, Huang PJ, Liu ZM, Shih CL, Su SJ, Chen LM, Tien YC
Cartilage 2021 Dec;13(2_suppl):238S-253S
Cartilage 2021 Dec;13(2_suppl):238S-253S
The effects of Omarigliptin on promoting osteoblastic differentiation.
Liao F, Hu X, Chen R
Bioengineered 2021 Dec;12(2):11837-11846
Bioengineered 2021 Dec;12(2):11837-11846
Protective effect of combination of anakinra and MCC950 against acute lung injury is achieved through suppression of the NF-κB-mediated-MAPK and NLRP3-caspase pathways.
Wang X, Chen S, Zhao L, Shi X
International immunopharmacology 2021 Aug;97:107506
International immunopharmacology 2021 Aug;97:107506
The miR-223-3p/MAP1B axis aggravates TGF-β-induced proliferation and migration of BPH-1 cells.
Wang Z, Zhang Y, Zhao C, Li Y, Hu X, Wu L, Chen M, Tong S
Cellular signalling 2021 Aug;84:110004
Cellular signalling 2021 Aug;84:110004
Guanosine and uridine alleviate airway inflammation via inhibition of the MAPK and NF-κB signals in OVA-induced asthmatic mice.
Luo Y, Chen H, Huang R, Wu Q, Li Y, He Y
Pulmonary pharmacology & therapeutics 2021 Aug;69:102049
Pulmonary pharmacology & therapeutics 2021 Aug;69:102049
Suramin attenuates intervertebral disc degeneration by inhibiting NF-κB signalling pathway.
Liu ZM, Lu CC, Shen PC, Chou SH, Shih CL, Chen JC, Tien YC
Bone & joint research 2021 Aug;10(8):498-513
Bone & joint research 2021 Aug;10(8):498-513
Polysaccharides from Ulva prolifera O.F. Müller inhibit cell proliferation via activating MAPK signaling in A549 and H1650 cells.
Yang JJ, Wang YH, Yin J, Leng H, Shen SD
Food & function 2021 Aug 2;12(15):6915-6924
Food & function 2021 Aug 2;12(15):6915-6924
Fab Fragment of Immunoglobulin Y Modulates NF-κB and MAPK Signaling through TLR4 and αVβ3 Integrin and Inhibits the Inflammatory Effect on R264.7 Macrophages.
Zhou X, Ahn DU, Xia M, Zeng Q, Li X, Cai Z
Journal of agricultural and food chemistry 2021 Aug 11;69(31):8747-8757
Journal of agricultural and food chemistry 2021 Aug 11;69(31):8747-8757
Ophiocordyceps lanpingensis polysaccharides alleviate chronic kidney disease through MAPK/NF-κB pathway.
Zhou S, He Y, Zhang W, Xiong Y, Jiang L, Wang J, Cui X, Qu Y, Ge F
Journal of ethnopharmacology 2021 Aug 10;276:114189
Journal of ethnopharmacology 2021 Aug 10;276:114189
Anti-thrombotic activity of phenolic acids obtained from Salvia miltiorrhiza f. alba in TNF-α-stimulated endothelial cells via the NF-κB/JNK/p38 MAPK signaling pathway.
Zheng X, Liu H, Ma M, Ji J, Zhu F, Sun L
Archives of pharmacal research 2021 Apr;44(4):427-438
Archives of pharmacal research 2021 Apr;44(4):427-438
The orphan nuclear receptor Nurr1 agonist amodiaquine mediates neuroprotective effects in 6-OHDA Parkinson's disease animal model by enhancing the phosphorylation of P38 mitogen-activated kinase but not PI3K/AKT signaling pathway.
Kambey PA, Chengcheng M, Xiaoxiao G, Abdulrahman AA, Kanwore K, Nadeem I, Jiao W, Gao D
Metabolic brain disease 2021 Apr;36(4):609-625
Metabolic brain disease 2021 Apr;36(4):609-625
KLF5-mediated Eppk1 expression promotes cell proliferation in cervical cancer via the p38 signaling pathway.
Ma D, Pan Z, Chang Q, Zhang JJ, Liu X, Hua N, Li GH
BMC cancer 2021 Apr 8;21(1):377
BMC cancer 2021 Apr 8;21(1):377
Ginsenoside Rh4 alleviates antibiotic-induced intestinal inflammation by regulating the TLR4-MyD88-MAPK pathway and gut microbiota composition.
Bai X, Fu R, Duan Z, Liu Y, Zhu C, Fan D
Food & function 2021 Apr 7;12(7):2874-2885
Food & function 2021 Apr 7;12(7):2874-2885
CDKN2a/p16 Antagonizes Hepatic Stellate Cell Activation and Liver Fibrosis by Modulating ROS Levels.
Lv F, Li N, Kong M, Wu J, Fan Z, Miao D, Xu Y, Ye Q, Wang Y
Frontiers in cell and developmental biology 2020;8:176
Frontiers in cell and developmental biology 2020;8:176
WJ-39, an Aldose Reductase Inhibitor, Ameliorates Renal Lesions in Diabetic Nephropathy by Activating Nrf2 Signaling.
Zhou X, Liu Z, Ying K, Wang H, Liu P, Ji X, Chi T, Zou L, Wang S, He Z
Oxidative medicine and cellular longevity 2020;2020:7950457
Oxidative medicine and cellular longevity 2020;2020:7950457
Rhein Suppresses Neuroinflammation via Multiple Signaling Pathways in LPS-Stimulated BV2 Microglia Cells.
Zheng P, Tian X, Zhang W, Yang Z, Zhou J, Zheng J, Cui H, Tang T, Luo J, Wang Y
Evidence-based complementary and alternative medicine : eCAM 2020;2020:7210627
Evidence-based complementary and alternative medicine : eCAM 2020;2020:7210627
Protein Kinase A Is Involved in Neuropathic Pain by Activating the p38MAPK Pathway to Mediate Spinal Cord Cell Apoptosis.
Deng Y, Yang L, Xie Q, Yang F, Li G, Zhang G, Li S, Wu Z, Wang J, Kang X
Mediators of inflammation 2020;2020:6420425
Mediators of inflammation 2020;2020:6420425
Thymoquinone Protects against Hyperlipidemia-Induced Cardiac Damage in Low-Density Lipoprotein Receptor-Deficient (LDL-R(-/-)) Mice via Its Anti-inflammatory and Antipyroptotic Effects.
Pei ZW, Guo Y, Zhu HL, Dong M, Zhang Q, Wang F
BioMed research international 2020;2020:4878704
BioMed research international 2020;2020:4878704
Antiprolactinoma Effect of Hordenine by Inhibiting MAPK Signaling Pathway Activation in Rats.
