12912-3-AP

antibody from Proteintech Group

Targeting: TGM1 ICR2, LI, LI1, TGASE, TGK

Provider product page for 12912-3-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [44]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 12912-3-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#12912-3-AP, RRID:AB_2271748
Product name: TGM1 antibody
Antibody type: Polyclonal
Description: TGM1 antibody (Cat. #12912-3-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

TGM1 protein structure - 12912-3-AP shown in red.

Submitted references TGM1 as a novel signature gene in psoriasis identified by integrative bioinformatics and experimental validation.

Guo P, Sun M, Zhang J, Yuan Q, Cui H, Huang J, Luo J, Zhu Q, Zhang B, Hu L
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Gapmer Antisense Oligonucleotide Targeting E-Cadherin Rescues Abnormal Keratinization in X-Linked Ichthyosis Models.

Kwak JH, Kwon TU, Kwon YJ, Park H, Kang YJ, Shin J, Chun YJ
Biomolecules & therapeutics 2026 Jan 1;34(1):213-224

Spectrin coordinates cell shape and signaling essential for epidermal differentiation.

Soffer A, Bhosale A, Ghodrat R, Peskoller M, Matsui T, Niessen CM, Luxenburg C, Rübsam M
The Journal of cell biology 2026 Apr 6;225(4)

KSHV and HPV modulate epithelial-to-mesenchymal transition in oral epithelial cells.

Li Q, Hopcraft SE, Lange PT, Pluta L, Dittmer DP, Moody CA, Damania B
mBio 2025 Sep 10;16(9):e0048425

Spongiotic psoriasiform dermatitis with dual features of eczema and psoriasis: Janus kinase inhibition as a potential therapeutic option.

Cheng W, Pan C, Xu Q, Li J, Wang X, Wang Y, Sun P, Chen X, Yang J, Yao Z, Li C
Clinical and experimental dermatology 2025 Nov 25;50(12):2431-2438

Spatiotemporal transcriptomic maps of mouse intracerebral hemorrhage at single-cell resolution.

Xiang R, Wang J, Chen Z, Tao J, Peng Q, Ding R, Zhou T, Tu Z, Wang S, Yang T, Chen J, Jia Z, Li X, Zhang X, Chen S, Cheng N, Zhao M, Li J, Xue Q, Zhang H, Jiang C, Xing N, Ouyang K, Pekny A, Michalowska MM, de Pablo Y, Wilhelmsson U, Mitsios N, Liu C, Xu X, Fan X, Pekna M, Pekny M, Chen X, Liu L, Mulder J, Wang M, Wang J
Neuron 2025 Jul 9;113(13):2102-2122.e7

Loss of ERBB2 and ERBB3 Receptors Impacts Epidermal Differentiation in Mice.

Hommel T, Meisel PF, Camera E, Bottillo G, Teufelberger AR, Benezeder TH, Wolf P, Kleissl L, Stary G, Posch C, Schneider MR, Dahlhoff M
The Journal of investigative dermatology 2025 Jan;145(1):204-208.e6

Revealing the Therapeutic Potential: Investigating the Impact of a Novel Witch Hazel Formula on Anti-Inflammation and Antioxidation.

Liu X, Hage TW, Chen LC, Wang EHC, Liao IC, Goldberg J, Gosto S, Cziryak P, Senna M, Chen Y, Zheng Q
Journal of cosmetic dermatology 2025 Feb;24(2):e16662

In Vitro Bioactivity of a Recombinant Human Collagen Peptide in a Filler Biomimetic Skin Model.

He C, Wang R, Zhang Q, Wang Y, Huang N
Journal of cosmetic dermatology 2025 Dec;24(12):e70592

In Vitro Evidence for Oral Soft Tissue Regenerative Effects of a Polynucleotide-Hyaluronan Formulation.

Mladenova I, Song X, Nica C, Sculean A, Asparuhova MB
Clinical and experimental dental research 2025 Dec;11(6):e70253

Molecular and mechanical signatures contributing to mouse epidermal differentiation and barrier formation.

Prado-Mantilla A, Ning W, Lechler T
eLife 2025 Aug 7;13

The Adhesion GPCR ADGRL2 engages Gα13 to Enable Epidermal Differentiation.

Yang X, He F, Porter DF, Garbett K, Meyers RM, Reynolds DL, Bui DLH, Hong A, Ducoli L, Siprashvili Z, Lopez-Pajares V, Mondal S, Ko L, Jing Y, Tao S, Singal B, Sando R, Skiniotis G, Khavari PA
bioRxiv : the preprint server for biology 2025 Apr 14;

Hydrophobic binary mixtures containing amphotericin B as lipophilic solutions for the treatment of cutaneous leishmaniasis.

Augis L, Nguyễn CH, Ciseran C, Wacha A, Mercier-Nomé F, Domenichini S, Sizun C, Fourmentin S, Legrand FX
International journal of pharmaceutics 2024 Sep 5;662:124486

PRSS3/mesotrypsin as a putative regulator of the biophysical characteristics of epidermal keratinocytes in superficial layers.

