14961-1-AP

antibody from Proteintech Group

Targeting: RAD51 BRCC5, FANCR, HsRad51, HsT16930, RAD51A, RECA

Provider product page for 14961-1-AP

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Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [68]
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Validations
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Product number: 14961-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14961-1-AP, RRID:AB_2177083
Product name: RAD51 antibody
Antibody type: Polyclonal
Description: KD/KO validated RAD51 antibody (Cat. #14961-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IP, WB, ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

RAD51 protein structure - 14961-1-AP shown in red.

Submitted references Bevacizumab increases the sensitivity of olaparib to homologous recombination-proficient ovarian cancer by suppressing CRY1 via PI3K/AKT pathway.

Iida Y, Yanaihara N, Yoshino Y, Saito M, Saito R, Tabata J, Kawabata A, Takenaka M, Chiba N, Okamoto A
Frontiers in oncology 2024;14:1302850

An interpretable artificial intelligence framework for designing synthetic lethality-based anti-cancer combination therapies.

Wang J, Wen Y, Zhang Y, Wang Z, Jiang Y, Dai C, Wu L, Leng D, He S, Bo X
Journal of advanced research 2024 Nov;65:329-343

YAP1-CPNE3 positive feedback pathway promotes gastric cancer cell progression.

Li X, Zhong H, Shi Q, Ruan R, Huang C, Wen Q, Zeng S, Xia Y, Zeng Q, Xiong J, Wang S, Chen J, Lei W, Deng J
Cellular and molecular life sciences : CMLS 2024 Mar 17;81(1):143

Reconstitution of the antagonistic effect between C1orf112/FIRRM-FIGNL1 and BRCA2 on RAD51 filament stabilization.

Zhou Z, Yang H, Liang X, Zhou T, Liu Q, Wang J, Wang W
STAR protocols 2024 Mar 15;5(1):102791

IGF-I protects porcine granulosa cells from hypoxia-induced apoptosis by promoting homologous recombination repair through the PI3K/AKT/E2F8/RAD51 pathway.

Liu Z, Feng C, Li C, He T, Wu G, Fu C, Li H, Shen M, Liu H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan;38(1):e23332

Deep-targeted gene sequencing reveals ARID1A mutation as an important driver of glioblastoma.

Xiao M, Cui X, Xu C, Xin L, Zhao J, Yang S, Hong B, Tan Y, Zhang J, Li X, Li J, Kang C, Fang C
CNS neuroscience & therapeutics 2024 Apr;30(4):e14698

Abrogation of KLF5 sensitizes BRCA1-proficient pancreatic cancer to PARP inhibition.

Zhang Z, Liu Y, Xu Y, Xu Z, Jia J, Jin Y, Wang W, Liu L
Acta biochimica et biophysica Sinica 2024 Apr 25;56(4):576-585

Identification of key enzalutamide-resistance-related genes in castration-resistant prostate cancer and verification of RAD51 functions.

Xu W, Liu L, Cui Z, Li M, Ni J, Huang N, Zhang Y, Luo J, Sun L, Sun F
Open medicine (Warsaw, Poland) 2023;18(1):20230715

Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages.

Kim H, Aliar K, Tharmapalan P, McCloskey CW, Kuttanamkuzhi A, Grünwald BT, Palomero L, Mahendralingam MJ, Waas M, Mer AS, Elliott MJ, Zhang B, Al-Zahrani KN, Langille ER, Parsons M, Narala S, Hofer S, Waterhouse PD, Hakem R, Haibe-Kains B, Kislinger T, Schramek D, Cescon DW, Pujana MA, Berman HK, Khokha R
Cell reports 2023 Oct 31;42(10):113256

KLF5 Promotes Tumor Progression and Parp Inhibitor Resistance in Ovarian Cancer.

Wu Y, Chen S, Shao Y, Su Y, Li Q, Wu J, Zhu J, Wen H, Huang Y, Zheng Z, Chen X, Ju X, Huang S, Wu X, Hu Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Nov;10(31):e2304638

Modulation of cell cycle increases CRISPR-mediated homology-directed DNA repair.

Li G, Yang X, Luo X, Wu Z, Yang H
Cell & bioscience 2023 Nov 25;13(1):215

Micelle encapsulation zinc-doped copper oxide nanocomposites reverse Olaparib resistance in ovarian cancer by disrupting homologous recombination repair.