Wang X, Guo RZ, Ma L, Ding QY, Meng JH, Chen YG, Wu JH
Evidence-based complementary and alternative medicine : eCAM 2020;2020:3107290
Evidence-based complementary and alternative medicine : eCAM 2020;2020:3107290
25-Hydroxycholesterol protects against myocardial ischemia-reperfusion injury via inhibiting PARP activity.
Lv S, Ju C, Peng J, Liang M, Zhu F, Wang C, Huang K, Cheng M, Zhang F
International journal of biological sciences 2020;16(2):298-308
International journal of biological sciences 2020;16(2):298-308
Changes in inflammatory factors in SV40MES13 mesangial cells after silencing ApoM gene.
Liu J, Zhang Y, Zhang X, Zhang S, Hu Y, Wang L, Gao J, Zhang Y
International journal of clinical and experimental pathology 2020;13(6):1451-1456
International journal of clinical and experimental pathology 2020;13(6):1451-1456
Fatty acid extracts facilitate cutaneous wound healing through activating AKT, ERK, and TGF-β/Smad3 signaling and promoting angiogenesis.
Zong J, Jiang J, Shi P, Liu J, Wang W, Li B, Zhao T, Pan T, Zhang Z, Bi L, Diao Y, Wang S
American journal of translational research 2020;12(2):478-492
American journal of translational research 2020;12(2):478-492
Recombinant Dual-target MDM2/MDMX Inhibitor Reverses Doxorubicin Resistance through Activation of the TAB1/TAK1/p38 MAPK Pathway in Wild-type p53 Multidrug-resistant Breast Cancer Cells.
Fan Y, Ma K, Jing J, Wang C, Hu Y, Shi Y, Li E, Geng Q
Journal of Cancer 2020;11(1):25-40
Journal of Cancer 2020;11(1):25-40
Huangkui Capsule Ameliorates Renal Fibrosis in a Unilateral Ureteral Obstruction Mouse Model Through TRPC6 Dependent Signaling Pathways.
Gu LF, Ge HT, Zhao L, Wang YJ, Zhang F, Tang HT, Cao ZY, Yu BY, Chai CZ
Frontiers in pharmacology 2020;11:996
Frontiers in pharmacology 2020;11:996
Corilagin Ameliorates Atherosclerosis in Peripheral Artery Disease via the Toll-Like Receptor-4 Signaling Pathway in vitro and in vivo.
Li Y, Wang Y, Chen Y, Wang Y, Zhang S, Liu P, Chen Z, Song P, Luo L, Luo Y, Dang Y, Zhao L
Frontiers in immunology 2020;11:1611
Frontiers in immunology 2020;11:1611
DHZCP Modulates Microglial M1/M2 Polarization via the p38 and TLR4/NF-κB Signaling Pathways in LPS-Stimulated Microglial Cells.
Zhou L, Wang D, Qiu X, Zhang W, Gong Z, Wang Y, Xu X
Frontiers in pharmacology 2020;11:1126
Frontiers in pharmacology 2020;11:1126
Inhibiting MAPK14 showed anti-prolactinoma effect.
Ding QY, Zhang Y, Ma L, Chen YG, Wu JH, Zhang HF, Wang X
BMC endocrine disorders 2020 Sep 7;20(1):138
BMC endocrine disorders 2020 Sep 7;20(1):138
A multifunctional anti-inflammatory drug that can specifically target activated macrophages, massively deplete intracellular H(2)O(2), and produce large amounts CO for a highly efficient treatment of osteoarthritis.
Yang G, Fan M, Zhu J, Ling C, Wu L, Zhang X, Zhang M, Li J, Yao Q, Gu Z, Cai X
Biomaterials 2020 Oct;255:120155
Biomaterials 2020 Oct;255:120155
Effect of autophagy on irradiation‑induced damage in osteoblast‑like MC3T3‑E1 cells.
Li R, Yang W, Hu X, Zhou D, Huang K, Wang C, Li Y, Liu B
Molecular medicine reports 2020 Oct;22(4):3473-3481
Molecular medicine reports 2020 Oct;22(4):3473-3481
Daidzein ameliorates LPS-induced hepatocyte injury by inhibiting inflammation and oxidative stress.
Yu Z, Yang L, Deng S, Liang M
European journal of pharmacology 2020 Oct 15;885:173399
European journal of pharmacology 2020 Oct 15;885:173399
The anti-inflammatory potential of protein-bound anthocyanin compounds from purple sweet potato in LPS-induced RAW264.7 macrophages.
Jiang T, Zhou J, Liu W, Tao W, He J, Jin W, Guo H, Yang N, Li Y
Food research international (Ottawa, Ont.) 2020 Nov;137:109647
Food research international (Ottawa, Ont.) 2020 Nov;137:109647
Enhancement of anti-acne effect of Scutellaria baicalensis extract by fermentation with symbiotic fungus Penicillium decumbens.
Zhu X, Mao Y, Guo M, Yu H, Hao L, Hua Q, Lu Z, Hong M, An F
Journal of bioscience and bioengineering 2020 Nov;130(5):457-463
Journal of bioscience and bioengineering 2020 Nov;130(5):457-463
The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies.
Prager BC, Vasudevan HN, Dixit D, Bernatchez JA, Wu Q, Wallace LC, Bhargava S, Lee D, King BH, Morton AR, Gimple RC, Pekmezci M, Zhu Z, Siqueira-Neto JL, Wang X, Xie Q, Chen C, Barnett GH, Vogelbaum MA, Mack SC, Chavez L, Perry A, Raleigh DR, Rich JN
Cancer discovery 2020 Nov;10(11):1722-1741
Cancer discovery 2020 Nov;10(11):1722-1741
Long-wave Ultraviolet Ray Promotes Inflammation in Keloid-derived Fibroblasts by Activating P38-NFκB1 Signaling Pathway.
Niu X, Lin X, Chen X, Xu S, Huang Z, Tang Q
Journal of burn care & research : official publication of the American Burn Association 2020 Nov 30;41(6):1231-1239
Journal of burn care & research : official publication of the American Burn Association 2020 Nov 30;41(6):1231-1239
Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice.
Zhu Y, Zhu C, Yang H, Deng J, Fan D
Pharmacological research 2020 May;155:104746
Pharmacological research 2020 May;155:104746
Downregulation of GLYR1 contributes to microsatellite instability colorectal cancer by targeting p21 via the p38MAPK and PI3K/AKT pathways.
Hu Z, Long T, Ma Y, Zhu J, Gao L, Zhong Y, Wang X, Wang X, Li Z
Journal of experimental & clinical cancer research : CR 2020 May 5;39(1):76
Journal of experimental & clinical cancer research : CR 2020 May 5;39(1):76
In vitro and in vivo anti-Listeria effect of Succinoglycan Riclin through regulating MAPK/IL-6 axis and metabolic profiling.
