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Western blot
Immunocytochemistry
Proximity ligation assayAntibody data
- Antibody Data
- Antigen structure
- References [54]
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- Western blot [7]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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- Product number
- GTX70230 - Provider product page
- Provider
- GeneTex
- Proper citation
- GeneTex Cat#GTX70230, RRID:AB_372856
- Product name
- Rad51 antibody [14B4]
- Antibody type
- Monoclonal
- Reactivity
- Human, Mouse, Rat, Chicken/Avian
- Host
- Mouse
Submitted references The F-Box Domain-Dependent Activity of EMI1 Regulates PARPi Sensitivity in Triple-Negative Breast Cancers.
TPX2/Aurora kinase A signaling as a potential therapeutic target in genomically unstable cancer cells.
Mechanisms of Targeting the MDM2-p53-FOXM1 Axis in Well-Differentiated Intestinal Neuroendocrine Tumors.
Melatonin Sensitizes Hepatocellular Carcinoma Cells to Chemotherapy Through Long Non-Coding RNA RAD51-AS1-Mediated Suppression of DNA Repair.
Corylin increases the sensitivity of hepatocellular carcinoma cells to chemotherapy through long noncoding RNA RAD51-AS1-mediated inhibition of DNA repair.
The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair.
Prolonged exposure to particulate chromate inhibits RAD51 nuclear import mediator proteins.
Enhanced dependency of KRAS-mutant colorectal cancer cells on RAD51-dependent homologous recombination repair identified from genetic interactions in Saccharomyces cerevisiae.
A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability.
Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells.
Lung Basal Stem Cells Rapidly Repair DNA Damage Using the Error-Prone Nonhomologous End-Joining Pathway.
Chromatin organization revealed by nanostructure of irradiation induced γH2AX, 53BP1 and Rad51 foci.
Overexpression of TNKS1BP1 in lung cancers and its involvement in homologous recombination pathway of DNA double-strand breaks.
Delayed DNA double-strand break repair following platin-based chemotherapy predicts treatment response in head and neck squamous cell carcinoma.
Hyperthermia Synergizes with Chemotherapy by Inhibiting PARP1-Dependent DNA Replication Arrest.
Hypoxia Potentiates the Radiation-Sensitizing Effect of Olaparib in Human Non-Small Cell Lung Cancer Xenografts by Contextual Synthetic Lethality.
A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choice.
Synthesis, molecular modeling, and biological evaluation of novel RAD51 inhibitors.
Sensitization of Pancreatic Cancers to Gemcitabine Chemoradiation by WEE1 Kinase Inhibition Depends on Homologous Recombination Repair.
Inhibition of Homologous Recombination and Promotion of Mutagenic Repair of DNA Double-Strand Breaks Underpins Arabinoside-Nucleoside Analogue Radiosensitization.
CDK-mediated RNF4 phosphorylation regulates homologous recombination in S-phase.
NKX3.1 Suppresses TMPRSS2-ERG Gene Rearrangement and Mediates Repair of Androgen Receptor-Induced DNA Damage.
A mRad51-GFP antimorphic allele affects homologous recombination and DNA damage sensitivity.
Whole genomes redefine the mutational landscape of pancreatic cancer.
Ssb2/Nabp1 is dispensable for thymic maturation, male fertility, and DNA repair in mice.
Interplay of Rad51 with NF-κB pathway stimulates expression of HIV-1.
Rad51 activates polyomavirus JC early transcription.
A synthetic lethal screen identifies the Vitamin D receptor as a novel gemcitabine sensitizer in pancreatic cancer cells.
Re-purposing clinical kinase inhibitors to enhance chemosensitivity by overriding checkpoints.
Functional ex vivo assay to select homologous recombination-deficient breast tumors for PARP inhibitor treatment.
RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2.
Combined inhibition of Wee1 and PARP1/2 for radiosensitization in pancreatic cancer.
PI3K Inhibition Augments the Therapeutic Efficacy of a 3a-aza-Cyclopenta[α]indene Derivative in Lung Cancer Cells
PI3K Inhibition Augments the Therapeutic Efficacy of a 3a-aza-Cyclopenta[α]indene Derivative in Lung Cancer Cells.
