66854-1-Ig

antibody from Proteintech Group

Targeting: RIPK1 RIP

Provider product page for 66854-1-Ig

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Antibody data

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Product number: 66854-1-Ig - Provider product page
Provider: Proteintech Group
Product name: Phospho-RIPK1 (Ser161) antibody
Antibody type: Monoclonal
Description: Phospho-RIPK1 (Ser161) antibody (Cat. #66854-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human and has been validated for the following applications: IF, IHC, WB, ELISA.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 1B2G1
Vial size: 20ul, 100ul

RIPK1 protein structure - 66854-1-Ig shown in red.

Submitted references Targeted Induction of Cancer Cell Necroptosis Potentiates Anti-PD-1 Immunotherapy via CD80 Activation.

Zhang X, Zhang D, Zhou Z, Liu W, Zhu S, Xiong S, Chen X, Peng C
International journal of biological sciences 2026;22(4):2085-2100

Curcumol Induces Necroptosis of Hepatic Stellate Cells by Targeting KAT8 to Suppress HK2 Lactylation and Promote HUWE1-Dependent Ubiquitination.

Guo X, Lin Y, Jiang Y, Wang M, Li Y, Gao Y, Chen B, Bao Z, Tian H, Chu X, Zhang Z, Shao J, Zhang F, Wang H, Xuan J, Xu X, Zheng S
International journal of biological sciences 2026;22(3):1648-1673

Targeting ROS-metabolism dual pathways to trigger PANoptosis by cobalt-vanadium oxides biomimetic nanocakes for tumor immunotherapy.

Du S, Ma G, Li X, Chao M, Fan L, Zhao Z, Tang R, Li J, Jing C, Liu Y, Yu D, Liu Z, Gao F
Biomaterials 2026 Mar;326:123726

NPM3 functions as a lactyltransferase to promote necroptosis in male diabetic cardiomyopathy mice models via FASN transcription modulation.

Xu H, Jiang X, Wang F, Meng F, Liu Y, Huang J, Li J, Zhu M
Nature communications 2026 Mar 9;17(1)

Obacunone inhibits RIPK1/RIPK3/MLKL-mediated necroptosis by suppressing mitochondrial ROS and MIF signaling in intestinal ischemia-reperfusion injury.

Li XY, Xie JY, Yin YT, Weng XG, Huang ZY, Wang LS, Ding K, Chen R, Meng QT
International immunopharmacology 2026 Jan 1;168(Pt 2):115901

NLK facilitates Caspase-8 activation to drive macrophage PANoptosis in sepsis.

Xia Y, Yao RQ, Liu HF, Jing GQ, Aidebaike D, Zuo J, Wan SQ, Wu D, Zhao PY, Gong HL, Wang X, Zhou HM, Dong N, Wu Y, Liu S, Wu XJ, Yao YM, Song XM
Clinical and translational medicine 2026 Feb;16(2):e70616

From Hit to Lead: Discovery of Novel Selective RIPK1 Inhibitor with Pyridoimidazole Scaffold for the Treatment of Autoimmune Diseases through Phenotypic Screening and Structural Optimization.

Wan J, Xiong XY, Geng Z, Yuan B, Ma Y, Zhao Y, Dorothy Wong ZY, Kang X, Fan R, Min D, Yan H, Chen Y, He DY, Zuo JP, Xu HC, Ding Y, Liu Z, Hu Z, Li F, Sun N, Zhao Y, Lin ZM, Tang ML
Journal of medicinal chemistry 2026 Feb 12;69(3):3252-3288

Sirtuin 5-mediated desuccinylation of PRDX6 inhibits ferroptosis and alleviates sepsis-associated acute kidney injury.

Lin W, Dong C, Jiang Q, Lou Y, Wang L, He Z
Redox report : communications in free radical research 2026 Dec 31;31(1):2657075

Lupenone regulates LOXL2-mediated PANoptosis signaling through E3 ubiquitin ligases RNF168 to improve radiation-induced lung injury.

Wang SY, Zhu WJ, Xiu MX, Zhao GY, Hou Y, Sun HM
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157983

Metformin Attenuates Myocardial Ischemia-Reperfusion Injury in Rats by Modulating JNK Pathway and Inhibiting PANoptosis Mechanisms.

