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- References [414]
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- Product number
- 19987-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#19987-1-AP, RRID:AB_10646429
- Product name
- LDHA-Specific antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated LDHA-Specific antibody (Cat. #19987-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Curcumol Induces Necroptosis of Hepatic Stellate Cells by Targeting KAT8 to Suppress HK2 Lactylation and Promote HUWE1-Dependent Ubiquitination.
Gomphus floccosus (Schw.) Sing. extract attenuates alcoholic liver disease by suppressing macrophage glycolysis and M1 polarization.
Microvascular endothelial metabolic dysfunction drives cerebral edema through bioenergetic failure after ischemia-reperfusion.
A putative prognostic model for lung adenocarcinoma based on crotonylation-related genes by bioinformatics and experimental verification.
Elevated lactate production exacerbates PM2.5-induced pulmonary fibrosis by stabilizing TGF-β1.
YTHDF3 Mediates the Occurrence and Development of Breast Cancer by Regulating Glycolysis Through the mTOR-HIF1α-LHDA Axis.
Phosphoglucomutase 5 suppresses gallbladder cancer progression by inhibiting lactate-driven STAT3 signaling.
HKDC1 promotes the H3K18 lactylation of the promoter of ORMDL3 to induce the activation of hepatic stellate cells in liver cirrhosis.
Lactate Metabolism-Immune Regulation-Related Gene Signature in Lower-Grade Gliomas: Prognostic Model Development and Immune Characterization.
USP5-mediated CD73 deubiquitination drives osimertinib resistance via PI3K/AKT and glycolysis activation in LUAD.
TCF7L2/DEPDC1 axis contributes to tumor progression by promoting cell proliferation, aerobic glycolysis, and immunosuppression in pancreatic cancer.
Bie-Jia-Jian Pill: Inhibiting tumor glycolysis and promoting CD8(+) cell-mediated anti-tumor immunity by targeting HIF-1α-PI3K/AKT/mTOR and CCL20 in hepatocellular carcinoma.
Neuronal ACVR1-mediated H3K18 lactylation drives NLRP3 pyroptosis to sustain neuropathic pain via metabolic-epigenetic coupling.
Ailanthone ameliorates CCl(4)-induced liver fibrosis by targeting PKM2-mediated macrophage M1 polarization and glycolytic reprogramming.
Stiripentol-loaded self-nanoemulsifying delivery system for glioblastoma: therapeutic efficacy in 3D spheroid and xenograft model.
Lactylation Enhances the Activity of Lactate Dehydrogenase A and Promotes the Chemoresistance to Cisplatin Through Facilitating DNA Nonhomologous End Junction in Lung Adenocarcinoma.
Ptbp2 Alleviates Neuroinflammation and Blood-brain Barrier Disruption via Modulating Microglial Polarization in Ischemic Stroke.
Narciclasine Alleviates Endothelial Inflammation and Atherosclerosis Initiation by Inhibiting Histone Lactylation-Mediated NF-κB Activation.
Spatial heterogeneity of lactylation: insights into gene expression, metabolism, and lactate transport in human embryonic stem cells.
Porcine epidemic diarrhea virus promotes viral replication via ROS/HIF-1α-mediated glycolysis.
Integrative Analysis of Cytotoxic Lymphocytes-Mediated Tumour Killing Related Genes Reveals LDHA as a Novel Glioblastoma Therapeutic Target.
Mitochondrial oxidative stress under hypoxia promotes gastric mucosal injury in portal hypertensive gastropathy.
Histone lactylation increases CXCL1 expression for neutrophil infiltration and immune escape in pancreatic cancer.
Metabolic Flexibility and Energy Substrate Utilization Regulate Contractility in the Human Myometrium.
Circadian tryptophan metabolism contributes to systemic aryl hydrocarbon receptor activity.
The glycolytic enzyme PFKM promotes renal fibrosis by activating the NF-κB pathway via lactate-mediated H3K18 lactylation.
The role of glutamine/Nrf2-enhanced PHGDH in Cadmium-induced lactate utilization.
LRRN3 protects dopaminergic neurons by inhibiting glycolysis in Parkinson's disease.
Lactate derived from macrophages drives skin dermal fibroblasts phenotypic remodeling via MCT1-primed histone H3 lysine 23 lactylation in hypertrophic scar.
Gut-confined fullerene reprograms lactate metabolism to Rescue hypoxia-induced exercise intolerance.
Baicalin alleviates repeated superovulation induced ovarian dysfunction and oocyte impairment by suppressing excessive glycolysis.
Designed bone-targeting ROS-responsive nanoplatform for precision glycolysis inhibition in postmenopausal osteoporosis.
PMM2 interacts with TRIM28 to recruit E2F4 and promote KIFC3-mediated tumor glycolysis and colorectal cancer progression.
ANGPT2/Tie2 Enhances H3K18la-Mediated Macrophage M2 Polarization to Promote Endothelial Cell Proliferation in the Chronically Ischaemic Brain.
An Activity-Dependent NEPAS-PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment.
Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1-Mediated M1 Macrophage Polarization in Sarcoidosis.
Targeting the SIN1 mediated TTK/LDHA-H3K18la-GLUT3 axis disrupts metabolic-epigenetic crosstalk and suppresses progression in hyperglycolytic breast cancer.
KSR2 functions as a metabolic checkpoint for anti-PD-1 resistance by reprogramming glucose metabolism.
SIRT6-mediated immunometabolic reprogramming of macrophages drives neutrophilic asthma via LDHA-dependent glycolysis.
Silica Promotes Silicosis via the ROS/NF-κB p65 Signaling-Activated Hypoxia-Lactate Axis in Rats.
Pharmacological targeting of the NLRP3 LRR domain with isothiazolinones overcomes CRID3-resistant inflammation.
FBXO39 promotes LDHA-mediated aerobic glycolysis and colorectal cancer progression by p53 degradation.
Mechanistic Insights Into Qidan Yixin Decoction for Diabetic Cardiomyopathy via Macrophage Polarization.
Lactate Facilitates Pancreatic Repair Following Acute Pancreatitis by Promoting Reparative Macrophage Polarization.
Enhancing Quercetin's Potential: A Nanoliposome Delivery System for High Altitude Pulmonary Edema.
Integrated multi-omics analysis reveals a glycolytic signature that predicts pan-cancer immune checkpoint inhibitor response and LDHA as a combinatorial target in fumarate hydratase-deficient renal cell carcinoma.
Neutrophil hitchhiking liposomal drugs for starvation therapy in endometriosis.
NFIA-dependent upregulation of SMC4 promotes metastasis and metabolic reprogramming in glioma.
Rewired glycolysis by DTL accelerates oncometabolite L-lactate generation to promote breast cancer progression.
SNHG12 downregulation induces follicular dysplasia by modulating the glycolysis of granulosa cell in polycystic ovary syndrome.
Activation of sclerostin inhibits Isg20-Mediated aerobic glycolysis ameliorating renal Fibrosis: the renoprotective mechanism of hederagenin in CKD.
Glyphosate targets FYN to regulate glycolysis and promote glioblastoma proliferation: A network toxicology study.
Triflupromazine and tranylcypromine alleviate primary cisplatin resistance in lung adenocarcinoma by promoting LDHA-mediated AMBRA1 ubiquitination.
EMSY enhances glycolysis in ovarian cancer cells.
Menin regulates YBX1 nucleus translocation to boost the HKDC1 transcription and affects pancreatic cancer glycolysis.
A potent NLRP3 inhibitor effective against both MCC950-sensitive and -resistant inflammation.
HMGA2/PHGDH axis-mediated glycolysis under hypoxia is required for cadmium-induced A549 cell migration.
Integrated cartilage metabolomics and proteomics analysis reveals the therapeutic effect of Wenjing Tongluo Decoction on Knee osteoarthritis rats.
Excavating Precursors from Herb Pairs Polygala tenuifolia and Acori tatarinowii: Synthesis and Anticonvulsant Activity Evaluation of 3,4,5-Trimethoxycinnamic Acid (TMCA) Piperazine Amide Derivatives.
A non-canonical aryl hydrocarbon receptor pathway authorizes and safeguards clinical-scale expansion of functional human endothelial cells.
3D printing-biomimetic local stiff niche enhances glycolysis to boost PDAC cell stem-like phenotype via N6-methyladenosine-suppressed YAP1 mRNA decay.
PKM2 alleviates mitochondrial oxidative stress and neuronal apoptosis through metabolic and non-metabolic pathways to protect SOD1(G93A) mice.
FAM3B activates hepatic stellate cells to accelerate hepatic fibrosis by promoting glucose metabolism.
[SF3B3 overexpression promotes proliferation of gastric cancer cells and correlates with poor patient prognosis].
Histone H3 lysine 18 lactylation attenuates neuroinflammation and neurological damage by regulating microglial plxnb2 after ischemic stroke.
GDF15 attenuates sepsis-induced acute lung injury by suppressing the HIF-1α/LDHA pathway.
Baicalin attenuates the immune escape of oral squamous cell carcinoma by reducing lactate accumulation in tumor microenvironment.
FAM111B enhances glycolysis and promotes metastasis of prostate cancer by upregulating LDHA.
The ubiquitin-binding protein ANKRD13A mediates VCP-dependent mitochondrial outer membrane rupture during PINK1/Parkin-mediated mitophagy.
TRPM7 Deficiency Accelerates Vascular Senescence by Inhibiting H3K18 Lactylation.
Mechanosensory activation of Piezo1 via cupping therapy: Harnessing neural networks to modulate AMPK pathway for metabolic restoration in a mouse model of psoriasis.
Dysregulated oxidative stress and lactate levels in treatment-resistant schizophrenia.
PSMD14-Mediated LDHA Deubiquitination Upregulates ACLY Expression via H3K18 Lactylation to Promote Lipid Synthesis and Pancreatic Cancer Progression.
Multi-omics analyses identify mannose phosphate isomerase-centered hypoxia-induced angiogenesis signature in colorectal cancer.
Inflammation and Mitochondrial Dysfunction in Cirrhotic Cardiomyopathy: Therapeutic Implications.
Breviscapine targets EGFR and SRC to abrogate diabetes-driven GPX4 lactylation and ferroptosis resistance in gastric cancer.
USP13 promotes colorectal cancer progression by deubiquitinating and stabilizing HIF-1α.
Glucagon-like peptide-1 receptor signaling activation in alveolar type II cells enhances lung development in neonatal rats exposed to hyperoxia.
S-palmitoylation modulates ATG2-dependent non-vesicular lipid transport during starvation-induced autophagy.
SIRT5-mediated desuccinylation of PPA2 enhances HIF-1alpha-dependent adaptation to hypoxic stress and colorectal cancer metastasis.
Patient-derived organotypic tissue cultures as a platform to evaluate metabolic reprogramming in breast cancer patients.
Cardiac PDK4 promotes neutrophilic PFKL methylation and drives the innate immune response in diabetic myocardial infarction.
NUDT21 lactylation reprograms alternative polyadenylation to promote cuproptosis resistance.
IGFBP5 promotes EndoMT and renal fibrosis through H3K18 lactylation in diabetic nephropathy.
Ferroptosis-activating metabolite acrolein antagonizes necroptosis and anti-cancer therapeutics.
HCK regulates NLRP12-mediated PANoptosis.
Lactate-associated gene MCU promotes the proliferation, migration, and invasion of pancreatic ductal adenocarcinoma.
LncRNA NEAT1 regulation of the miR-101-3p/RAC1 axis affects cervical cancer aerobic glycolysis and progression.
LONP1 facilitates pulmonary artery smooth muscle cell glycolytic reprogramming by degrading MPC1 in pulmonary hypertension.
Compressive force-induced succinate production via metabolic reprogramming in periodontal ligament cells promotes orthodontic tooth movement.
Astragaloside IV prevents liver fibrosis by blocking glycolysis-mediated macrophage M1 polarization.
Effects of polystyrene microparticles exposures on spermatogenic cell differentiation and reproductive endpoints in male mice.
Interplay and cooperation between GLI2 and master transcription factors promote progression of esophageal squamous cell carcinoma.
Lactate Dehydrogenase A Is a Novel Positive Regulator of Vascular Smooth Muscle Cell Ferroptosis During Aortic Dissection.
Deciphering key roles of B cells in prognostication and tailored therapeutic strategies for lung adenocarcinoma: a multi-omics and machine learning approach towards predictive, preventive, and personalized treatment strategies.
The critical role of the ZBP1-NINJ1 axis and IRF1/IRF9 in ethanol-induced cell death, PANoptosis, and alcohol-associated liver disease.
Administration of Porphyromonas gingivalis in pregnant mice enhances glycolysis and histone lactylation/ADAM17 leading to cleft palate in offspring.
Identification of biomarkers associated with macrophage polarization in diabetic cardiomyopathy based on bioinformatics and machine learning approaches.
Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model.
H3K18 lactylation-mediated SIX1 upregulation contributes to silica-induced epithelial-mesenchymal transition in airway epithelial cells.
ENTR1 affects the progression of colon cancer by regulating energy metabolism under the influence of glycolysis.
TAMs-derived SPP1, regulated by HIF-1α/STAT3 signaling pathway, influences colorectal cancer malignant progression by activation of EMT via integrin αvβ3.
GCLM lactylation mediated by ACAT2 promotes ferroptosis resistance in KRAS(G12D)-mutant cancer.
Formoterol, the Most Effective Bronchodilator, Has No Anti-Inflammatory nor Metabolic Modulatory Effects in Severe Asthma Induced by Aspergillus fumigatus.
The role of RAB12 in inhibiting osteogenic differentiation and driving metabolic dysregulation in osteoporosis.
Serum amyloid A drive microglia shift to a resolving phenotype through Nrf2.
Innate immune sensor NLRP3 drives PANoptosome formation and PANoptosis.
IER3 Facilitates Tumor Progression and Aberrant Glycolysis via Activating wnt/β-Catenin Pathway in Oral Squamous Cell Carcinoma.
HBx Drives Liver Cancer Stem Cell Generation Through Stimulating Glucose Metabolic Reprogramming.
Lactate production by tumor-resident Staphylococcus promotes metastatic colonization in lung adenocarcinoma.
Adipocytes-induced ANGPTL4/KLF4 axis drives glycolysis and metastasis in triple-negative breast cancer.
Overexpression of PPM1G promotes cell metabolism and activates the NOTCH signaling pathway in lung adenocarcinoma.
Salvianolic Acid B Attenuates Liver Fibrosis via Suppression of Glycolysis-Dependent m1 Macrophage Polarization.
FBP1 as a key regulator of focal adhesion kinase-mediated hepatic stellate cell activation: Multi-omics and experimental validation.
Nuclear Lactate Dehydrogenase A Resists Cardiomyocyte Cell Cycle Arrest Induced by Oxidative Stress.
Beta sitosterol inhibits the proliferation and migration of synoviocytes in rheumatoid arthritis via lactylation of GPI.
Extracellular vesicle-derived lncRNA VIM-AS1 promotes diabetic wound healing by promoting glycolysis and alleviating cellular senescence.
AMPK-regulated glycerol excretion maintains metabolic crosstalk between reductive and energetic stress.
Hypoxia-induced BNIP3 facilitates the progression and metastasis of uveal melanoma by driving metabolic reprogramming.
CASC8 activates the pentose phosphate pathway to inhibit disulfidptosis in pancreatic ductal adenocarcinoma though the c-Myc-GLUT1 axis.
ITGA3 promotes pancreatic cancer progression through HIF1α- and c-Myc-driven glycolysis in a collagen I-dependent autocrine manner.
Targeting Metabolic Adaptation of Colorectal Cancer with Vanadium-Doped Nanosystem to Enhance Chemotherapy and Immunotherapy.
Specific effects of hypoxia-immune core gene ARHGAP11A on lung adenocarcinoma.
CPT1A mediates succinylation of LDHA at K318 site promoteing metabolic reprogramming in NK/T-cell lymphoma nasal type.
HSP90 co-regulates the formation and nuclear distribution of the glycolytic output complex to promote resistance and poor prognosis in gastric cancer patients.
Juglone targets MMP-1 to inhibit gastric cancer progression.
Matrix stiffness-sensitive LDHA drives autophagy of pancreatic ductal adenocarcinoma via inducing FOXO3 expression and lactylation.
CPSF6 loss mediates LDHA 3'UTR shortening to promote fibroblast glycolysis and pulmonary fibrosis.
Protective role of interleukin-37 in oral lichen planus: Regulation of Jurkat cell glycolysis through the mTOR pathway.
Cyclin B2 facilitates glycolysis and tumor progression in pancreatic ductal adenocarcinoma by promoting histone lactylation.
Shikonin alleviates rotenone-induced Parkinson's disease neuroinflammation by targeting PKM2-mediated glycolytic MG-Hs production.
Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis.
Lypd6b depletion promotes CD8(+) T cell-mediated anti-tumor immunity via metabolic reprogramming in colorectal cancer.
