66234-1-Ig

antibody from Proteintech Group

Targeting: MAPK14 CSBP1, CSBP2, CSPB1, Mxi2, p38, PRKM14, PRKM15

Provider product page for 66234-1-Ig

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [65]
Comments [0]
Validations [0]

Submit

Product number: 66234-1-Ig - Provider product page
Provider: Proteintech Group
Product name: p38 MAPK antibody
Antibody type: Monoclonal
Description: KD/KO validated p38 MAPK antibody (Cat. #66234-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, pig and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Porcine
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 1A1C2
Vial size: 20ul, 150ul

MAPK14 protein structure - 66234-1-Ig shown in red.

Submitted references Blockade of the ADAM8-Fra-1 complex attenuates neuroinflammation by suppressing the Map3k4/MAPKs axis after spinal cord injury.

Qian Z, Li R, Zhao T, Xie K, Li P, Li G, Shen N, Gong J, Hong X, Yang L, Li H
Cellular & molecular biology letters 2024 May 16;29(1):75

Resveratrol-loaded sulfated Hericium erinaceus β-glucan-chitosan nanoparticles: Preparation, characterization and synergistic anti-inflammatory effects.

Zhang Z, Ge M, Wu D, Li W, Chen W, Liu P, Zhang H, Yang Y
Carbohydrate polymers 2024 May 15;332:121916

Fucoidan Improves Early Stage Diabetic Nephropathy via the Gut Microbiota-Mitochondria Axis in High-Fat Diet-Induced Diabetic Mice.

Zhong Z, Zhang Y, Wei Y, Li X, Ren L, Li Y, Zhang X, Chen C, Yin X, Liu R, Wang Q
Journal of agricultural and food chemistry 2024 May 1;72(17):9755-9767

Tectoridin inhibits the growth of bladder cancer by regulating PI3K/MAPK pathway through RAB27B.

Zhang Q, Wang L, Yu L, Yu Q, Xue L, Shen Z
Molecular carcinogenesis 2024 Jun;63(6):1106-1116

ZeXieYin formula alleviates atherosclerosis by inhibiting the MAPK/NF-κB signaling pathway in APOE-/- mice to attenuate vascular inflammation and increase plaque stability.

Huang R, Sun Y, Liu R, Zhu B, Zhang H, Wu H
Journal of ethnopharmacology 2024 Jun 12;327:117969

Rack1-mediated ferroptosis affects hindgut development in rats with anorectal malformations: Spatial transcriptome insights.

Wang CY, Li MY, Li SY, Wei XG, Dong NX, Liu ST, Yuan ZW, Li B, Pierro A, Tang XB, Bai YZ
Cell proliferation 2024 Jul;57(7):e13618

GRP78 Downregulation in Keratinocytes Promotes Skin Inflammation through the Recruitment and Activation of CCR6(+) IL-17A-Producing γδ T Cells.

Zhao L, Li J, Jiang B, Yang J, Lan J, Li D, Wen J, Xia Y, Nie W, Wang Z, Lv Y, Zeng F, Li Y, Shen G, Lei P, Tao J
The Journal of investigative dermatology 2024 Jul;144(7):1557-1567.e11

Revealing the improvement of diabetes by Si Wei Jiang Huang Tang San through ERK/HIF1α signaling pathway via network pharmacology.

Xu T, He P, namWangdu S, Xu C, Hou B, Ma P, Wang Z, Zhang L, Du G, Ring T, Ji T, Qiang G
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117254

Dietary supplementation of benzoic acid and essential oils combination enhances intestinal resilience against LPS stimulation in weaned piglets.

Cui C, Wei Y, Wang Y, Ma W, Zheng X, Wang J, Ma Z, Wu C, Chu L, Zhang S, Guan W, Chen F
Journal of animal science and biotechnology 2024 Jan 19;15(1):4

C-C Motif Chemokine 2 Regulates Macrophage Polarization and Contributes to Myocardial Infarction Healing.

Chen L, Pan D, Zhang Y, Zhang E, Ma L
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2024 Feb;44(2):68-79

FSH preserves the viability of hypoxic granulosa cells via activating the HIF-1α-GAS6-Axl-Akt pathway.