Hou B, Hou X, Zhang L, Liu T, Li Y, Dong R
Cardiovascular therapeutics 2025;2025:4642838

Oxidative stress-mediated PANoptosis and ferroptosis: Exploration of multimodal cell death triggered by an AIE-active nano-photosensitizer via photodynamic therapy.

Wang Y, Chai C, Lin W, Cao J, Li Z, Jin Y, Xu Y, Zhang J, Qu Y, Zhan J, Zhao T, Chen Y, Gao M, Huang C, Li M
Theranostics 2025;15(14):6665-6685

Protective effects of Exocarpium Citri Grandis against sepsis-induced acute lung injury via PANoptosis inhibition.

Xu Z, Wang K, Hu H, Chen Y, Qiu Y, Cai J, Li W, Luo Z, Li H, Huang J
Frontiers in nutrition 2025;12:1661404

Salvianolic Acid B Inhibits ZBP1-Mediated PANoptosis in Mycobacterium tuberculosis-Infected Macrophages by Targeting TNFR1.

Shen J, Fu Y, Liu F, Wu J, Zhang H, Sun J, Miao Z, Jiang X
Phytotherapy research : PTR 2025 Sep;39(9):4028-4045

PPP1R3G Deletion Blocks RIPK1-Mediated Apoptosis and Necroptosis in Doxorubicin-Induced Cardiotoxicity.

Ma X, Chen K, Wang Z
bioRxiv : the preprint server for biology 2025 Sep 28;

Inhibition of MMP9 ameliorates neutrophil extracellular traps-mediated necroptosis through regulation of impaired autophagy in severe acute pancreatitis.

Zhang H, Wang Z, Li J, Jia Y, Xie X, Ding Y, Cao F, Li F
International immunopharmacology 2025 Sep 23;162:115109

Methyl 3,4-dihydrobenzoate attenuates muscle fiber necroptosis and macrophage pyroptosis by regulating oxidative stress in inflammatory myopathies.

Tang Q, Cheng J, Zhu T, Zhou Z, Xia P
International immunopharmacology 2025 May 8;154:114608

Baitouweng decoction modulates gut microbial production of indole-3-propionic acid and epithelial necroptosis to alleviate DSS-induced colitis in mice.

Hu J, Chen H, Zhu L, Tong Y, Cheng C, Yan G, Shen H
Chinese medicine 2025 Jul 31;20(1):119

PGAM5 promotes RIPK1-PANoptosome activity by phosphorylating and activating RIPK1 to mediate PANoptosis after subarachnoid hemorrhage in rats.

Jiajia D, Wen Y, Enyan J, Xiaojian Z, Zhen F, Jia Z, Jikai W, Xiaoxin Y, Aihua L, Fangen K, Fei L
Experimental neurology 2025 Feb;384:115072

E3 ubiquitin ligase Pellino1 suppresses acinar cell necroptosis and alleviates severe acute pancreatitis by promoting ubiquitin-dependent receptor-interacting protein kinase 3 (RIP3) degradation.

Chen J, Huang Z, Jing P, Shi H, Liu S, Feng L, Long Y, Ye M, Fu W, Tan P
British journal of pharmacology 2025 Dec;182(24):6100-6119

ZIKV infection causes placental inflammation through activating PANoptosis.

Zhang S, Chen D, Zhang K, Liu M, Liang H, Liang L, Liang J, Liang M, An S, Lyu M, Zhu J, Li S, Hu D, Zhu X, Wu J, He Z, Li M
Journal of virology 2025 Dec 23;99(12):e0175925

Nucleosome assembly protein-like 1 degradation-dependent novel cardioprotection mechanism of Wnt2 against ischemia‒reperfusion injury.

Wang Y, Chen L, Lin J, Liu X, Jin K, Huang C, Wang H, Jia J, Wu J, Ding Z, Gao P, Ge J, Gong H, Zou Y
Signal transduction and targeted therapy 2025 Dec 16;10(1):403

Cilostazol attenuates vascular inflammation via the regulation of TICAM1/IRF3 signaling pathway.

