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- References [17]
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- Product number
- 22426-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- HNF1A antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated HNF1A antibody (Cat. #22426-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat, mouse and has been validated for the following applications: IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references OGT-enriched Hepatocyte-derived Extracellular Vesicles Promote Capillarization of Liver Sinusoidal Endothelial Cells in Metabolic Dysfunction-associated Steatotic Liver Disease.
FTO mediates m6A demethylation of HNF1A and drives hepatic steatosis in metabolic dysfunction-associated steatotic liver disease.
Epigenetic Regulation of DAPK1 and Netrin-1 Drives Diabetic Encephalopathy.
Dietary curcumin prevents hypercholesterolemia by inhibiting the transcriptional activity of SREBP-2 and HNF1α and reducing intestinal and hepatic NPC1L1 expression in high-fat diet-fed hamsters.
HNF1A induces glioblastoma by upregulating EPS8 and activating PI3K/AKT signaling pathway.
Impaired Hepatic Very Low-Density Lipoprotein Secretion Promotes Tumorigenesis and Is Accelerated with Fabp1 Deletion.
20( S )-Protopanaxatriol Improves Atherosclerosis by Inhibiting Low-Density Lipoprotein Receptor Degradation in ApoE KO Mice.
SPOP inhibits HBV transcription and replication by ubiquitination and degradation of HNF1α.
The accessible promoter-mediated supplementary effect of host factors provides new insight into the tropism of SARS-CoV-2.
ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer.
Effect of fucoidan on ethanol-induced liver injury and steatosis in mice and the underlying mechanism.
CBP/p300 HAT maintains the gene network critical for β cell identity and functional maturity.
Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer.
Aloe-emodin exerts cholesterol-lowering effects by inhibiting proprotein convertase subtilisin/kexin type 9 in hyperlipidemic rats.
Hepatocyte nuclear factor 1 alpha (HNF1A) regulates transcription of O-GlcNAc transferase in a negative feedback mechanism.
Small Heterodimer Partner Regulates Circadian Cytochromes p450 and Drug-Induced Hepatotoxicity.
6-Formylindolo(3,2-b)carbazole induced aryl hydrocarbon receptor activation prevents intestinal barrier dysfunction through regulation of claudin-2 expression.
Wang Y, Zhou X, Zhang Y, Yang F, Chen Y, Wu Y, Zhang L, Tan J, Luo W, Zhou J, Yan Y
Cellular and molecular gastroenterology and hepatology 2026;20(5):101721
Cellular and molecular gastroenterology and hepatology 2026;20(5):101721
FTO mediates m6A demethylation of HNF1A and drives hepatic steatosis in metabolic dysfunction-associated steatotic liver disease.
Tan J, Shi C, Wang G, Zhang L, Li F, Yan G, Jin Y, Ding H, Jiang F, Li X
Biochimica et biophysica acta. Molecular and cell biology of lipids 2026 Apr;1871(3):159732
Biochimica et biophysica acta. Molecular and cell biology of lipids 2026 Apr;1871(3):159732
Epigenetic Regulation of DAPK1 and Netrin-1 Drives Diabetic Encephalopathy.
Zhou Y, Kou JX, Zheng K, Guo ZX, Fan HW, Li WL, Chu LL, Yin JW, Liu LJ, Brazhe N, Xiang ZG, Hu F, Shu K, Zhu LQ, Liu D
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(37):e02535
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(37):e02535
Dietary curcumin prevents hypercholesterolemia by inhibiting the transcriptional activity of SREBP-2 and HNF1α and reducing intestinal and hepatic NPC1L1 expression in high-fat diet-fed hamsters.
Cao Z, Yang J, Mai H, Hong T, Chen X, Feng D
Nutrition & metabolism 2025 Oct 28;22(1):128
Nutrition & metabolism 2025 Oct 28;22(1):128
HNF1A induces glioblastoma by upregulating EPS8 and activating PI3K/AKT signaling pathway.
Yang G, Su F, Han BX, Su HX, Guo CH, Yu SH, Guan QL, Hou XM
Biochemical pharmacology 2024 May;223:116133
Biochemical pharmacology 2024 May;223:116133
Impaired Hepatic Very Low-Density Lipoprotein Secretion Promotes Tumorigenesis and Is Accelerated with Fabp1 Deletion.