Conformational Dynamics of PKM2 Regulate Hypoxia-Induced Pathological Retinal Angiogenesis.
m6A-mediated regulation of ECA39 promotes renal fibrosis in chronic kidney disease by enhancing glycolysis and epithelial-mesenchymal transition.
Elevated Histone Lactylation Mediates Ferroptosis Resistance in Endometriosis Through the METTL3-Regulated HIF1A/HMOX1 Signaling Pathway.
Silybin Mitigates Post-Myocardial Infarction Heart Failure in Mice via Modulation of HIF-1α-Driven Glycolysis and Energy Metabolism.
Extracellular lactate improves neurogenesis by modulating H3K9 lactylation and SnoN expression under hypoxic conditions.
Targeting TSPAN1 promotes ferroptosis in endometrial cancer cells, reduces energy metabolism and inhibits malignant behavior.
Lactylation-boosted polycomb repression of KLF4 elicits glycolysis in retinoblastoma: A positive feedback circuit between histone modifications.
USP19 potentiates autophagic cell death via inhibiting mTOR pathway through deubiquitinating NEK9 in pancreatic cancer.
Shikonin Derivative Suppresses Colorectal Cancer Cells Growth via Reactive Oxygen Species-Mediated Mitochondrial Apoptosis and PI3K/AKT Pathway.
Impact of diabetes and metformin on cuproptosis and ferroptosis in breast cancer patients: an immunohistochemical analysis.
Lactate drives senescence-resistant lineages in hepatocellular carcinoma via histone H2B lactylation of NDRG1.
Activation of GPR35 by kynurenic acid inhibits IL-1β secretion in macrophages during CR-hvKP-induced pneumonia.
Hypoxia-induced PRMT1 methylates HIF2β to promote breast tumorigenesis via enhancing glycolytic gene transcription.
ETV4/ALYREF-mediated glycolytic metabolism through PKM2 enhances resistance to ferroptosis and promotes the development of intrahepatic cholangiocarcinoma.
ACVR2A attenuation impacts lactate production and hyperglycolytic conditions attracting regulatory T cells in hepatocellular carcinoma.
miR-526b enhances glucose metabolism in breast cancer cells, an effect reversed by targeting the COX-2/EP4 pathway.
Muscle-derived small extracellular vesicles induce liver fibrosis during overtraining.
Mitochondrial Dysfunction by FADDosome Promotes Gastric Mucosal Injury in Portal Hypertensive Gastropathy.
The m6A modification-mediated positive feedback between glycolytic lncRNA SLC2A1-DT and c-Myc promotes tumorigenesis of hepatocellular carcinoma.
Bufalin-Loaded Multifunctional Photothermal Nanoparticles Inhibit the Anaerobic Glycolysis by Targeting SRC-3/HIF-1α Pathway for Improved Mild Photothermal Therapy in CRC.
Dipeptide alanine-glutamine ameliorates retinal neurodegeneration in an STZ-induced rat model.
LINC00908 attenuates LUAD tumorigenesis through DEAD-box helicase 54.
Decreased lncRNA HNF4A-AS1 facilitates resistance to sorafenib-induced ferroptosis of hepatocellular carcinoma by reprogramming lipid metabolism.
ETV4 promotes the progression of cholangiocarcinoma by regulating glycolysis via the TGF-β signaling.
Classical apoptotic stimulus, staurosporine, induces lytic inflammatory cell death, PANoptosis.
The miR-199a-5p/HIF1α dual-regulatory axis participates in hypoxia-induced aggressive phenotypes of oral squamous cell carcinoma (OSCC) cells.
Acetate enables metabolic fitness and cognitive performance during sleep disruption.
The type 2 cytokine Fc-IL-4 revitalizes exhausted CD8(+) T cells against cancer.
LncRNA SLC9A3-AS1 knockdown increases the sensitivity of liver cancer cell to triptolide by regulating miR-449b-5p-mediated glycolysis.
UBE2S promotes glycolysis in hepatocellular carcinoma by enhancing E3 enzyme-independent polyubiquitination of VHL.
O-GlcNAcylation mediates Wnt-stimulated bone formation by rewiring aerobic glycolysis.
Direct mitochondrial import of lactate supports resilient carbohydrate oxidation.
CHAC1 blockade suppresses progression of lung adenocarcinoma by interfering with glucose metabolism via hijacking PKM2 nuclear translocation.
Characteristics of Myocardial Structure and Central Carbon Metabolism during the Early and Compensatory Stages of Cardiac Hypertrophy.
The chemically stable analogue of resolvin D1 ameliorates experimental autoimmune encephalomyelitis by mediating the resolution of inflammation.
Oxygen Glucose Deprivation-Induced Lactylation of H3K9 Contributes to M1 Polarization and Inflammation of Microglia Through TNF Pathway.
TRIM33 promotes glycolysis through regulating P53 K48-linked ubiquitination to promote esophageal squamous cell carcinoma growth.
Oroxylin A, a broad‑spectrum anticancer agent, relieves monocrotaline‑induced pulmonary arterial hypertension by inhibiting the Warburg effect in rats.
Trans-resveratrol mitigates miR-204-3p mediated progression of allergic rhinitis by regulating the EGLN3/HIF-1α/IL33/ST2 signalling pathway.
MTFR2 accelerates hepatocellular carcinoma mediated by metabolic reprogramming via the Akt signaling pathway.
Lactylation stabilizes TFEB to elevate autophagy and lysosomal activity.
Construction and validation of a prognostic model based on oxidative stress-related genes in non-small cell lung cancer (NSCLC): predicting patient outcomes and therapy responses.
Histone lactylation mediated by Fam172a in POMC neurons regulates energy balance.
Acrolein exposure affects ovarian function by interfering with glycolysis and mitochondrial energy metabolism in mouse.
Ulinastatin attenuates renal fibrosis by regulating AMPK/HIF-1α signaling pathway-mediated glycolysis.
The protein phosphatase PP6 promotes RIPK1-dependent PANoptosis.
Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation.
Energy stress-induced circDDX21 promotes glycolysis and facilitates hepatocellular carcinogenesis.
Serine/Arginine-Rich Splicing Factor 7 Knockdown Inhibits Aerobic Glycolysis and Growth in HepG2 Cells by Regulating PKM2 Expression.
Epigenetic silencing of LDHB promotes hepatocellular carcinoma by remodeling the tumor microenvironment.
Qing Xia Jie Yi Formula granules alleviated acute pancreatitis through inhibition of M1 macrophage polarization by suppressing glycolysis.
The opposite role of lactate dehydrogenase a (LDHA) in cervical cancer under energy stress conditions.
Region-specific cellular and molecular basis of liver regeneration after acute pericentral injury.
Lactate dehydrogenase A regulates tumor-macrophage symbiosis to promote glioblastoma progression.
Histone lactylation-boosted ALKBH3 potentiates tumor progression and diminished promyelocytic leukemia protein nuclear condensates by m1A demethylation of SP100A.
p53-dependent HIF-1α /autophagy mediated glycolysis to support Cr(VI)-induced cell growth and cell migration.
METTL3 orchestrates glycolysis by stabilizing the c-Myc/WDR5 complex in triple-negative breast cancer.
Inactivation of KDM6A promotes the progression of colorectal cancer by enhancing the glycolysis.
NAT1 inhibits liver metastasis of colorectal cancer by regulating EMT and glycolysis.
The walnut-derived peptide TW-7 improves mouse parthenogenetic embryo development of vitrified MII oocytes potentially by promoting histone lactylation.
NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance.
Electroacupuncture improves articular microcirculation and attenuates cartilage hypoxia in a male rabbit model of knee osteoarthritis.
Bergenin alleviates proliferative arterial diseases by modulating glucose metabolism in vascular smooth muscle cells.
HOXC4 promotes proliferation of pancreatic cancer cells by increasing LDHA-mediated glycolysis.
SEC61 translocon gamma subunit is correlated with glycolytic activity, epithelial mesenchymal transition and the immune suppressive phenotype of lung adenocarcinoma.
Glycolytic enzyme PGK1 promotes M1 macrophage polarization and induces pyroptosis of acute lung injury via regulation of NLRP3.
LDHA contributes to nicotine induced cardiac fibrosis through autophagy flux impairment.
DEPDC1 as a metabolic target regulates glycolysis in renal cell carcinoma through AKT/mTOR/HIF1α pathway.
Altered neuronal lactate dehydrogenase A expression affects cognition in a sex- and age-dependent manner.
The ubiquitin-like protein UBTD1 promotes colorectal cancer progression by stabilizing c-Myc to upregulate glycolysis.
A vesicular Warburg effect: Aerobic glycolysis occurs on axonal vesicles for local NAD+ recycling and transport.
Tumor-derived lactate promotes resistance to bevacizumab treatment by facilitating autophagy enhancer protein RUBCNL expression through histone H3 lysine 18 lactylation (H3K18la) in colorectal cancer.
Cryptotanshinone suppresses ovarian cancer via simultaneous inhibition of glycolysis and oxidative phosphorylation.
Autophagy induces hair follicle stem cell activation and hair follicle regeneration by regulating glycolysis.
AKT1 phosphorylation of cytoplasmic ME2 induces a metabolic switch to glycolysis for tumorigenesis.
Salvianolic Acid B Alleviates Liver Injury by Regulating Lactate-Mediated Histone Lactylation in Macrophages.
Single-cell transcriptome analysis reveals immunosuppressive landscape in overweight and obese colorectal cancer.
NINJ1 mediates inflammatory cell death, PANoptosis, and lethality during infection conditions and heat stress.
Atractylenolide II Suppresses Glycolysis and Induces Apoptosis by Blocking the PADI3-ERK Signaling Pathway in Endometrial Cancer Cells.
ATF4/PHGDH mediates the effects of ER stress on cadmium-induced autophagy and glycolysis.
Activation of ferritin light chain (FTL) by transcription factor salmonella pathogenicity island 1 modulates glycolysis to drive metastasis of ovarian cancer cells.
Swimming upregulates APOL3 through regulating macrophage polarization to inhibit glycolysis and the development of melanoma.
Uric acid mediates kidney tubular inflammation through the LDHA/ROS/NLRP3 pathway.
Activated DRP1 promotes mitochondrial fission and induces glycolysis in ATII cells under hyperoxia.
Colorectal cancer cells establish metabolic reprogramming with cancer-associated fibroblasts (CAFs) through lactate shuttle to enhance invasion, migration, and angiogenesis.
Ubiquitin-specific protease 7 maintains c-Myc stability to support pancreatic cancer glycolysis and tumor growth.
Phosphorylation determines the glucose metabolism reprogramming and tumor-promoting activity of sine oculis homeobox 1.
Lactate Dehydrogenase Inhibition Protects against Hepatic Fibrosis by Regulating Metabolic Reprogramming of Hepatic Stellate Cells.
Hypoxic mesenchymal stem cell-derived exosomal circDennd2a regulates granulosa cell glycolysis by interacting with LDHA.
Low level exposure to BDE-47 facilitates the development of prostate cancer through TOP2A/LDHA/lactylation positive feedback circuit.
RBM15 drives the progression of lung adenocarcinoma by regulating N6-methyladenosine-mediated LDHA mRNA stability.
PGC-1α/LDHA signaling facilitates glycolysis initiation to regulate mechanically induced bone remodeling under inflammatory microenvironment.
TRIB3 promotes the growth of oral squamous cell carcinoma by regulating JNK/JUN-mediated aerobic glycolysis.
Discovery of a Highly Potent and Selective HDAC8 Degrader: Advancing the Functional Understanding and Therapeutic Potential of HDAC8.
A CLIC1 network coordinates matrix stiffness and the Warburg effect to promote tumor growth in pancreatic cancer.
A novel HMGA2/MPC-1/mTOR signaling pathway promotes cell growth via facilitating Cr (VI)-induced glycolysis.
N(6)-methyladenosine-modified SRPK1 promotes aerobic glycolysis of lung adenocarcinoma via PKM splicing.
The Protective Effect of Quercetin against the Cytotoxicity Induced by Fumonisin B1 in Sertoli Cells.
The mechanism of extracellular CypB promotes glioblastoma adaptation to glutamine deprivation microenvironment.
Mitochondrial dysfunction induced by HIF-1α under hypoxia contributes to the development of gastric mucosal lesions.
Gli1(+) Progenitors Mediate Glucocorticoid-Induced Osteoporosis In Vivo.
Identification and validation of a lactate metabolism-related six-gene prognostic signature in intrahepatic cholangiocarcinoma.
Palmitoylation alters LDHA activity and pancreatic cancer response to chemotherapy.
Metabolic reprogramming of cancer-associated fibroblasts in pancreatic cancer contributes to the intratumor heterogeneity of PET-CT.
Increased α-HB links colorectal cancer and diabetes by potentiating NF-κB signaling.
α-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure.
Immune regulator IRF1 contributes to ZBP1-, AIM2-, RIPK1-, and NLRP12-PANoptosome activation and inflammatory cell death (PANoptosis).
Osteogenic microenvironment affects palatal development through glycolysis.
NAD(H) homeostasis underlies host protection mediated by glycolytic myeloid cells in tuberculosis.
LncRNA CCAT1 facilitates the progression of gastric cancer via PTBP1-mediated glycolysis enhancement.
Dexamethasone protects against Aspergillus fumigatus-induced severe asthma via modulating pulmonary immunometabolism.
Chaetocochin J exhibits anti-hepatocellular carcinoma effect independent of hypoxia.
LDHA-regulated tumor-macrophage symbiosis promotes glioblastoma progression.
MYL9 promotes squamous cervical cancer migration and invasion by enhancing aerobic glycolysis.
Heat shock protein B7 (HSPB7) inhibits lung adenocarcinoma progression by inhibiting glycolysis.
GPR37 promotes colorectal cancer liver metastases by enhancing the glycolysis and histone lactylation via Hippo pathway.
CTRP6 regulates M1 macrophage polarization via the PPAR-γ/NF-κB pathway and reprogramming glycolysis in recurrent spontaneous abortion.
Progesterone Activates the Histone Lactylation-Hif1α-glycolysis Feedback Loop to Promote Decidualization.
Inhibition of ATF4-mediated elevation of both autophagy and AKT/mTOR was involved in antitumorigenic activity of curcumin.
Ectopic endometriotic stromal cells-derived lactate induces M2 macrophage polarization via Mettl3/Trib1/ERK/STAT3 signalling pathway in endometriosis.
LPLUNC1 reduces glycolysis in nasopharyngeal carcinoma cells through the PHB1-p53/c-Myc axis.
Extracellular Calcium-Induced Calcium Transient Regulating the Proliferation of Osteoblasts through Glycolysis Metabolism Pathways.
Environmentally relevant perinatal exposure to DBP accelerated spermatogenesis by promoting the glycolipid metabolism of Sertoli cells in male offspring mice.
PDK1 regulates the progression of esophageal squamous cell carcinoma through metabolic reprogramming.
LncRNA GLTC targets LDHA for succinylation and enzymatic activity to promote progression and radioiodine resistance in papillary thyroid cancer.
C11orf54 promotes DNA repair via blocking CMA-mediated degradation of HIF1A.
Targeting ACYP1-mediated glycolysis reverses lenvatinib resistance and restricts hepatocellular carcinoma progression.
Adipocytes promote pancreatic cancer migration and invasion through fatty acid metabolic reprogramming.
Loss of SPRY2 contributes to cancer-associated fibroblasts activation and promotes breast cancer development.
Enhanced autophagy reversed aflatoxin B1-induced decrease in lactate secretion of dairy goat Sertoli cells.
Novel function of Roxadustat (FG-4592) as an anti-shock drug in sepsis by regulating mitochondrial oxidative stress and energy metabolism.
ER stress-enhanced HMGA2 plays an important role in Cr (VI)-induced glycolysis and inhibited oxidative phosphorylation by targeting the transcription of ATF4.
AMPK regulates homeostasis of invasion and viability in trophoblasts by redirecting glucose metabolism: Implications for pre-eclampsia.
PKM2-mediated neuronal hyperglycolysis enhances the risk of Parkinson's disease in diabetic rats.
Glycolysis-related lncRNA TMEM105 upregulates LDHA to facilitate breast cancer liver metastasis via sponging miR-1208.
mTOR inhibitor, gemcitabine and PD-L1 antibody blockade combination therapy suppresses pancreatic cancer progression via metabolic reprogramming and immune microenvironment remodeling in Trp53(flox/+)LSL-Kras(G12D/+)Pdx-1-Cre murine models.
SIRT3 promotes metabolic maturation of human iPSC-derived cardiomyocytes via OPA1-controlled mitochondrial dynamics.
Efferocytosis-induced lactate enables the proliferation of pro-resolving macrophages to mediate tissue repair.
BMP4 participates in the pathogenesis of PCOS by regulating glucose metabolism and autophagy in granulosa cells under hyperandrogenic environment.
