Antibody data
- Antibody Data
- Antigen structure
- References [45]
- Comments [0]
- Validations [0]
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- Product number
- 66950-1-Ig - Provider product page

- Provider
- Proteintech Group
- Product name
- CDK4 antibody
- Antibody type
- Monoclonal
- Description
- CDK4 antibody (Cat. #66950-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, Mouse, Rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 1G2C12
- Vial size
- 20ul, 150ul
Submitted references Muscle RING finger-1 facilitates skeletal muscle regeneration via regulating myoblast proliferation and differentiation.
FAM50A as a novel prognostic marker modulates the proliferation of colorectal cancer cells via CylinA2/CDK2 pathway.
Bavachin suppresses proliferation of laryngopharyngeal cancer by regulating the STAT3 and MAPK signaling pathways.
NCAPH-YAP1 interaction promotes breast cancer stemness and tumor progression.
Icaritin Represses Autophagy to Promote Colorectal Cancer Cell Apoptosis and Sensitized Low-Temperature Photothermal Therapy via Targeting HSP90-TXNDC9 Interactions.
CDK4 loss-of-function mutations cause microcephaly and short stature.
CTSG restraines the proliferation and metastasis of head and neck squamous cell carcinoma by blocking the JAK2/STAT3 pathway.
Apigenin prevents hypertensive vascular remodeling by regulating the TP53 pathway.
Glycyrrhizic acid promotes liver regeneration through activating β-catenin in acetaminophen-induced liver injury.
Ilicicolin C suppresses the progression of prostate cancer by inhibiting PI3K/AKT/mTOR pathway.
Pyrrolidinium Fullerenes as YTHDF1 Inhibitors for Targeted Tumor Therapy.
Avermectin B1 mediates antitumor activity and induces autophagy in osteosarcoma through the AMPK/ULK1 signaling pathway.
FAM83D promotes the progression of 4NQO-induced esophageal carcinoma via inhibiting FBWX7.
CARM1 drives triple-negative breast cancer progression by coordinating with HIF1A.
Talaketides A-G, linear polyketides with prostate cancer cytotoxic activity from the mangrove sediment-derived fungus Talaromyces sp. SCSIO 41027.
Disulfiram Upgrades the Radiosensitivity of Osteosarcoma by Enhancing Apoptosis and P53-Induced Cell Cycle Arrest.
Transcriptomics and molecular docking reveal the potential mechanism of lycorine against pancreatic cancer.
Discovery of potent and selective c-Met inhibitors for MET-amplified hepatocellular carcinoma treatment.
Design, Synthesis, and Biological Evaluation for First GPX4 and CDK Dual Inhibitors.
Cyclosporine A Causes Gingival Overgrowth by Promoting Entry into the S Phase at the G1/S Cell Cycle Checkpoint in Gingival Fibroblasts Exposed to Lipopolysaccharide.
Rapamycin inhibits B16 melanoma cell viability invitro and invivo by inducing autophagy and inhibiting the mTOR/p70‑S6k pathway.
Ebastine exerts antitumor activity and induces autophagy by activating AMPK/ULK1 signaling in an IPMK-dependent manner in osteosarcoma.
HSP105 suppresses the progression of cutaneous squamous cell carcinoma by activating the P53 signaling pathway.
Morusinol extracted from Morus alba induces cell cycle arrest and apoptosis via inhibition of DNA damage response in melanoma by CHK1 degradation through the ubiquitin-proteasome pathway.
Antiovarian cancer mechanism of esculetin: inducing G0/G1 arrest and apoptosis via JAK2/STAT3 signalling pathway.
Transcriptome sequencing identifies prognostic genes involved in gastric adenocarcinoma.
NCAPG is transcriptionally regulated by CBX3 and activates the Wnt/β-catenin signaling pathway to promote proliferation and the cell cycle and inhibit apoptosis in colorectal cancer.
Structural Characterization and Anti-breast Cancer Activity in vitro of a Novel Polysaccharide From Cymbopogon citratus.
Analysis of regulating activities of 5'-epiequisetin on proliferation, apoptosis, and migration of prostate cancer cells in vitro and in vivo.
Membrane-associated RING-CH protein (MARCH8) is a novel glycolysis repressor targeted by miR-32 in colorectal cancer.
RAI14 Promotes Melanoma Progression by Regulating the FBXO32/c-MYC Pathway.
LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis.
LINC02154 promotes the proliferation and metastasis of hepatocellular carcinoma by enhancing SPC24 promoter activity and activating the PI3K-AKT signaling pathway.