Yi J, Luo X, Xing J, Gedanken A, Lin X, Zhang C, Qiao G
Bioengineering & translational medicine 2023 May;8(3):e10507

Creatine kinase brain-type regulates BCAR1 phosphorylation to facilitate DNA damage repair.

Yang B, Zhang W, Sun L, Lu B, Yin C, Zhang Y, Jiang H
iScience 2023 May 19;26(5):106684

Alphaherpesvirus upregulates NDRG1 expression to facilitate the nuclear import of viral UL31 and UL34 proteins.

Zhang S, Ming SL, Zeng L, Wang LF, Zhang C, Zhu HS, Yang GY, Zhang GP, Chu BB, Wang J
Journal of medical virology 2023 Mar;95(3):e28591

C11orf54 promotes DNA repair via blocking CMA-mediated degradation of HIF1A.

Tan J, Wang W, Liu X, Xu J, Che Y, Liu Y, Hu J, Hu L, Li J, Zhou Q
Communications biology 2023 Jun 5;6(1):606

LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer.

Dey G, Bharti R, Braley C, Alluri R, Esakov E, Crean-Tate K, McCrae K, Joehlin-Price A, Rose PG, Lathia J, Gong Z, Reizes O
Journal of ovarian research 2023 Jun 27;16(1):122

Transcriptionally regulated miR-26a-5p may act as BRCAness in Triple-Negative Breast Cancer.

Zhang Y, Lv L, Zheng R, Xie R, Yu Y, Liao H, Chen J, Zhang B
Breast cancer research : BCR 2023 Jun 26;25(1):75

Radiation resistance of cancer cells caused by mitochondrial dysfunction depends on SIRT3-mediated mitophagy.

Wei Y, Xiao G, Xu H, Sun X, Shi Y, Wang F, Kang J, Peng J, Zhou F
The FEBS journal 2023 Jul;290(14):3629-3645

Cancer-Associated Fibroblasts Promote Radioresistance of Breast Cancer Cells via the HGF/c-Met Signaling Pathway.

Wang B, Liu W, Liu C, Du K, Guo Z, Zhang G, Huang Z, Lin S, Cen B, Tian Y, Yuan Y, Bu J
International journal of radiation oncology, biology, physics 2023 Jul 1;116(3):640-654

Paclitaxel sensitizes homologous recombination-proficient ovarian cancer cells to PARP inhibitor via the CDK1/BRCA1 pathway.

Yanaihara N, Yoshino Y, Noguchi D, Tabata J, Takenaka M, Iida Y, Saito M, Yanagida S, Iwamoto M, Kiyokawa T, Chiba N, Okamoto A
Gynecologic oncology 2023 Jan;168:83-91

Antitumor efficacy of a recombinant EGFR-targeted fusion protein conjugate that induces telomere shortening and telomerase downregulation.

Tao HY, He SM, Zhao CY, Wang Y, Sheng WJ, Zhen YS
International journal of biological macromolecules 2023 Jan 31;226:1088-1099

ERCC6L facilitates the progression of laryngeal squamous cell carcinoma by the binding of FOXM1 and KIF4A.

Cui M, Chang Y, Wang J, Wu J, Li G, Tan J
Cell death discovery 2023 Feb 2;9(1):41

Regulation of DNA damage response by trimeric G-proteins.

Abd El-Hafeez AA, Sun N, Chakraborty A, Ear J, Roy S, Chamarthi P, Rajapakse N, Das S, Luker KE, Hazra TK, Luker GD, Ghosh P
iScience 2023 Feb 17;26(2):105973

GAPDH facilitates homologous recombination repair by stabilizing RAD51 in an HDAC1-dependent manner.

Shi M, Hou J, Liang W, Li Q, Shao S, Ci S, Shu C, Zhao X, Zhao S, Huang M, Wu C, Hu Z, He L, Guo Z, Pan F
EMBO reports 2023 Aug 3;24(8):e56437

C1orf112 teams up with FIGNL1 to facilitate RAD51 filament disassembly and DNA interstrand cross-link repair.

Zhou Z, Yang H, Liang X, Zhou T, Zhang T, Yang Y, Wang J, Wang W
Cell reports 2023 Aug 29;42(8):112907

SOSSB1 and SOSSB2 mutually regulate protein stability through competitive binding of SOSSA.