NR3C2 inhibits the proliferation of colorectal cancer via regulating glucose metabolism and phosphorylating AMPK.
Targeting pancreatic cancer with combinatorial treatment of CPI-613 and inhibitors of lactate metabolism.
Alpha-solanine Anti-tumor Effects in Non-small Cell Lung Cancer Through Regulating the Energy Metabolism Pathway.
TRIM16 promotes aerobic glycolysis and pancreatic cancer metastasis by modulating the NIK-SIX1 axis in a ligase-independent manner.
Transcriptional Repression of Aerobic Glycolysis by OVOL2 in Breast Cancer.
Hnrnpk maintains chondrocytes survival and function during growth plate development via regulating Hif1α-glycolysis axis.
Metabolism-Based Molecular Subtyping Endows Effective Ketogenic Therapy in p53-Mutant Colon Cancer.
HMGA2 mediates Cr (VI)-induced metabolic reprogramming through binding to mitochondrial D-Loop region.
Curcumin attenuates Cr (VI)-induced cell growth and migration by targeting autophagy-dependent reprogrammed metabolism.
Therapeutic targeting of glutamate dehydrogenase 1 that links metabolic reprogramming and Snail-mediated epithelial-mesenchymal transition in drug-resistant lung cancer.
Quantitative proteomics identified circulating biomarkers in lung adenocarcinoma diagnosis.
Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.
Jumonji-C domain-containing protein 5 suppresses proliferation and aerobic glycolysis in pancreatic cancer cells in a c-Myc-dependent manner.
Berberine Modulates Macrophage Activation by Inducing Glycolysis.
A positive feedback circuit comprising p21 and HIF-1α aggravates hypoxia-induced radioresistance of glioblastoma by promoting Glut1/LDHA-mediated glycolysis.
MYB proto-oncogene like 2 promotes hepatocellular carcinoma growth and glycolysis via binding to the Optic atrophy 3 promoter and activating its expression.
Short isoform thymic stromal lymphopoietin reduces inflammation and aerobic glycolysis of asthmatic airway epithelium by antagonizing long isoform thymic stromal lymphopoietin.
Tanshinone IIA inhibits cell growth by suppressing SIX1-induced aerobic glycolysis in non-small cell lung cancer cells.
Development of a one-plasmid system to replace the endogenous protein with point mutation for post-translational modification studies.
Protein arginine methyltransferase 3 promotes glycolysis and hepatocellular carcinoma growth by enhancing arginine methylation of lactate dehydrogenase A.
ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer.
The anti-MDR efficacy of YAN against A549/Taxol cells is associated with its inhibition on glycolysis and is further enhanced by 2-deoxy-d-glucose.
Metabolic enzyme LDHA activates Rac1 GTPase as a noncanonical mechanism to promote cancer.
Long non-coding RNA CTSLP8 mediates ovarian cancer progression and chemotherapy resistance by modulating cellular glycolysis and regulating c-Myc expression through PKM2.
SMYD3 associates with the NuRD (MTA1/2) complex to regulate transcription and promote proliferation and invasiveness in hepatocellular carcinoma cells.
Aerobic glycolysis and tumor progression of hepatocellular carcinoma are mediated by ubiquitin of P53 K48-linked regulated by TRIM37.
Nonylphenol inhibited HIF-1alpha regulated aerobic glycolysis and induced ROS mediated apoptosis in rat Sertoli cells.
Glycometabolic reprogramming-mediated proangiogenic phenotype enhancement of cancer-associated fibroblasts in oral squamous cell carcinoma: role of PGC-1α/PFKFB3 axis.
Sirolimus increases the anti-cancer effect of Huai Er by regulating hypoxia inducible factor-1α-mediated glycolysis in hepatocellular carcinoma.
Capsaicin ameliorates inflammation in a TRPV1-independent mechanism by inhibiting PKM2-LDHA-mediated Warburg effect in sepsis.
Tubular epithelial cell-derived extracellular vesicles induce macrophage glycolysis by stabilizing HIF-1α in diabetic kidney disease.
HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine.
CYLD deficiency enhances metabolic reprogramming and tumor progression in nasopharyngeal carcinoma via PFKFB3.
Enhancement of anaerobic glycolysis - a role of PGC-1α4 in resistance exercise.
SIX1 Activation Is Involved in Cell Proliferation, Migration, and Anti-inflammation of Acute Ischemia/Reperfusion Injury in Mice.
Study on the Antitumor Effect and Glycolysis of Andrographolide in Anaplastic Thyroid Carcinoma.
Protective Effects of Hif2 Inhibitor PT-2385 on a Neurological Disorder Induced by Deficiency of Irp2.
Myosin 1b promotes migration, invasion and glycolysis in cervical cancer via ERK/HIF-1α pathway.
Trametinib Inhibits the Growth and Aerobic Glycolysis of Glioma Cells by Targeting the PKM2/c-Myc Axis.
Anlotinib Inhibits PFKFB3-Driven Glycolysis in Myofibroblasts to Reverse Pulmonary Fibrosis.
A Novel Integrated Metabolism-Immunity Gene Expression Model Predicts the Prognosis of Lung Adenocarcinoma Patients.
The Role of cAMP-PKA Pathway in Lactate-Induced Intramuscular Triglyceride Accumulation and Mitochondria Content Increase in Mice.
Alpha-Enolase Protects Hepatocyte Against Heat Stress Through Focal Adhesion Kinase-Mediated Phosphatidylinositol 3-Kinase/Akt Pathway.
Qian Yang Yu Yin Granule Improves Renal Injury of Hypertension by Regulating Metabolic Reprogramming Mediated by HIF-1α/PKM2 Positive Feedback Loop.
Biochanin A Inhibits Glioblastoma Growth via Restricting Glycolysis and Mitochondrial Oxidative Phosphorylation.
The Warburg effect as a therapeutic target for bladder cancers and intratumoral heterogeneity in associated molecular targets.
Dual Inhibition of Endoplasmic Reticulum Stress and Oxidation Stress Manipulates the Polarization of Macrophages under Hypoxia to Sensitize Immunotherapy.
Normalizing HIF-1α Signaling Improves Cellular Glucose Metabolism and Blocks the Pathological Pathways of Hyperglycemic Damage.
A requirement for autophagy in HMGA2-induced metabolic reprogramming to support Cd-induced migration.
Dysfunctional lactate metabolism in human alveolar type II cells from idiopathic pulmonary fibrosis lung explant tissue.
2-Deoxy-D-glucose impedes T cell-induced apoptosis of keratinocytes in oral lichen planus.
Reciprocal regulation of LOXL2 and HIF1α drives the Warburg effect to support pancreatic cancer aggressiveness.
Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice.
ETV4 promotes breast cancer cell stemness by activating glycolysis and CXCR4-mediated sonic Hedgehog signaling.
Expression of lactate dehydrogenase A and B isoforms in the mouse kidney.
Long noncoding RNA LINC00518 induces radioresistance by regulating glycolysis through an miR-33a-3p/HIF-1α negative feedback loop in melanoma.
Trim21-mediated HIF-1α degradation attenuates aerobic glycolysis to inhibit renal cancer tumorigenesis and metastasis.
Cynaroside prevents macrophage polarization into pro-inflammatory phenotype and alleviates cecal ligation and puncture-induced liver injury by targeting PKM2/HIF-1α axis.
Hypoxia-induced FOXO4/LDHA axis modulates gastric cancer cell glycolysis and progression.
OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development.
Di-methylation of CD147-K234 Promotes the Progression of NSCLC by Enhancing Lactate Export.
Short-form RON (sf-RON) enhances glucose metabolism to promote cell proliferation via activating β-catenin/SIX1 signaling pathway in gastric cancer.
Jiedu Sangen decoction inhibits chemoresistance to 5-fluorouracil of colorectal cancer cells by suppressing glycolysis via PI3K/AKT/HIF-1α signaling pathway.
Loss of DSTYK activates Wnt/β-catenin signaling and glycolysis in lung adenocarcinoma.
The deubiquitinase USP38 promotes cell proliferation through stabilizing c-Myc.
STAT3/LINC00671 axis regulates papillary thyroid tumor growth and metastasis via LDHA-mediated glycolysis.
Contribution of Connexin Hemichannels to the Pathogenesis of Acute Lung Injury.
PCK1 Regulates Glycolysis and Tumor Progression in Clear Cell Renal Cell Carcinoma Through LDHA.
Long Noncoding RNA MIR210HG Promotes the Warburg Effect and Tumor Growth by Enhancing HIF-1α Translation in Triple-Negative Breast Cancer.
High fat diet impairs spermatogenesis by regulating glucose and lipid metabolism in Sertoli cells.
ATF4-mediated autophagy-dependent glycolysis plays an important role in attenuating apoptosis induced by Cr (VI) in A549 cells.
MiR-103a-3p promotes tumour glycolysis in colorectal cancer via hippo/YAP1/HIF1A axis.
Correlation of hyperpolarized (13) C-MRI data with tissue extract measurements.
Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis.
All-trans retinoic acid enhances the effect of Fra-1 to inhibit cell proliferation and metabolism in cervical cancer.
Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2.
CD38 is involved in cell energy metabolism via activating the PI3K/AKT/mTOR signaling pathway in cervical cancer cells.
HIF1α/PLD2 axis linked to glycolysis induces T-cell immunity in oral lichen planus.
TAB1 regulates glycolysis and activation of macrophages in diabetic nephropathy.
Ginsenoside Rh4 suppresses aerobic glycolysis and the expression of PD-L1 via targeting AKT in esophageal cancer.
Bcl2 inhibitor ABT737 reverses the Warburg effect via the Sirt3-HIF1α axis to promote oxidative stress-induced apoptosis in ovarian cancer cells.
In vivo [U-(13)C]glucose labeling to assess heart metabolism in murine models of pressure and volume overload.
Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression.
Metabolomic Study on Nude Mice Models of Gastric Cancer Treated with Modified Si Jun Zi Tang via HILIC UHPLC-Q-TOF/MS Analysis.
Proteomic analysis of human periodontal ligament cells under hypoxia.
The KLF14 Transcription Factor Regulates Glycolysis by Downregulating LDHB in Colorectal Cancer.
Recombinant Viral Capsid Protein L2 (rVL2) of HPV 16 Suppresses Cell Proliferation and Glucose Metabolism via ITGB7/C/EBPβ Signaling Pathway in Cervical Cancer Cell Lines.
LINC01123, a c-Myc-activated long non-coding RNA, promotes proliferation and aerobic glycolysis of non-small cell lung cancer through miR-199a-5p/c-Myc axis.
ROS/KRAS/AMPK Signaling Contributes to Gemcitabine-Induced Stem-like Cell Properties in Pancreatic Cancer.
Accelerated Metabolite Levels of Aerobic Glycolysis and the Pentose Phosphate Pathway Are Required for Efficient Replication of Infectious Spleen and Kidney Necrosis Virus in Chinese Perch Brain Cells.
Apatinib inhibits glycolysis by suppressing the VEGFR2/AKT1/SOX5/GLUT4 signaling pathway in ovarian cancer cells.
Metabolic adaptation to glycolysis is a basic defense mechanism of macrophages for Mycobacterium tuberculosis infection.
Homeodomain-interacting protein kinase 2 suppresses proliferation and aerobic glycolysis via ERK/cMyc axis in pancreatic cancer.
Cloxiquine, a traditional antituberculosis agent, suppresses the growth and metastasis of melanoma cells through activation of PPARγ.
p53/Lactate dehydrogenase A axis negatively regulates aerobic glycolysis and tumor progression in breast cancer expressing wild-type p53.
The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression.
Type Iγ phosphatidylinositol phosphate kinase promotes tumor growth by facilitating Warburg effect in colorectal cancer.
UHRF1 promotes aerobic glycolysis and proliferation via suppression of SIRT4 in pancreatic cancer.
Blockade of glycolysis-dependent contraction by oroxylin a via inhibition of lactate dehydrogenase-a in hepatic stellate cells.
Carpesium abrotanoides (L.) Root as a Potential Source of Natural Anticancer Compounds: Targeting Glucose Metabolism and PKM2/HIF-1α Axis of Breast Cancer Cells.
Sideroflexin 4 affects Fe-S cluster biogenesis, iron metabolism, mitochondrial respiration and heme biosynthetic enzymes.
The anti-androgenic effects of cypermethrin mediated by non-classical testosterone pathway activation of mitogen-activated protein kinase cascade in mouse Sertoli cells.
Resveratrol Inhibits ROS-Promoted Activation and Glycolysis of Pancreatic Stellate Cells via Suppression of miR-21.
Cryptotanshinone suppresses cell proliferation and glucose metabolism via STAT3/SIRT3 signaling pathway in ovarian cancer cells.
miR‑199a‑3p/Sp1/LDHA axis controls aerobic glycolysis in testicular tumor cells.
NKILA lncRNA promotes tumor immune evasion by sensitizing T cells to activation-induced cell death.
Anti-Cancer Effects of Emodin on HepG2 Cells as Revealed by (1)H NMR Based Metabolic Profiling.
BRD7 inhibits the Warburg effect and tumor progression through inactivation of HIF1α/LDHA axis in breast cancer.
The lncRNA MACC1-AS1 promotes gastric cancer cell metabolic plasticity via AMPK/Lin28 mediated mRNA stability of MACC1.
Transcriptional Regulation of the Warburg Effect in Cancer by SIX1.
Klotho negatively regulated aerobic glycolysis in colorectal cancer via ERK/HIF1α axis.
Programmed death ligand 1 promotes lymph node metastasis and glucose metabolism in cervical cancer by activating integrin β4/SNAI1/SIRT3 signaling pathway.
Detachment from the primary site and suspension in ascites as the initial step in metabolic reprogramming and metastasis to the omentum in ovarian cancer.
RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis.
TCF7L2 positively regulates aerobic glycolysis via the EGLN2/HIF-1α axis and indicates prognosis in pancreatic cancer.
Nalmefene attenuates malignant potential in colorectal cancer cell via inhibition of opioid receptor.
PPARγ maintains the metabolic heterogeneity and homeostasis of renal tubules.
GPx1 is involved in the induction of protective autophagy in pancreatic cancer cells in response to glucose deprivation.
AAED1 modulates proliferation and glycolysis in gastric cancer.
Expression and prognostic value of lactate dehydrogenase-A and -D subunits in human uterine myoma and uterine sarcoma.
A new facet of NDRG1 in pancreatic ductal adenocarcinoma: Suppression of glycolytic metabolism.
Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission.
Mitochondrial toxicity of perfluorooctane sulfonate in mouse embryonic stem cell-derived cardiomyocytes.
ARF6, induced by mutant Kras, promotes proliferation and Warburg effect in pancreatic cancer.
Copper therapy reduces intravascular hemolysis and derepresses ferroportin in mice with mosaic mutation (Atp7a(mo-ms)): An implication for copper-mediated regulation of the Slc40a1 gene expression.
Expression of HMGB2 indicates worse survival of patients and is required for the maintenance of Warburg effect in pancreatic cancer.
Ischemia/Reperfusion-Induced Translocation of PKCβII to Mitochondria as an Important Mediator of a Protective Signaling Mechanism in an Ischemia-Resistant Region of the Hippocampus.
miR-30a-5p suppresses breast tumor growth and metastasis through inhibition of LDHA-mediated Warburg effect.
Inhibition of mTORC1 signaling sensitizes hepatocellular carcinoma cells to glycolytic stress.
Redox homeostasis protects mitochondria through accelerating ROS conversion to enhance hypoxia resistance in cancer cells.
Overexpression of ABCC3 promotes cell proliferation, drug resistance, and aerobic glycolysis and is associated with poor prognosis in urinary bladder cancer patients.
The epigenetic regulation of HIF-1α by SIRT1 in MPP(+) treated SH-SY5Y cells.
NKG2D ligand expression in pediatric brain tumors.
Glutaredoxins concomitant with optimal ROS activate AMPK through S-glutathionylation to improve glucose metabolism in type 2 diabetes.
ROS-mediated glucose metabolic reprogram induces insulin resistance in type 2 diabetes.
MiR-34b-3 and miR-449a inhibit malignant progression of nasopharyngeal carcinoma by targeting lactate dehydrogenase A.
Inhibition of LDHA suppresses tumor progression in prostate cancer.
Alpha-enolase promotes cell glycolysis, growth, migration, and invasion in non-small cell lung cancer through FAK-mediated PI3K/AKT pathway.
Enolase-1 is a therapeutic target in endometrial carcinoma.
The c-Myc-LDHA axis positively regulates aerobic glycolysis and promotes tumor progression in pancreatic cancer.
cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.
Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1.