Newberry EP, Molitor EA, Liu A, Chong K, Liu X, Alonso C, Mato JM, Davidson NO
The American journal of pathology 2024 Jun;194(6):958-974
The American journal of pathology 2024 Jun;194(6):958-974
20( S )-Protopanaxatriol Improves Atherosclerosis by Inhibiting Low-Density Lipoprotein Receptor Degradation in ApoE KO Mice.
Huang YW, Luo F, Zhang M, Wang L, Meng W, Hu D, Yang J, Sheng J, Wang X
Journal of cardiovascular pharmacology 2024 Jul 1;84(1):45-57
Journal of cardiovascular pharmacology 2024 Jul 1;84(1):45-57
SPOP inhibits HBV transcription and replication by ubiquitination and degradation of HNF1α.
Pi Y, Li Y, Yan Q, Luo H, Zhou P, Chang W, Gong D, Hu Y, Wang K, Tang N, Huang A, Chen Y
Journal of medical virology 2023 Dec;95(12):e29254
Journal of medical virology 2023 Dec;95(12):e29254
The accessible promoter-mediated supplementary effect of host factors provides new insight into the tropism of SARS-CoV-2.
Du G, Xu X, Wang J, Wang X, Ding Y, Li F, Sun Y, Tao H, Luo Y, Li H, Bo X, Chen H
Molecular therapy. Nucleic acids 2022 Jun 14;28:249-258
Molecular therapy. Nucleic acids 2022 Jun 14;28:249-258
ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer.
Dong S, Liang S, Cheng Z, Zhang X, Luo L, Li L, Zhang W, Li S, Xu Q, Zhong M, Zhu J, Zhang G, Hu S
Journal of experimental & clinical cancer research : CR 2022 Jan 8;41(1):15
Journal of experimental & clinical cancer research : CR 2022 Jan 8;41(1):15
Effect of fucoidan on ethanol-induced liver injury and steatosis in mice and the underlying mechanism.
Xue M, Liang H, Zhou Z, Liu Y, He X, Zhang Z, Sun T, Yang J, Qin Y, Qin K
Food & nutrition research 2021;65
Food & nutrition research 2021;65
CBP/p300 HAT maintains the gene network critical for β cell identity and functional maturity.
Zhang L, Sheng C, Zhou F, Zhu K, Wang S, Liu Q, Yuan M, Xu Z, Liu Y, Lu J, Liu J, Zhou L, Wang X
Cell death & disease 2021 May 12;12(5):476
Cell death & disease 2021 May 12;12(5):476
Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer.
Teng S, Li YE, Yang M, Qi R, Huang Y, Wang Q, Zhang Y, Chen S, Li S, Lin K, Cao Y, Ji Q, Gu Q, Cheng Y, Chang Z, Guo W, Wang P, Garcia-Bassets I, Lu ZJ, Wang D
Cell research 2020 Jan;30(1):34-49
Cell research 2020 Jan;30(1):34-49
Aloe-emodin exerts cholesterol-lowering effects by inhibiting proprotein convertase subtilisin/kexin type 9 in hyperlipidemic rats.
Su ZL, Hang PZ, Hu J, Zheng YY, Sun HQ, Guo J, Liu KY, Du ZM
Acta pharmacologica Sinica 2020 Aug;41(8):1085-1092
Acta pharmacologica Sinica 2020 Aug;41(8):1085-1092
Hepatocyte nuclear factor 1 alpha (HNF1A) regulates transcription of O-GlcNAc transferase in a negative feedback mechanism.
Zhang C, Xie F, Li L, Zhang C, Zhang Y, Ying W, Liu L, Yan X, Yin F, Zhang L
FEBS letters 2019 May;593(10):1050-1060
FEBS letters 2019 May;593(10):1050-1060
Small Heterodimer Partner Regulates Circadian Cytochromes p450 and Drug-Induced Hepatotoxicity.
Zhang T, Yu F, Guo L, Chen M, Yuan X, Wu B
Theranostics 2018;8(19):5246-5258
Theranostics 2018;8(19):5246-5258
6-Formylindolo(3,2-b)carbazole induced aryl hydrocarbon receptor activation prevents intestinal barrier dysfunction through regulation of claudin-2 expression.
Ma Y, Wang Q, Yu K, Fan X, Xiao W, Cai Y, Xu P, Yu M, Yang H
Chemico-biological interactions 2018 May 25;288:83-90
Chemico-biological interactions 2018 May 25;288:83-90
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The HNF1A antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human HNF1A. This antibody recognizes human, rat antigen. The HNF1A antibody has been validated for the following applications: ELISA, WB analysis.