A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization.
EGFR-activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity.
A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia.
Targeted radiosensitization by the Chk1 inhibitor SAR-020106.
A small ubiquitin binding domain inhibits ubiquitin-dependent protein recruitment to DNA repair foci.
Inhibition of protein phosphatase 2A radiosensitizes pancreatic cancers by modulating CDC25C/CDK1 and homologous recombination repair.
Sensitization of pancreatic cancer to chemoradiation by the Chk1 inhibitor MK8776.
Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment.
REV1 and polymerase ζ facilitate homologous recombination repair.
A mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressor.
ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery.
Evidence of an adaptive response targeting DNA nonhomologous end joining and its transmission to bystander cells.
A novel and simple micro-irradiation technique for creating localized DNA double-strand breaks.
A marker of homologous recombination predicts pathologic complete response to neoadjuvant chemotherapy in primary breast cancer.
NKX3.1 activates cellular response to DNA damage.
DNA-damage response, survival and differentiation in vitro of a human neural stem cell line in relation to ATM expression.
Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90.
Phenotypic effects of heterozygosity for a BRCA2 mutation.
Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response.
The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51.
Marzio A, Puccini J, Kwon Y, Maverakis NK, Arbini A, Sung P, Bar-Sagi D, Pagano M
Molecular cell 2019 Jan 17;73(2):224-237.e6
Molecular cell 2019 Jan 17;73(2):224-237.e6
TPX2/Aurora kinase A signaling as a potential therapeutic target in genomically unstable cancer cells.
van Gijn SE, Wierenga E, van den Tempel N, Kok YP, Heijink AM, Spierings DCJ, Foijer F, van Vugt MATM, Fehrmann RSN
Oncogene 2019 Feb;38(6):852-867
Oncogene 2019 Feb;38(6):852-867
Mechanisms of Targeting the MDM2-p53-FOXM1 Axis in Well-Differentiated Intestinal Neuroendocrine Tumors.
Briest F, Grass I, Sedding D, Möbs M, Christen F, Benecke J, Fuchs K, Mende S, Kaemmerer D, Sänger J, Kunze A, Geisler C, Freitag H, Lewens F, Worpenberg L, Iwaszkiewicz S, Siegmund B, Walther W, Hummel M, Grabowski P
Neuroendocrinology 2018;107(1):1-23
Neuroendocrinology 2018;107(1):1-23
Melatonin Sensitizes Hepatocellular Carcinoma Cells to Chemotherapy Through Long Non-Coding RNA RAD51-AS1-Mediated Suppression of DNA Repair.
Chen CC, Chen CY, Wang SH, Yeh CT, Su SC, Ueng SH, Chuang WY, Hsueh C, Wang TH
Cancers 2018 Sep 10;10(9)
Cancers 2018 Sep 10;10(9)
Corylin increases the sensitivity of hepatocellular carcinoma cells to chemotherapy through long noncoding RNA RAD51-AS1-mediated inhibition of DNA repair.
Chen CC, Chen CY, Ueng SH, Hsueh C, Yeh CT, Ho JY, Chou LF, Wang TH
Cell death & disease 2018 May 1;9(5):543
Cell death & disease 2018 May 1;9(5):543
The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair.
Baranes-Bachar K, Levy-Barda A, Oehler J, Reid DA, Soria-Bretones I, Voss TC, Chung D, Park Y, Liu C, Yoon JB, Li W, Dellaire G, Misteli T, Huertas P, Rothenberg E, Ramadan K, Ziv Y, Shiloh Y
Molecular cell 2018 Mar 1;69(5):866-878.e7
Molecular cell 2018 Mar 1;69(5):866-878.e7
Prolonged exposure to particulate chromate inhibits RAD51 nuclear import mediator proteins.
Browning CL, Wise JP Sr
Toxicology and applied pharmacology 2017 Sep 15;331:101-107
Toxicology and applied pharmacology 2017 Sep 15;331:101-107
Enhanced dependency of KRAS-mutant colorectal cancer cells on RAD51-dependent homologous recombination repair identified from genetic interactions in Saccharomyces cerevisiae.
