Antibody data
- Antibody Data
- Antigen structure
- References [9]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 15271-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15271-1-AP, RRID:AB_2127260
- Product name
- INTS10 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated INTS10 antibody (Cat. #15271-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references A combinatorial approach to uncover an additional Integrator subunit.
PGC-1α senses the CBC of pre-mRNA to dictate the fate of promoter-proximally paused RNAPII.
INTS13 variants causing a recessive developmental ciliopathy disrupt assembly of the Integrator complex.
Integrator endonuclease drives promoter-proximal termination at all RNA polymerase II-transcribed loci.
Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination.
INTS10-INTS13-INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module.
Molecular basis for the interaction between Integrator subunits IntS9 and IntS11 and its functional importance.
CRISPR-Cas9 mediated genetic engineering for the purification of the endogenous integrator complex from mammalian cells.
DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes.
Offley SR, Pfleiderer MM, Zucco A, Fraudeau A, Welsh SA, Razew M, Galej WP, Gardini A
Cell reports 2023 Mar 28;42(3):112244
Cell reports 2023 Mar 28;42(3):112244
PGC-1α senses the CBC of pre-mRNA to dictate the fate of promoter-proximally paused RNAPII.
Rambout X, Cho H, Blanc R, Lyu Q, Miano JM, Chakkalakal JV, Nelson GM, Yalamanchili HK, Adelman K, Maquat LE
Molecular cell 2023 Jan 19;83(2):186-202.e11
Molecular cell 2023 Jan 19;83(2):186-202.e11
INTS13 variants causing a recessive developmental ciliopathy disrupt assembly of the Integrator complex.
Mascibroda LG, Shboul M, Elrod ND, Colleaux L, Hamamy H, Huang KL, Peart N, Singh MK, Lee H, Merriman B, Jodoin JN, Sitaram P, Lee LA, Fathalla R, Al-Rawashdeh B, Ababneh O, El-Khateeb M, Escande-Beillard N, Nelson SF, Wu Y, Tong L, Kenney LJ, Roy S, Russell WK, Amiel J, Reversade B, Wagner EJ
Nature communications 2022 Oct 13;13(1):6054
Nature communications 2022 Oct 13;13(1):6054
Integrator endonuclease drives promoter-proximal termination at all RNA polymerase II-transcribed loci.
Stein CB, Field AR, Mimoso CA, Zhao C, Huang KL, Wagner EJ, Adelman K
Molecular cell 2022 Nov 17;82(22):4232-4245.e11
Molecular cell 2022 Nov 17;82(22):4232-4245.e11
Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination.
Huang KL, Jee D, Stein CB, Elrod ND, Henriques T, Mascibroda LG, Baillat D, Russell WK, Adelman K, Wagner EJ
Molecular cell 2020 Oct 15;80(2):345-358.e9
Molecular cell 2020 Oct 15;80(2):345-358.e9
INTS10-INTS13-INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module.
Sabath K, Stäubli ML, Marti S, Leitner A, Moes M, Jonas S
Nature communications 2020 Jul 9;11(1):3422
Nature communications 2020 Jul 9;11(1):3422
Molecular basis for the interaction between Integrator subunits IntS9 and IntS11 and its functional importance.
Wu Y, Albrecht TR, Baillat D, Wagner EJ, Tong L
Proceedings of the National Academy of Sciences of the United States of America 2017 Apr 25;114(17):4394-4399
Proceedings of the National Academy of Sciences of the United States of America 2017 Apr 25;114(17):4394-4399
CRISPR-Cas9 mediated genetic engineering for the purification of the endogenous integrator complex from mammalian cells.
Baillat D, Russell WK, Wagner EJ
Protein expression and purification 2016 Dec;128:101-8
Protein expression and purification 2016 Dec;128:101-8
DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes.
Yamamoto J, Hagiwara Y, Chiba K, Isobe T, Narita T, Handa H, Yamaguchi Y
Nature communications 2014 Jun 27;5:4263
Nature communications 2014 Jun 27;5:4263
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Supportive validation
- Submitted by
- Proteintech Group (provider)
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- Experimental details
- The INTS10 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human INTS10. This antibody recognizes human, mouse, rat antigen. The INTS10 antibody has been validated for the following applications: ELISA, WB analysis.