Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations
- Blocking/Neutralizing [1]
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Validation data
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- Product number
- MAB705-100 - Provider product page
- Provider
- R&D Systems
- Product name
- Mouse IL-5 Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects mouse IL-5.
- Reactivity
- Mouse
- Host
- Rat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- TRFK4
- Vial size
- 100 ug
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Ectopic lung transplantation induces the accumulation of eosinophil progenitors in the recipients' lungs through an allergen- and interleukin-5-dependent mechanism.
Xavier-Elsas P, Santos-Maximiano E, Queto T, Mendonça-Sales S, Joseph D, Gaspar-Elsas MI, Vargaftig BB
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2007 Jan;37(1):29-38
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2007 Jan;37(1):29-38
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Supportive validation
- Submitted by
- R&D Systems (provider)
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- Experimental details
- Cell Proliferation Induced by IL-5 and Neutralization by Mouse IL-5 Antibody. Recombinant Mouse IL-5 (Catalog # 405-ML) stimulates proliferation in the TF-1 human erythroleukemic cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Mouse IL-5 (1.25 ng/mL) is neutralized (green line) by increasing concentrations of Mouse IL-5 Monoclonal Antibody (Catalog # MAB705). The ND50 is typically 0.7-3.5 µg/mL.