Antibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations
- Flow cytometry [1]
- Blocking/Neutralizing [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- MAB290 - Provider product page
- Provider
- R&D Systems
- Product name
- Human IL-9R Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from ascites. Detects human IL-9 R in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) IL-4 R, rhIL-5 R alpha , rhIL-5 R beta , rhIL-13 R alpha 1, rhIL-13 R alpha 2, or recombinant mouse IL-9 R is observed.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 33423
- Vial size
- 500 ug
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references IL-9 promotes the pathogenesis of ulcerative colitis through STAT3/SOCS3 signaling.
Expression of IL-9 receptor alpha chain on human germinal center B cells modulates IgE secretion.
Interleukin-9 induces goblet cell hyperplasia during repair of human airway epithelia.
Tian L, Li Y, Zhang J, Chang R, Li J, Huo L
Bioscience reports 2018 Dec 21;38(6)
Bioscience reports 2018 Dec 21;38(6)
Expression of IL-9 receptor alpha chain on human germinal center B cells modulates IgE secretion.
Fawaz LM, Sharif-Askari E, Hajoui O, Soussi-Gounni A, Hamid Q, Mazer BD
The Journal of allergy and clinical immunology 2007 Nov;120(5):1208-15
The Journal of allergy and clinical immunology 2007 Nov;120(5):1208-15
Interleukin-9 induces goblet cell hyperplasia during repair of human airway epithelia.
Vermeer PD, Harson R, Einwalter LA, Moninger T, Zabner J
American journal of respiratory cell and molecular biology 2003 Mar;28(3):286-95
American journal of respiratory cell and molecular biology 2003 Mar;28(3):286-95
No comments: Submit comment
Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of IL-9 R in Human Monocytes by Flow Cytometry. Human whole blood monocytes were stained with Mouse Anti-Human IL-9 R Subunit Monoclonal Antibody (Catalog # MAB290, filled histogram) or isotype control antibody (Catalog # MAB002, open histogram), followed by Phycoerythrin-conjugated Anti-Mouse IgG F(ab')2 Secondary Antibody (Catalog # F0102B).
Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Cell Proliferation Induced by IL-9 and Neutralization by Human IL-9 R Antibody. Recombinant Human IL-9 (Catalog # 209-IL) stimulates proliferation in the MO7e human megakaryocytic leukemic cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Human IL-9 (2 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-Human IL-9 R Subunit Mono-clonal Antibody (Catalog # MAB290). The ND50 is typically 2-4 µg/mL.