IFITM5

This gene encodes a membrane protein thought to play a role in bone mineralization. This gene is located on chromosome 11 in a cluster of related genes which are induced by interferon, however, this gene has not been shown to be interferon inducible. A similar gene, located in a gene cluster on mouse chromosome 7, is a member of the interferon-inducible fragilis gene family. The mouse gene encodes a transmembrane protein described as participating in germ cell competence. A mutation in the 5' UTR of this gene has been associated with osteogenesis imperfecta type V (PMID: 22863190, 22863195). [provided by RefSeq, Aug 2012]

Description

Interferon induced transmembrane protein 5

Tissue specificity

Group enriched (brain, pancreas)

Subcell location

Vesicles, Plasma membrane, Cytosol

Predicted location

Membrane

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

11 (298200 - 299526)

Ensembl ID

ENSG00000206013  (ver. 103.38)

Orthologs

Mouse Ifitm5: ENSMUSG00000025489

UniProt

A6NNB3

neXtProt

NX_A6NNB3

Human splice variants
Mouse splice variants

Protein structure