The role of ER stress and ATP/AMPK in oxidative stress meditated hepatotoxicity induced by citrinin.
Identification of PDCD2 as a Candidate Target of Andrographolide That Arrests the Tumor Cell Cycle by Human Proteome-Scale Screening.
NLGN3 Upregulates Expression of ADAM10 to Promote the Cleavage of NLGN3 via Activating the LYN Pathway in Human Gliomas.
LHPP-Mediated Histidine Dephosphorylation Suppresses the Self-Renewal of Mouse Embryonic Stem Cells.
Discovery and Verification of Key Liver Cancer Genes and Alternative Splicing Events Based on Second-Generation Sequencing Data Analysis.
MICAL2 Contributes to Gastric Cancer Cell Proliferation by Promoting YAP Dephosphorylation and Nuclear Translocation.
CKAP2L, as an Independent Risk Factor, Closely Related to the Prognosis of Glioma.
Discovery of a novel HDACi structure that inhibits the proliferation of ovarian cancer cells in vivo and in vitro.
PSMD7 downregulation suppresses lung cancer progression by regulating the p53 pathway.
The novel LSD1 inhibitor ZY0511 suppresses diffuse large B-cell lymphoma proliferation by inducing apoptosis and autophagy.
Long noncoding RNA GAS5 accelerates diabetic wound healing and promotes lymphangiogenesis via miR-217/Prox1 axis.
GBP1 promotes erlotinib resistance via PGK1‑activated EMT signaling in non‑small cell lung cancer.
Yang M, Ji S, Gao H, Ge H, Han X, Zhan J, Zhang Q, Xu L, Li Y, Tang Z, Bu B
Journal of translational medicine 2026 Jan 29;24(1)
Journal of translational medicine 2026 Jan 29;24(1)
FAM50A as a novel prognostic marker modulates the proliferation of colorectal cancer cells via CylinA2/CDK2 pathway.
Li L, Ji Z, Li G, Gu H, Sun Y
PloS one 2025;20(2):e0318776
PloS one 2025;20(2):e0318776
Bavachin suppresses proliferation of laryngopharyngeal cancer by regulating the STAT3 and MAPK signaling pathways.
Yang X, Ding Z, Hua H, Gan R, Meng D, Zang Y, Xiao H, Wang D, Jiang W, Si D, Wei X, Zhang M, Zhang H, Gao C
Journal of Cancer 2025;16(7):2339-2352
Journal of Cancer 2025;16(7):2339-2352
NCAPH-YAP1 interaction promotes breast cancer stemness and tumor progression.
Qiu C, Wei Y, Li J
Stem cell research & therapy 2025 Sep 25;16(1):494
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Icaritin Represses Autophagy to Promote Colorectal Cancer Cell Apoptosis and Sensitized Low-Temperature Photothermal Therapy via Targeting HSP90-TXNDC9 Interactions.
He D, Chen S, Wang X, Wen X, Gong C, Liu L, He G
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CDK4 loss-of-function mutations cause microcephaly and short stature.
Verdu Schlie A, Leitch A, Arismendi MI, Stok C, Castro Leal A, Parry DA, Marcondes Lerario A, Harley ME, Lucheze B, Carroll PL, Musialik KI, Auer JMT, Martin CA, Gerasimavicius L, Quigley AJ, de Menezes Correia-Deur JE, Marsh JA, Reijns MAM, Lampe AK, Jackson AP, Jorge AAL, Tamayo-Orrego L
Genes & development 2025 May 2;39(9-10):634-651
Genes & development 2025 May 2;39(9-10):634-651
CTSG restraines the proliferation and metastasis of head and neck squamous cell carcinoma by blocking the JAK2/STAT3 pathway.
Hua H, Yang X, Meng D, Gan R, Chen N, He L, Wang D, Jiang W, Si D, Wang X, Zhang X, Wei X, Wang Y, Li B, Zhang H, Gao C
Cellular signalling 2025 Mar;127:111562
Cellular signalling 2025 Mar;127:111562
Apigenin prevents hypertensive vascular remodeling by regulating the TP53 pathway.
Gao J, Wang D, Zhang X, Yang G, Xi D, Qin X, Wang Y, Jin Y, Guo Y, Li X, Ma K
International immunopharmacology 2025 Jun 5;157:114706
International immunopharmacology 2025 Jun 5;157:114706
Glycyrrhizic acid promotes liver regeneration through activating β-catenin in acetaminophen-induced liver injury.