Zhang Q, Hao R, Chen H, Zhou G
Cell death discovery 2023 Aug 28;9(1):319

Combination with vorinostat enhances the antitumor activity of cisplatin in castration-resistant prostate cancer by inhibiting DNA damage repair pathway and detoxification of GSH.

Chang T, Lian Z, Ma S, Liang Z, Ma X, Wen X, Wang Y, Liu R
The Prostate 2023 Apr;83(5):470-486

The Pathogenic R3052W BRCA2 Variant Disrupts Homology-Directed Repair by Failing to Localize to the Nucleus.

Jimenez-Sainz J, Krysztofiak A, Garbarino J, Rogers F, Jensen RB
Frontiers in genetics 2022;13:884210

ITGB5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting DNA damage repair and the MEK/ERK signaling pathway.

Wen X, Chen S, Chen X, Qiu H, Wang W, Zhang N, Liu W, Wang T, Ding X, Zhang L
Frontiers in oncology 2022;12:887068

BRCA2 BRC missense variants disrupt RAD51-dependent DNA repair.

Jimenez-Sainz J, Mathew J, Moore G, Lahiri S, Garbarino J, Eder JP, Rothenberg E, Jensen RB
eLife 2022 Sep 13;11

KIAA1529 regulates RAD51 expression to confer PARP inhibitors resistance in ovarian cancer.

Qiao Y, Yu X, Zhou B, Zhang K, Huang J, Liao J
Translational oncology 2022 Oct;24:101497

Identification of Candidate Genes in Breast Cancer Induced by Estrogen Plus Progestogens Using Bioinformatic Analysis.

Deng Y, Huang H, Shi J, Jin H
International journal of molecular sciences 2022 Oct 6;23(19)

Venetoclax enhances DNA damage induced by XPO1 inhibitors: A novel mechanism underlying the synergistic antileukaemic effect in acute myeloid leukaemia.

Yu H, Wu S, Liu S, Li X, Gai Y, Lin H, Wang Y, Edwards H, Ge Y, Wang G
Journal of cellular and molecular medicine 2022 May;26(9):2646-2657

METTL3 promotes homologous recombination repair and modulates chemotherapeutic response in breast cancer by regulating the EGF/RAD51 axis.

Li E, Xia M, Du Y, Long K, Ji F, Pan F, He L, Hu Z, Guo Z
eLife 2022 May 3;11

SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early meiotic recombination.

Guan Y, Lin H, Leu NA, Ruthel G, Fuchs SY, Busino L, Luo M, Wang PJ
Nucleic acids research 2022 May 20;50(9):5129-5144

Acquired temozolomide resistance in MGMT(low) gliomas is associated with regulation of homologous recombination repair by ROCK2.

Zhang X, Li T, Yang M, Du Q, Wang R, Fu B, Tan Y, Cao M, Chen Y, Wang Q, Hu R
Cell death & disease 2022 Feb 10;13(2):138

Mitochondrial dysfunction induces radioresistance in colorectal cancer by activating [Ca(2+)](m)-PDP1-PDH-histone acetylation retrograde signaling.

Shi Y, Wang Y, Jiang H, Sun X, Xu H, Wei X, Wei Y, Xiao G, Song Z, Zhou F
Cell death & disease 2021 Sep 6;12(9):837

Predictive value of RAD51 on the survival and drug responsiveness of ovarian cancer.

Feng Y, Wang D, Xiong L, Zhen G, Tan J
Cancer cell international 2021 May 5;21(1):249

Hollow PtCo alloy nanospheres as a high-Z and oxygen generating nanozyme for radiotherapy enhancement in non-small cell lung cancer.

Li S, Sun W, Luo Y, Gao Y, Jiang X, Yuan C, Han L, Cao K, Gong Y, Xie C
Journal of materials chemistry. B 2021 Jun 16;9(23):4643-4653

HORMAD1 promotes docetaxel resistance in triple negative breast cancer by enhancing DNA damage tolerance.

Zong B, Sun L, Peng Y, Wang Y, Yu Y, Lei J, Zhang Y, Guo S, Li K, Liu S
Oncology reports 2021 Jul;46(1)

AEG-1 Knockdown Sensitizes Glioma Cells to Radiation Through Impairing Homologous Recombination Via Targeting RFC5.

