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- Antibody Data
- Antigen structure
- References [14]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 18843-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#18843-1-AP, RRID:AB_10603469
- Product name
- RAB12 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated RAB12 antibody (Cat. #18843-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references LRRK2 mediates haloperidol-induced changes in indirect pathway striatal projection neurons.
A potential patient stratification biomarker for Parkinson´s disease based on LRRK2 kinase-mediated centrosomal alterations in peripheral blood-derived cells.
Mitochondrial dysfunction and mitophagy defects in LRRK2-R1441C Parkinson's disease models.
Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes.
Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson's disease-linked LRRK2 kinase.
Directing LRRK2 to membranes of the endolysosomal pathway triggers RAB phosphorylation and JIP4 recruitment.
Rab12 Promotes Radioresistance of HPV-Positive Cervical Cancer Cells by Increasing G2/M Arrest.
Impact of Type II LRRK2 inhibitors on signaling and mitophagy.
Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes.
Biochemical and structural insights into Rab12 interactions with RILP and its family members.
The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human.
Rab12 Regulates Retrograde Transport of Mast Cell Secretory Granules by Interacting with the RILP-Dynein Complex.
Phosphorylation of the exchange factor DENND3 by ULK in response to starvation activates Rab12 and induces autophagy.
Rab12 localizes to Shiga toxin-induced plasma membrane invaginations and controls toxin transport.
Chen C, Masotti M, Shepard N, Promes V, Tombesi G, Arango D, Manzoni C, Greggio E, Hilfiker S, Kozorovitskiy Y, Parisiadou L
bioRxiv : the preprint server for biology 2024 Jun 8;
bioRxiv : the preprint server for biology 2024 Jun 8;
A potential patient stratification biomarker for Parkinson´s disease based on LRRK2 kinase-mediated centrosomal alterations in peripheral blood-derived cells.
Naaldijk Y, Fernández B, Fasiczka R, Fdez E, Leghay C, Croitoru I, Kwok JB, Boulesnane Y, Vizeneux A, Mutez E, Calvez C, Destée A, Taymans JM, Aragon AV, Yarza AB, Padmanabhan S, Delgado M, Alcalay RN, Chatterton Z, Dzamko N, Halliday G, Ruiz-Martínez J, Chartier-Harlin MC, Hilfiker S
NPJ Parkinson's disease 2024 Jan 8;10(1):12
NPJ Parkinson's disease 2024 Jan 8;10(1):12
Mitochondrial dysfunction and mitophagy defects in LRRK2-R1441C Parkinson's disease models.
Williamson MG, Madureira M, McGuinness W, Heon-Roberts R, Mock ED, Naidoo K, Cramb KML, Caiazza MC, Malpartida AB, Lavelle M, Savory K, Humble SW, Patterson R, Davis JB, Connor-Robson N, Ryan BJ, Wade-Martins R
Human molecular genetics 2023 Sep 5;32(18):2808-2821
Human molecular genetics 2023 Sep 5;32(18):2808-2821
Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes.
Wang X, Bondar VV, Davis OB, Maloney MT, Agam M, Chin MY, Cheuk-Nga Ho A, Ghosh R, Leto DE, Joy D, Calvert MEK, Lewcock JW, Di Paolo G, Thorne RG, Sweeney ZK, Henry AG
eLife 2023 Oct 24;12
eLife 2023 Oct 24;12
Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson's disease-linked LRRK2 kinase.
Dhekne HS, Tonelli F, Yeshaw WM, Chiang CY, Limouse C, Jaimon E, Purlyte E, Alessi DR, Pfeffer SR
eLife 2023 Oct 24;12
eLife 2023 Oct 24;12
Directing LRRK2 to membranes of the endolysosomal pathway triggers RAB phosphorylation and JIP4 recruitment.
Kluss JH, Bonet-Ponce L, Lewis PA, Cookson MR
Neurobiology of disease 2022 Aug;170:105769
Neurobiology of disease 2022 Aug;170:105769
Rab12 Promotes Radioresistance of HPV-Positive Cervical Cancer Cells by Increasing G2/M Arrest.
Huang Y, Tian Y, Zhang W, Liu R, Zhang W
Frontiers in oncology 2021;11:586771
Frontiers in oncology 2021;11:586771
Impact of Type II LRRK2 inhibitors on signaling and mitophagy.
Tasegian A, Singh F, Ganley IG, Reith AD, Alessi DR
The Biochemical journal 2021 Oct 15;478(19):3555-3573
The Biochemical journal 2021 Oct 15;478(19):3555-3573
Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes.
Boecker CA, Goldsmith J, Dou D, Cajka GG, Holzbaur ELF
Current biology : CB 2021 May 24;31(10):2140-2154.e6
Current biology : CB 2021 May 24;31(10):2140-2154.e6
Biochemical and structural insights into Rab12 interactions with RILP and its family members.
Omar J, Rosenbaum E, Efergan A, Sneineh BA, Yeheskel A, Maruta Y, Fukuda M, Sagi-Eisenberg R
Scientific reports 2021 May 13;11(1):10317
Scientific reports 2021 May 13;11(1):10317
The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human.
Mir R, Tonelli F, Lis P, Macartney T, Polinski NK, Martinez TN, Chou MY, Howden AJM, König T, Hotzy C, Milenkovic I, Brücke T, Zimprich A, Sammler E, Alessi DR
The Biochemical journal 2018 Jun 6;475(11):1861-1883
The Biochemical journal 2018 Jun 6;475(11):1861-1883
Rab12 Regulates Retrograde Transport of Mast Cell Secretory Granules by Interacting with the RILP-Dynein Complex.
Efergan A, Azouz NP, Klein O, Noguchi K, Rothenberg ME, Fukuda M, Sagi-Eisenberg R
Journal of immunology (Baltimore, Md. : 1950) 2016 Feb 1;196(3):1091-101
Journal of immunology (Baltimore, Md. : 1950) 2016 Feb 1;196(3):1091-101
Phosphorylation of the exchange factor DENND3 by ULK in response to starvation activates Rab12 and induces autophagy.
Xu J, Fotouhi M, McPherson PS
EMBO reports 2015 Jun;16(6):709-18
EMBO reports 2015 Jun;16(6):709-18
Rab12 localizes to Shiga toxin-induced plasma membrane invaginations and controls toxin transport.
Rydell GE, Renard HF, Garcia-Castillo MD, Dingli F, Loew D, Lamaze C, Römer W, Johannes L
Traffic (Copenhagen, Denmark) 2014 Jul;15(7):772-87
Traffic (Copenhagen, Denmark) 2014 Jul;15(7):772-87
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 18843-1-AP(RAB12 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 18843-1-AP(RAB12 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The RAB12 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human RAB12. This antibody recognizes human, mouse, rat antigen. The RAB12 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