Wu Z, Cheng Y, Yang Y, Gao Y, Sun X, Wang L, Sun Q, Zhang J, Xu X
International journal of biological macromolecules 2020 May 1;150:802-813
International journal of biological macromolecules 2020 May 1;150:802-813
Sodium acetate alleviated high-carbohydrate induced intestinal inflammation by suppressing MAPK and NF-κB signaling pathways in Nile tilapia (Oreochromis niloticus).
Li M, Hu FC, Qiao F, Du ZY, Zhang ML
Fish & shellfish immunology 2020 Mar;98:758-765
Fish & shellfish immunology 2020 Mar;98:758-765
Synthesis and biological evaluation of myricetin-pentadienone hybrids as potential anti-inflammatory agents in vitro and in vivo.
Liu C, Han X, Yu PJ, Chen LZ, Xue W, Liu XH
Bioorganic chemistry 2020 Mar;96:103597
Bioorganic chemistry 2020 Mar;96:103597
TXNIP deficiency mitigates podocyte apoptosis via restraining the activation of mTOR or p38 MAPK signaling in diabetic nephropathy.
Song S, Qiu D, Wang Y, Wei J, Wu H, Wu M, Wang S, Zhou X, Shi Y, Duan H
Experimental cell research 2020 Mar 15;388(2):111862
Experimental cell research 2020 Mar 15;388(2):111862
Sodium tanshinone IIA sulfonate prevents radiation-induced damage in primary rat cardiac fibroblasts.
Zhou D, Yang WK, Zhang YF, Xie JH, Ma L, Yang HD, Li Y, Xie P
Chinese journal of natural medicines 2020 Jun;18(6):436-445
Chinese journal of natural medicines 2020 Jun;18(6):436-445
Antioxidants suppress radiation-induced apoptosis via inhibiting MAPK pathway in nasopharyngeal carcinoma cells.
Meng DF, Guo LL, Peng LX, Zheng LS, Xie P, Mei Y, Li CZ, Peng XS, Lang YH, Liu ZJ, Wang MD, Xie DH, Shu DT, Hu H, Lin ST, Li HF, Luo FF, Sun R, Huang BJ, Qian CN
Biochemical and biophysical research communications 2020 Jun 30;527(3):770-777
Biochemical and biophysical research communications 2020 Jun 30;527(3):770-777
BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer.
Liu JZ, Hu YL, Feng Y, Jiang Y, Guo YB, Liu YF, Chen X, Yang JL, Chen YY, Mao QS, Xue WJ
Journal of experimental & clinical cancer research : CR 2020 Jun 30;39(1):123
Journal of experimental & clinical cancer research : CR 2020 Jun 30;39(1):123
Si-Miao-Yong-An decoction attenuates cardiac fibrosis via suppressing TGF-β1 pathway and interfering with MMP-TIMPs expression.
Su C, Wang Q, Luo H, Jiao W, Tang J, Li L, Tian L, Chen X, Liu B, Yu X, Li S, Guo S, Wang W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jul;127:110132
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jul;127:110132
Discovery of novel TNNI3K inhibitor suppresses pyroptosis and apoptosis in murine myocardial infarction injury.
Pang H, Wang N, Chai J, Wang X, Zhang Y, Bi Z, Wu W, He G
European journal of medicinal chemistry 2020 Jul 1;197:112314
European journal of medicinal chemistry 2020 Jul 1;197:112314
Gamabufotalin induces a negative feedback loop connecting ATP1A3 expression and the AQP4 pathway to promote temozolomide sensitivity in glioblastoma cells by targeting the amino acid Thr794.
Lan YL, Chen C, Wang X, Lou JC, Xing JS, Zou S, Hu JL, Lyu W, Zhang B
Cell proliferation 2020 Jan;53(1):e12732
Cell proliferation 2020 Jan;53(1):e12732
Spondin 2 promotes the proliferation, migration and invasion of gastric cancer cells.
Lu H, Feng Y, Hu Y, Guo Y, Liu Y, Mao Q, Xue W
Journal of cellular and molecular medicine 2020 Jan;24(1):98-113
Journal of cellular and molecular medicine 2020 Jan;24(1):98-113
Protective effects of Salidroside on spermatogenesis in streptozotocin induced type-1 diabetic male mice by inhibiting oxidative stress mediated blood-testis barrier damage.
Jiang YP, Ye RJ, Yang JM, Liu N, Zhang WJ, Ma L, Sun T, Niu JG, Zheng P, Yu JQ
Chemico-biological interactions 2020 Jan 5;315:108869
Chemico-biological interactions 2020 Jan 5;315:108869
Alisol A-24-acetate promotes glucose uptake via activation of AMPK in C2C12 myotubes.
Chen JX, Li HY, Li TT, Fu WC, Du X, Liu CH, Zhang W
BMC complementary medicine and therapies 2020 Jan 29;20(1):22
BMC complementary medicine and therapies 2020 Jan 29;20(1):22
Isorhamnetin attenuates Streptococcus suis virulence by inhibiting the inflammatory response.
Li G, Wang G, Wang S, Sun M, Wen Z
Antonie van Leeuwenhoek 2020 Feb;113(2):303-310
Antonie van Leeuwenhoek 2020 Feb;113(2):303-310
PP2A alleviates oxidized LDL-induced endothelial dysfunction by regulating LOX-1/ROS/MAPK axis.
Xu K, Liu X, Yin D, Ren G, Zhao Y
Life sciences 2020 Feb 15;243:117270
Life sciences 2020 Feb 15;243:117270
Mincle/Syk Signalling Promotes Intestinal Mucosal Inflammation Through Induction of Macrophage Pyroptosis in Crohn's Disease.
Gong W, Zheng T, Guo K, Fang M, Xie H, Li W, Tang Q, Hong Z, Ren H, Gu G, Wang G, Wu X, Zhao Y, Ren J
Journal of Crohn's & colitis 2020 Dec 2;14(12):1734-1747
Journal of Crohn's & colitis 2020 Dec 2;14(12):1734-1747
Increased Blood Pressure Causes Lymphatic Endothelial Dysfunction via Oxidative Stress in Spontaneously Hypertensive Rats.
Mukohda M, Mizuno R, Ozaki H
Hypertension (Dallas, Tex. : 1979) 2020 Aug;76(2):598-606
Hypertension (Dallas, Tex. : 1979) 2020 Aug;76(2):598-606
Baicalein Alleviates Erectile Dysfunction Associated With Streptozotocin-Induced Type I Diabetes by Ameliorating Endothelial Nitric Oxide Synthase Dysfunction, Inhibiting Oxidative Stress and Fibrosis.