Kida M, Abe J, Hori H, Hirai Y
Scientific reports 2024 May 29;14(1):12383

Characterization of heterogeneous skin constructs for full thickness skin regeneration in murine wound models.

Ifediba M, Baetz N, Lambert L, Benzon H, Page V, Anderson N, Roth S, Miess J, Nicolosi I, Beck S, Sopko N, Garrett C
Tissue & cell 2024 Jun;88:102403

Superior COL7A1 and TGM1 gene expression in difficult-to-transfect skin cell mediated by highly branched poly(β-amino esters) through stepwise fractionation.

Pan C, Wang C, Zhao Y, Bo T, Han L, Yao D, Wang Y, Wang X, Shi L, Zhao A, Cao Q, Chen F, He W, Ye Y, Zhang S, Li M
Journal of controlled release : official journal of the Controlled Release Society 2024 Jun;370:82-94

Sensory neurons increase keratinocyte proliferation through CGRP release in a tissue engineered in vitro model of innervation in psoriasis.

Pepin R, Ringuet J, Beaudet MJ, Bellenfant S, Galbraith T, Veillette H, Pouliot R, Berthod F
Acta biomaterialia 2024 Jul 1;182:1-13

Construction of a dual-component hydrogel matrix for 3D biomimetic skin based on photo-crosslinked chondroitin sulfate/collagen.

He S, Li H, Chi B, Zhang X, Wang Y, Wu J, Huang Q
International journal of biological macromolecules 2024 Jan;254(Pt 3):127940

Proteomics analysis of the brain from a Gaucher disease mouse identifies pathological pathways including a possible role for transglutaminase 1.

Blumenreich S, Ben-Yashar DP, Shalit T, Kupervaser M, Milenkovic I, Joseph T, Futerman AH
Journal of neurochemistry 2024 Jan;168(1):52-65

Early concentrate starter introduction induces rumen epithelial parakeratosis by blocking keratinocyte differentiation with excessive ruminal butyrate accumulation.

Zhang K, Zhang Y, Qin J, Zhu H, Liu N, Sun D, Yin Y, Mao S, Zhu W, Huang Z, Liu J
Journal of advanced research 2024 Dec;66:71-86

Integration of transcriptomics and spatial biology analyses reveals Galactomyces ferment filtrate promotes epidermal interconnectivity via induction of keratinocyte differentiation, proliferation and cellular bioenergetics.

Snowball JM, Jarrold BB, DeAngelis Y, Li C, Rovito HA, Hare MC, Laughlin T, Evdokiou AL, Oblong JE
International journal of cosmetic science 2024 Dec;46(6):927-940

TGM1/3-mediated transamidation of Exo70 promotes tumor metastasis upon LKB1 inactivation.

Hou J, Mei K, Wang D, Ke S, Chen X, Shang J, Li G, Gao Y, Xiong H, Zhang H, Chen L, Zhang W, Deng Y, Hong X, Liu DA, Hu T, Guo W, Zhan YY
Cell reports 2024 Aug 27;43(8):114604

Functional properties and skin care effects of sodium trehalose sulfate.

Maeda K, Zhou Z, Guo M, Zhang J, Chen L, Yang F
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 2024 Apr;30(4):e13666

The decline in cellular iron is crucial for differentiation in keratinocytes.

Abe J, Aono Y, Hirai Y
Metallomics : integrated biometal science 2024 Apr 5;16(4)

Comprehensive cornified envelope protein profile of odontogenic keratocysts clarifies the characteristics of non-keratinized oral epithelium.

Roy RR, Ochiai T, Shimada K, Hasegawa H
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2023 Sep;52(8):758-765

Role of syntaxin3 an apical polarity protein in poorly polarized keratinocytes: regulation of asymmetric barrier formations in the skin epidermis.

Hayashi K, Nozaki S, Tokushima K, Tanaka F, Hirai Y
Cell and tissue research 2023 Sep;393(3):523-535

Cathelicidin LL-37 Activates Human Keratinocyte Autophagy through the P2X₇, Mechanistic Target of Rapamycin, and MAPK Pathways.

Ikutama R, Peng G, Tsukamoto S, Umehara Y, Trujillo-Paez JV, Yue H, Nguyen HLT, Takahashi M, Kageyama S, Komatsu M, Okumura K, Ogawa H, Ikeda S, Niyonsaba F
The Journal of investigative dermatology 2023 May;143(5):751-761.e7

Targeting Multiple Hallmarks of Skin Aging: Preclinical and Clinical Efficacy of a Novel Growth Factor-Based Skin Care Serum.

Naughton GK, Jiang LI, Makino ET, Chung R, Nguyen A, Cheng T, Kadoya K, Mehta RC
Dermatology and therapy 2023 Jan;13(1):169-186

A Newly Developed Chemically Defined Serum-Free Medium Suitable for Human Primary Keratinocyte Culture and Tissue Engineering Applications.