Zhao X, Sun Y, Sun X, Li J, Shi X, Liang Z, Ma Y, Zhang X
DNA and cell biology 2021 Jul;40(7):895-905

MET inhibition enhances PARP inhibitor efficacy in castration-resistant prostate cancer by suppressing the ATM/ATR and PI3K/AKT pathways.

Zhou S, Dai Z, Wang L, Gao X, Yang L, Wang Z, Wang Q, Liu Z
Journal of cellular and molecular medicine 2021 Dec;25(24):11157-11169

BRD4 inhibition sensitizes cervical cancer to radiotherapy by attenuating DNA repair.

Ni M, Li J, Zhao H, Xu F, Cheng J, Yu M, Ke G, Wu X
Oncogene 2021 Apr;40(15):2711-2724

CRSP8 promotes thyroid cancer progression by antagonizing IKKα-induced cell differentiation.

Liao Y, Hua Y, Li Y, Zhang C, Yu W, Guo P, Zou K, Li W, Sun Y, Wang R, Zuo Y, Sui S, Tian C, Hao J, Chen M, Hu S, Chen M, Long Q, Wang X, Zou L, Xie F, Guo W, Deng W
Cell death and differentiation 2021 Apr;28(4):1347-1363

MFP-FePt-GO Nanocomposites Promote Radiosensitivity of Non-Small Cell Lung Cancer Via Activating Mitochondrial-Mediated Apoptosis and Impairing DNA Damage Repair.

Peng S, Sun Y, Luo Y, Ma S, Sun W, Tang G, Li S, Zhang N, Ren J, Xiao Y, Liu X, Zhang J, Gong Y, Xie C
International journal of biological sciences 2020;16(12):2145-2158

Dual inhibition of VEGF and PARP suppresses KRAS-mutant colorectal cancer.

Zhong L, Wang R, Wang Y, Peng S, Ma Y, Ding S, Yang H, Chen S, Luo X, Wang W
Neoplasia (New York, N.Y.) 2020 Sep;22(9):365-375

Inhibition of survivin induces spindle disorganization, chromosome misalignment, and DNA damage during mouse embryo development.

Pan MH, Ju JQ, Li XH, Xu Y, Wang JD, Ren YP, Lu X, Sun SC
Cell cycle (Georgetown, Tex.) 2020 Sep;19(17):2148-2157

CHK1 monitors spindle assembly checkpoint and DNA damage repair during the first cleavage of mouse early embryos.

Ju JQ, Li XH, Pan MH, Xu Y, Sun MH, Xu Y, Sun SC
Cell proliferation 2020 Oct;53(10):e12895

YY1-mediated PTEN dephosphorylation antagonizes IR-induced DNA repair contributing to tongue squamous cell carcinoma radiosensitization.

Zhao L, Li R, Qiu JZ, Yu JB, Cao Y, Yuan RT
Molecular and cellular probes 2020 Oct;53:101577

UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation.

Sun J, Zhu Z, Li W, Shen M, Cao C, Sun Q, Guo Z, Liu L, Wu D
Journal of experimental & clinical cancer research : CR 2020 Oct 21;39(1):222

Cell type-specific genotoxicity in estrogen-exposed ovarian and fallopian epithelium.

Song L, Tang Z, Peng C, Yang Y, Guo C, Wang D, Guo L, Chen J, Liu C
BMC cancer 2020 Oct 21;20(1):1020

Rab1A promotes cancer metastasis and radioresistance through activating GSK-3β/Wnt/β-catenin signaling in nasopharyngeal carcinoma.

Yang XZ, Chen XM, Zeng LS, Deng J, Ma L, Jin C, Wang R, Wang MH, Wen YF, Wu XL, Wang HY, Cui SZ
Aging 2020 Oct 17;12(20):20380-20395

DNA methylation‑regulated miR‑155‑5p depresses sensitivity of esophageal carcinoma cells to radiation and multiple chemotherapeutic drugs via suppression of MAP3K10.

Luo W, Zhang H, Liang X, Xia R, Deng H, Yi Q, Lv L, Qian L
Oncology reports 2020 May;43(5):1692-1704

β-Elemene enhances radiosensitivity in non-small-cell lung cancer by inhibiting epithelial-mesenchymal transition and cancer stem cell traits via Prx-1/NF-kB/iNOS signaling pathway.