Kalimutho M, Bain AL, Mukherjee B, Nag P, Nanayakkara DM, Harten SK, Harris JL, Subramanian GN, Sinha D, Shirasawa S, Srihari S, Burma S, Khanna KK
Molecular oncology 2017 May;11(5):470-490
Molecular oncology 2017 May;11(5):470-490
A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability.
Tan SLW, Chadha S, Liu Y, Gabasova E, Perera D, Ahmed K, Constantinou S, Renaudin X, Lee M, Aebersold R, Venkitaraman AR
Cell 2017 Jun 1;169(6):1105-1118.e15
Cell 2017 Jun 1;169(6):1105-1118.e15
Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells.
Schoonen PM, Talens F, Stok C, Gogola E, Heijink AM, Bouwman P, Foijer F, Tarsounas M, Blatter S, Jonkers J, Rottenberg S, van Vugt MATM
Nature communications 2017 Jul 17;8:15981
Nature communications 2017 Jul 17;8:15981
Lung Basal Stem Cells Rapidly Repair DNA Damage Using the Error-Prone Nonhomologous End-Joining Pathway.
Weeden CE, Chen Y, Ma SB, Hu Y, Ramm G, Sutherland KD, Smyth GK, Asselin-Labat ML
PLoS biology 2017 Jan;15(1):e2000731
PLoS biology 2017 Jan;15(1):e2000731
Chromatin organization revealed by nanostructure of irradiation induced γH2AX, 53BP1 and Rad51 foci.
Reindl J, Girst S, Walsh DW, Greubel C, Schwarz B, Siebenwirth C, Drexler GA, Friedl AA, Dollinger G
Scientific reports 2017 Jan 17;7:40616
Scientific reports 2017 Jan 17;7:40616
Overexpression of TNKS1BP1 in lung cancers and its involvement in homologous recombination pathway of DNA double-strand breaks.
Tan W, Guan H, Zou LH, Wang Y, Liu XD, Rang WQ, Zhou PK, Pei HD, Zhong CG
Cancer medicine 2017 Feb;6(2):483-493
Cancer medicine 2017 Feb;6(2):483-493
Delayed DNA double-strand break repair following platin-based chemotherapy predicts treatment response in head and neck squamous cell carcinoma.
Bhide SA, Thway K, Lee J, Wong K, Clarke P, Newbold KL, Nutting CM, Harrington KJ
British journal of cancer 2016 Sep 27;115(7):825-30
British journal of cancer 2016 Sep 27;115(7):825-30
Hyperthermia Synergizes with Chemotherapy by Inhibiting PARP1-Dependent DNA Replication Arrest.
Schaaf L, Schwab M, Ulmer C, Heine S, Mürdter TE, Schmid JO, Sauer G, Aulitzky WE, van der Kuip H
Cancer research 2016 May 15;76(10):2868-75
Cancer research 2016 May 15;76(10):2868-75
Hypoxia Potentiates the Radiation-Sensitizing Effect of Olaparib in Human Non-Small Cell Lung Cancer Xenografts by Contextual Synthetic Lethality.
Jiang Y, Verbiest T, Devery AM, Bokobza SM, Weber AM, Leszczynska KB, Hammond EM, Ryan AJ
International journal of radiation oncology, biology, physics 2016 Jun 1;95(2):772-81
International journal of radiation oncology, biology, physics 2016 Jun 1;95(2):772-81
A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choice.
Zhang H, Liu H, Chen Y, Yang X, Wang P, Liu T, Deng M, Qin B, Correia C, Lee S, Kim J, Sparks M, Nair AA, Evans DL, Kalari KR, Zhang P, Wang L, You Z, Kaufmann SH, Lou Z, Pei H
Nature communications 2016 Jan 5;7:10201
Nature communications 2016 Jan 5;7:10201
Synthesis, molecular modeling, and biological evaluation of novel RAD51 inhibitors.
Zhu J, Chen H, Guo XE, Qiu XL, Hu CM, Chamberlin AR, Lee WH
European journal of medicinal chemistry 2015;96:196-208
European journal of medicinal chemistry 2015;96:196-208
Sensitization of Pancreatic Cancers to Gemcitabine Chemoradiation by WEE1 Kinase Inhibition Depends on Homologous Recombination Repair.