Guo X, Lin Y, Jiang Y, Wang M, Li Y, Gao Y, Chen B, Bao Z, Tian H, Chu X, Zhang Z, Shao J, Zhang F, Wang H, Xuan J, Xu X, Zheng S
International journal of biological sciences 2026;22(3):1648-1673
International journal of biological sciences 2026;22(3):1648-1673
Gomphus floccosus (Schw.) Sing. extract attenuates alcoholic liver disease by suppressing macrophage glycolysis and M1 polarization.
Ruan T, Li X, Li M, Wang S, Shen L, Liu C, Peng Y, Tao Y
Frontiers in immunology 2026;17:1772592
Frontiers in immunology 2026;17:1772592
Microvascular endothelial metabolic dysfunction drives cerebral edema through bioenergetic failure after ischemia-reperfusion.
Zhou YF, Yang SB, Zhang F, Sun XD, Chang BH, Li YN, Wu JH, Jin HJ, Huang M, Chen SC, Yang H, Zhu DY, Menon BK, Hu B
Theranostics 2026;16(7):3577-3598
Theranostics 2026;16(7):3577-3598
A putative prognostic model for lung adenocarcinoma based on crotonylation-related genes by bioinformatics and experimental verification.
Wang W, Cui B, Li H, Zhen Z, Song X, Yuan X, Cui Q, Yuan Q, Liu Y
Frontiers in cell and developmental biology 2026;14:1639773
Frontiers in cell and developmental biology 2026;14:1639773
Elevated lactate production exacerbates PM2.5-induced pulmonary fibrosis by stabilizing TGF-β1.
Liu Z, Liu W, Wei H, Ping Y, Yu Z, Dong Z, Ren J, Zhang S, Liu S
Journal of advanced research 2026 May;83:299-314
Journal of advanced research 2026 May;83:299-314
YTHDF3 Mediates the Occurrence and Development of Breast Cancer by Regulating Glycolysis Through the mTOR-HIF1α-LHDA Axis.
Liu Z, Jiang T, Li P, Dong K, Wang X, Geng C, Zhang X, Zuo D, Zhao G
Journal of cellular and molecular medicine 2026 May;30(9):e71105
Journal of cellular and molecular medicine 2026 May;30(9):e71105
Phosphoglucomutase 5 suppresses gallbladder cancer progression by inhibiting lactate-driven STAT3 signaling.
Ma W, Zhang C, Gou A, Hu M, Huang Y, Jiang X, Ao J, Wang J
Translational oncology 2026 Mar;65:102678
Translational oncology 2026 Mar;65:102678
HKDC1 promotes the H3K18 lactylation of the promoter of ORMDL3 to induce the activation of hepatic stellate cells in liver cirrhosis.
Zhang Y, Li L, Li G, Zhu J, Qi Z, Zhang C
Biochimica et biophysica acta. Molecular basis of disease 2026 Mar;1872(3):168140
Biochimica et biophysica acta. Molecular basis of disease 2026 Mar;1872(3):168140
Lactate Metabolism-Immune Regulation-Related Gene Signature in Lower-Grade Gliomas: Prognostic Model Development and Immune Characterization.
Zhang E, Wei L, Ren H, Zhang J, Yang H, Sun M, Gao X, Huang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Mar 31;40(6):e71637
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Mar 31;40(6):e71637
USP5-mediated CD73 deubiquitination drives osimertinib resistance via PI3K/AKT and glycolysis activation in LUAD.
Chen R, Han XH, Zhang Z, Han XJ, Xie J
iScience 2026 Mar 20;29(3):114916
iScience 2026 Mar 20;29(3):114916
TCF7L2/DEPDC1 axis contributes to tumor progression by promoting cell proliferation, aerobic glycolysis, and immunosuppression in pancreatic cancer.
Tasiheng Y, Kenjiabieke J, Tasiheng N, Adilijiang K, Cheng H
Clinical and experimental medicine 2026 Mar 19;26(1)
Clinical and experimental medicine 2026 Mar 19;26(1)
Bie-Jia-Jian Pill: Inhibiting tumor glycolysis and promoting CD8(+) cell-mediated anti-tumor immunity by targeting HIF-1α-PI3K/AKT/mTOR and CCL20 in hepatocellular carcinoma.
Liu Y, Yang X, Qin M, Chen W, Liu C, Jiang W, Wang Y, Tan S, Sun H, Chen J, Sun H, He S
Journal of ethnopharmacology 2026 Jun 28;365:121554
Journal of ethnopharmacology 2026 Jun 28;365:121554
Neuronal ACVR1-mediated H3K18 lactylation drives NLRP3 pyroptosis to sustain neuropathic pain via metabolic-epigenetic coupling.
Zhao X, Zhang X, Li Y, Fu C, Yuan L, Cong T, Niu Z
Neurobiology of disease 2026 Jun 15;224:107397
Neurobiology of disease 2026 Jun 15;224:107397
Ailanthone ameliorates CCl(4)-induced liver fibrosis by targeting PKM2-mediated macrophage M1 polarization and glycolytic reprogramming.
Wan Y, Wang T, Wang K, Huo Q, Cheng X
International immunopharmacology 2026 Jun 15;179:116640
International immunopharmacology 2026 Jun 15;179:116640
Stiripentol-loaded self-nanoemulsifying delivery system for glioblastoma: therapeutic efficacy in 3D spheroid and xenograft model.
Yadav A, Patel H, Bhutkar S, Khairnar R, Kumar S, Patel K, Dukhande V
Nanomedicine (London, England) 2026 Jan;21(1):39-54
Nanomedicine (London, England) 2026 Jan;21(1):39-54
Lactylation Enhances the Activity of Lactate Dehydrogenase A and Promotes the Chemoresistance to Cisplatin Through Facilitating DNA Nonhomologous End Junction in Lung Adenocarcinoma.
Li J, Xun W, Wang X, Luo R, Hu Q, Zhou Z, Yuan J, Wang Y, Wan X, Zhao T, Han T, Wang JB
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(3):e10733
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(3):e10733
Ptbp2 Alleviates Neuroinflammation and Blood-brain Barrier Disruption via Modulating Microglial Polarization in Ischemic Stroke.
Xu W, Li L, Zhou M, Zhang C, Zhang X
Molecular neurobiology 2026 Jan 30;63(1):408
Molecular neurobiology 2026 Jan 30;63(1):408
Narciclasine Alleviates Endothelial Inflammation and Atherosclerosis Initiation by Inhibiting Histone Lactylation-Mediated NF-κB Activation.
Wang Z, Zhang Z, Xin R, Ma M, Sun Z, Li Z, Zhang C, Liu L, Wu Z, Zhang Y, Chen Y
Inflammation 2026 Jan 16;49(1):49
Inflammation 2026 Jan 16;49(1):49
Spatial heterogeneity of lactylation: insights into gene expression, metabolism, and lactate transport in human embryonic stem cells.
Kozlov AM, Leung ZCL, Wilson RB, Bhangal S, Nygard K, Powell AM, Borradaile NM, Betts DH, Cumming RC
Biology open 2026 Jan 1;15(1)
Biology open 2026 Jan 1;15(1)
Porcine epidemic diarrhea virus promotes viral replication via ROS/HIF-1α-mediated glycolysis.
Xu Y, Zhang J, Yin C, Liu L, Wang Z, Fu S, Fan R, Zhao Y, Miao J
Redox biology 2026 Feb;89:104008
Redox biology 2026 Feb;89:104008
Integrative Analysis of Cytotoxic Lymphocytes-Mediated Tumour Killing Related Genes Reveals LDHA as a Novel Glioblastoma Therapeutic Target.
Yu S, Li X, Wu J, Wang M, Gong Z, Zhang B, Shi H, Wang X, Xiang W
Journal of cellular and molecular medicine 2026 Feb;30(4):e71054
Journal of cellular and molecular medicine 2026 Feb;30(4):e71054
Mitochondrial oxidative stress under hypoxia promotes gastric mucosal injury in portal hypertensive gastropathy.
Luo J, Xie K, Ou X, Tan S
Biomedical reports 2026 Feb;24(2):29
Biomedical reports 2026 Feb;24(2):29
Histone lactylation increases CXCL1 expression for neutrophil infiltration and immune escape in pancreatic cancer.
Zhang P, Ma J, Wan Y, Li C, Liu L, He M, Zhang N, Ma Y, Hu J, Zhao L, Zhong Z, Lei X, Gong J, Zeng T, Ma J, Da Y, Zhou Z, Yang J, Wang X, Gong T, Zhang C
Nature communications 2026 Feb 9;17(1)
Nature communications 2026 Feb 9;17(1)
Metabolic Flexibility and Energy Substrate Utilization Regulate Contractility in the Human Myometrium.
Prifti KK, Dave RM, Mitchum KT, Rich JL, Gill RM, Mbadhi MN, Frolova AI
bioRxiv : the preprint server for biology 2026 Feb 4;
bioRxiv : the preprint server for biology 2026 Feb 4;
Circadian tryptophan metabolism contributes to systemic aryl hydrocarbon receptor activity.
Morgan EW, Murray IA, Coslo DM, Patterson AD, Perdew GH
iScience 2026 Feb 20;29(2):114680
iScience 2026 Feb 20;29(2):114680
The glycolytic enzyme PFKM promotes renal fibrosis by activating the NF-κB pathway via lactate-mediated H3K18 lactylation.
Chen Y, Wang W, Cheng M, Wei L, Sang Y, Gao Y, Zhang W, Zhang L, Dai R, Wang Y
Cellular and molecular life sciences : CMLS 2026 Feb 19;83(1)
Cellular and molecular life sciences : CMLS 2026 Feb 19;83(1)
The role of glutamine/Nrf2-enhanced PHGDH in Cadmium-induced lactate utilization.
Pang Y, Li S, Zhang Q, Liu Y, Kong Y, Cao J
Free radical biology & medicine 2026 Feb 16;244:296-311
Free radical biology & medicine 2026 Feb 16;244:296-311
LRRN3 protects dopaminergic neurons by inhibiting glycolysis in Parkinson's disease.
Gao J, Qin K, Xian W, Ren J, Xie A, Hou B
Brain research 2026 Feb 15;1873:150119
Brain research 2026 Feb 15;1873:150119
Lactate derived from macrophages drives skin dermal fibroblasts phenotypic remodeling via MCT1-primed histone H3 lysine 23 lactylation in hypertrophic scar.
Yuan Y, Xiao Y, Zou J, Luo L, Li M, Shen K, Wei L, Zhang Y, Wang P, Chen Y, Zhuo S, Zhang H, Song S, Jia Y, Wang K, Jiang S, Guan H, Hu D
Nature communications 2026 Feb 12;17(1)
Nature communications 2026 Feb 12;17(1)
Gut-confined fullerene reprograms lactate metabolism to Rescue hypoxia-induced exercise intolerance.
Chen S, Pan Y, Liu M, Liu C, Xu Y, Ma J, Li J, Wang X, Yang L, Wang Y, Li B, Wang Z, Zhang Y, Shen H, Wulan Q, Li J, Wang C, Bai C
Biomaterials 2026 Aug;331:124075
Biomaterials 2026 Aug;331:124075
Baicalin alleviates repeated superovulation induced ovarian dysfunction and oocyte impairment by suppressing excessive glycolysis.
Li LF, Shen H, Qi ZM, Luo T, Liu SM, Ou LL, Xu CL, Liu Y
Theriogenology 2026 Aug;260:117934
Theriogenology 2026 Aug;260:117934
Designed bone-targeting ROS-responsive nanoplatform for precision glycolysis inhibition in postmenopausal osteoporosis.
Wu Q, Miao J, Chen Y, Yang Y, Liang H, Yu C, Wang C, Tu Y, Wu Y, Xu Y, Yang X, Kwan KYH, Shi C, Wang X, Xu J, Jin H
Bioactive materials 2026 Apr;58:1-18
Bioactive materials 2026 Apr;58:1-18
PMM2 interacts with TRIM28 to recruit E2F4 and promote KIFC3-mediated tumor glycolysis and colorectal cancer progression.
Peng Z, Ma B, Song Z, Zhao Y, Yang Y, Liu Y, Li C, Zhang Y
Oncogene 2026 Apr;45(12):1145-1160
Oncogene 2026 Apr;45(12):1145-1160
ANGPT2/Tie2 Enhances H3K18la-Mediated Macrophage M2 Polarization to Promote Endothelial Cell Proliferation in the Chronically Ischaemic Brain.
Tai C, Ling C, Yang Y, Mo N, Yao C, Lv S, Zhang B, Wang H, Chen C
CNS neuroscience & therapeutics 2026 Apr;32(4):e70879
CNS neuroscience & therapeutics 2026 Apr;32(4):e70879
An Activity-Dependent NEPAS-PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment.
Hu B, Chen Z, Sun B, Gao J, Xu J, Guo X, Gao F, Wang Z, Wu J, Ji X, Liu P, Huang B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 7;:e21069
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 7;:e21069
Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1-Mediated M1 Macrophage Polarization in Sarcoidosis.
Liu M, Han Y, Xie B, Zhu L, Xu W, Han Y, Liao Y, Gao S, Jiang D, Geng J, Li Z, Hu Y, Dai H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 3;:e20635
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 3;:e20635
Targeting the SIN1 mediated TTK/LDHA-H3K18la-GLUT3 axis disrupts metabolic-epigenetic crosstalk and suppresses progression in hyperglycolytic breast cancer.
Zhao Z, Jia W, Li Z, Shi S, Zhou J, Ning C, Yu Z, Liu X, Cao X, Zheng H, Wang X, Wang X, Yu Y
Cancer letters 2026 Apr 28;644:218328
Cancer letters 2026 Apr 28;644:218328
KSR2 functions as a metabolic checkpoint for anti-PD-1 resistance by reprogramming glucose metabolism.
Ge Y, Zhou Q, Zhang Q, Hu Y, Wang R
Cancer immunology, immunotherapy : CII 2026 Apr 21;75(5)
Cancer immunology, immunotherapy : CII 2026 Apr 21;75(5)
SIRT6-mediated immunometabolic reprogramming of macrophages drives neutrophilic asthma via LDHA-dependent glycolysis.
Su G, Peng J, Quan J, Feng Z, Zhong Y, Xiong Z, Huang J, Zhao Z, Lv Y, Hou W, Luo L, Li X, Shao Y, Duan J, Gao X, Lai T
Cell reports 2026 Apr 21;45(5):117294
Cell reports 2026 Apr 21;45(5):117294
Silica Promotes Silicosis via the ROS/NF-κB p65 Signaling-Activated Hypoxia-Lactate Axis in Rats.
Fu YY, Zhou YF, Hu HJ, Liu YR, Zhang ZQ, Han GZ
Journal of applied toxicology : JAT 2026 Apr 21;
Journal of applied toxicology : JAT 2026 Apr 21;
Pharmacological targeting of the NLRP3 LRR domain with isothiazolinones overcomes CRID3-resistant inflammation.
Woo H, Jang Y, Kim S, Kim W, Zhang F, Mall R, Patel CN, Kurera M, Ngo C, Jiang SH, Nicotra A, Py BF, Zheng M, Man SM, Karki R
EMBO molecular medicine 2026 Apr 17;
EMBO molecular medicine 2026 Apr 17;
FBXO39 promotes LDHA-mediated aerobic glycolysis and colorectal cancer progression by p53 degradation.
Liu J, Xiao T, Huang J
Journal of translational medicine 2026 Apr 1;24(1)
Journal of translational medicine 2026 Apr 1;24(1)
Mechanistic Insights Into Qidan Yixin Decoction for Diabetic Cardiomyopathy via Macrophage Polarization.
Liu Y, Zhang J, Gao W, Han Q, Xue Y, Liu X
Journal of diabetes research 2025;2025:7578626
Journal of diabetes research 2025;2025:7578626
Lactate Facilitates Pancreatic Repair Following Acute Pancreatitis by Promoting Reparative Macrophage Polarization.
Jiang J, Wang R, Song P, Peng Q, Jin X, Li B, Ni J, Shen J, Bao J, Wu Z, Ge X, Wang X, Hu G
Cellular and molecular gastroenterology and hepatology 2025;19(9):101535
Cellular and molecular gastroenterology and hepatology 2025;19(9):101535
Enhancing Quercetin's Potential: A Nanoliposome Delivery System for High Altitude Pulmonary Edema.
Lin L, Shen B, Cui J, Gao Y, Wang L, Yang T, Weng J, Lai C, Tang X, Xiao C, Shen X, Gao Y
Drug design, development and therapy 2025;19:9151-9167
Drug design, development and therapy 2025;19:9151-9167
Integrated multi-omics analysis reveals a glycolytic signature that predicts pan-cancer immune checkpoint inhibitor response and LDHA as a combinatorial target in fumarate hydratase-deficient renal cell carcinoma.
Liu S, Yuan Y, He J, Zhou Y, Wang Y, Ye X, Wang J, Zhang J
Frontiers in immunology 2025;16:1666121
Frontiers in immunology 2025;16:1666121
Neutrophil hitchhiking liposomal drugs for starvation therapy in endometriosis.