Chen Y, Zhou B, Yu Z, Yuan P, Sun T, Gong J, Zhang Y, Wang T, Wang S, Liu K, Liu J
The journal of sexual medicine 2020 Aug;17(8):1434-1447
The journal of sexual medicine 2020 Aug;17(8):1434-1447
Reelin Promotes Cisplatin Resistance by Induction of Epithelial-Mesenchymal Transition via p38/GSK3β/Snail Signaling in Non-Small Cell Lung Cancer.
Li JM, Yang F, Li J, Yuan WQ, Wang H, Luo YQ
Medical science monitor : international medical journal of experimental and clinical research 2020 Aug 7;26:e925298
Medical science monitor : international medical journal of experimental and clinical research 2020 Aug 7;26:e925298
Chlorogenic acid attenuates cyclophosphamide-induced rat interstitial cystitis.
Luo J, Yang C, Luo X, Yang Y, Li J, Song B, Zhao J, Li L
Life sciences 2020 Aug 1;254:117590
Life sciences 2020 Aug 1;254:117590
HMGB1 Mediates Paraquat-Induced Neuroinflammatory Responses via Activating RAGE Signaling Pathway.
Huang M, Guo M, Wang K, Wu K, Li Y, Tian T, Wang Y, Yan W, Zhou Z, Yang H
Neurotoxicity research 2020 Apr;37(4):913-925
Neurotoxicity research 2020 Apr;37(4):913-925
A Combination of Formic Acid and Monolaurin Attenuates Enterotoxigenic Escherichia coli Induced Intestinal Inflammation in Piglets by Inhibiting the NF-κB/MAPK Pathways with Modulation of Gut Microbiota.
Ren C, Wang Y, Lin X, Song H, Zhou Q, Xu W, Shi K, Chen J, Song J, Chen F, Zhang S, Guan W
Journal of agricultural and food chemistry 2020 Apr 8;68(14):4155-4165
Journal of agricultural and food chemistry 2020 Apr 8;68(14):4155-4165
The protective effects of β-sitosterol and vermicularin from Thamnolia vermicularis (Sw.) Ach. against skin aging in vitro.
Haiyuan YU, Shen X, Liu D, Hong M, Lu Y
Anais da Academia Brasileira de Ciencias 2019;91(4):e20181088
Anais da Academia Brasileira de Ciencias 2019;91(4):e20181088
Protective Effect of Methane-Rich Saline on Acetic Acid-Induced Ulcerative Colitis via Blocking the TLR4/NF-κB/MAPK Pathway and Promoting IL-10/JAK1/STAT3-Mediated Anti-inflammatory Response.
Wang G, Xu B, Shi F, Du M, Li Y, Yu T, Chen L
Oxidative medicine and cellular longevity 2019;2019:7850324
Oxidative medicine and cellular longevity 2019;2019:7850324
Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-β1/Smad3 and TGF-β1/p38 MAPK Pathways.
Liu N, Feng J, Lu X, Yao Z, Liu Q, Lv Y, Han Y, Deng J, Zhou Y
Mediators of inflammation 2019;2019:6175091
Mediators of inflammation 2019;2019:6175091
Bu Shen Zhu Yun Decoction Improves Endometrial Receptivity via VEGFR-2-Mediated Angiogenesis.
Li L, Jiang H, Wei X, Geng D, He M, Du H
Evidence-based complementary and alternative medicine : eCAM 2019;2019:3949824
Evidence-based complementary and alternative medicine : eCAM 2019;2019:3949824
Dual-target MDM2/MDMX inhibitor increases the sensitization of doxorubicin and inhibits migration and invasion abilities of triple-negative breast cancer cells through activation of TAB1/TAK1/p38 MAPK pathway.
Fan Y, Li M, Ma K, Hu Y, Jing J, Shi Y, Li E, Dong D
Cancer biology & therapy 2019;20(5):617-632
Cancer biology & therapy 2019;20(5):617-632
L-Cysteine-Derived H(2)S Promotes Microglia M2 Polarization via Activation of the AMPK Pathway in Hypoxia-Ischemic Neonatal Mice.
Zhou X, Chu X, Xin D, Li T, Bai X, Qiu J, Yuan H, Liu D, Wang D, Wang Z
Frontiers in molecular neuroscience 2019;12:58
Frontiers in molecular neuroscience 2019;12:58
Adipose-derived mesenchymal stem cells ameliorate the inflammatory reaction in CLP-induced septic acute lung injury rats via sTNFR1.
Ding XF, Liang HY, Sun JY, Liu SH, Kan QC, Wang LX, Sun TW
Journal of cellular physiology 2019 Sep;234(9):16582-16591
Journal of cellular physiology 2019 Sep;234(9):16582-16591
N‑acetyl cysteine inhibits lipopolysaccharide‑induced apoptosis of human umbilical vein endothelial cells via the p38MAPK signaling pathway.
Xiong T, Zhang Z, Zheng R, Huang J, Guo L
Molecular medicine reports 2019 Sep;20(3):2945-2953
Molecular medicine reports 2019 Sep;20(3):2945-2953
The Potential of Neoagaro-Oligosaccharides as a Treatment of Type II Diabetes in Mice.
Lin F, Yang D, Huang Y, Zhao Y, Ye J, Xiao M
Marine drugs 2019 Sep 20;17(10)
Marine drugs 2019 Sep 20;17(10)
Up-regulated cathepsin C induces macrophage M1 polarization through FAK-triggered p38 MAPK/NF-κB pathway.
Alam S, Liu Q, Liu S, Liu Y, Zhang Y, Yang X, Liu G, Fan K, Ma J
Experimental cell research 2019 Sep 15;382(2):111472
Experimental cell research 2019 Sep 15;382(2):111472
Regulation of circadian rhythms by NEAT1 mediated TMAO-induced endothelial proliferation: A protective role of asparagus extract.
Wu X, Chen L, Zeb F, Huang Y, An J, Ren J, Yang F, Feng Q
Experimental cell research 2019 Sep 1;382(1):111451
Experimental cell research 2019 Sep 1;382(1):111451
PM(2.5) upregulates rat mesenteric arteries 5-HT(2A) receptor via inflammatory-mediated mitogen-activated protein kinases signaling pathway.
Wang R, Cao L, Shen ZX, Cao YX, Yu J
Environmental toxicology 2019 Oct;34(10):1094-1104
Environmental toxicology 2019 Oct;34(10):1094-1104
Dehydroepiandrosterone alleviates E. Coli O157:H7-induced inflammation by preventing the activation of p38 MAPK and NF-κB pathways in mice peritoneal macrophages.
Zhao J, Cao J, Yu L, Ma H
Molecular immunology 2019 Oct;114:114-122
Molecular immunology 2019 Oct;114:114-122
CD146 Regulates Growth Factor-Induced mTORC2 Activity Independent of the PI3K and mTORC1 Pathways.