Chiu HW, Shih CC, Huang HJ, Huang TH, Sung LC
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Aug;189:118275

[Tianma Gouteng Granule improves motor deficits in mouse models of Parkinson's disease by regulating the necroptosis pathway].

Chen D, Ren Q, Lü M, Zhang B, Liu X, Zhang M, Wang Y, Kou X
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2025 Aug 20;45(8):1571-1580

MyoD is essential in rhabdomyosarcoma by promoting survival through differentiation and CYLD.

Oles AR, Yu PY, Udeme AA, Sharma S, Londhe P, Pryce BR, Talbert EE, Hill EM, Miranda CJ, Kaspar BK, Arnold MA, Hyland J, London CA, Houghton PJ, Wang DJ, Roberts RD, Guttridge DC
iScience 2025 Aug 15;28(8):113149

Faecalibacterium prausnitzii-derived outer membrane vesicles reprogram gut microbiota metabolism to alleviate Porcine Epidemic Diarrhea Virus infection.

Xing J, Niu T, Yu T, Zou B, Shi C, Wang Y, Fan S, Li M, Bao M, Sun Y, Gao K, Qiu J, Zhang D, Wang N, Jiang Y, Huang H, Cao X, Zeng Y, Wang J, Zhang S, Hu J, Zhang D, Sun W, Yang G, Yang W, Wang C
Microbiome 2025 Apr 2;13(1):90

A Small Molecule Inhibitor of Leucine Carboxyl Methyltransferase-1 Inhibits Cancer Cell Survival.

Arosarena OA, Saribas AS, Papadopoulos EP
Frontiers in drug discovery 2024;4

Targeting the PANoptosis signaling pathway for myocardial protection: therapeutic potential of Xian Ling Gu Bao capsule.

Wu X, Wei J, Zhang W, Yi Y, Wang T, Gong Q, Liu X, Li H, Gao J
Frontiers in pharmacology 2024;15:1391511

Aurantiamide mitigates acute kidney injury by suppressing renal necroptosis and inflammation via GRPR-dependent mechanism.

He RB, Li W, Yao R, Xu MY, Dong W, Chen Y, Ni WJ, Xie SS, Sun ZH, Li C, Liu D, Li SJ, Ji ML, Ru YX, Zhao T, Zhu Q, Wen JG, Li J, Jin J, Yao RS, Meng XM
International immunopharmacology 2024 Sep 30;139:112745

RIPK1 inhibition mitigates neuroinflammation and rescues depressive-like behaviors in a mouse model of LPS-induced depression.

Gong Q, Ali T, Hu Y, Gao R, Mou S, Luo Y, Yang C, Li A, Li T, Hao LL, He L, Yu X, Li S
Cell communication and signaling : CCS 2024 Sep 2;22(1):427

Bimetallic peroxide nanoparticles induce PANoptosis by disrupting ion homeostasis for enhanced immunotherapy.

Hou G, Chen Y, Lei H, Lu Y, Liu L, Han Z, Sun S, Li J, Cheng L
Science advances 2024 Nov 8;10(45):eadp7160

Supplemented Gegen Qinlian Decoction Formula attenuates podocyte mitochondrial fission and renal fibrosis in diabetic kidney disease by inhibiting TNF-α-mediated necroptosis, compared with empagliflozin.

Wang Y, Yu L, Li Y, Cha S, Shi L, Wang J, Ge F, Huang C, Huang H, Tu Y, Wan Y, Shen S
Journal of ethnopharmacology 2024 Nov 15;334:118572

NR4A1 depletion inhibits colorectal cancer progression by promoting necroptosis via the RIG-I-like receptor pathway.

Zhu J, Li J, Yang K, Chen Y, Wang J, He Y, Shen K, Wang K, Shi T, Chen W
Cancer letters 2024 Mar 31;585:216693

Low-intensity pulsed ultrasound delays the progression of osteoarthritis by regulating the YAP-RIPK1-NF-κB axis and influencing autophagy.

Pan C, Lu F, Hao X, Deng X, Liu J, Sun K, Hou W, Shang X, Chi R, Guo F, Xu T
Journal of translational medicine 2024 Mar 16;22(1):286

lncRNA FLJ20021 regulates CDK1-mediated PANoptosis in a ZBP1-dependent manner to increase the sensitivity of laryngeal cancer-resistant cells to cisplatin.

