Antibody data
- Antibody Data
- Antigen structure
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- Product number
- BS8275 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- FRS2 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human FRS2.
- Description
- FRS2 (also designated SNT or p90) is a lipid-anchored docking protein that becomes tyrosine phosphorylated in response to FGF or NGF stimulation and subsequently binds to GRB2/Sos complexes . The GRB2 adapter protein links receptor tyrosine kinases to the Ras/MAPK signaling pathway but does not interact directly with FGF receptors . FRS2 thus provides a link between activation of FGF and NGF receptors and the Ras/MAPK pathway. FRS2 contains four Grb2 binding sites, a myristylation sequence and a PTP domain. Myristylation of FRS2 is essential for membrane localization, tyrosine phosphorylation, GRB2/Sos recruitment and MAPK activation . The function of FRS2 in FGF receptor signaling is analogous to that of IRS1 in response to insulin receptor stimulation .
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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