Xu W, Hua H, Chiu YH, Li G, Zhi H, Yu Z, Ren F, Luo Y, Cui W
Cell reports 2019 Oct 29;29(5):1311-1322.e5
Cell reports 2019 Oct 29;29(5):1311-1322.e5
Caveolin-1 promotes Rfng expression via Erk-Jnk-p38 signaling pathway in mouse hepatocarcinoma cells.
Zhang C, Wu Q, Huang H, Chen X, Huang T, Li W, Liu Y, Zhang J
Journal of physiology and biochemistry 2019 Nov;75(4):549-559
Journal of physiology and biochemistry 2019 Nov;75(4):549-559
Association and clinicopathologic significance of p38MAPK-ERK-JNK-CDC25C with polyploid giant cancer cell formation.
Liu K, Lu R, Zhao Q, Du J, Li Y, Zheng M, Zhang S
Medical oncology (Northwood, London, England) 2019 Nov 16;37(1):6
Medical oncology (Northwood, London, England) 2019 Nov 16;37(1):6
Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs.
Jia YN, Peng YL, Zhao YP, Cheng XF, Zhou Y, Chai CL, Zeng LS, Pan MH, Xu L
Journal of agricultural and food chemistry 2019 May 15;67(19):5521-5529
Journal of agricultural and food chemistry 2019 May 15;67(19):5521-5529
NRP1 regulates HMGB1 in vascular endothelial cells under high homocysteine condition.
Ma Y, Zhang Z, Chen R, Shi R, Zeng P, Chen R, Leng Y, Chen AF
American journal of physiology. Heart and circulatory physiology 2019 May 1;316(5):H1039-H1046
American journal of physiology. Heart and circulatory physiology 2019 May 1;316(5):H1039-H1046
Chitosan Hydrogel Delivery System Containing Herbal Compound Functions as a Potential Antineuroinflammatory Agent.
Zhou J, Zheng J, Zhang Y, Zheng P, Tang T, Luo JK, Cui HJ, Song RR, Wang Y
ACS omega 2019 Jun 30;4(6):10185-10191
ACS omega 2019 Jun 30;4(6):10185-10191
Caveolin-1 promotes invasion and metastasis by upregulating Pofut1 expression in mouse hepatocellular carcinoma.
Zhang C, Huang H, Zhang J, Wu Q, Chen X, Huang T, Li W, Liu Y, Zhang J
Cell death & disease 2019 Jun 17;10(7):477
Cell death & disease 2019 Jun 17;10(7):477
Small molecule inhibitor of TGF-β signaling enables robust osteogenesis of autologous GMSCs to successfully repair minipig severe maxillofacial bone defects.
Shi A, Heinayati A, Bao D, Liu H, Ding X, Tong X, Wang L, Wang B, Qin H
Stem cell research & therapy 2019 Jun 13;10(1):172
Stem cell research & therapy 2019 Jun 13;10(1):172
Chlorogenic acid: A potent molecule that protects cardiomyocytes from TNF-α-induced injury via inhibiting NF-κB and JNK signals.
Tian L, Su CP, Wang Q, Wu FJ, Bai R, Zhang HM, Liu JY, Lu WJ, Wang W, Lan F, Guo SZ
Journal of cellular and molecular medicine 2019 Jul;23(7):4666-4678
Journal of cellular and molecular medicine 2019 Jul;23(7):4666-4678
Red yeast rice ameliorates high-fat diet-induced atherosclerosis in Apoe(-/-) mice in association with improved inflammation and altered gut microbiota composition.
Dong Y, Cheng H, Liu Y, Xue M, Liang H
Food & function 2019 Jul 17;10(7):3880-3889
Food & function 2019 Jul 17;10(7):3880-3889
Isosteviol Sodium Protects Neural Cells Against Hypoxia-Induced Apoptosis Through Inhibiting MAPK and NF-κB Pathways.
Zhong KL, Lu MY, Liu F, Mei Y, Zhang XJ, Zhang H, Zan J, Sun XO, Tan W
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2019 Jan;28(1):175-184
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2019 Jan;28(1):175-184
PKP3 interactions with MAPK-JNK-ERK1/2-mTOR pathway regulates autophagy and invasion in ovarian cancer.
Lim V, Zhu H, Diao S, Hu L, Hu J
Biochemical and biophysical research communications 2019 Jan 8;508(2):646-653
Biochemical and biophysical research communications 2019 Jan 8;508(2):646-653
Tobacco smoke induced hepatic cancer stem cell-like properties through IL-33/p38 pathway.
Xie C, Zhu J, Wang X, Chen J, Geng S, Wu J, Zhong C, Li X
Journal of experimental & clinical cancer research : CR 2019 Jan 28;38(1):39
Journal of experimental & clinical cancer research : CR 2019 Jan 28;38(1):39
Catalpol promotes the osteogenic differentiation of bone marrow mesenchymal stem cells via the Wnt/β-catenin pathway.
Zhu Y, Wang Y, Jia Y, Xu J, Chai Y
Stem cell research & therapy 2019 Jan 22;10(1):37
Stem cell research & therapy 2019 Jan 22;10(1):37
Intermedin in Paraventricular Nucleus Attenuates Sympathoexcitation and Decreases TLR4-Mediated Sympathetic Activation via Adrenomedullin Receptors in Rats with Obesity-Related Hypertension.
Sun J, Ren XS, Kang Y, Dai HB, Ding L, Tong N, Zhu GQ, Zhou YB
Neuroscience bulletin 2019 Feb;35(1):34-46
Neuroscience bulletin 2019 Feb;35(1):34-46
Activation of the Omega-3 Fatty Acid Receptor GPR120 Protects against Focal Cerebral Ischemic Injury by Preventing Inflammation and Apoptosis in Mice.
Ren Z, Chen L, Wang Y, Wei X, Zeng S, Zheng Y, Gao C, Liu H
Journal of immunology (Baltimore, Md. : 1950) 2019 Feb 1;202(3):747-759
Journal of immunology (Baltimore, Md. : 1950) 2019 Feb 1;202(3):747-759
Protective effects of betaine on diabetic induced disruption of the male mice blood-testis barrier by regulating oxidative stress-mediated p38 MAPK pathways.
Jiang YP, Yang JM, Ye RJ, Liu N, Zhang WJ, Ma L, Zheng P, Niu JG, Liu P, Yu JQ
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Dec;120:109474
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Dec;120:109474
Grape Seed Proanthocyanidins Induce Autophagy and Modulate Survivin in HepG2 Cells and Inhibit Xenograft Tumor Growth in Vivo.