Yin X, Zhang H, Wang J, Bian Y, Jia Q, Yang Z, Shan C
Discover oncology 2024 Jul 5;15(1):265

IRF1 regulation of ZBP1 links mitochondrial DNA and chondrocyte damage in osteoarthritis.

Sun K, Lu F, Hou L, Zhang X, Pan C, Liu H, Zheng Z, Guo Z, Ruan Z, Hou Y, Zhang J, Guo F, Zhu W
Cell communication and signaling : CCS 2024 Jul 18;22(1):366

NUAK1 promotes metabolic dysfunction-associated steatohepatitis progression by activating Caspase 6-driven pyroptosis and inflammation.

Sheng M, Huo S, Jia L, Weng Y, Liu W, Lin Y, Yu W
Hepatology communications 2024 Jul 1;8(7)

JianPiYiShen formula prevents cisplatin-induced acute kidney injury in mice by improving necroptosis through MAPK pathway.

Li Z, He R, Liu J, Jin X, Jiang B, Lao Y, Yang S
BMC complementary medicine and therapies 2024 Feb 24;24(1):101

Prosapogenin A induces GSDME-dependent pyroptosis of anaplastic thyroid cancer through vacuolar ATPase activation-mediated lysosomal over-acidification.

Liu Y, Guo Y, Zeng Q, Hu Y, He R, Ma W, Qian C, Hua T, Song F, Cai Y, Zhu L, Ren X, Xu J, Zheng C, Ding L, Ge J, Wang W, Xu H, Ge M, Zheng G
Cell death & disease 2024 Aug 13;15(8):586

A natural chalcone cardamonin inhibits necroptosis and ameliorates dextran sulfate sodium (DSS)-induced colitis by targeting RIPK1/3 kinases.

Shen X, Chen H, Wen T, Liu L, Yang Y, Xie F, Wang L
European journal of pharmacology 2023 Sep 5;954:175840

Ursolic Acid Promotes Autophagy by Inhibiting Akt/mTOR and TNF-α/TNFR1 Signaling Pathways to Alleviate Pyroptosis and Necroptosis in Mycobacterium tuberculosis-Infected Macrophages.

Shen J, Fu Y, Liu F, Ning B, Jiang X
Inflammation 2023 Oct;46(5):1749-1763

Functional Characterization of a Familial ALS-Associated Missense TBK1 (p-Arg573Gly) Mutation in Patient-Derived Lymphoblasts.

Porras G, Ruiz S, Maestro I, Borrego-Hernández D, Redondo AG, Martínez A, Martín-Requero Á
International journal of molecular sciences 2023 Feb 2;24(3)

Lactoferrin attenuated urban particulate matter-induced nephrotoxicity by regulating the CSF2/CENPE axis.

Liu WC, Chiu HW, Chou CL, Chiu YJ, Lee YH
Environmental pollution (Barking, Essex : 1987) 2023 Feb 1;318:120871

Identification of necroptosis-related genes for predicting prognosis and exploring immune infiltration landscape in colon adenocarcinoma.

Wang Y, Lin MG, Meng L, Chen ZM, Wei ZJ, Ying SC, Xu A
Frontiers in oncology 2022;12:941156

Myo-inositol oxygenase overexpression exacerbates cadmium-induced kidney injury via oxidant stress and necroptosis.

Zheng X, Deng F, Sharma I, Kanwar YS
American journal of physiology. Renal physiology 2022 Mar 1;322(3):F344-F359

LRG-1 promotes fat graft survival through the RAB31-mediated inhibition of hypoxia-induced apoptosis.

Ho CK, Zheng D, Sun J, Wen D, Wu S, Yu L, Gao Y, Zhang Y, Li Q
Journal of cellular and molecular medicine 2022 Jun;26(11):3153-3168

Exosome-Derived LncRNA TCONS_00072128 Mediated Osteogenic Differentiation and Inflammation by Caspase 8 Regulation.

Yang Y, Miao L, Chang S, Zhang Q, Yu L, He P, Zhang Y, Fan W, Liu J, Hao X
Frontiers in genetics 2021;12:831420

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