Zhou M, Wang Y, Li C, Li J, Dou R, Jiang H, Zhang Y, Chen D, Zhang J, Zhu S
Theranostics 2025;15(10):4848-4860
Theranostics 2025;15(10):4848-4860
NFIA-dependent upregulation of SMC4 promotes metastasis and metabolic reprogramming in glioma.
Li G, Zhao Y, He Y, Qian Z, Li X, Song Z, Liu Z
Frontiers in oncology 2025;15:1624370
Frontiers in oncology 2025;15:1624370
Rewired glycolysis by DTL accelerates oncometabolite L-lactate generation to promote breast cancer progression.
Liu Y, Li J, Cao Y, Lv M
Frontiers in oncology 2025;15:1583752
Frontiers in oncology 2025;15:1583752
SNHG12 downregulation induces follicular dysplasia by modulating the glycolysis of granulosa cell in polycystic ovary syndrome.
Yan S, Qu B, Chen Y, Wu Q, Ding J, Qiu H
Frontiers in cell and developmental biology 2025;13:1585987
Frontiers in cell and developmental biology 2025;13:1585987
Activation of sclerostin inhibits Isg20-Mediated aerobic glycolysis ameliorating renal Fibrosis: the renoprotective mechanism of hederagenin in CKD.
Han RY, Tan RZ, Xu LH, Lin JY, Li T, Su HW, Li P, Liu P, Lan HY, Wang L
Redox biology 2025 Sep;85:103762
Redox biology 2025 Sep;85:103762
Glyphosate targets FYN to regulate glycolysis and promote glioblastoma proliferation: A network toxicology study.
Ma A, Yang Z, He Q, Wang W, Ren H, Zhai C, Lan J
International journal of biological macromolecules 2025 Sep;321(Pt 3):146486
International journal of biological macromolecules 2025 Sep;321(Pt 3):146486
Triflupromazine and tranylcypromine alleviate primary cisplatin resistance in lung adenocarcinoma by promoting LDHA-mediated AMBRA1 ubiquitination.
Wang Q, Zhang Y, Zhang Y, Zhai Y, Zhou X, Qin Y, Ding M, Tian Y, Zhang Z, Zhang P, Xu F
Biochemical pharmacology 2025 Sep;239:117073
Biochemical pharmacology 2025 Sep;239:117073
EMSY enhances glycolysis in ovarian cancer cells.
Wang S, Xie N, Zha P, Li Y, Wei M, Bai J, Zhao X
European journal of medical research 2025 Sep 29;30(1):890
European journal of medical research 2025 Sep 29;30(1):890
Menin regulates YBX1 nucleus translocation to boost the HKDC1 transcription and affects pancreatic cancer glycolysis.
Ni C, Yang J, Lu Y, Ma H, Hu H, Shi X, He T, Zhang Y, Jin G, Cheng P
iScience 2025 Sep 19;28(9):113245
iScience 2025 Sep 19;28(9):113245
A potent NLRP3 inhibitor effective against both MCC950-sensitive and -resistant inflammation.
Kim W, Kim S, Woo H, Jojare RA, Mall R, Nicotra A, Py BF, Ngo C, Man SM, Patel CN, Karki R
Cell chemical biology 2025 Sep 18;32(9):1125-1139.e7
Cell chemical biology 2025 Sep 18;32(9):1125-1139.e7
HMGA2/PHGDH axis-mediated glycolysis under hypoxia is required for cadmium-induced A549 cell migration.
Gao C, Xie Q, Li L, Luo S, Fan J, Cao J
Ecotoxicology and environmental safety 2025 Sep 15;303:118787
Ecotoxicology and environmental safety 2025 Sep 15;303:118787
Integrated cartilage metabolomics and proteomics analysis reveals the therapeutic effect of Wenjing Tongluo Decoction on Knee osteoarthritis rats.
Wei W, Peng C, Gu R, Yan X, Ye J, Kang A, Sun L
Journal of pharmaceutical and biomedical analysis 2025 Sep 1;262:116869
Journal of pharmaceutical and biomedical analysis 2025 Sep 1;262:116869
Excavating Precursors from Herb Pairs Polygala tenuifolia and Acori tatarinowii: Synthesis and Anticonvulsant Activity Evaluation of 3,4,5-Trimethoxycinnamic Acid (TMCA) Piperazine Amide Derivatives.
Zhao Z, Lei M, Wang Y, Bai Y, Qiao H
Pharmaceuticals (Basel, Switzerland) 2025 Sep 1;18(9)
Pharmaceuticals (Basel, Switzerland) 2025 Sep 1;18(9)
A non-canonical aryl hydrocarbon receptor pathway authorizes and safeguards clinical-scale expansion of functional human endothelial cells.
Lin Y, Geng F, Shieh JH, Torres LK, Sominskaia M, Gao M, Wingo M, Chen K, Rustam S, Chavez R, Shaykhiev R, Kopacz A, Pearson B, Redmond D, Schreiner R, Rafii S
Nature cardiovascular research 2025 Oct;4(10):1329-1344
Nature cardiovascular research 2025 Oct;4(10):1329-1344
3D printing-biomimetic local stiff niche enhances glycolysis to boost PDAC cell stem-like phenotype via N6-methyladenosine-suppressed YAP1 mRNA decay.
Wu D, Guan X, Yang T, Yan J, Zhu B, Zhou J, Guo Y, Lu Y
Materials today. Bio 2025 Oct;34:102176
Materials today. Bio 2025 Oct;34:102176
PKM2 alleviates mitochondrial oxidative stress and neuronal apoptosis through metabolic and non-metabolic pathways to protect SOD1(G93A) mice.
Zhang Z, Guo X, Liu Y, Ke P, Meng Y, Gu J, Hu L, Yuan Z, Duan R, Luo J, Xiao F
Free radical biology & medicine 2025 Oct;238:1-16
Free radical biology & medicine 2025 Oct;238:1-16
FAM3B activates hepatic stellate cells to accelerate hepatic fibrosis by promoting glucose metabolism.
Wei WJ, Lin C, Luo SH, Huang JJ, Hu RT, Li JX, Ma HZ, Wei JZ, Wang CF, Lim CS, Deng YB
Biochemical and biophysical research communications 2025 Oct 30;786:152703
Biochemical and biophysical research communications 2025 Oct 30;786:152703
[SF3B3 overexpression promotes proliferation of gastric cancer cells and correlates with poor patient prognosis].
Lu H, Song B, Shi J, Wang S, Chen X, Yang J, Ge S, Zuo L
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2025 Oct 20;45(10):2240-2249
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2025 Oct 20;45(10):2240-2249
Histone H3 lysine 18 lactylation attenuates neuroinflammation and neurological damage by regulating microglial plxnb2 after ischemic stroke.
Li P, Wang Y, Xu Y, Feng L, Jiang N, Fang Y, Song G, Yu L, Xu L, Zhu Z, Zhu S, Wang W, Xie M
Neurobiology of disease 2025 Oct 15;215:107061
Neurobiology of disease 2025 Oct 15;215:107061
GDF15 attenuates sepsis-induced acute lung injury by suppressing the HIF-1α/LDHA pathway.
Kuang X, Niu Z, Huang Z, Cai X, Wang L, Zhang Y, Luo J, Zhao X, Shuo L, Zhang P
International immunopharmacology 2025 Oct 10;163:115198
International immunopharmacology 2025 Oct 10;163:115198
Baicalin attenuates the immune escape of oral squamous cell carcinoma by reducing lactate accumulation in tumor microenvironment.
Cui Y, Liu J, Wang X, Wu Y, Chang Y, Hu X, Zhao W
Journal of advanced research 2025 Nov;77:721-732
Journal of advanced research 2025 Nov;77:721-732
FAM111B enhances glycolysis and promotes metastasis of prostate cancer by upregulating LDHA.
He Q, Li H, Cong Y, Chen K, Cheng L, Lv F, Zhang P, Ju Y, Yu Z, Chen J, Wang C, Song Y, Li X, Chen L, Xing Y
Neoplasia (New York, N.Y.) 2025 Nov;69:101227
Neoplasia (New York, N.Y.) 2025 Nov;69:101227
The ubiquitin-binding protein ANKRD13A mediates VCP-dependent mitochondrial outer membrane rupture during PINK1/Parkin-mediated mitophagy.
Chu WH, Lin YS, Guo J, Jane WN, Wang WJ, Lin YY, Liu PH, Huang PY, Chiang WC
The Journal of biological chemistry 2025 Nov;301(11):110739
The Journal of biological chemistry 2025 Nov;301(11):110739
TRPM7 Deficiency Accelerates Vascular Senescence by Inhibiting H3K18 Lactylation.
Wang Y, Chen J, Wang X, Li J, Yang S, Zhu L, Li Z, Li C, Wu W, Bai Y
Aging cell 2025 Nov;24(11):e70244
Aging cell 2025 Nov;24(11):e70244
Mechanosensory activation of Piezo1 via cupping therapy: Harnessing neural networks to modulate AMPK pathway for metabolic restoration in a mouse model of psoriasis.
Xi RF, Liu X, Wang Y, Lu HZ, Yuan SJ, Guo DJ, Zhu JY, Li FL, Duan YJ
Journal of integrative medicine 2025 Nov;23(6):721-732
Journal of integrative medicine 2025 Nov;23(6):721-732
Dysregulated oxidative stress and lactate levels in treatment-resistant schizophrenia.
Fang Y, Zhang T, Xu K, Wang L, He J, Liao Y, Yuan N, Tang J
Brain, behavior, and immunity 2025 Nov;130:106111
Brain, behavior, and immunity 2025 Nov;130:106111
PSMD14-Mediated LDHA Deubiquitination Upregulates ACLY Expression via H3K18 Lactylation to Promote Lipid Synthesis and Pancreatic Cancer Progression.
Lu RS, Ren LK, Fei XB, Liu SB, Gao YJ, Hou JY, Wang C, Liu P, Zhu CH, Wang X, Pan YZ
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(44):e05762
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(44):e05762
Multi-omics analyses identify mannose phosphate isomerase-centered hypoxia-induced angiogenesis signature in colorectal cancer.
Liu S, Zhang Y, Meng Y, Huang Q, Feng Z, Wen L, Yang X, Zhang Y, Qiu L, Wang Z, Zhang B, Chen Z, Han J
Journal of translational medicine 2025 Nov 7;23(1):1246
Journal of translational medicine 2025 Nov 7;23(1):1246
Inflammation and Mitochondrial Dysfunction in Cirrhotic Cardiomyopathy: Therapeutic Implications.
Ding Y, Huang C, Yang G, Liu E, Wang Z, Su Y, Ge C
Journal of clinical and translational hepatology 2025 Nov 28;13(11):905-917
Journal of clinical and translational hepatology 2025 Nov 28;13(11):905-917
Breviscapine targets EGFR and SRC to abrogate diabetes-driven GPX4 lactylation and ferroptosis resistance in gastric cancer.
Hu HM, Deng JL, Pan Y, Wang ZH, Zhang J, Yu Gu X, Fan SX, Zhao JZ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157387
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157387
USP13 promotes colorectal cancer progression by deubiquitinating and stabilizing HIF-1α.
Gu B, Chang SY, Li KK, Wang BQ, Ke SB, Zhang XD, Du RL
Cell communication and signaling : CCS 2025 Nov 21;23(1):502
Cell communication and signaling : CCS 2025 Nov 21;23(1):502
Glucagon-like peptide-1 receptor signaling activation in alveolar type II cells enhances lung development in neonatal rats exposed to hyperoxia.
Sun T, Yu H, Zhang D, Zhang D, Li D, Fu J
Redox biology 2025 May;82:103586
Redox biology 2025 May;82:103586
S-palmitoylation modulates ATG2-dependent non-vesicular lipid transport during starvation-induced autophagy.
Zheng W, Pu M, Zeng S, Zhang H, Wang Q, Chen T, Zhou T, Chang C, Neculai D, Liu W
The EMBO journal 2025 May;44(9):2596-2619
The EMBO journal 2025 May;44(9):2596-2619
SIRT5-mediated desuccinylation of PPA2 enhances HIF-1alpha-dependent adaptation to hypoxic stress and colorectal cancer metastasis.
Zhang X, Di Y, Wang Y, Qin J, Ye L, Wen X, Ke Z, Wang Z, He W
The EMBO journal 2025 May;44(9):2514-2540
The EMBO journal 2025 May;44(9):2514-2540
Patient-derived organotypic tissue cultures as a platform to evaluate metabolic reprogramming in breast cancer patients.
Fan TW, Yan J, Goncalves CFL, Islam JMM, Lin P, Kaddah MMY, Higashi RM, Lane AN, Wang X, Zhu C
The Journal of biological chemistry 2025 May;301(5):108495
The Journal of biological chemistry 2025 May;301(5):108495
Cardiac PDK4 promotes neutrophilic PFKL methylation and drives the innate immune response in diabetic myocardial infarction.
Yang S, Yan L, Chen L, Su G, Yang L, Gong L, Liu L
Pharmacological research 2025 May;215:107731
Pharmacological research 2025 May;215:107731
NUDT21 lactylation reprograms alternative polyadenylation to promote cuproptosis resistance.
Lin J, Yin Y, Cao J, Zhang Y, Chen J, Chen R, Zou B, Huang C, Lv Y, Xu S, Yang H, Lin P, Xie D
Cell discovery 2025 May 28;11(1):52
Cell discovery 2025 May 28;11(1):52
IGFBP5 promotes EndoMT and renal fibrosis through H3K18 lactylation in diabetic nephropathy.
Hu X, Chen W, Yang M, Li M, Li X, Ouyang S
Cellular and molecular life sciences : CMLS 2025 May 27;82(1):215
Cellular and molecular life sciences : CMLS 2025 May 27;82(1):215
Ferroptosis-activating metabolite acrolein antagonizes necroptosis and anti-cancer therapeutics.
Bae H, Moon S, Chang M, Zhang F, Jang Y, Kim W, Kim S, Fu M, Lim J, Park S, Patel CN, Mall R, Zheng M, Man SM, Karki R
Nature communications 2025 May 27;16(1):4919
Nature communications 2025 May 27;16(1):4919
HCK regulates NLRP12-mediated PANoptosis.
Nadendla EK, Alluri P, Sundaram B, Kumar SP, Chadchan SB, Sarkar R, Kanneganti TD
Proceedings of the National Academy of Sciences of the United States of America 2025 May 27;122(21):e2422079122
Proceedings of the National Academy of Sciences of the United States of America 2025 May 27;122(21):e2422079122
Lactate-associated gene MCU promotes the proliferation, migration, and invasion of pancreatic ductal adenocarcinoma.
Chen Y, Zhang F, Dai S, Zhao J, Cai W, Zhang K, Liao X, Chen L
BMC cancer 2025 May 21;25(1):913
BMC cancer 2025 May 21;25(1):913
LncRNA NEAT1 regulation of the miR-101-3p/RAC1 axis affects cervical cancer aerobic glycolysis and progression.
Cao L, Abudureheman W, Shen G, Ouyang Y, Yang W, Zhao Q, Lu T, Lin C
Scientific reports 2025 May 20;15(1):17436
Scientific reports 2025 May 20;15(1):17436
LONP1 facilitates pulmonary artery smooth muscle cell glycolytic reprogramming by degrading MPC1 in pulmonary hypertension.
Li M, Zhang W, Zhang M, Li L, Yao Y, Qin Y, Wang D, Yan G, Qiao Y, Tang C
Clinical science (London, England : 1979) 2025 May 20;139(10):479-501
Clinical science (London, England : 1979) 2025 May 20;139(10):479-501
Compressive force-induced succinate production via metabolic reprogramming in periodontal ligament cells promotes orthodontic tooth movement.
Shi J, Wang L, Shan L, Zhu M, Chen Y, Li H, Lei L
Progress in orthodontics 2025 May 19;26(1):17
Progress in orthodontics 2025 May 19;26(1):17
Astragaloside IV prevents liver fibrosis by blocking glycolysis-mediated macrophage M1 polarization.
Hu Y, Kuang M, Song H, Tan Y, Zhou F, Pei G, Jiao L
European journal of pharmacology 2025 May 15;995:177353
European journal of pharmacology 2025 May 15;995:177353
Effects of polystyrene microparticles exposures on spermatogenic cell differentiation and reproductive endpoints in male mice.
Shen R, Xia P, Guo Y, Ji P, Yuan X, Wang L, Shuang S, Zhou L, Tong R, Zhang L, Liu D, Wang D
Environmental pollution (Barking, Essex : 1987) 2025 May 15;373:126200
Environmental pollution (Barking, Essex : 1987) 2025 May 15;373:126200
Interplay and cooperation between GLI2 and master transcription factors promote progression of esophageal squamous cell carcinoma.
