BS8275

antibody from Bioworld Technology, Inc
Targeting: FRS2 FRS2A, FRS2alpha, SNT-1, SNT1
Provider product page for BS8275
Western blot
Immunohistochemistry

Antibody data

Product number
BS8275 - Provider product page
Provider
Bioworld Technology, Inc
Product name
FRS2 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human FRS2.
Description
FRS2 (also designated SNT or p90) is a lipid-anchored docking protein that becomes tyrosine phosphorylated in response to FGF or NGF stimulation and subsequently binds to GRB2/Sos complexes . The GRB2 adapter protein links receptor tyrosine kinases to the Ras/MAPK signaling pathway but does not interact directly with FGF receptors . FRS2 thus provides a link between activation of FGF and NGF receptors and the Ras/MAPK pathway. FRS2 contains four Grb2 binding sites, a myristylation sequence and a PTP domain. Myristylation of FRS2 is essential for membrane localization, tyrosine phosphorylation, GRB2/Sos recruitment and MAPK activation . The function of FRS2 in FGF receptor signaling is analogous to that of IRS1 in response to insulin receptor stimulation .
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
FRS2 protein structure - BS8275 shown in red.