Li C, Fu C, He T, Liu Z, Zhou J, Wu G, Liu H, Shen M
Journal of cellular physiology 2024 Feb;239(2):e31162

Puerarin inhibits NHE1 activity by interfering with the p38 pathway and attenuates mitochondrial damage induced by myocardial calcium overload in heart failure rats.

Pan G, Cui B, Han M, Lin L, Li Y, Wang L, Guo S, Yin Y, Zhan H, Li P
Acta biochimica et biophysica Sinica 2024 Feb 25;56(2):270-279

The involvement of Neuregulin-1 in the process of facial nerve injury repair through the utilization of dental pulp stem cells.

Yao L, Xu W, Liu L, Xu X, Xi H, Xue B, Cao X, Lin S, Piao G, Sun J, Wang X
BMC oral health 2024 Feb 14;24(1):238

METTL3-mediated RanGAP1 promotes colorectal cancer progression through the MAPK pathway by recruiting YTHDF1.

Yang R, Yang C, Su D, Song Y, Min J, Qian Z, Shen X, Li J, Su H
Cancer gene therapy 2024 Apr;31(4):562-573

Network pharmacology and experimental validation of effects of total saponins extracted from Abrus cantoniensis Hance on acetaminophen-induced liver injury.

He J, Chen L, Wang P, Cen B, Li J, Wei Y, Yao X, Xu Z
Journal of ethnopharmacology 2024 Apr 24;324:117740

The Role of p38 Mitogen-Activated Protein Kinase-Mediated F-Actin in the Acupuncture-Induced Mitigation of Inflammatory Pain in Arthritic Rats.

Zhou X, Zhang YC, Lu KQ, Xiao R, Tang WC, Wang F
Brain sciences 2024 Apr 14;14(4)

Indirubin alleviates CCl(4)-induced liver fibrosis by regulation of TGF-β-mediated signaling pathways.

Li X, Yao Y, Wei L
Iranian journal of basic medical sciences 2023;26(9):1047-1052

LINC00938 alleviates hypoxia ischemia encephalopathy induced neonatal brain injury by regulating oxidative stress and inhibiting JNK/p38 MAPK signaling pathway.

Zhao J, Le M, Li J, Huang Q, Chen H, Zhang W, Mao H, Sun Q, Li A, Zhao Y, Yu L, Yi M, Wang J, Li X, Zhang G, Ma J, Dong X
Experimental neurology 2023 Sep;367:114449

CD73 inhibits titanium particle-associated aseptic loosening by alternating activation of macrophages.

Sun Z, Kang J, Yang S, Zhang Y, Huang N, Zhang X, Du G, Jiang J, Ning B
International immunopharmacology 2023 Sep;122:110561

3,5,6-Trichloro-2-pyridinol confirms ototoxicity in mouse cochlear organotypic cultures and induces cytotoxicity in HEI-OC1 cells.

Huang M, Zou M, Mao S, Xu W, Hong Y, Wang H, Gui F, Yang L, Lian F, Chen R
Toxicology and applied pharmacology 2023 Sep 15;475:116612

Theabrownin Isolated from Pu-Erh Tea Enhances the Innate Immune and Anti-Inflammatory Effects of RAW264.7 Macrophages via the TLR2/4-Mediated Signaling Pathway.

Zhao L, Miao Y, Shan B, Zhao C, Peng C, Gong J
Foods (Basel, Switzerland) 2023 Mar 30;12(7)

Differences in p38-STAT3-S100A11 signaling after the administration of aristolochic acid I and IVa may account for the disparity in their nephrotoxicity.

Xian Z, Tian J, Zhao Y, Yi Y, Li C, Han J, Zhang Y, Wang Y, Wang L, Liu S, Pan C, Liu C, Wang D, Meng J, Tang X, Wang F, Liang A
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154815

Patrinia villosa treat colorectal cancer by activating PI3K/Akt signaling pathway.

Li XC, Wang S, Yang XX, Li TJ, Gu JX, Zhao L, Bao YR, Meng XS
Journal of ethnopharmacology 2023 Jun 12;309:116264

Role of PDLIM1 in hepatic stellate cell activation and liver fibrosis progression.