Liu YQ, Zheng ZJ, Fang WK, Li YS, Li C, Yang M, Han DC, Zhou JH, Xie YH, Zhang YY, Kang ZY, Xu YW, Xie JJ
American journal of human genetics 2025 May 1;112(5):1039-1061
American journal of human genetics 2025 May 1;112(5):1039-1061
Lactate Dehydrogenase A Is a Novel Positive Regulator of Vascular Smooth Muscle Cell Ferroptosis During Aortic Dissection.
Feng X, Yi X, Huo B, Luo H, Chen J, Guo X, Fang ZM, Gong FH, Wei X, Jiang DS, Chen Y
Antioxidants & redox signaling 2025 Mar;42(7-9):378-392
Antioxidants & redox signaling 2025 Mar;42(7-9):378-392
Deciphering key roles of B cells in prognostication and tailored therapeutic strategies for lung adenocarcinoma: a multi-omics and machine learning approach towards predictive, preventive, and personalized treatment strategies.
Zhang J, Hu D, Fang P, Qi M, Sun G
The EPMA journal 2025 Mar;16(1):127-163
The EPMA journal 2025 Mar;16(1):127-163
The critical role of the ZBP1-NINJ1 axis and IRF1/IRF9 in ethanol-induced cell death, PANoptosis, and alcohol-associated liver disease.
Qin Q, Chen W, King CD, Kumar SP, Vogel P, Tweedell RE, Kanneganti TD
bioRxiv : the preprint server for biology 2025 Mar 14;
bioRxiv : the preprint server for biology 2025 Mar 14;
Administration of Porphyromonas gingivalis in pregnant mice enhances glycolysis and histone lactylation/ADAM17 leading to cleft palate in offspring.
Zhao X, Zheng X, Wang Y, Chen J, Wang X, Peng X, Yuan D, Liu Y, Wang Z, Du J
International journal of oral science 2025 Mar 13;17(1):18
International journal of oral science 2025 Mar 13;17(1):18
Identification of biomarkers associated with macrophage polarization in diabetic cardiomyopathy based on bioinformatics and machine learning approaches.
Liu Y, Zhang J, Han Q, Li Y, Xue Y, Liu X
Life sciences 2025 Mar 1;364:123443
Life sciences 2025 Mar 1;364:123443
Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model.
Ding X, Chen C, Zhao H, Dai B, Ye L, Song T, Huang S, Wang J, You T
Neural regeneration research 2025 Mar 1;20(3):858-872
Neural regeneration research 2025 Mar 1;20(3):858-872
H3K18 lactylation-mediated SIX1 upregulation contributes to silica-induced epithelial-mesenchymal transition in airway epithelial cells.
Liu S, He Y, Jin L, Shi S, Zhang J, Xie W, Yang M, Zhang Q, Kong H
Toxicology 2025 Jun;514:154109
Toxicology 2025 Jun;514:154109
ENTR1 affects the progression of colon cancer by regulating energy metabolism under the influence of glycolysis.
Ma A, Zhai C, He Q, Wang W, Ren H, Mao K, Lan W, Lan J
BMC cancer 2025 Jun 3;25(1):992
BMC cancer 2025 Jun 3;25(1):992
TAMs-derived SPP1, regulated by HIF-1α/STAT3 signaling pathway, influences colorectal cancer malignant progression by activation of EMT via integrin αvβ3.
Qu Y, Wang X, Li J, Luo H, Liu H, Wang T, Han X
International immunopharmacology 2025 Jun 26;159:114947
International immunopharmacology 2025 Jun 26;159:114947
GCLM lactylation mediated by ACAT2 promotes ferroptosis resistance in KRAS(G12D)-mutant cancer.
Chen Y, Yan Q, Ruan S, Cui J, Li Z, Zhang Z, Yang J, Fang J, Liu S, Huang S, Hou B, Zhang C
Cell reports 2025 Jun 24;44(6):115774
Cell reports 2025 Jun 24;44(6):115774
Formoterol, the Most Effective Bronchodilator, Has No Anti-Inflammatory nor Metabolic Modulatory Effects in Severe Asthma Induced by Aspergillus fumigatus.
Gan PXL, Linke KM, Liao W, Wong WSF
ACS pharmacology & translational science 2025 Jun 13;8(6):1556-1566
ACS pharmacology & translational science 2025 Jun 13;8(6):1556-1566
The role of RAB12 in inhibiting osteogenic differentiation and driving metabolic dysregulation in osteoporosis.
Ji P, Li Q, Zhang Y, Jin J, Zhang Y, Yuan Z, Shen G, Cao Q, Wu Y, Wang P, Liu W
Life sciences 2025 Jun 1;370:123590
Life sciences 2025 Jun 1;370:123590
Serum amyloid A drive microglia shift to a resolving phenotype through Nrf2.
Li Q, Huang Y, Ban T, Chen K, Zhen X, Dai Q, Zhang G
Neuropharmacology 2025 Jun 1;270:110374
Neuropharmacology 2025 Jun 1;270:110374
Innate immune sensor NLRP3 drives PANoptosome formation and PANoptosis.
Sharma BR, Choudhury SM, Abdelaal HM, Wang Y, Kanneganti TD
Journal of immunology (Baltimore, Md. : 1950) 2025 Jun 1;214(6):1236-1246
Journal of immunology (Baltimore, Md. : 1950) 2025 Jun 1;214(6):1236-1246
IER3 Facilitates Tumor Progression and Aberrant Glycolysis via Activating wnt/β-Catenin Pathway in Oral Squamous Cell Carcinoma.
Yin C, Miao Y, Lu W, Liu Z
Advanced biology 2025 Jul;9(7):e2400564
Advanced biology 2025 Jul;9(7):e2400564
HBx Drives Liver Cancer Stem Cell Generation Through Stimulating Glucose Metabolic Reprogramming.
Liu J, Wu X, Yin Q, Zhang L, Liu K, Huang K, Xu J, Li X, Lin B, Zhu M, Li M
Journal of cellular and molecular medicine 2025 Jul;29(14):e70722
Journal of cellular and molecular medicine 2025 Jul;29(14):e70722
Lactate production by tumor-resident Staphylococcus promotes metastatic colonization in lung adenocarcinoma.
Yu H, Du Y, He Y, Sun Y, Li J, Jia B, Chen J, Peng X, An T, Li J, Chi Y, Wang M, Cao L, Tai Y, Zhai X, Nuersulitan R, Li S, Wu N, Wang J, Xiong H, Wan S, Liu J, Yang X, Hu X, Lin D, Sun W, Wang Y, An G, Ji X, Kong L, Ding L, Ma Y, Tian Z, Dong B, Bi Y, Wu J, Wang Z
Cell host & microbe 2025 Jul 9;33(7):1089-1105.e7
Cell host & microbe 2025 Jul 9;33(7):1089-1105.e7
Adipocytes-induced ANGPTL4/KLF4 axis drives glycolysis and metastasis in triple-negative breast cancer.
Yin D, Fang N, Zhu Y, Bao X, Yang J, Zhang Q, Wang R, Huang J, Wu Q, Ma F, Wei X
Journal of experimental & clinical cancer research : CR 2025 Jul 4;44(1):192
Journal of experimental & clinical cancer research : CR 2025 Jul 4;44(1):192
Overexpression of PPM1G promotes cell metabolism and activates the NOTCH signaling pathway in lung adenocarcinoma.
Xi G, Zhang C, Yu C, Wang Y, Fu J, Qi H, Suda K, Wu G
Translational lung cancer research 2025 Jul 31;14(7):2771-2787
Translational lung cancer research 2025 Jul 31;14(7):2771-2787
Salvianolic Acid B Attenuates Liver Fibrosis via Suppression of Glycolysis-Dependent m1 Macrophage Polarization.
Song H, Li ZW, Xu W, Tan Y, Kuang M, Pei G, Wang ZQ
Current issues in molecular biology 2025 Jul 29;47(8)
Current issues in molecular biology 2025 Jul 29;47(8)
FBP1 as a key regulator of focal adhesion kinase-mediated hepatic stellate cell activation: Multi-omics and experimental validation.
Wu HY, Han L, Ran T, Sun Y, Zhang QX, Huang T, Zou GL, Zhang Y, Zhou YM, Lin GY, Chen SJ, Wang JL, Pan C, Lu F, Pu HF, Zhao XK
World journal of gastroenterology 2025 Jul 28;31(28):107361
World journal of gastroenterology 2025 Jul 28;31(28):107361
Nuclear Lactate Dehydrogenase A Resists Cardiomyocyte Cell Cycle Arrest Induced by Oxidative Stress.
Cao M, Luo J, Fu K, Xu Y, Wang Y, Duan J, Chen R, Yuan W
Journal of cardiovascular development and disease 2025 Jul 21;12(7)
Journal of cardiovascular development and disease 2025 Jul 21;12(7)
Beta sitosterol inhibits the proliferation and migration of synoviocytes in rheumatoid arthritis via lactylation of GPI.
Tan Y, Zhong X, He X, Yuan Y, Deng Y, Huang J, Zhou Y, Xie C, Peng H
Scientific reports 2025 Jul 11;15(1):25045
Scientific reports 2025 Jul 11;15(1):25045
Extracellular vesicle-derived lncRNA VIM-AS1 promotes diabetic wound healing by promoting glycolysis and alleviating cellular senescence.
Liang F, Huang N, Tian Y, Fang Y, Huang C, Qiu B, Lu T, Zheng L, Cheng J, Zhu B, Zhao J
Stem cell research & therapy 2025 Jul 1;16(1):341
Stem cell research & therapy 2025 Jul 1;16(1):341
AMPK-regulated glycerol excretion maintains metabolic crosstalk between reductive and energetic stress.
Zhai X, Yang R, Chu Q, Guo Z, Hou P, Li X, Bai C, Lu Z, Qiao L, Fu Y, Niu J, Li B
Nature cell biology 2025 Jan;27(1):141-153
Nature cell biology 2025 Jan;27(1):141-153
Hypoxia-induced BNIP3 facilitates the progression and metastasis of uveal melanoma by driving metabolic reprogramming.
Sun J, Ding J, Yue H, Xu B, Sodhi A, Xue K, Ren H, Qian J
Autophagy 2025 Jan;21(1):191-209
Autophagy 2025 Jan;21(1):191-209
CASC8 activates the pentose phosphate pathway to inhibit disulfidptosis in pancreatic ductal adenocarcinoma though the c-Myc-GLUT1 axis.
Yao HF, Ge J, Chen J, Tang X, Li C, Hu X, Ahmed AA, Pu Y, Zhou G, Zhang T, Cai Z, Jiang C
Journal of experimental & clinical cancer research : CR 2025 Jan 27;44(1):26
Journal of experimental & clinical cancer research : CR 2025 Jan 27;44(1):26
ITGA3 promotes pancreatic cancer progression through HIF1α- and c-Myc-driven glycolysis in a collagen I-dependent autocrine manner.
Li R, Ji Q, Fu S, Gu J, Liu D, Wang L, Yuan X, Wen Y, Dai C, Li H
Cancer gene therapy 2025 Feb;32(2):240-253
Cancer gene therapy 2025 Feb;32(2):240-253
Targeting Metabolic Adaptation of Colorectal Cancer with Vanadium-Doped Nanosystem to Enhance Chemotherapy and Immunotherapy.
Cheng Q, Chen Y, Zou D, Li Q, Shi X, Qin Q, Liu M, Wang L, Wang Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(7):e2409329
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(7):e2409329
Specific effects of hypoxia-immune core gene ARHGAP11A on lung adenocarcinoma.
Sun K, Wang L, Zhang X, Chen H, Wang Z, Zhang J, Wang X, Lian C
Translational cancer research 2025 Feb 28;14(2):778-795
Translational cancer research 2025 Feb 28;14(2):778-795
CPT1A mediates succinylation of LDHA at K318 site promoteing metabolic reprogramming in NK/T-cell lymphoma nasal type.
Tian H, Ge Y, Yu J, Chen X, Wang H, Cai X, Shan Z, Zuo L, Liu Y
Cell biology and toxicology 2025 Feb 11;41(1):42
Cell biology and toxicology 2025 Feb 11;41(1):42
HSP90 co-regulates the formation and nuclear distribution of the glycolytic output complex to promote resistance and poor prognosis in gastric cancer patients.
Shen G, Liu S, Cao Y, Chen Z, Wang G, Yu L, Sun L, Ran Y
Journal of translational medicine 2025 Feb 10;23(1):172
Journal of translational medicine 2025 Feb 10;23(1):172
Juglone targets MMP-1 to inhibit gastric cancer progression.
Zhou F, Xie Y, Li X, Peng P
Biochemical pharmacology 2025 Dec;242(Pt 2):117289
Biochemical pharmacology 2025 Dec;242(Pt 2):117289
Matrix stiffness-sensitive LDHA drives autophagy of pancreatic ductal adenocarcinoma via inducing FOXO3 expression and lactylation.
Gong T, Han Q, Zhang Y, Zhu K, Chen Y, Tao Y, Xing H, Wu D, Ma Y, Zhang S
Biomaterials advances 2025 Dec;177:214401
Biomaterials advances 2025 Dec;177:214401
CPSF6 loss mediates LDHA 3'UTR shortening to promote fibroblast glycolysis and pulmonary fibrosis.
Yang H, Han M, Zhang L, Yao C, Xu Q
Cellular signalling 2025 Dec;136:112165
Cellular signalling 2025 Dec;136:112165
Protective role of interleukin-37 in oral lichen planus: Regulation of Jurkat cell glycolysis through the mTOR pathway.
Wu T, Bai Y, Chen F
Journal of stomatology, oral and maxillofacial surgery 2025 Dec;126(6S):102511
Journal of stomatology, oral and maxillofacial surgery 2025 Dec;126(6S):102511
Cyclin B2 facilitates glycolysis and tumor progression in pancreatic ductal adenocarcinoma by promoting histone lactylation.
Ma B, Li X, Ma Z, Yin Z, Gao L, Wang Y, Shi J, Liu X, Chen H
BMC cancer 2025 Dec 7;26(1):63
BMC cancer 2025 Dec 7;26(1):63
Shikonin alleviates rotenone-induced Parkinson's disease neuroinflammation by targeting PKM2-mediated glycolytic MG-Hs production.
Zhao Y, Wang D, Mu D, Qu L, Li R
Cell communication and signaling : CCS 2025 Dec 29;23(1):537
Cell communication and signaling : CCS 2025 Dec 29;23(1):537
Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis.
Wang Y, Lu J, Carisey AF, Chadchan SB, Lee HW, Malireddi RKS, Sharma BR, Pandian N, Tweedell RE, Palacios G, Becerra Mora N, Robinson CG, Pitre A, Vogel P, Chen T, Murphy MP, Kanneganti TD
Cell 2025 Dec 11;188(25):7155-7174.e25
Cell 2025 Dec 11;188(25):7155-7174.e25
Lypd6b depletion promotes CD8(+) T cell-mediated anti-tumor immunity via metabolic reprogramming in colorectal cancer.
Liu T, Zeng F, Li Z, Cheng L, Yan X, Chen H, Liu Q, Li X, Li Z, Yao J, Xu D, Chen Z, Wang F, Wang J, Zhang J
Nature communications 2025 Dec 11;17(1):675
Nature communications 2025 Dec 11;17(1):675
Conformational Dynamics of PKM2 Regulate Hypoxia-Induced Pathological Retinal Angiogenesis.
Zhu P, Chang H, Yang Q, Chen W, Chang Q
Investigative ophthalmology & visual science 2025 Dec 1;66(15):23
Investigative ophthalmology & visual science 2025 Dec 1;66(15):23
m6A-mediated regulation of ECA39 promotes renal fibrosis in chronic kidney disease by enhancing glycolysis and epithelial-mesenchymal transition.
Tong Z, Zhao H, Cui C, Hong M, Ma Y, Sui L, Wang J, Yuan Q, Sun L
Biochimica et biophysica acta. Molecular cell research 2025 Aug;1872(6):119981
Biochimica et biophysica acta. Molecular cell research 2025 Aug;1872(6):119981
Elevated Histone Lactylation Mediates Ferroptosis Resistance in Endometriosis Through the METTL3-Regulated HIF1A/HMOX1 Signaling Pathway.
Liang Z, Liu J, Gou Y, Wang H, Li Z, Cao Y, Zhang H, Bai R, Zhang Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(31):e08220
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(31):e08220
Silybin Mitigates Post-Myocardial Infarction Heart Failure in Mice via Modulation of HIF-1α-Driven Glycolysis and Energy Metabolism.
Wang M, Chen J, Zhang Z, Wang T, Zhao J, Wang X, Wang J, Zhuang H
Nutrients 2025 Aug 28;17(17)
Nutrients 2025 Aug 28;17(17)
Extracellular lactate improves neurogenesis by modulating H3K9 lactylation and SnoN expression under hypoxic conditions.