Ghio SC, Barbier MA, Doucet EJ, Debbah I, Safoine M, Le-Bel G, Cartier A, Jolibois E, Morissette A, Larouche D, Fradette J, Guérin SL, Garnier A, Germain L
International journal of molecular sciences 2023 Jan 17;24(3)

Horse-Derived Ceramide Accentuates Glucosylceramide Synthase and Ceramide Synthase 3 by Activating PPARβ/δ and/or PPARγ to Stimulate Ceramide Synthesis.

Igarashi T, Yanagi H, Yagi M, Ichihashi M, Imokawa G
Biomedicines 2023 Feb 13;11(2)

Production of Tissue-Engineered Skin Substitutes for Clinical Applications: Elimination of Serum.

Doucet EJ, Cortez Ghio S, Barbier MA, Savard É, Magne B, Safoine M, Larouche D, Fradette J, Germain L
International journal of molecular sciences 2023 Aug 8;24(16)

Increased Osteoclastogenesis in Absence of TG2 Is Reversed by Transglutaminase Inhibition-Evidence for the Role for TG1 in Osteoclast Formation.

Ebrahimi Samani S, Kaartinen MT
Cells 2023 Aug 24;12(17)

Divergent transcriptional regulation of astrocyte reactivity across disorders.

Burda JE, O'Shea TM, Ao Y, Suresh KB, Wang S, Bernstein AM, Chandra A, Deverasetty S, Kawaguchi R, Kim JH, McCallum S, Rogers A, Wahane S, Sofroniew MV
Nature 2022 Jun;606(7914):557-564

Inhibiting Hyper-O-GlcNAcylation of c-Myc accelerate diabetic wound healing by alleviating keratinocyte dysfunction.

Zhang J, Yang P, Liu D, Gao M, Wang J, Yu T, Zhang X, Liu Y
Burns & trauma 2021;9:tkab031

Enhancement of Cornified Envelope-Related Gene and Protein Expression by Carba Cyclic Phosphatidic Acid in Normal Human Epidermal Keratinocytes.

Saito E, Kage M, Tokudome Y
Biological & pharmaceutical bulletin 2021;44(3):453-457

Effect of Lactic Fermentation Products on Human Epidermal Cell Differentiation, Ceramide Content, and Amino Acid Production.

Otsuka M, Tamane T, Tokudome Y
Skin pharmacology and physiology 2021;34(2):103-114

c-Myc Upregulated by High Glucose Inhibits HaCaT Differentiation by S100A6 Transcriptional Activation.

Zhang J, Yang P, Liu D, Gao M, Wang J, Wang X, Liu Y, Zhang X
Frontiers in endocrinology 2021;12:676403

Investigation of Omega-3 Polyunsaturated Fatty Acid Biological Activity in a Tissue-Engineered Skin Model Involving Psoriatic Cells.

Simard M, Rioux G, Morin S, Martin C, Guérin SL, Flamand N, Julien P, Fradette J, Pouliot R
The Journal of investigative dermatology 2021 Oct;141(10):2391-2401.e13

Contribution of transglutaminases and their substrate proteins to the formation of cornified cell envelope in oral mucosal epithelium.

Roy RR, Shimada K, Murakami S, Hasegawa H
European journal of oral sciences 2021 Feb;129(1):e12760

Docosahexaenoic Acid Modulates Paracellular Absorption of Testosterone and Claudin-1 Expression in a Tissue-Engineered Skin Model.

Tremblay A, Simard M, Morin S, Pouliot R
International journal of molecular sciences 2021 Dec 3;22(23)

Restoration of calcium-induced differentiation potential and tight junction formation in HaCaT keratinocytes by functional attenuation of overexpressed high mobility group box-1 protein.

Tanaka F, Uda M, Hirose Y, Hirai Y
Cytotechnology 2020 Feb;72(1):165-174

Specialized Living Wound Dressing Based on the Self-Assembly Approach of Tissue Engineering.

Cantin-Warren L, Guignard R, Cortez Ghio S, Larouche D, Auger FA, Germain L
Journal of functional biomaterials 2018 Sep 15;9(3)

Characterization of Epidermal Lipoxygenase Expression in Normal Human Skin and Tissue-Engineered Skin Substitutes.

Simard-Bisson C, Parent LA, Moulin VJ, Fruteau de Laclos B
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2018 Nov;66(11):813-824

Filaggrin silencing by shRNA directly impairs the skin barrier function of normal human epidermal keratinocytes and then induces an immune response.

Dang NN, Pang SG, Song HY, An LG, Ma XL
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2015 Jan;48(1):39-45

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse thymus tissue were subjected to SDS PAGE followed by western blot with 12912-3-AP(TGM1 antibody) at dilution of 1:400
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The TGM1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TGM1. This antibody recognizes human, mouse, rat antigen. The TGM1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 12912-3-AP.pdf

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