Ye B, Yu M, Yue M, Yin M, Zhang C, Wang Q, Ding X, Shen W, Zhao Z
Scientific reports 2023 Jul 6;13(1):10946

Tea Polyphenols Protects Tracheal Epithelial Tight Junctions in Lung during Actinobacillus pleuropneumoniae Infection via Suppressing TLR-4/MAPK/PKC-MLCK Signaling.

Li X, Liu Z, Gao T, Liu W, Yang K, Guo R, Li C, Tian Y, Wang N, Zhou D, Bei W, Yuan F
International journal of molecular sciences 2023 Jul 24;24(14)

HIV Tat-Conjugated Histone H3 Peptides Induce Tumor Cell Death Via Cellular Stress Responses.

Xu Q, Zhu F, Pan Y, Ren Y, Li J, Huang N, Liu K, Wang Y
Human gene therapy 2023 Jan;34(1-2):42-55

Sodium houttuyfonate against cardiac fibrosis attenuates isoproterenol-induced heart failure by binding to MMP2 and p38.

Tan R, You Q, Cui J, Wang M, Song N, An K, Lin L, Adu-Amankwaah J, Yuan J, Sun H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;109:154590

LncRNA BCAR4 promotes migration, invasion, and chemo-resistance by inhibiting miR-644a in breast cancer.

Wu T, Li X, Yan G, Tan Z, Zhao D, Liu S, Wang H, Xiang Y, Chen W, Lu H, Liao X, Li Y, Lu Z
Journal of experimental & clinical cancer research : CR 2023 Jan 10;42(1):14

Anti-inflammatory effects of extracellular vesicles from Morchella on LPS-stimulated RAW264.7 cells via the ROS-mediated p38 MAPK signaling pathway.

Chen Q, Che C, Yang S, Ding P, Si M, Yang G
Molecular and cellular biochemistry 2023 Feb;478(2):317-327

GABA induced by sleep deprivation promotes the proliferation and migration of colon tumors through miR-223-3p endogenous pathway and exosome pathway.

Bao H, Peng Z, Cheng X, Jian C, Li X, Shi Y, Zhu W, Hu Y, Jiang M, Song J, Fang F, Chen J, Shu X
Journal of experimental & clinical cancer research : CR 2023 Dec 18;42(1):344

Comprehensive serum metabolomics and network analysis to reveal the mechanism of gypenosides in treating lung cancer and enhancing the pharmacological effects of cisplatin.

Qi YS, Xiao MY, Xie P, Xie JB, Guo M, Li FF, Piao XL
Frontiers in pharmacology 2022;13:1070948

Traditional herbal formula Jiao-tai-wan improves chronic restrain stress-induced depression-like behaviors in mice.

Tang Y, Wang H, Nie K, Gao Y, Su H, Wang Z, Lu F, Huang W, Dong H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113284

Impact of Resolvin D1 on the inflammatory phenotype of periodontal ligament cell response to hypoxia.

Cai J, Liu J, Yan J, Lu X, Wang X, Li S, Mustafa K, Wang H, Xue Y, Mustafa M, Kantarci A, Xing Z
Journal of periodontal research 2022 Oct;57(5):1034-1042

Knockdown of TTC9 inhibits the proliferation, migration and invasion, but induces the apoptosis of lung adenocarcinoma cells.

Huang X, Jiang L, Wen Z, Yuan M, Zhong Y
Heliyon 2022 Nov;8(11):e11254

Hypotonic induction of aquaporin5 expression in rat astrocytes through p38 MAPK pathway.

Yi Y, Qiu G, Liu H, Gao F, Liu X, Chen Y, Yang M
Anatomia, histologia, embryologia 2022 Nov;51(6):769-780

Protective Effect of Resveratrol on Immortalized Duck Intestinal Epithelial Cells Exposed to H(2)O(2).

Zhou N, Tian Y, Wu H, Cao Y, Li R, Zou K, Xu W, Lu L
Molecules (Basel, Switzerland) 2022 May 31;27(11)

CX-5461 is a potent immunosuppressant which inhibits T cell-mediated alloimmunity via p53-DUSP5.

Pan G, Zhang J, Han Y, Chen Y, Guo X, Cui X, Cheng M, Gao H, Wang J, Jiang F
Pharmacological research 2022 Mar;177:106120

ERK/p38/ROS burst responses to environmentally relevant concentrations of diphenyl phosphate-evoked neutrophil extracellular traps formation: Assessing the role of autophagy.