Xu W, Zhao A, Han R, Wei J, Yu Q, Wang M, Li H, Xu B, Li M, Chi G
Stem cell research & therapy 2025 Aug 27;16(1):462
Stem cell research & therapy 2025 Aug 27;16(1):462
Targeting TSPAN1 promotes ferroptosis in endometrial cancer cells, reduces energy metabolism and inhibits malignant behavior.
Fan Y, Xiao H, Wu Y, Yan R, Li P, Ma H
Gene 2025 Aug 20;962:149553
Gene 2025 Aug 20;962:149553
Lactylation-boosted polycomb repression of KLF4 elicits glycolysis in retinoblastoma: A positive feedback circuit between histone modifications.
Yang L, Zuo S, Jia R, Gu X, Liao Q, Hua Y, Ge S, He M, Fan J, Tong X, Yuan T, Jia R, Fan X, Chai P, Wen X
Cancer letters 2025 Aug 10;625:217804
Cancer letters 2025 Aug 10;625:217804
USP19 potentiates autophagic cell death via inhibiting mTOR pathway through deubiquitinating NEK9 in pancreatic cancer.
Wang G, Dai S, Chen J, Zhang K, Huang C, Zhang J, Xie K, Lin F, Wang H, Gao Y, Yin L, Jiang K, Miao Y, Lu Z
Cell death and differentiation 2025 Apr;32(4):702-713
Cell death and differentiation 2025 Apr;32(4):702-713
Shikonin Derivative Suppresses Colorectal Cancer Cells Growth via Reactive Oxygen Species-Mediated Mitochondrial Apoptosis and PI3K/AKT Pathway.
Han H, Wen Z, Yang M, Wang C, Ma Y, Chen Q, Jiang D, Xu Y, Fazal A, Jie W, Lv X, Yin T, Lin H, Lu G, Qi J, Yang Y, Xu G
Chemistry & biodiversity 2025 Apr;22(4):e202403291
Chemistry & biodiversity 2025 Apr;22(4):e202403291
Impact of diabetes and metformin on cuproptosis and ferroptosis in breast cancer patients: an immunohistochemical analysis.
Li C, Chen T, Li Y, Zhou C, Du J, Li X, Tang C, Ma C, Deng N, Cui H
Discover oncology 2025 Apr 29;16(1):634
Discover oncology 2025 Apr 29;16(1):634
Lactate drives senescence-resistant lineages in hepatocellular carcinoma via histone H2B lactylation of NDRG1.
Li L, Dong J, Xu C, Wang S
Cancer letters 2025 Apr 28;616:217567
Cancer letters 2025 Apr 28;616:217567
Activation of GPR35 by kynurenic acid inhibits IL-1β secretion in macrophages during CR-hvKP-induced pneumonia.
Zhang Q, Meng B, Tang M, Li C, Xu Y, Pan J, Yu L, Li Y, Yang Y, Liu Y, Li H, Hu L, Wu T, Li J
International immunopharmacology 2025 Apr 24;153:114416
International immunopharmacology 2025 Apr 24;153:114416
Hypoxia-induced PRMT1 methylates HIF2β to promote breast tumorigenesis via enhancing glycolytic gene transcription.
Li WJ, Chen YC, Lin YA, Zou YQ, Hu GS, Yang JJ, Nie XY, Li MY, Wang YR, He YH, Zhao Y, Tan YH, Deng X, He WL, Cheng Y, Fu FM, Liu W
Cell reports 2025 Apr 22;44(4):115487
Cell reports 2025 Apr 22;44(4):115487
ETV4/ALYREF-mediated glycolytic metabolism through PKM2 enhances resistance to ferroptosis and promotes the development of intrahepatic cholangiocarcinoma.
Wang X, Duan W, Ma Z, Wen H, Mao X, Liu C
Cancer & metabolism 2025 Apr 22;13(1):19
Cancer & metabolism 2025 Apr 22;13(1):19
ACVR2A attenuation impacts lactate production and hyperglycolytic conditions attracting regulatory T cells in hepatocellular carcinoma.
Yasukawa K, Shimada S, Akiyama Y, Taniai T, Igarashi Y, Tsukihara S, Tanji Y, Umemura K, Kamachi A, Nara A, Yamane M, Akahoshi K, Shimizu A, Soejima Y, Tanabe M, Tanaka S
Cell reports. Medicine 2025 Apr 15;6(4):102038
Cell reports. Medicine 2025 Apr 15;6(4):102038
miR-526b enhances glucose metabolism in breast cancer cells, an effect reversed by targeting the COX-2/EP4 pathway.
Nault BD, Majumder M
Molecular biology reports 2025 Apr 1;52(1):351
Molecular biology reports 2025 Apr 1;52(1):351
Muscle-derived small extracellular vesicles induce liver fibrosis during overtraining.
Liu Y, Zhou R, Guo Y, Hu B, Xie L, An Y, Wen J, Liu Z, Zhou M, Kuang W, Xiao Y, Wang M, Xie G, Zhou H, Lu R, Peng H, Huang Y
Cell metabolism 2025 Apr 1;37(4):824-841.e8
Cell metabolism 2025 Apr 1;37(4):824-841.e8
Mitochondrial Dysfunction by FADDosome Promotes Gastric Mucosal Injury in Portal Hypertensive Gastropathy.
Xiao Y, Zhang Y, Xie K, Huang X, Liu X, Luo J, Tan S
International journal of biological sciences 2024;20(7):2658-2685
International journal of biological sciences 2024;20(7):2658-2685
The m6A modification-mediated positive feedback between glycolytic lncRNA SLC2A1-DT and c-Myc promotes tumorigenesis of hepatocellular carcinoma.
Zeng Z, Wang J, Xu F, Hu P, Hu Y, Zhuo W, Chen D, Han S, Wang F, Zhao Y, Huang Y, Zhao G
International journal of biological sciences 2024;20(5):1744-1762
International journal of biological sciences 2024;20(5):1744-1762
Bufalin-Loaded Multifunctional Photothermal Nanoparticles Inhibit the Anaerobic Glycolysis by Targeting SRC-3/HIF-1α Pathway for Improved Mild Photothermal Therapy in CRC.
Shang J, Xia Q, Sun Y, Wang H, Chen J, Li Y, Gao F, Yin P, Yuan Z
International journal of nanomedicine 2024;19:7831-7850
International journal of nanomedicine 2024;19:7831-7850
Dipeptide alanine-glutamine ameliorates retinal neurodegeneration in an STZ-induced rat model.
Zhang Y, Wei M, Wang X, Xu Y, Zong R, Lin X, Li S, Chen W, Liu Z, Chen Q
Frontiers in pharmacology 2024;15:1490443
Frontiers in pharmacology 2024;15:1490443
LINC00908 attenuates LUAD tumorigenesis through DEAD-box helicase 54.
Zhao J, Yang X, Gong W, Zhang L, Li C, Han X, Zhang Y, Chu X
American journal of cancer research 2024;14(5):2371-2389
American journal of cancer research 2024;14(5):2371-2389
Decreased lncRNA HNF4A-AS1 facilitates resistance to sorafenib-induced ferroptosis of hepatocellular carcinoma by reprogramming lipid metabolism.
Zhao Y, Han S, Zeng Z, Zheng H, Li Y, Wang F, Huang Y, Zhao Y, Zhuo W, Lv G, Wang H, Zhao G, Zhao E, Hu Y, Hu P, Zhao G
Theranostics 2024;14(18):7088-7110
Theranostics 2024;14(18):7088-7110
ETV4 promotes the progression of cholangiocarcinoma by regulating glycolysis via the TGF-β signaling.
Liu F, Wang Q, Wang Z, Zhang S, Ni Q, Chang H
Translational oncology 2024 Sep;47:102035
Translational oncology 2024 Sep;47:102035
Classical apoptotic stimulus, staurosporine, induces lytic inflammatory cell death, PANoptosis.
Sarkar R, Choudhury SM, Kanneganti TD
The Journal of biological chemistry 2024 Sep;300(9):107676
The Journal of biological chemistry 2024 Sep;300(9):107676
The miR-199a-5p/HIF1α dual-regulatory axis participates in hypoxia-induced aggressive phenotypes of oral squamous cell carcinoma (OSCC) cells.
Chen X, Yu J, Tian H, Cai X
International journal of clinical oncology 2024 Sep;29(9):1244-1254
International journal of clinical oncology 2024 Sep;29(9):1244-1254
Acetate enables metabolic fitness and cognitive performance during sleep disruption.
He Q, Ji L, Wang Y, Zhang Y, Wang H, Wang J, Zhu Q, Xie M, Ou W, Liu J, Tang K, Lu K, Liu Q, Zhou J, Zhao R, Cai X, Li N, Cao Y, Li T
Cell metabolism 2024 Sep 3;36(9):1998-2014.e15
Cell metabolism 2024 Sep 3;36(9):1998-2014.e15
The type 2 cytokine Fc-IL-4 revitalizes exhausted CD8(+) T cells against cancer.
Feng B, Bai Z, Zhou X, Zhao Y, Xie YQ, Huang X, Liu Y, Enbar T, Li R, Wang Y, Gao M, Bonati L, Peng MW, Li W, Tao B, Charmoy M, Held W, Melenhorst JJ, Fan R, Guo Y, Tang L
Nature 2024 Oct;634(8034):712-720
Nature 2024 Oct;634(8034):712-720
LncRNA SLC9A3-AS1 knockdown increases the sensitivity of liver cancer cell to triptolide by regulating miR-449b-5p-mediated glycolysis.
Zhao L, Zhang H, Ren P, Sun X
Biotechnology & genetic engineering reviews 2024 Oct;40(2):1389-1405
Biotechnology & genetic engineering reviews 2024 Oct;40(2):1389-1405
UBE2S promotes glycolysis in hepatocellular carcinoma by enhancing E3 enzyme-independent polyubiquitination of VHL.
Zhang R, Li C, Zhang S, Kong L, Liu Z, Guo Y, Sun Y, Zhang C, Yong Y, Lv J, Lu M, Liu M, Wu D, Zhang T, Yang H, Wei D, Chen Z, Bian H
Clinical and molecular hepatology 2024 Oct;30(4):771-792
Clinical and molecular hepatology 2024 Oct;30(4):771-792
O-GlcNAcylation mediates Wnt-stimulated bone formation by rewiring aerobic glycolysis.
You C, Shen F, Yang P, Cui J, Ren Q, Liu M, Hu Y, Li B, Ye L, Shi Y
EMBO reports 2024 Oct;25(10):4465-4487
EMBO reports 2024 Oct;25(10):4465-4487
Direct mitochondrial import of lactate supports resilient carbohydrate oxidation.
Cluntun AA, Visker JR, Velasco-Silva JN, Lang MJ, Cedeño-Rosario L, Shankar TS, Hamouche R, Ling J, Kim JE, Toshniwal AG, Low HK, Cunningham CN, Carrington J, Catrow JL, Pearce Q, Jeong MY, Bott AJ, Narbona-Pérez ÁJ, Stanley CE, Li Q, Eberhardt DR, Morgan JT, Yadav T, Wells CE, Ramadurai DKA, Swiatek WI, Chaudhuri D, Rothstein JD, Muoio DM, Paulo JA, Gygi SP, Baker SA, Navankasattusas S, Cox JE, Funai K, Drakos SG, Rutter J, Ducker GS
bioRxiv : the preprint server for biology 2024 Oct 8;
bioRxiv : the preprint server for biology 2024 Oct 8;
CHAC1 blockade suppresses progression of lung adenocarcinoma by interfering with glucose metabolism via hijacking PKM2 nuclear translocation.
Pan J, Wu S, Pan Q, Zhang Y, He L, Yao Q, Chen J, Li J, Xu Y
Cell death & disease 2024 Oct 5;15(10):728
Cell death & disease 2024 Oct 5;15(10):728
Characteristics of Myocardial Structure and Central Carbon Metabolism during the Early and Compensatory Stages of Cardiac Hypertrophy.
Chen Y, Luo YM, Li D, Liu H, Luo X, Zhang X, Ling Y, Ouyang W
Journal of proteome research 2024 Oct 4;23(10):4229-4241
Journal of proteome research 2024 Oct 4;23(10):4229-4241
The chemically stable analogue of resolvin D1 ameliorates experimental autoimmune encephalomyelitis by mediating the resolution of inflammation.
Zhang Q, Zhang Y, Zou M, Wu H, Liu C, Mi Y, Zhu J, Wang Y, Jin T
International immunopharmacology 2024 Oct 25;140:112740
International immunopharmacology 2024 Oct 25;140:112740
Oxygen Glucose Deprivation-Induced Lactylation of H3K9 Contributes to M1 Polarization and Inflammation of Microglia Through TNF Pathway.
He L, Yin R, Hang W, Han J, Chen J, Wen B, Chen L
Biomedicines 2024 Oct 17;12(10)
Biomedicines 2024 Oct 17;12(10)
TRIM33 promotes glycolysis through regulating P53 K48-linked ubiquitination to promote esophageal squamous cell carcinoma growth.
Xia T, Meng L, Xu G, Sun H, Chen H
Cell death & disease 2024 Oct 10;15(10):740
Cell death & disease 2024 Oct 10;15(10):740
Oroxylin A, a broad‑spectrum anticancer agent, relieves monocrotaline‑induced pulmonary arterial hypertension by inhibiting the Warburg effect in rats.
Wang Y, Fan Y, Zhou Y, Chen T, Xu S, Liu J, Li L
Molecular medicine reports 2024 Nov;30(5)
Molecular medicine reports 2024 Nov;30(5)
Trans-resveratrol mitigates miR-204-3p mediated progression of allergic rhinitis by regulating the EGLN3/HIF-1α/IL33/ST2 signalling pathway.
Mao W, Wang B, Chen F, Luo D, Li Y, Liu Y, Liu Y, Dong P, Huang R
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Nov;134:155967
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Nov;134:155967
MTFR2 accelerates hepatocellular carcinoma mediated by metabolic reprogramming via the Akt signaling pathway.
Bao Z, Yang M, Guo Y, Ge Q, Zhang H
Cellular signalling 2024 Nov;123:111366
Cellular signalling 2024 Nov;123:111366
Lactylation stabilizes TFEB to elevate autophagy and lysosomal activity.
Huang Y, Luo G, Peng K, Song Y, Wang Y, Zhang H, Li J, Qiu X, Pu M, Liu X, Peng C, Neculai D, Sun Q, Zhou T, Huang P, Liu W
The Journal of cell biology 2024 Nov 4;223(11)
The Journal of cell biology 2024 Nov 4;223(11)
Construction and validation of a prognostic model based on oxidative stress-related genes in non-small cell lung cancer (NSCLC): predicting patient outcomes and therapy responses.
Sun D, Lu J, Zhao W, Chen X, Xiao C, Hua F, Hydbring P, Gabazza EC, Tartarone A, Zhao X, Yang W
Translational lung cancer research 2024 Nov 30;13(11):3152-3174
Translational lung cancer research 2024 Nov 30;13(11):3152-3174
Histone lactylation mediated by Fam172a in POMC neurons regulates energy balance.
Chen Z, Wan B, Zhang H, Zhang L, Zhang R, Li L, Zhang Y, Hu C
Nature communications 2024 Nov 22;15(1):10111
Nature communications 2024 Nov 22;15(1):10111
Acrolein exposure affects ovarian function by interfering with glycolysis and mitochondrial energy metabolism in mouse.
Chen YZ, Wang WK, Yang YF, Cheng SY, Li LF, Shen H, Qi ZM, Liu Y
Environmental pollution (Barking, Essex : 1987) 2024 Nov 15;361:124776
Environmental pollution (Barking, Essex : 1987) 2024 Nov 15;361:124776
Ulinastatin attenuates renal fibrosis by regulating AMPK/HIF-1α signaling pathway-mediated glycolysis.
Wei X, Long M, Fan Z, Hou Y, Yang L, Du Y
Scientific reports 2024 Nov 14;14(1):28032
Scientific reports 2024 Nov 14;14(1):28032
The protein phosphatase PP6 promotes RIPK1-dependent PANoptosis.
Bynigeri RR, Malireddi RKS, Mall R, Connelly JP, Pruett-Miller SM, Kanneganti TD
BMC biology 2024 May 29;22(1):122
BMC biology 2024 May 29;22(1):122
Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation.
Zhang Y, Jiang H, Dong M, Min J, He X, Tan Y, Liu F, Chen M, Chen X, Yin Q, Zheng L, Shao Y, Li X, Chen H
Cell reports 2024 May 28;43(5):114180
Cell reports 2024 May 28;43(5):114180
Energy stress-induced circDDX21 promotes glycolysis and facilitates hepatocellular carcinogenesis.
Luo J, Yang Y, Zhang G, Fang D, Liu K, Mei Y, Wang F
Cell death & disease 2024 May 21;15(5):354
Cell death & disease 2024 May 21;15(5):354
Serine/Arginine-Rich Splicing Factor 7 Knockdown Inhibits Aerobic Glycolysis and Growth in HepG2 Cells by Regulating PKM2 Expression.