Wang L, Huang W, Zhan J
Nutrients 2019 Dec 6;11(12)
Nutrients 2019 Dec 6;11(12)
Dietary resveratrol supplementation inhibits heat stress-induced high-activated innate immunity and inflammatory response in spleen of yellow-feather broilers.
He S, Yu Q, He Y, Hu R, Xia S, He J
Poultry science 2019 Dec 1;98(12):6378-6387
Poultry science 2019 Dec 1;98(12):6378-6387
Quercetin reduces Streptococcus suis virulence by inhibiting suilysin activity and inflammation.
Li G, Shen X, Wei Y, Si X, Deng X, Wang J
International immunopharmacology 2019 Apr;69:71-78
International immunopharmacology 2019 Apr;69:71-78
Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation.
Zheng J, Fan R, Wu H, Yao H, Yan Y, Liu J, Ran L, Sun Z, Yi L, Dang L, Gan P, Zheng P, Yang T, Zhang Y, Tang T, Wang Y
Nature communications 2019 Apr 8;10(1):1604
Nature communications 2019 Apr 8;10(1):1604
Immunomodulatory effects of an acidic polysaccharide fraction from herbal Gynostemma pentaphyllum tea in RAW264.7 cells.
Ren D, Zhao Y, Zheng Q, Alim A, Yang X
Food & function 2019 Apr 1;10(4):2186-2197
Food & function 2019 Apr 1;10(4):2186-2197
SIRT6 Suppresses NFATc4 Expression and Activation in Cardiomyocyte Hypertrophy.
Li Z, Zhang X, Guo Z, Zhong Y, Wang P, Li J, Li Z, Liu P
Frontiers in pharmacology 2018;9:1519
Frontiers in pharmacology 2018;9:1519
Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1β Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes.
Liang S, Lv ZT, Zhang JM, Wang YT, Dong YH, Wang ZG, Chen K, Cheng P, Yang Q, Guo FJ, Lu WW, Zhu WT, Chen AM
Frontiers in pharmacology 2018;9:1378
Frontiers in pharmacology 2018;9:1378
The Long Noncoding RNA 150Rik Promotes Mesangial Cell Proliferation via miR-451/IGF1R/p38 MAPK Signaling in Diabetic Nephropathy.
Zhang Y, Sun Y, Peng R, Liu H, He W, Zhang L, Peng H, Zhang Z
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;51(3):1410-1428
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;51(3):1410-1428
PPP5C promotes cell proliferation and survival in human prostate cancer by regulating of the JNK and ERK1/2 phosphorylation.
Lv JM, Chen L, Gao Y, Huang H, Pan XW, Liu X, Chen M, Qu FJ, Li L, Wang JK, Cui XG, Xu DF
OncoTargets and therapy 2018;11:5797-5809
OncoTargets and therapy 2018;11:5797-5809
Apoptosis of bone marrow mesenchymal stromal/stem cells via the MAPK and endoplasmic reticulum stress signaling pathways.
Chen T, Zhu H, Wang Y, Zhao P, Chen J, Sun J, Zhang X, Zhu G
American journal of translational research 2018;10(8):2555-2566
American journal of translational research 2018;10(8):2555-2566
Prostaglandin F(2α) Facilitates Hepatic Glucose Production Through CaMKIIγ/p38/FOXO1 Signaling Pathway in Fasting and Obesity.
Wang Y, Yan S, Xiao B, Zuo S, Zhang Q, Chen G, Yu Y, Chen D, Liu Q, Liu Y, Shen Y, Yu Y
Diabetes 2018 Sep;67(9):1748-1760
Diabetes 2018 Sep;67(9):1748-1760
New insights into meningitic Escherichia coli infection of brain microvascular endothelial cells from quantitative proteomics analysis.
Liu WT, Lv YJ, Yang RC, Fu JY, Liu L, Wang H, Cao Q, Tan C, Chen HC, Wang XR
Journal of neuroinflammation 2018 Oct 19;15(1):291
Journal of neuroinflammation 2018 Oct 19;15(1):291
Neuroprotective Effect of Oxysophocarpine by Modulation of MAPK Pathway in Rat Hippocampal Neurons Subject to Oxygen-Glucose Deprivation and Reperfusion.
Zhao P, Chang RY, Liu N, Wang J, Zhou R, Qi X, Liu Y, Ma L, Niu Y, Sun T, Li YX, He YP, Yu JQ
Cellular and molecular neurobiology 2018 Mar;38(2):529-540
Cellular and molecular neurobiology 2018 Mar;38(2):529-540
All-Trans Retinoic Acid Ameliorates the Early Experimental Cerebral Ischemia-Reperfusion Injury in Rats by Inhibiting the Loss of the Blood-Brain Barrier via the JNK/P38MAPK Signaling Pathway.
Li M, Tian X, An R, Yang M, Zhang Q, Xiang F, Liu H, Wang Y, Xu L, Dong Z
Neurochemical research 2018 Jun;43(6):1283-1296
Neurochemical research 2018 Jun;43(6):1283-1296
Network pharmacology-based strategy for predicting active ingredients and potential targets of Yangxinshi tablet for treating heart failure.
Chen L, Cao Y, Zhang H, Lv D, Zhao Y, Liu Y, Ye G, Chai Y
Journal of ethnopharmacology 2018 Jun 12;219:359-368
Journal of ethnopharmacology 2018 Jun 12;219:359-368
Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-α pathway in mice.
Lu X, Liu T, Chen K, Xia Y, Dai W, Xu S, Xu L, Wang F, Wu L, Li J, Li S, Wang W, Yu Q, Feng J, Fan X, Zhou Y, Niu P, Guo C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jul;103:800-811
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jul;103:800-811
Asperuloside and Asperulosidic Acid Exert an Anti-Inflammatory Effect via Suppression of the NF-κB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages.
He J, Lu X, Wei T, Dong Y, Cai Z, Tang L, Liu M
International journal of molecular sciences 2018 Jul 12;19(7)
International journal of molecular sciences 2018 Jul 12;19(7)
Neuroprotective Effect of Curcumin Against Cerebral Ischemia-Reperfusion Via Mediating Autophagy and Inflammation.
Huang L, Chen C, Zhang X, Li X, Chen Z, Yang C, Liang X, Zhu G, Xu Z
Journal of molecular neuroscience : MN 2018 Jan;64(1):129-139
Journal of molecular neuroscience : MN 2018 Jan;64(1):129-139
Correlation of TGN-020 with the analgesic effects via ERK pathway activation after chronic constriction injury.
Zhao L, Li D, Liu N, Liu L, Zhang Z, Gao C, Kawano H, Zhou FY, Li HP
Molecular pain 2018 Jan-Dec;14:1744806918796057
Molecular pain 2018 Jan-Dec;14:1744806918796057
Scandoside Exerts Anti-Inflammatory Effect Via Suppressing NF-κB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages.