Kausar T, Schreiber JS, Karnak D, Parsels LA, Parsels JD, Davis MA, Zhao L, Maybaum J, Lawrence TS, Morgan MA
Neoplasia (New York, N.Y.) 2015 Oct;17(10):757-66
Neoplasia (New York, N.Y.) 2015 Oct;17(10):757-66
Inhibition of Homologous Recombination and Promotion of Mutagenic Repair of DNA Double-Strand Breaks Underpins Arabinoside-Nucleoside Analogue Radiosensitization.
Magin S, Papaioannou M, Saha J, Staudt C, Iliakis G
Molecular cancer therapeutics 2015 Jun;14(6):1424-33
Molecular cancer therapeutics 2015 Jun;14(6):1424-33
CDK-mediated RNF4 phosphorylation regulates homologous recombination in S-phase.
Luo K, Deng M, Li Y, Wu C, Xu Z, Yuan J, Lou Z
Nucleic acids research 2015 Jun 23;43(11):5465-75
Nucleic acids research 2015 Jun 23;43(11):5465-75
NKX3.1 Suppresses TMPRSS2-ERG Gene Rearrangement and Mediates Repair of Androgen Receptor-Induced DNA Damage.
Bowen C, Zheng T, Gelmann EP
Cancer research 2015 Jul 1;75(13):2686-98
Cancer research 2015 Jul 1;75(13):2686-98
A mRad51-GFP antimorphic allele affects homologous recombination and DNA damage sensitivity.
Uringa EJ, Baldeyron C, Odijk H, Wassenaar E, van Cappellen WA, Maas A, Hoeijmakers JH, Baarends WM, Kanaar R, Essers J
DNA repair 2015 Jan;25:27-40
DNA repair 2015 Jan;25:27-40
Whole genomes redefine the mutational landscape of pancreatic cancer.
Waddell N, Pajic M, Patch AM, Chang DK, Kassahn KS, Bailey P, Johns AL, Miller D, Nones K, Quek K, Quinn MC, Robertson AJ, Fadlullah MZ, Bruxner TJ, Christ AN, Harliwong I, Idrisoglu S, Manning S, Nourse C, Nourbakhsh E, Wani S, Wilson PJ, Markham E, Cloonan N, Anderson MJ, Fink JL, Holmes O, Kazakoff SH, Leonard C, Newell F, Poudel B, Song S, Taylor D, Waddell N, Wood S, Xu Q, Wu J, Pinese M, Cowley MJ, Lee HC, Jones MD, Nagrial AM, Humphris J, Chantrill LA, Chin V, Steinmann AM, Mawson A, Humphrey ES, Colvin EK, Chou A, Scarlett CJ, Pinho AV, Giry-Laterriere M, Rooman I, Samra JS, Kench JG, Pettitt JA, Merrett ND, Toon C, Epari K, Nguyen NQ, Barbour A, Zeps N, Jamieson NB, Graham JS, Niclou SP, Bjerkvig R, Grützmann R, Aust D, Hruban RH, Maitra A, Iacobuzio-Donahue CA, Wolfgang CL, Morgan RA, Lawlor RT, Corbo V, Bassi C, Falconi M, Zamboni G, Tortora G, Tempero MA, Australian Pancreatic Cancer Genome Initiative., Gill AJ, Eshleman JR, Pilarsky C, Scarpa A, Musgrove EA, Pearson JV, Biankin AV, Grimmond SM
Nature 2015 Feb 26;518(7540):495-501
Nature 2015 Feb 26;518(7540):495-501
Ssb2/Nabp1 is dispensable for thymic maturation, male fertility, and DNA repair in mice.
Boucher D, Vu T, Bain AL, Tagliaro-Jahns M, Shi W, Lane SW, Khanna KK
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 Aug;29(8):3326-34
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 Aug;29(8):3326-34
Interplay of Rad51 with NF-κB pathway stimulates expression of HIV-1.
Kaminski R, Wollebo HS, Datta PK, White MK, Amini S, Khalili K
PloS one 2014;9(5):e98304
PloS one 2014;9(5):e98304
Rad51 activates polyomavirus JC early transcription.
