Antibody data
- Antibody Data
- Antigen structure
- References [9]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- MAB683 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Mouse Monoclonal RANK/TNFRSF11A Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human RANK/TNFRSF11A in ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) 4-1BB, rhBAFF R, rhCD27, rhCD30, rhCD40, rhDR3, rhDR6, rhEDAR, rhFas, rhGITR, rhHVEM, rhLymphotoxin beta R, rhNGF R, rhOPG, rhTAJ, rhTNF RI, rhTNF RII, or recombinant mouse (rm) OX40, and rmRANK is observed.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 500 ug
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references Caveolin‑1 enhances RANKL‑induced gastric cancer cell migration.
Characterization and application of two RANK-specific antibodies with different biological activities.
Langerhans cell precursors acquire RANK/CD265 in prenatal human skin.
RANKL expression, function, and therapeutic targeting in multiple myeloma and chronic lymphocytic leukemia.
Receptor activator for NF-κB ligand in acute myeloid leukemia: expression, function, and modulation of NK cell immunosurveillance.
Regulatory T cells in the bone marrow microenvironment in patients with prostate cancer.
Epidermal receptor activator of NF-kappaB ligand controls Langerhans cells numbers and proliferation.
Epidermal receptor activator of NF-kappaB ligand controls Langerhans cells numbers and proliferation.
High expression levels of receptor activator of nuclear factor-kappa B ligand associated with human chronic periodontitis are mainly secreted by CD4+ T lymphocytes.
Wang Y, Song Y, Che X, Zhang L, Wang Q, Zhang X, Qu J, Li Z, Xu L, Zhang Y, Fan Y, Hou K, Liu Y, Qu X
Oncology reports 2018 Sep;40(3):1287-1296
Oncology reports 2018 Sep;40(3):1287-1296
Characterization and application of two RANK-specific antibodies with different biological activities.
Chypre M, Seaman J, Cordeiro OG, Willen L, Knoop KA, Buchanan A, Sainson RC, Williams IR, Yagita H, Schneider P, Mueller CG
Immunology letters 2016 Mar;171:5-14
Immunology letters 2016 Mar;171:5-14
Langerhans cell precursors acquire RANK/CD265 in prenatal human skin.
Schöppl A, Botta A, Prior M, Akgün J, Schuster C, Elbe-Bürger A
Acta histochemica 2015 May-Jun;117(4-5):425-30
Acta histochemica 2015 May-Jun;117(4-5):425-30
RANKL expression, function, and therapeutic targeting in multiple myeloma and chronic lymphocytic leukemia.
Schmiedel BJ, Scheible CA, Nuebling T, Kopp HG, Wirths S, Azuma M, Schneider P, Jung G, Grosse-Hovest L, Salih HR
Cancer research 2013 Jan 15;73(2):683-94
Cancer research 2013 Jan 15;73(2):683-94
Receptor activator for NF-κB ligand in acute myeloid leukemia: expression, function, and modulation of NK cell immunosurveillance.
Schmiedel BJ, Nuebling T, Steinbacher J, Malinovska A, Wende CM, Azuma M, Schneider P, Grosse-Hovest L, Salih HR
Journal of immunology (Baltimore, Md. : 1950) 2013 Jan 15;190(2):821-31
Journal of immunology (Baltimore, Md. : 1950) 2013 Jan 15;190(2):821-31
Regulatory T cells in the bone marrow microenvironment in patients with prostate cancer.
Zhao E, Wang L, Dai J, Kryczek I, Wei S, Vatan L, Altuwaijri S, Sparwasser T, Wang G, Keller ET, Zou W
Oncoimmunology 2012 Mar 1;1(2):152-161
Oncoimmunology 2012 Mar 1;1(2):152-161
Epidermal receptor activator of NF-kappaB ligand controls Langerhans cells numbers and proliferation.
Barbaroux JB, Beleut M, Brisken C, Mueller CG, Groves RW
Journal of immunology (Baltimore, Md. : 1950) 2008 Jul 15;181(2):1103-8
Journal of immunology (Baltimore, Md. : 1950) 2008 Jul 15;181(2):1103-8
Epidermal receptor activator of NF-kappaB ligand controls Langerhans cells numbers and proliferation.
Barbaroux JB, Beleut M, Brisken C, Mueller CG, Groves RW
Journal of immunology (Baltimore, Md. : 1950) 2008 Jul 15;181(2):1103-8
Journal of immunology (Baltimore, Md. : 1950) 2008 Jul 15;181(2):1103-8
High expression levels of receptor activator of nuclear factor-kappa B ligand associated with human chronic periodontitis are mainly secreted by CD4+ T lymphocytes.
Vernal R, Dutzan N, Hernández M, Chandía S, Puente J, León R, García L, Del Valle I, Silva A, Gamonal J
Journal of periodontology 2006 Oct;77(10):1772-80
Journal of periodontology 2006 Oct;77(10):1772-80
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Detection of RANK/TNFRSF11A in A431 Human Cell Line by Flow Cytometry. A431 human epithelial carcinoma cell line was stained with Mouse Anti-Human RANK/TNFRSF11A Monoclonal Antibody (Catalog # MAB683, filled histogram) or isotype control antibody (Catalog # MAB002, open histogram), followed by Phycoerythrin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0102B).