Li S, Ma Y, Ye S, Hu D, Xiao F
Journal of hazardous materials 2022 Jan 5;421:126758

γ-mangostin attenuates amyloid-β42-induced neuroinflammation and oxidative stress in microglia-like BV2 cells via the mitogen-activated protein kinases signaling pathway.

Kong C, Jia L, Jia J
European journal of pharmacology 2022 Feb 15;917:174744

Salidroside inhibited cerebral ischemia/reperfusion-induced oxidative stress and apoptosis via Nrf2/Trx1 signaling pathway.

Li F, Mao Q, Wang J, Zhang X, Lv X, Wu B, Yan T, Jia Y
Metabolic brain disease 2022 Dec;37(8):2965-2978

Effects of natural 24-epibrassinolide on inducing apoptosis and restricting metabolism in hepatocarcinoma cells.

Zhou H, Zhuang W, Huang H, Ma N, Lei J, Jin G, Wu S, Zhou S, Zhao X, Lan L, Xia H, Shangguan F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Dec;107:154428

Incomplete autophagy promotes the proliferation of Mycoplasma hyopneumoniae through the JNK and Akt pathways in porcine alveolar macrophages.

Wen Y, Chen Z, Tian Y, Yang M, Dong Q, Yang Y, Ding H
Veterinary research 2022 Aug 4;53(1):62

Targeting Forkhead box O1-aquaporin 5 axis mitigates neuropathic pain in a CCI rat model through inhibiting astrocytic and microglial activation.

Yu Y, Wang M, Yu X, Yan Y, Yu B, Zhang D
Bioengineered 2022 Apr;13(4):8567-8580

Elevation of α-1,3 fucosylation promotes the binding ability of TNFR1 to TNF-α and contributes to osteoarthritic cartilage destruction and apoptosis.

Yu H, Li M, Wen X, Yang J, Liang X, Li X, Bao X, Shu J, Ren X, Chen W, Li Z, Li Y
Arthritis research & therapy 2022 Apr 29;24(1):93

Gut Microbiota Was Involved in the Process of Liver Injury During Intra-Abdominal Hypertension.

Zhao Z, Guo Z, Yin Z, Qiu Y, Zhou B
Frontiers in physiology 2021;12:790182

The Anti-Inflammatory Effect of a Combination of Five Compounds From Five Chinese Herbal Medicines Used in the Treatment of COPD.

Li J, Zhao P, Tian Y, Li K, Zhang L, Guan Q, Mei X, Qin Y
Frontiers in pharmacology 2021;12:709702

A network pharmacology strategy to investigate the anti-osteoarthritis mechanism of main lignans components of Schisandrae Fructus.

Min L, Wu Y, Cao G, Mi D, Chen C
International immunopharmacology 2021 Sep;98:107873

Shikonin Induced Program Cell Death through Generation of Reactive Oxygen Species in Renal Cancer Cells.

Tsai MF, Chen SM, Ong AZ, Chung YH, Chen PN, Hsieh YH, Kang YT, Hsu LS
Antioxidants (Basel, Switzerland) 2021 Nov 18;10(11)

Proof-of-concept study investigating the role of S100P-RAGE in nasopharyngeal carcinoma.

Wang C, Wang X, Han A, Wang Y, Jiang H
Experimental and therapeutic medicine 2021 May;21(5):470

Anti-thrombotic effects mediated by dihydromyricetin involve both platelet inhibition and endothelial protection.

Chen S, Lv K, Sharda A, Deng J, Zeng W, Zhang C, Hu Q, Jin P, Yao G, Xu X, Ming Z, Fang C
Pharmacological research 2021 May;167:105540

Berberine-photodynamic therapy sensitizes melanoma cells to cisplatin-induced apoptosis through ROS-mediated P38 MAPK pathways.

Wang X, Gong Q, Song C, Fang J, Yang Y, Liang X, Huang X, Liu J
Toxicology and applied pharmacology 2021 May 1;418:115484

A neutral polysaccharide from Ophiocordyceps lanpingensis restrains cisplatin-induced nephrotoxicity.