White MK, Kaminski R, Khalili K, Wollebo HS
PloS one 2014;9(10):e110122
PloS one 2014;9(10):e110122
A synthetic lethal screen identifies the Vitamin D receptor as a novel gemcitabine sensitizer in pancreatic cancer cells.
Bhattacharjee V, Zhou Y, Yen TJ
Cell cycle (Georgetown, Tex.) 2014;13(24):3839-56
Cell cycle (Georgetown, Tex.) 2014;13(24):3839-56
Re-purposing clinical kinase inhibitors to enhance chemosensitivity by overriding checkpoints.
Beeharry N, Banina E, Hittle J, Skobeleva N, Khazak V, Deacon S, Andrake M, Egleston BL, Peterson JR, Astsaturov I, Yen TJ
Cell cycle (Georgetown, Tex.) 2014;13(14):2172-91
Cell cycle (Georgetown, Tex.) 2014;13(14):2172-91
Functional ex vivo assay to select homologous recombination-deficient breast tumors for PARP inhibitor treatment.
Naipal KA, Verkaik NS, Ameziane N, van Deurzen CH, Ter Brugge P, Meijers M, Sieuwerts AM, Martens JW, O'Connor MJ, Vrieling H, Hoeijmakers JH, Jonkers J, Kanaar R, de Winter JP, Vreeswijk MP, Jager A, van Gent DC
Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Sep 15;20(18):4816-26
Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Sep 15;20(18):4816-26
RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2.
Pefani DE, Latusek R, Pires I, Grawenda AM, Yee KS, Hamilton G, van der Weyden L, Esashi F, Hammond EM, O'Neill E
Nature cell biology 2014 Oct;16(10):962-71, 1-8
Nature cell biology 2014 Oct;16(10):962-71, 1-8
Combined inhibition of Wee1 and PARP1/2 for radiosensitization in pancreatic cancer.
Karnak D, Engelke CG, Parsels LA, Kausar T, Wei D, Robertson JR, Marsh KB, Davis MA, Zhao L, Maybaum J, Lawrence TS, Morgan MA
Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Oct 1;20(19):5085-96
Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Oct 1;20(19):5085-96
PI3K Inhibition Augments the Therapeutic Efficacy of a 3a-aza-Cyclopenta[α]indene Derivative in Lung Cancer Cells
Sanjiv K, Chen C, Kakadiya R, Tala S, Suman S, Wu M, Chen Y, Su T, Lee T
Translational Oncology 2014 April;7(2):256-266
Translational Oncology 2014 April;7(2):256-266
PI3K Inhibition Augments the Therapeutic Efficacy of a 3a-aza-Cyclopenta[α]indene Derivative in Lung Cancer Cells.
Sanjiv K, Chen CW, Kakadiya R, Tala S, Suman S, Wu MH, Chen YH, Su TL, Lee TC
Translational oncology 2014 Apr;7(2):256-266.e5
Translational oncology 2014 Apr;7(2):256-266.e5
A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization.
Jeyasekharan AD, Liu Y, Hattori H, Pisupati V, Jonsdottir AB, Rajendra E, Lee M, Sundaramoorthy E, Schlachter S, Kaminski CF, Ofir-Rosenfeld Y, Sato K, Savill J, Ayoub N, Venkitaraman AR
Nature structural & molecular biology 2013 Oct;20(10):1191-8
Nature structural & molecular biology 2013 Oct;20(10):1191-8
EGFR-activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity.
Pfäffle HN, Wang M, Gheorghiu L, Ferraiolo N, Greninger P, Borgmann K, Settleman J, Benes CH, Sequist LV, Zou L, Willers H
Cancer research 2013 Oct 15;73(20):6254-63
Cancer research 2013 Oct 15;73(20):6254-63
A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia.
Zhu J, Zhou L, Wu G, Konig H, Lin X, Li G, Qiu XL, Chen CF, Hu CM, Goldblatt E, Bhatia R, Chamberlin AR, Chen PL, Lee WH
EMBO molecular medicine 2013 Mar;5(3):353-65
EMBO molecular medicine 2013 Mar;5(3):353-65
Targeted radiosensitization by the Chk1 inhibitor SAR-020106.