He J, Li J, Liu H, Yang Z, Zhou F, Wei T, Dong Y, Xue H, Tang L, Liu M
International journal of molecular sciences 2018 Feb 3;19(2)
International journal of molecular sciences 2018 Feb 3;19(2)
Metformin Protects against LPS-Induced Intestinal Barrier Dysfunction by Activating AMPK Pathway.
Wu W, Wang S, Liu Q, Shan T, Wang Y
Molecular pharmaceutics 2018 Aug 6;15(8):3272-3284
Molecular pharmaceutics 2018 Aug 6;15(8):3272-3284
Cold atmospheric plasma conveys selectivity on triple negative breast cancer cells both in vitro and in vivo.
Xiang L, Xu X, Zhang S, Cai D, Dai X
Free radical biology & medicine 2018 Aug 20;124:205-213
Free radical biology & medicine 2018 Aug 20;124:205-213
l-Homocysteine-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinaemia.
Leng YP, Ma YS, Li XG, Chen RF, Zeng PY, Li XH, Qiu CF, Li YP, Zhang Z, Chen AF
British journal of pharmacology 2018 Apr;175(8):1157-1172
British journal of pharmacology 2018 Apr;175(8):1157-1172
LPS‑induced proinflammatory cytokine expression in human airway epithelial cells and macrophages via NF‑κB, STAT3 or AP‑1 activation.
Liu X, Yin S, Chen Y, Wu Y, Zheng W, Dong H, Bai Y, Qin Y, Li J, Feng S, Zhao P
Molecular medicine reports 2018 Apr;17(4):5484-5491
Molecular medicine reports 2018 Apr;17(4):5484-5491
IAPP modulates cellular autophagy, apoptosis, and extracellular matrix metabolism in human intervertebral disc cells.
Wu X, Song Y, Liu W, Wang K, Gao Y, Li S, Duan Z, Shao Z, Yang S, Yang C
Cell death discovery 2017;3:16107
Cell death discovery 2017;3:16107
Salidroside pretreatment attenuates apoptosis and autophagy during hepatic ischemia-reperfusion injury by inhibiting the mitogen-activated protein kinase pathway in mice.
Feng J, Zhang Q, Mo W, Wu L, Li S, Li J, Liu T, Xu S, Fan X, Guo C
Drug design, development and therapy 2017;11:1989-2006
Drug design, development and therapy 2017;11:1989-2006
Anti-inflammatory activity of coptisine free base in mice through inhibition of NF-κB and MAPK signaling pathways.
Chen HB, Luo CD, Liang JL, Zhang ZB, Lin GS, Wu JZ, Li CL, Tan LH, Yang XB, Su ZR, Xie JH, Zeng HF
European journal of pharmacology 2017 Sep 15;811:222-231
European journal of pharmacology 2017 Sep 15;811:222-231
Spiroplasma eriocheiris induces mouse 3T6-Swiss albino cell apoptosis that associated with the infection mechanism.
Hou L, Gu W, Zhu H, Yao W, Wang W, Meng Q
Molecular immunology 2017 Nov;91:75-85
Molecular immunology 2017 Nov;91:75-85
Hepatoprotective effect of quercetin against LPS/d-GalN induced acute liver injury in mice by inhibiting the IKK/NF-κB and MAPK signal pathways.
Peng Z, Gong X, Yang Y, Huang L, Zhang Q, Zhang P, Wan R, Zhang B
International immunopharmacology 2017 Nov;52:281-289
International immunopharmacology 2017 Nov;52:281-289
The liver protection of propylene glycol alginate sodium sulfate preconditioning against ischemia reperfusion injury: focusing MAPK pathway activity.
Xu S, Niu P, Chen K, Xia Y, Yu Q, Liu N, Li J, Li S, Wu L, Feng J, Wang W, Lu X, Liu T, Wang F, Dai W, Fan X, Mo W, Xu L, Guo C
Scientific reports 2017 Nov 9;7(1):15175
Scientific reports 2017 Nov 9;7(1):15175
Antioxidation, anti-inflammation and anti-apoptosis by paeonol in LPS/d-GalN-induced acute liver failure in mice.
Gong X, Yang Y, Huang L, Zhang Q, Wan RZ, Zhang P, Zhang B
International immunopharmacology 2017 May;46:124-132
International immunopharmacology 2017 May;46:124-132
Diosmetin exerts anti-oxidative, anti-inflammatory and anti-apoptotic effects to protect against endotoxin-induced acute hepatic failure in mice.
Yang Y, Gong XB, Huang LG, Wang ZX, Wan RZ, Zhang P, Zhang QY, Chen Z, Zhang BS
Oncotarget 2017 May 9;8(19):30723-30733
Oncotarget 2017 May 9;8(19):30723-30733
Interactions between Sirt1 and MAPKs regulate astrocyte activation induced by brain injury in vitro and in vivo.
Li D, Liu N, Zhao HH, Zhang X, Kawano H, Liu L, Zhao L, Li HP
Journal of neuroinflammation 2017 Mar 29;14(1):67
Journal of neuroinflammation 2017 Mar 29;14(1):67
Chemical characterization of a novel polysaccharide ASKP-1 from Artemisia sphaerocephala Krasch seed and its macrophage activation via MAPK, PI3k/Akt and NF-κB signaling pathways in RAW264.7 cells.
Ren D, Lin D, Alim A, Zheng Q, Yang X
Food & function 2017 Mar 22;8(3):1299-1312
Food & function 2017 Mar 22;8(3):1299-1312
Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells.
Tu J, Li W, Zhang Y, Wu X, Song Y, Kang L, Liu W, Wang K, Li S, Hua W, Yang C
Inflammation 2017 Jun;40(3):725-734
Inflammation 2017 Jun;40(3):725-734
The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis.
Fan L, Cao X, Yan H, Wang Q, Tian X, Zhang L, He X, Borjihan G, Morigen
Oncotarget 2017 Jul 18;8(29):47250-47268
Oncotarget 2017 Jul 18;8(29):47250-47268
Protective effect of resveratrol against nigrostriatal pathway injury in striatum via JNK pathway.
Li D, Liu N, Zhao L, Tong L, Kawano H, Yan HJ, Li HP
Brain research 2017 Jan 1;1654(Pt A):1-8
Brain research 2017 Jan 1;1654(Pt A):1-8
Sinomenine hydrochloride attenuates the proliferation, migration, invasiveness, angiogenesis and epithelial-mesenchymal transition of clear-cell renal cell carcinoma cells via targeting Smad in vitro.