Zhou S, Zhou Y, Yu J, Jiang L, Xiang Y, Wang J, Du Y, Cui X, Ge F
Food science & nutrition 2021 Jul;9(7):3602-3616

FOXO1 mediates hypoxia-induced G0/G1 arrest in ovarian somatic granulosa cells by activating the TP53INP1-p53-CDKN1A pathway.

Li C, Liu Z, Wu G, Zang Z, Zhang JQ, Li X, Tao J, Shen M, Liu H
Development (Cambridge, England) 2021 Jul 15;148(14)

Possible relationship between mitochondrial changes and oxidative stress under low dose-rate irradiation.

Meng Q, Zaharieva EK, Sasatani M, Kobayashi J
Redox report : communications in free radical research 2021 Dec;26(1):160-169

Metformin inhibits MAPK signaling and rescues pancreatic aquaporin 7 expression to induce insulin secretion in type 2 diabetes mellitus.

He X, Gao F, Hou J, Li T, Tan J, Wang C, Liu X, Wang M, Liu H, Chen Y, Yu Z, Yang M
The Journal of biological chemistry 2021 Aug;297(2):101002

Circular RNA 0001313 Knockdown Suppresses Non-Small Cell Lung Cancer Cell Proliferation and Invasion via the microRNA-452/HMGB3/ERK/MAPK Axis.

Zhang S, Liu J, Yuan T, Liu H, Wan C, Le Y
International journal of general medicine 2020;13:1495-1507

Cardamonin Reduces Acetaminophen-Induced Acute Liver Injury in Mice via Activating Autophagy and NFE2L2 Signaling.

Xu Q, Fan Y, Loor JJ, Liang Y, Sun X, Jia H, Zhao C, Xu C
Frontiers in pharmacology 2020;11:601716

LMP1 promotes nasopharyngeal carcinoma metastasis through NTRK2-mediated anoikis resistance.

Li Z, Zhou Z, Wu X, Zhou Q, Liao C, Liu Y, Li D, Shen L, Feng D, Yang L
American journal of cancer research 2020;10(7):2083-2099

The AKT/GSK3-Mediated Slug Expression Contributes to Oxaliplatin Resistance in Colorectal Cancer via Upregulation of ERCC1.

Wei W, Ma XD, Jiang GM, Shi B, Zhong W, Sun CL, Zhao L, Hou YJ, Wang H
Oncology research 2020 Sep 1;28(4):423-438

lncRNA TPTEP1 inhibits stemness and radioresistance of glioma through miR‑106a‑5p‑mediated P38 MAPK signaling.

Tang T, Wang LX, Yang ML, Zhang RM
Molecular medicine reports 2020 Dec;22(6):4857-4867

Effects of RhoC downregulation on the angiogenesis characteristics of myeloma vascular endothelial cells.

Zhao Z, Liu K, Tian X, Sun M, Wei N, Zhu X, Yang H, Wang T, Jiang G, Chen K
Cancer medicine 2019 Jul;8(7):3502-3510

Cathepsin C promotes microglia M1 polarization and aggravates neuroinflammation via activation of Ca(2+)-dependent PKC/p38MAPK/NF-κB pathway.

Liu Q, Zhang Y, Liu S, Liu Y, Yang X, Liu G, Shimizu T, Ikenaka K, Fan K, Ma J
Journal of neuroinflammation 2019 Jan 16;16(1):10

Melamine causes testicular toxicity by destroying blood-testis barrier in piglets.

Chang L, Lu Z, Li D, Zhang L, Wang Z, Du Q, Huang Y, Zhao X, Tong D
Toxicology letters 2018 Oct 15;296:114-124

Cathelicidin-WA attenuates LPS-induced inflammation and redox imbalance through activation of AMPK signaling.

Wu W, Wang S, Liu Q, Wang X, Shan T, Wang Y
Free radical biology & medicine 2018 Dec;129:338-353

Mda‑7/IL‑24 induces the differentiation of B cell lymphoma via activation of the P38 mitogen activated protein kinase signaling pathway.

Ma M, Yang X, Zhao L, Liu L, Zhang C, Wang X, Shan B
Molecular medicine reports 2017 Oct;16(4):5633-5642

No comments: Submit comment

No validations: Submit validation data