Borst GR, McLaughlin M, Kyula JN, Neijenhuis S, Khan A, Good J, Zaidi S, Powell NG, Meier P, Collins I, Garrett MD, Verheij M, Harrington KJ
International journal of radiation oncology, biology, physics 2013 Mar 15;85(4):1110-8
International journal of radiation oncology, biology, physics 2013 Mar 15;85(4):1110-8
A small ubiquitin binding domain inhibits ubiquitin-dependent protein recruitment to DNA repair foci.
Helchowski CM, Skow LF, Roberts KH, Chute CL, Canman CE
Cell cycle (Georgetown, Tex.) 2013 Dec 15;12(24):3749-58
Cell cycle (Georgetown, Tex.) 2013 Dec 15;12(24):3749-58
Inhibition of protein phosphatase 2A radiosensitizes pancreatic cancers by modulating CDC25C/CDK1 and homologous recombination repair.
Wei D, Parsels LA, Karnak D, Davis MA, Parsels JD, Marsh AC, Zhao L, Maybaum J, Lawrence TS, Sun Y, Morgan MA
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Aug 15;19(16):4422-32
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Aug 15;19(16):4422-32
Sensitization of pancreatic cancer to chemoradiation by the Chk1 inhibitor MK8776.
Engelke CG, Parsels LA, Qian Y, Zhang Q, Karnak D, Robertson JR, Tanska DM, Wei D, Davis MA, Parsels JD, Zhao L, Greenson JK, Lawrence TS, Maybaum J, Morgan MA
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Aug 15;19(16):4412-21
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Aug 15;19(16):4412-21
Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment.
Oplustilova L, Wolanin K, Mistrik M, Korinkova G, Simkova D, Bouchal J, Lenobel R, Bartkova J, Lau A, O'Connor MJ, Lukas J, Bartek J
Cell cycle (Georgetown, Tex.) 2012 Oct 15;11(20):3837-50
Cell cycle (Georgetown, Tex.) 2012 Oct 15;11(20):3837-50
REV1 and polymerase ζ facilitate homologous recombination repair.
Sharma S, Hicks JK, Chute CL, Brennan JR, Ahn JY, Glover TW, Canman CE
Nucleic acids research 2012 Jan;40(2):682-91
Nucleic acids research 2012 Jan;40(2):682-91
A mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressor.
Lee M, Daniels MJ, Garnett MJ, Venkitaraman AR
Oncogene 2011 Jul 28;30(30):3360-9
Oncogene 2011 Jul 28;30(30):3360-9
ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery.
Ammazzalorso F, Pirzio LM, Bignami M, Franchitto A, Pichierri P
The EMBO journal 2010 Sep 15;29(18):3156-69
The EMBO journal 2010 Sep 15;29(18):3156-69
Evidence of an adaptive response targeting DNA nonhomologous end joining and its transmission to bystander cells.
Klammer H, Kadhim M, Iliakis G
Cancer research 2010 Nov 1;70(21):8498-506
Cancer research 2010 Nov 1;70(21):8498-506
A novel and simple micro-irradiation technique for creating localized DNA double-strand breaks.
Suzuki K, Yamauchi M, Oka Y, Suzuki M, Yamashita S
Nucleic acids research 2010 Jul;38(12):e129
Nucleic acids research 2010 Jul;38(12):e129
A marker of homologous recombination predicts pathologic complete response to neoadjuvant chemotherapy in primary breast cancer.
Graeser M, McCarthy A, Lord CJ, Savage K, Hills M, Salter J, Orr N, Parton M, Smith IE, Reis-Filho JS, Dowsett M, Ashworth A, Turner NC
Clinical cancer research : an official journal of the American Association for Cancer Research 2010 Dec 15;16(24):6159-68
Clinical cancer research : an official journal of the American Association for Cancer Research 2010 Dec 15;16(24):6159-68
NKX3.1 activates cellular response to DNA damage.
Bowen C, Gelmann EP
Cancer research 2010 Apr 15;70(8):3089-97
Cancer research 2010 Apr 15;70(8):3089-97
DNA-damage response, survival and differentiation in vitro of a human neural stem cell line in relation to ATM expression.