Cao R, Gong H, Xia S, Hu Z, Fan X, Zhai B, Guo L, Xia C, Jiang Z, Yan M
Journal of ethnopharmacology 2025 Jun 12;349:119895
Journal of ethnopharmacology 2025 Jun 12;349:119895
Ilicicolin C suppresses the progression of prostate cancer by inhibiting PI3K/AKT/mTOR pathway.
Gan X, Luo X, Chen J, Fang W, Nie M, Lu H, Liu Y, Wang X
Molecular and cellular biochemistry 2025 Feb;480(2):1089-1104
Molecular and cellular biochemistry 2025 Feb;480(2):1089-1104
Pyrrolidinium Fullerenes as YTHDF1 Inhibitors for Targeted Tumor Therapy.
Wang X, Zhang W, Huo J, Wang Z, Liu Y, Yang L, Zhang S, Chen S, Xu Y, Qi H, Sun J, Pan Y, Lu Y, Li B, Wang Y, Liu M, Li J, Li S, Zhao C, Li Y, Yu F, Wang Z, Guo Q, Li J, Wang C
Advanced healthcare materials 2025 Aug;14(22):e2501360
Advanced healthcare materials 2025 Aug;14(22):e2501360
Avermectin B1 mediates antitumor activity and induces autophagy in osteosarcoma through the AMPK/ULK1 signaling pathway.
Fei X, Li Z, Pan Z, Liang Y, Tan C, Cheng D, Yang Q
Cancer chemotherapy and pharmacology 2024 Oct;94(4):599-613
Cancer chemotherapy and pharmacology 2024 Oct;94(4):599-613
FAM83D promotes the progression of 4NQO-induced esophageal carcinoma via inhibiting FBWX7.
Li J, Tian J, Ma M, Qin Z, Cao B, Yang J, Wang X, Yang X
Experimental cell research 2024 Oct 1;442(2):114252
Experimental cell research 2024 Oct 1;442(2):114252
CARM1 drives triple-negative breast cancer progression by coordinating with HIF1A.
Feng D, Gao J, Liu R, Liu W, Gao T, Yang Y, Zhang D, Yang T, Yin X, Yu H, Huang W, Wang Y
Protein & cell 2024 Oct 1;15(10):744-765
Protein & cell 2024 Oct 1;15(10):744-765
Talaketides A-G, linear polyketides with prostate cancer cytotoxic activity from the mangrove sediment-derived fungus Talaromyces sp. SCSIO 41027.
Chen C, Wang X, Fang W, Liang J, Cai J, Yang D, Luo X, Gao C, Yi X, Liu Y, Zhou X
Chinese journal of natural medicines 2024 Nov;22(11):1047-1056
Chinese journal of natural medicines 2024 Nov;22(11):1047-1056
Disulfiram Upgrades the Radiosensitivity of Osteosarcoma by Enhancing Apoptosis and P53-Induced Cell Cycle Arrest.
Lian Q, Chen F, Sha Z, Zhao H, Li J, Chen T, Liu C, Wang B, Wang Z, Qiao S
Radiation research 2024 Nov 1;202(5):752-764
Radiation research 2024 Nov 1;202(5):752-764
Transcriptomics and molecular docking reveal the potential mechanism of lycorine against pancreatic cancer.
Zhou X, Guo Z, Liu S, Chen Z, Wang Y, Yang R, Li X, Ma K
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;122:155128
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;122:155128
Discovery of potent and selective c-Met inhibitors for MET-amplified hepatocellular carcinoma treatment.
Min W, Wang Y, Shen H, Zheng M, Tong C, Shen H, Wang D, Zhu Y, Wang X, Xiao Y, Zhang XY, Yang P
European journal of medicinal chemistry 2024 Jan 15;264:116025
European journal of medicinal chemistry 2024 Jan 15;264:116025
Design, Synthesis, and Biological Evaluation for First GPX4 and CDK Dual Inhibitors.
Zhu J, Cai Y, Kong M, Li Y, Zhu L, Zhang J, Yu Z, Xu S, Hong L, Chen C, Luo J, Kong L
Journal of medicinal chemistry 2024 Feb 22;67(4):2758-2776
Journal of medicinal chemistry 2024 Feb 22;67(4):2758-2776
Cyclosporine A Causes Gingival Overgrowth by Promoting Entry into the S Phase at the G1/S Cell Cycle Checkpoint in Gingival Fibroblasts Exposed to Lipopolysaccharide.
Takeuchi R, Kuwahara N, Amino Y, Hayashi S, Taguchi C, Suzuki I, Suzuki H, Nagashima T, Arikawa K, Okada Y, Nomoto T, Hiratsuka K
Diseases (Basel, Switzerland) 2024 Dec 10;12(12)
Diseases (Basel, Switzerland) 2024 Dec 10;12(12)
Rapamycin inhibits B16 melanoma cell viability invitro and invivo by inducing autophagy and inhibiting the mTOR/p70‑S6k pathway.