Zou K, Li Z, Zhang Y, Mu L, Chen M, Wang R, Deng W, Zou L, Liu J
Aging 2020 Dec 9;13(2):2575-2592

Berberine attenuates XRCC1-mediated base excision repair and sensitizes breast cancer cells to the chemotherapeutic drugs.

Gao X, Wang J, Li M, Wang J, Lv J, Zhang L, Sun C, Ji J, Yang W, Zhao Z, Mao W
Journal of cellular and molecular medicine 2019 Oct;23(10):6797-6804

MiR-34s negatively regulate homologous recombination through targeting RAD51.

Chen S, Liu R, Wang Q, Qi Z, Hu Y, Zhou P, Wang Z
Archives of biochemistry and biophysics 2019 May 15;666:73-82

Overexpression of KLF5 is associated with poor survival and G1/S progression in pancreatic cancer.

Li Y, Kong R, Chen H, Zhao Z, Li L, Li J, Hu J, Zhang G, Pan S, Wang Y, Wang G, Chen H, Sun B
Aging 2019 Jul 21;11(14):5035-5057

Triptolide interferes with XRCC1/PARP1-mediated DNA repair and confers sensitization of triple-negative breast cancer cells to cisplatin.

Zhang Z, Sun C, Zhang L, Chi X, Ji J, Gao X, Wang Y, Zhao Z, Liu L, Cao X, Yang Y, Mao W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jan;109:1541-1546

RDM1 promotes critical processes in breast cancer tumorigenesis.

Chen Y, Sun Z, Zhong T
Journal of cellular and molecular medicine 2019 Aug;23(8):5432-5439

LncRNA lnc-RI regulates homologous recombination repair of DNA double-strand breaks by stabilizing RAD51 mRNA as a competitive endogenous RNA.

Shen L, Wang Q, Liu R, Chen Z, Zhang X, Zhou P, Wang Z
Nucleic acids research 2018 Jan 25;46(2):717-729

Downregulation of Mitochondrial Single Stranded DNA Binding Protein (SSBP1) Induces Mitochondrial Dysfunction and Increases the Radiosensitivity in Non-Small Cell Lung Cancer Cells.

Wang Y, Hu L, Zhang X, Zhao H, Xu H, Wei Y, Jiang H, Xie C, Zhou Y, Zhou F
Journal of Cancer 2017;8(8):1400-1409

IER5 is involved in DNA Double-Strand Breaks Repair in Association with PAPR1 in Hela Cells.

Yu XP, Wu YM, Liu Y, Tian M, Wang JD, Ding KK, Ma T, Zhou PK
International journal of medical sciences 2017;14(12):1292-1300

Inhibition of Rad51 sensitizes breast cancer cells with wild-type PTEN to olaparib.

Zhao Q, Guan J, Zhang Z, Lv J, Wang Y, Liu L, Zhou Q, Mao W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Oct;94:165-168

Triptolide induces DNA breaks, activates caspase-3-dependent apoptosis and sensitizes B-cell lymphoma to poly(ADP-ribose) polymerase 1 and phosphoinositide 3-kinase inhibitors.

Guan J, Zhao Q, Lv J, Zhang Z, Sun S, Mao W
Oncology letters 2017 Oct;14(4):4965-4970

Nuclear PTEN interferes with binding of Ku70 at double-strand breaks through post-translational poly(ADP-ribosyl)ation.

Guan J, Zhao Q, Mao W
Biochimica et biophysica acta 2016 Dec;1863(12):3106-3115

Unpredicted Downregulation of RAD51 Suggests Genome Instability Induced by Tetrachlorobenzoquinone.

Song X, Shi Q, Liu Z, Wang Y, Wang Y, Song E, Song Y
Chemical research in toxicology 2016 Dec 19;29(12):2184-2193

5-Azacytidine enhances the radiosensitivity of CNE2 and SUNE1 cells in vitro and in vivo possibly by altering DNA methylation.

Jiang W, Li YQ, Liu N, Sun Y, He QM, Jiang N, Xu YF, Chen L, Ma J
PloS one 2014;9(4):e93273

Radiosensitisation of bladder cancer cells by panobinostat is modulated by Ku80 expression.

Groselj B, Kerr M, Kiltie AE
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2013 Sep;108(3):429-33

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The RAD51 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human RAD51. This antibody recognizes human, mouse, rat antigen. The RAD51 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 14961-1-AP.pdf

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