Carlessi L, De Filippis L, Lecis D, Vescovi A, Delia D
Cell death and differentiation 2009 Jun;16(6):795-806
Cell death and differentiation 2009 Jun;16(6):795-806
Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90.
Dungey FA, Caldecott KW, Chalmers AJ
Molecular cancer therapeutics 2009 Aug;8(8):2243-54
Molecular cancer therapeutics 2009 Aug;8(8):2243-54
Phenotypic effects of heterozygosity for a BRCA2 mutation.
Warren M, Lord CJ, Masabanda J, Griffin D, Ashworth A
Human molecular genetics 2003 Oct 15;12(20):2645-56
Human molecular genetics 2003 Oct 15;12(20):2645-56
Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response.
Kao GD, McKenna WG, Guenther MG, Muschel RJ, Lazar MA, Yen TJ
The Journal of cell biology 2003 Mar 31;160(7):1017-27
The Journal of cell biology 2003 Mar 31;160(7):1017-27
The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51.
Masson JY, Davies AA, Hajibagheri N, Van Dyck E, Benson FE, Stasiak AZ, Stasiak A, West SC
The EMBO journal 1999 Nov 15;18(22):6552-60
The EMBO journal 1999 Nov 15;18(22):6552-60
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Enhanced validation
Supportive validation
- Submitted by
- GeneTex (provider)
- Enhanced method
- Genetic validation
- Main image
- Experimental details
- Non-transfected (¡V) and transfected (+) 293T whole cell extracts (30 ?g) were separated by 10% SDS-PAGE, and the membrane was blotted with Rad51 antibody [14B4] (GTX70230) diluted at 1:500. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.
Supportive validation
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Rad51 WB analysis on Hela (lane 1) & T24 (lane 2) cell lysates.
- Validation comment
- WB
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Rad51 antibody [14B4] detects Rad51 protein by western blot analysis. Various whole cell extracts (30 ?g) were separated by 10% SDS-PAGE, and the membrane was blotted with Rad51 antibody [14B4] (GTX70230) diluted at a dilution of 1:500 and developed with Trident Sharp-ECL (GTX14698).
- Validation comment
- WB
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Whole cell extract (30 ?g) was separated by 10% SDS-PAGE, and the membrane was blotted with Rad51 antibody [14B4] (GTX70230) diluted at 1:500. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced.
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Various whole cell extracts (30 ?g) were separated by 10% SDS-PAGE, and the membrane was blotted with Rad51 antibody [14B4] (GTX70230) diluted at 1:500. The HRP-conjugated anti-mouset IgG antibody (GTX213111-01) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced.
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Various whole cell extracts (30 ?g) were separated by 10% SDS-PAGE, and the membrane was blotted with Rad51 antibody [14B4] (GTX70230) diluted at 1:500. The HRP-conjugated anti-mouset IgG antibody (GTX213111-01) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced.
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Non-transfected (¡V) and transfected (+) 293T whole cell extracts (30 ?g) were separated by 10% SDS-PAGE, and the membrane was blotted with Rad51 antibody [14B4] (GTX70230) diluted at 1:500. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.
Supportive validation
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- Immunofluorecent staning of RAD51 nuclear foci in U2OS cells using RAD51 14B4 antibody (GTX70230). Cells were pre-extracted with CSK buffer before fixation with 4% PFA. RAD51 14B4 was used at 1:1000 dultion. DAPI was used to counterstain the nucleus. Scale bar, 10 mciro-meter.
Supportive validation
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- Mouse anti-RAD51 14B4 antibody (GTX70230) was used in IP assay (immunoprecipitation) using HeLa cell extract prepared with lysis 180 buffer (40 mM Tris-HCl pH8.0, 180 mM NaCl, 1 mMEDTA, 0.5% NP-40).Rabbit anti-RAD51 antibody (GTX100469) was used for subsequent WB detection of immunoprecipated RAD51.Whole cell extract was used as input.
Supportive validation
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- RAD51 antibody 14B4 (GTX70230) detects RAD51 in nucleus on BT483 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded BT483 xenograft.RAD51 antibody 14B4 (GTX702308) dilution: 1:200.