Wang P, Zhang H, Guo K, Liu C, Chen S, Pu B, Chen S, Feng T, Jiao H, Gao C
Oncology letters 2024 Apr;27(4):140
Oncology letters 2024 Apr;27(4):140
Ebastine exerts antitumor activity and induces autophagy by activating AMPK/ULK1 signaling in an IPMK-dependent manner in osteosarcoma.
Pan Z, Li SJ, Guo H, Li ZH, Fei X, Chang SM, Yang QC, Cheng DD
International journal of biological sciences 2023;19(2):537-551
International journal of biological sciences 2023;19(2):537-551
HSP105 suppresses the progression of cutaneous squamous cell carcinoma by activating the P53 signaling pathway.
Jia M, Zhou KY, Deng LJ, Fang S
American journal of cancer research 2023;13(7):3013-3026
American journal of cancer research 2023;13(7):3013-3026
Morusinol extracted from Morus alba induces cell cycle arrest and apoptosis via inhibition of DNA damage response in melanoma by CHK1 degradation through the ubiquitin-proteasome pathway.
Guo L, Dong Z, Zhang X, Yang Y, Hu X, Ji Y, Li C, Wan S, Xu J, Liu C, Zhang Y, Liu L, Shi Y, Wu Z, Liu Y, Cui H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154765
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154765
Antiovarian cancer mechanism of esculetin: inducing G0/G1 arrest and apoptosis via JAK2/STAT3 signalling pathway.
Yin W, Fu X, Chang W, Han L, Meng J, Cao A, Ren X, Fan Z, Zhou S
The Journal of pharmacy and pharmacology 2023 Jan 31;75(1):87-97
The Journal of pharmacy and pharmacology 2023 Jan 31;75(1):87-97
Transcriptome sequencing identifies prognostic genes involved in gastric adenocarcinoma.
Li M, Bai M, Wu Y, Yang S, Zheng L, Sun L, Yu C, Huang Y
Molecular and cellular biochemistry 2023 Dec;478(12):2891-2906
Molecular and cellular biochemistry 2023 Dec;478(12):2891-2906
NCAPG is transcriptionally regulated by CBX3 and activates the Wnt/β-catenin signaling pathway to promote proliferation and the cell cycle and inhibit apoptosis in colorectal cancer.
Yang H, Pu L, Li R, Zhu R
Journal of gastrointestinal oncology 2023 Apr 29;14(2):900-912
Journal of gastrointestinal oncology 2023 Apr 29;14(2):900-912
Structural Characterization and Anti-breast Cancer Activity in vitro of a Novel Polysaccharide From Cymbopogon citratus.
Chen Y, Qiao S, Liu H, Xing H, Chen P
Frontiers in nutrition 2022;9:911838
Frontiers in nutrition 2022;9:911838
Analysis of regulating activities of 5'-epiequisetin on proliferation, apoptosis, and migration of prostate cancer cells in vitro and in vivo.
Wang X, Luo X, Gan X, Chen C, Yang Z, Wen J, Fang W, Huang H, Gao C, Zhou X, Feng X, Liu Y
Frontiers in pharmacology 2022;13:920554
Frontiers in pharmacology 2022;13:920554
Membrane-associated RING-CH protein (MARCH8) is a novel glycolysis repressor targeted by miR-32 in colorectal cancer.
Wang Z, Wang MM, Geng Y, Ye CY, Zang YS
Journal of translational medicine 2022 Sep 5;20(1):402
Journal of translational medicine 2022 Sep 5;20(1):402
RAI14 Promotes Melanoma Progression by Regulating the FBXO32/c-MYC Pathway.
Xu J, Shi P, Xia F, Zhao X, Chen J, Geng R, Cui H, Yang L
International journal of molecular sciences 2022 Oct 10;23(19)
International journal of molecular sciences 2022 Oct 10;23(19)
LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis.
Peng T, Liu M, Hu L, Guo D, Wang D, Qi B, Ren G, Hu C, Zhang F, Chun HJ, Song L, Hu J, Li Y
Biology direct 2022 Nov 16;17(1):32
Biology direct 2022 Nov 16;17(1):32
LINC02154 promotes the proliferation and metastasis of hepatocellular carcinoma by enhancing SPC24 promoter activity and activating the PI3K-AKT signaling pathway.