Zhao B, Liu L, Mao J, Liu K, Fan W, Liu J, Zhang Z, Li Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Dec;96:1036-1044
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Dec;96:1036-1044
Polysaccharides from Citrus grandis L. Osbeck suppress inflammation and relieve chronic pharyngitis.
Chen L, Lai Y, Dong L, Kang S, Chen X
Microbial pathogenesis 2017 Dec;113:365-371
Microbial pathogenesis 2017 Dec;113:365-371
Anti-colon cancer effect of caffeic acid p-nitro-phenethyl ester in vitro and in vivo and detection of its metabolites.
Tang H, Yao X, Yao C, Zhao X, Zuo H, Li Z
Scientific reports 2017 Aug 8;7(1):7599
Scientific reports 2017 Aug 8;7(1):7599
Radiation promotes epithelial-to-mesenchymal transition and invasion of pancreatic cancer cell by activating carcinoma-associated fibroblasts.
Li D, Qu C, Ning Z, Wang H, Zang K, Zhuang L, Chen L, Wang P, Meng Z
American journal of cancer research 2016;6(10):2192-2206
American journal of cancer research 2016;6(10):2192-2206
Charaterization and immunomodulatory activities of polysaccharide isolated from Pleurotus eryngii.
Xu D, Wang H, Zheng W, Gao Y, Wang M, Zhang Y, Gao Q
International journal of biological macromolecules 2016 Nov;92:30-36
International journal of biological macromolecules 2016 Nov;92:30-36
The p38 MAPK inhibitor BIRB796 enhances the antitumor effects of VX680 in cervical cancer.
Jin X, Mo Q, Zhang Y, Gao Y, Wu Y, Li J, Hao X, Ma D, Gao Q, Chen P
Cancer biology & therapy 2016 May 3;17(5):566-76
Cancer biology & therapy 2016 May 3;17(5):566-76
High Expression of Rab-like 3 (Rabl3) is Associated with Poor Survival of Patients with Non-Small Cell Lung Cancer via Repression of MAPK8/9/10-Mediated Autophagy.
Zhang W, Sun J, Luo J
Medical science monitor : international medical journal of experimental and clinical research 2016 May 10;22:1582-8
Medical science monitor : international medical journal of experimental and clinical research 2016 May 10;22:1582-8
Clinicopathological significance of p38β, p38γ, and p38δ and its biological roles in esophageal squamous cell carcinoma.
Zheng S, Yang C, Liu T, Liu Q, Dai F, Sheyhidin I, Lu X
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Jun;37(6):7255-66
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Jun;37(6):7255-66
Arsenic-induced anti-angiogenesis via miR-425-5p-regulated CCM3.
Gao Y, Yin Y, Xing X, Zhao Z, Lu Y, Sun Y, Zhuang Z, Wang M, Ji W, He Y
Toxicology letters 2016 Jul 8;254:22-31
Toxicology letters 2016 Jul 8;254:22-31
Preventive Effects of a Novel Polysaccharide from Sepia esculenta Ink on Ovarian Failure and Its Action Mechanisms in Cyclophosphamide-Treated Mice.
Liu HZ, Tao YX, Luo P, Deng CM, Gu YP, Yang L, Zhong JP
Journal of agricultural and food chemistry 2016 Jul 20;64(28):5759-66
Journal of agricultural and food chemistry 2016 Jul 20;64(28):5759-66
Ghrelin protects against palmitic acid or lipopolysaccharide-induced hepatocyte apoptosis through inhibition of MAPKs/iNOS and restoration of Akt/eNOS pathways.
Mao Y, Wang J, Yu F, Li Z, Li H, Guo C, Fan X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Dec;84:305-313
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Dec;84:305-313
Paper-based microreactor array for rapid screening of cell signaling cascades.
Huang CH, Lei KF, Tsang NM
Lab on a chip 2016 Aug 7;16(15):2911-20
Lab on a chip 2016 Aug 7;16(15):2911-20
Protective effects of p-nitro caffeic acid phenethyl ester on acute myocardial ischemia-reperfusion injury in rats.
DU Q, Hao C, Gou J, Li X, Zou K, He X, Li Z
Experimental and therapeutic medicine 2016 Apr;11(4):1433-1440
Experimental and therapeutic medicine 2016 Apr;11(4):1433-1440
Knee loading inhibits osteoclast lineage in a mouse model of osteoarthritis.
Li X, Yang J, Liu D, Li J, Niu K, Feng S, Yokota H, Zhang P
Scientific reports 2016 Apr 18;6:24668
Scientific reports 2016 Apr 18;6:24668
RhNRG-1β Protects the Myocardium against Irradiation-Induced Damage via the ErbB2-ERK-SIRT1 Signaling Pathway.
Gu A, Jie Y, Sun L, Zhao S, E M, You Q
PloS one 2015;10(9):e0137337
PloS one 2015;10(9):e0137337
Astaxanthin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy via the ROS/MAPK Pathway in Mice.
Li J, Wang F, Xia Y, Dai W, Chen K, Li S, Liu T, Zheng Y, Wang J, Lu W, Zhou Y, Yin Q, Lu J, Zhou Y, Guo C
Marine drugs 2015 May 27;13(6):3368-87
Marine drugs 2015 May 27;13(6):3368-87
Polychlorinated biphenyl quinone induces endothelial barrier dysregulation by setting the cross talk between VE-cadherin, focal adhesion, and MAPK signaling.
Zhang P, Feng S, Bai H, Zeng P, Chen F, Wu C, Peng Y, Zhang Q, Zhang Q, Ye Q, Xue Q, Xu X, Song E, Song Y
American journal of physiology. Heart and circulatory physiology 2015 May 15;308(10):H1205-14
American journal of physiology. Heart and circulatory physiology 2015 May 15;308(10):H1205-14
Effect of baicalin-copper on the induction of apoptosis in human hepatoblastoma cancer HepG2 cells.
Li X, Zou K, Gou J, Du Q, Li D, He X, Li Z
Medical oncology (Northwood, London, England) 2015 Mar;32(3):72
Medical oncology (Northwood, London, England) 2015 Mar;32(3):72
Neohesperidin Dihydrochalcone versus CCl₄-Induced Hepatic Injury through Different Mechanisms: The Implication of Free Radical Scavenging and Nrf2 Activation.
Su C, Xia X, Shi Q, Song X, Fu J, Xiao C, Chen H, Lu B, Sun Z, Wu S, Yang S, Li X, Ye X, Song E, Song Y
Journal of agricultural and food chemistry 2015 Jun 10;63(22):5468-75
Journal of agricultural and food chemistry 2015 Jun 10;63(22):5468-75
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The p38 MAPK antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human p38 MAPK. This antibody recognizes human,mouse,rat antigen. The p38 MAPK antibody has been validated for the following applications: ELISA, WB analysis.