Yue H, Wu K, Liu K, Gou L, Huang A, Tang H
Cellular oncology (Dordrecht, Netherlands) 2022 Jun;45(3):447-462
Cellular oncology (Dordrecht, Netherlands) 2022 Jun;45(3):447-462
The role of ER stress and ATP/AMPK in oxidative stress meditated hepatotoxicity induced by citrinin.
Wu J, Yang C, Yang M, Liang Z, Wu Y, Kong X, Fan H, Wang S, Ning C, Xiao W, Jin Y, Yi J, Yuan Z
Ecotoxicology and environmental safety 2022 Jun 1;237:113531
Ecotoxicology and environmental safety 2022 Jun 1;237:113531
Identification of PDCD2 as a Candidate Target of Andrographolide That Arrests the Tumor Cell Cycle by Human Proteome-Scale Screening.
Wang L, Li C, Chen P, Liu C, Cui Z, Deng S, Yang H
ACS pharmacology & translational science 2022 Jul 8;5(7):479-490
ACS pharmacology & translational science 2022 Jul 8;5(7):479-490
NLGN3 Upregulates Expression of ADAM10 to Promote the Cleavage of NLGN3 via Activating the LYN Pathway in Human Gliomas.
Dang NN, Li XB, Zhang M, Han C, Fan XY, Huang SH
Frontiers in cell and developmental biology 2021;9:662763
Frontiers in cell and developmental biology 2021;9:662763
LHPP-Mediated Histidine Dephosphorylation Suppresses the Self-Renewal of Mouse Embryonic Stem Cells.
Xia RM, Yao DB, Cai XM, Xu XQ
Frontiers in cell and developmental biology 2021;9:638815
Frontiers in cell and developmental biology 2021;9:638815
Discovery and Verification of Key Liver Cancer Genes and Alternative Splicing Events Based on Second-Generation Sequencing Data Analysis.
Cui M, Bai M, Zheng L, Bao Y, Sun L, Yu C, Sun Y, Song Z, Wang G, Yu Z, Li Y, Huang Y
Biological & pharmaceutical bulletin 2021;44(10):1433-1444
Biological & pharmaceutical bulletin 2021;44(10):1433-1444
MICAL2 Contributes to Gastric Cancer Cell Proliferation by Promoting YAP Dephosphorylation and Nuclear Translocation.
Qi C, Min P, Wang Q, Wang Y, Song Y, Zhang Y, Bibi M, Du J
Oxidative medicine and cellular longevity 2021;2021:9955717
Oxidative medicine and cellular longevity 2021;2021:9955717
CKAP2L, as an Independent Risk Factor, Closely Related to the Prognosis of Glioma.
Zhu L, Zheng Y, Hu R, Hu C
BioMed research international 2021;2021:5486131
BioMed research international 2021;2021:5486131
Discovery of a novel HDACi structure that inhibits the proliferation of ovarian cancer cells in vivo and in vitro.
Bai M, Cui M, Li M, Yao X, Wu Y, Zheng L, Sun L, Song Q, Wang S, Liu L, Yu C, Huang Y
International journal of biological sciences 2021;17(13):3493-3507
International journal of biological sciences 2021;17(13):3493-3507
PSMD7 downregulation suppresses lung cancer progression by regulating the p53 pathway.
Xu X, Xuan X, Zhang J, Xu H, Yang X, Zhang L, Zhao Y, Xu H, Li D
Journal of Cancer 2021;12(16):4945-4957
Journal of Cancer 2021;12(16):4945-4957
The novel LSD1 inhibitor ZY0511 suppresses diffuse large B-cell lymphoma proliferation by inducing apoptosis and autophagy.
Liu H, Wei J, Sang N, Zhong X, Zhou X, Yang X, Zhang J, Zuo Z, Zhou Y, Yang S, Du J, Zhao Y
Medical oncology (Northwood, London, England) 2021 Sep 7;38(10):124
Medical oncology (Northwood, London, England) 2021 Sep 7;38(10):124
Long noncoding RNA GAS5 accelerates diabetic wound healing and promotes lymphangiogenesis via miR-217/Prox1 axis.
He ZY, Huang MT, Cui X, Zhou ST, Wu Y, Zhang PH, Zhou J
Molecular and cellular endocrinology 2021 Jul 15;532:111283
Molecular and cellular endocrinology 2021 Jul 15;532:111283
GBP1 promotes erlotinib resistance via PGK1‑activated EMT signaling in non‑small cell lung cancer.
Cheng L, Gou L, Wei T, Zhang J
International journal of oncology 2020 Sep;57(3):858-870
International journal of oncology 2020 Sep;57(3):858-870
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