Shi W, Yao X, Cao X, Fu Y, Wang Y
Current issues in molecular biology 2024 May 20;46(5):5023-5036
Current issues in molecular biology 2024 May 20;46(5):5023-5036
Epigenetic silencing of LDHB promotes hepatocellular carcinoma by remodeling the tumor microenvironment.
Zhang P, Wan Y, Ma J, Gong J, Zhong Z, Cui Y, Zhang H, Da Y, Ma J, Li C, Liu L, Gong T, Tan Y, Zhang C
Cancer immunology, immunotherapy : CII 2024 May 13;73(7):127
Cancer immunology, immunotherapy : CII 2024 May 13;73(7):127
Qing Xia Jie Yi Formula granules alleviated acute pancreatitis through inhibition of M1 macrophage polarization by suppressing glycolysis.
Han X, Bao J, Ni J, Li B, Song P, Wan R, Wang X, Hu G, Chen C
Journal of ethnopharmacology 2024 May 10;325:117750
Journal of ethnopharmacology 2024 May 10;325:117750
The opposite role of lactate dehydrogenase a (LDHA) in cervical cancer under energy stress conditions.
Jia C, Wu Y, Gao F, Liu W, Li N, Chen Y, Sun L, Wang S, Yu C, Bao Y, Song Z
Free radical biology & medicine 2024 Mar;214:2-18
Free radical biology & medicine 2024 Mar;214:2-18
Region-specific cellular and molecular basis of liver regeneration after acute pericentral injury.
Wang S, Wang X, Shan Y, Tan Z, Su Y, Cao Y, Wang S, Dong J, Gu J, Wang Y
Cell stem cell 2024 Mar 7;31(3):341-358.e7
Cell stem cell 2024 Mar 7;31(3):341-358.e7
Lactate dehydrogenase A regulates tumor-macrophage symbiosis to promote glioblastoma progression.
Khan F, Lin Y, Ali H, Pang L, Dunterman M, Hsu WH, Frenis K, Grant Rowe R, Wainwright DA, McCortney K, Billingham LK, Miska J, Horbinski C, Lesniak MS, Chen P
Nature communications 2024 Mar 5;15(1):1987
Nature communications 2024 Mar 5;15(1):1987
Histone lactylation-boosted ALKBH3 potentiates tumor progression and diminished promyelocytic leukemia protein nuclear condensates by m1A demethylation of SP100A.
Gu X, Zhuang A, Yu J, Yang L, Ge S, Ruan J, Jia R, Fan X, Chai P
Nucleic acids research 2024 Mar 21;52(5):2273-2289
Nucleic acids research 2024 Mar 21;52(5):2273-2289
p53-dependent HIF-1α /autophagy mediated glycolysis to support Cr(VI)-induced cell growth and cell migration.
Yang Y, Song B, Guo M, Gao J, Jiang L, Li Q, Liu Y, Cao J
Ecotoxicology and environmental safety 2024 Mar 1;272:116076
Ecotoxicology and environmental safety 2024 Mar 1;272:116076
METTL3 orchestrates glycolysis by stabilizing the c-Myc/WDR5 complex in triple-negative breast cancer.
Yuan XN, Shao YC, Guan XQ, Liu Q, Chu MF, Yang ZL, Li H, Zhao S, Tian YH, Zhang JW, Wei L
Biochimica et biophysica acta. Molecular cell research 2024 Jun;1871(5):119716
Biochimica et biophysica acta. Molecular cell research 2024 Jun;1871(5):119716
Inactivation of KDM6A promotes the progression of colorectal cancer by enhancing the glycolysis.
Zhang D, Zhao X, Gao Y, Wang M, Xiao M, Zhu K, Niu W, Dai Y
European journal of medical research 2024 Jun 6;29(1):310
European journal of medical research 2024 Jun 6;29(1):310
NAT1 inhibits liver metastasis of colorectal cancer by regulating EMT and glycolysis.
Gu W, Li C, Shen T, Tong L, Yuan W, Zheng X, Wang T, Wang S, Zhu B, Zhang C, Zhang C
Aging 2024 Jun 24;16(12):10546-10562
Aging 2024 Jun 24;16(12):10546-10562
The walnut-derived peptide TW-7 improves mouse parthenogenetic embryo development of vitrified MII oocytes potentially by promoting histone lactylation.
Wei Y, Pan B, Qin J, Cao B, Lv T, Ye J, Ning A, Du K, Chen X, Zou S, Zang S, Yu G, Song T, Liang Q, Zhou G
Journal of animal science and biotechnology 2024 Jun 11;15(1):86
Journal of animal science and biotechnology 2024 Jun 11;15(1):86
NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance.
Chen H, Li Y, Li H, Chen X, Fu H, Mao D, Chen W, Lan L, Wang C, Hu K, Li J, Zhu C, Evans I, Cheung E, Lu D, He Y, Behrens A, Yin D, Zhang C
Nature 2024 Jul;631(8021):663-669
Nature 2024 Jul;631(8021):663-669
Electroacupuncture improves articular microcirculation and attenuates cartilage hypoxia in a male rabbit model of knee osteoarthritis.
Weiwei M, Mei D, Juan L, Longfei X, Xilin C, Tingyao H, Wenting Z, Changqing G
Journal of traditional and complementary medicine 2024 Jul;14(4):414-423
Journal of traditional and complementary medicine 2024 Jul;14(4):414-423
Bergenin alleviates proliferative arterial diseases by modulating glucose metabolism in vascular smooth muscle cells.
Song Y, Deng M, Qiu Y, Cui Y, Zhang B, Xin J, Feng L, Mu X, Cui J, Li H, Sun Y, Yi W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155592
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155592
HOXC4 promotes proliferation of pancreatic cancer cells by increasing LDHA-mediated glycolysis.
Zhang H, Han B, Tian S, Gong Y, Chen L, Liu L
Aging 2024 Jul 9;16(13):11103-11116
Aging 2024 Jul 9;16(13):11103-11116
SEC61 translocon gamma subunit is correlated with glycolytic activity, epithelial mesenchymal transition and the immune suppressive phenotype of lung adenocarcinoma.
Zhou C, Cui H, Yang Y, Chen L, Feng M, Gao Y, Li D, Li L, Chen X, Li X, Cao Y
Acta biochimica et biophysica Sinica 2024 Jul 8;56(12):1748-1760
Acta biochimica et biophysica Sinica 2024 Jul 8;56(12):1748-1760
Glycolytic enzyme PGK1 promotes M1 macrophage polarization and induces pyroptosis of acute lung injury via regulation of NLRP3.
Zhu G, Yu H, Peng T, Yang K, Xu X, Gu W
Respiratory research 2024 Jul 30;25(1):291
Respiratory research 2024 Jul 30;25(1):291
LDHA contributes to nicotine induced cardiac fibrosis through autophagy flux impairment.
Wu HH, Du JM, Liu P, Meng FL, Li YY, Li WJ, Wang SX, Du NL, Zheng Y, Zhang L, Wang HY, Liu YR, Song CH, Ni X, Li Y, Su GH
International immunopharmacology 2024 Jul 30;136:112338
International immunopharmacology 2024 Jul 30;136:112338
DEPDC1 as a metabolic target regulates glycolysis in renal cell carcinoma through AKT/mTOR/HIF1α pathway.
Di SC, Chen WJ, Yang W, Zhang XM, Dong KQ, Tian YJ, Sun Y, Qian C, Chen JX, Liu ZC, Gong ZX, Chu J, Zhou W, Pan XW, Cui XG
Cell death & disease 2024 Jul 27;15(7):533
Cell death & disease 2024 Jul 27;15(7):533
Altered neuronal lactate dehydrogenase A expression affects cognition in a sex- and age-dependent manner.
Frame AK, Sinka JL, Courchesne M, Muhammad RA, Grahovac-Nemeth S, Bernards MA, Bartha R, Cumming RC
iScience 2024 Jul 19;27(7):110342
iScience 2024 Jul 19;27(7):110342
The ubiquitin-like protein UBTD1 promotes colorectal cancer progression by stabilizing c-Myc to upregulate glycolysis.
Zhao L, Yu N, Zhai Y, Yang Y, Wang Y, Yang Y, Gong Z, Zhang Y, Zhang X, Guo W
Cell death & disease 2024 Jul 13;15(7):502
Cell death & disease 2024 Jul 13;15(7):502
A vesicular Warburg effect: Aerobic glycolysis occurs on axonal vesicles for local NAD+ recycling and transport.
Mc Cluskey M, Dubouchaud H, Nicot AS, Saudou F
Traffic (Copenhagen, Denmark) 2024 Jan;25(1):e12926
Traffic (Copenhagen, Denmark) 2024 Jan;25(1):e12926
Tumor-derived lactate promotes resistance to bevacizumab treatment by facilitating autophagy enhancer protein RUBCNL expression through histone H3 lysine 18 lactylation (H3K18la) in colorectal cancer.
Li W, Zhou C, Yu L, Hou Z, Liu H, Kong L, Xu Y, He J, Lan J, Ou Q, Fang Y, Lu Z, Wu X, Pan Z, Peng J, Lin J
Autophagy 2024 Jan;20(1):114-130
Autophagy 2024 Jan;20(1):114-130
Cryptotanshinone suppresses ovarian cancer via simultaneous inhibition of glycolysis and oxidative phosphorylation.
Wang T, Zhang M, Khan M, Li J, Wu X, Ma T, Li Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jan;170:115956
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jan;170:115956
Autophagy induces hair follicle stem cell activation and hair follicle regeneration by regulating glycolysis.
Sun P, Wang Z, Li S, Yin J, Gan Y, Liu S, Lin Z, Wang H, Fan Z, Qu Q, Hu Z, Li K, Miao Y
Cell & bioscience 2024 Jan 5;14(1):6
Cell & bioscience 2024 Jan 5;14(1):6
AKT1 phosphorylation of cytoplasmic ME2 induces a metabolic switch to glycolysis for tumorigenesis.
Chen T, Xie S, Cheng J, Zhao Q, Wu H, Jiang P, Du W
Nature communications 2024 Jan 23;15(1):686
Nature communications 2024 Jan 23;15(1):686
Salvianolic Acid B Alleviates Liver Injury by Regulating Lactate-Mediated Histone Lactylation in Macrophages.
Hu S, Yang Z, Li L, Yan Q, Hu Y, Zhou F, Tan Y, Pei G
Molecules (Basel, Switzerland) 2024 Jan 1;29(1)
Molecules (Basel, Switzerland) 2024 Jan 1;29(1)
Single-cell transcriptome analysis reveals immunosuppressive landscape in overweight and obese colorectal cancer.
Xiao G, Zheng Y, Chen H, Luo M, Yang C, Ren D, Qin P, Zhang H, Lin H
Journal of translational medicine 2024 Feb 4;22(1):134
Journal of translational medicine 2024 Feb 4;22(1):134
NINJ1 mediates inflammatory cell death, PANoptosis, and lethality during infection conditions and heat stress.
Han JH, Karki R, Malireddi RKS, Mall R, Sarkar R, Sharma BR, Klein J, Berns H, Pisharath H, Pruett-Miller SM, Bae SJ, Kanneganti TD
Nature communications 2024 Feb 26;15(1):1739
Nature communications 2024 Feb 26;15(1):1739
Atractylenolide II Suppresses Glycolysis and Induces Apoptosis by Blocking the PADI3-ERK Signaling Pathway in Endometrial Cancer Cells.
Tian S, Ren L, Liu C, Wang Z
Molecules (Basel, Switzerland) 2024 Feb 21;29(5)
Molecules (Basel, Switzerland) 2024 Feb 21;29(5)
ATF4/PHGDH mediates the effects of ER stress on cadmium-induced autophagy and glycolysis.
Yang Y, Li S, Yang Y, Li Q, Liu Y, Cao J
Toxicology 2024 Dec;509:153976
Toxicology 2024 Dec;509:153976
Activation of ferritin light chain (FTL) by transcription factor salmonella pathogenicity island 1 modulates glycolysis to drive metastasis of ovarian cancer cells.
Li C, Yang Y, Lin Y, Lian Y, Pan D, Lin L, Li L
Expert review of anticancer therapy 2024 Dec;24(12):1271-1282
Expert review of anticancer therapy 2024 Dec;24(12):1271-1282
Swimming upregulates APOL3 through regulating macrophage polarization to inhibit glycolysis and the development of melanoma.
Lyu Z, Mahenderan A, Radhakrishnan AKGK, Chin YS, Yin C
3 Biotech 2024 Dec;14(12):307
3 Biotech 2024 Dec;14(12):307
Uric acid mediates kidney tubular inflammation through the LDHA/ROS/NLRP3 pathway.
Ouyang J, Wang H, Gan Y, Huang J
Clinical and experimental hypertension (New York, N.Y. : 1993) 2024 Dec 31;46(1):2424834
Clinical and experimental hypertension (New York, N.Y. : 1993) 2024 Dec 31;46(1):2424834
Activated DRP1 promotes mitochondrial fission and induces glycolysis in ATII cells under hyperoxia.
Sun T, Yu H, Zhang D, Li D, Fu J
Respiratory research 2024 Dec 26;25(1):443
Respiratory research 2024 Dec 26;25(1):443
Colorectal cancer cells establish metabolic reprogramming with cancer-associated fibroblasts (CAFs) through lactate shuttle to enhance invasion, migration, and angiogenesis.
Wang X, Qu Y, Ji J, Liu H, Luo H, Li J, Han X
International immunopharmacology 2024 Dec 25;143(Pt 2):113470
International immunopharmacology 2024 Dec 25;143(Pt 2):113470
Ubiquitin-specific protease 7 maintains c-Myc stability to support pancreatic cancer glycolysis and tumor growth.
Gu J, Xiao X, Zou C, Mao Y, Jin C, Fu D, Li R, Li H
Journal of translational medicine 2024 Dec 20;22(1):1135
Journal of translational medicine 2024 Dec 20;22(1):1135
Phosphorylation determines the glucose metabolism reprogramming and tumor-promoting activity of sine oculis homeobox 1.
Lin Y, Li L, Yuan B, Luo F, Zhang X, Yang Y, Luo S, Lin J, Ye T, Zhang Y, Gao S, Ye Q
Signal transduction and targeted therapy 2024 Dec 2;9(1):337
Signal transduction and targeted therapy 2024 Dec 2;9(1):337
Lactate Dehydrogenase Inhibition Protects against Hepatic Fibrosis by Regulating Metabolic Reprogramming of Hepatic Stellate Cells.
Li L, Lei Q, Zhen Y, Cao L, Dong Y, Liu X, Wang M
Journal of agricultural and food chemistry 2024 Dec 18;72(50):27953-27964
Journal of agricultural and food chemistry 2024 Dec 18;72(50):27953-27964
Hypoxic mesenchymal stem cell-derived exosomal circDennd2a regulates granulosa cell glycolysis by interacting with LDHA.
Li W, Lu M, Shang J, Zhou J, Lin L, Liu Y, Zhao D, Zhu X
Stem cell research & therapy 2024 Dec 18;15(1):484
Stem cell research & therapy 2024 Dec 18;15(1):484
Low level exposure to BDE-47 facilitates the development of prostate cancer through TOP2A/LDHA/lactylation positive feedback circuit.
Tian L, Zhou N, Zhao N, Qiao M, He M, Mao Z, Xu W, Xu D, Wang Y, Xu Y, Chen T
Environmental research 2024 Dec 15;263(Pt 2):120094
Environmental research 2024 Dec 15;263(Pt 2):120094
RBM15 drives the progression of lung adenocarcinoma by regulating N6-methyladenosine-mediated LDHA mRNA stability.
Shi S, Wang C, Cai Q, Yang R, Peng M, Liang H, Qian B, Jiang Y, Xiao B, Wang L, Tao Y, Cai J, Zhao Z
Life sciences 2024 Dec 1;358:123146
Life sciences 2024 Dec 1;358:123146
PGC-1α/LDHA signaling facilitates glycolysis initiation to regulate mechanically induced bone remodeling under inflammatory microenvironment.
Liu J, Wang J, Wang Z, Ren H, Zhang Z, Fu Y, Li L, Shen Z, Li T, Tang S, Wei F
Bone 2024 Aug;185:117132
Bone 2024 Aug;185:117132
TRIB3 promotes the growth of oral squamous cell carcinoma by regulating JNK/JUN-mediated aerobic glycolysis.
Meng Z, Wang Y, Wang X, Han X
Archives of oral biology 2024 Aug;164:105977
Archives of oral biology 2024 Aug;164:105977
Discovery of a Highly Potent and Selective HDAC8 Degrader: Advancing the Functional Understanding and Therapeutic Potential of HDAC8.
Xiao Y, Awasthee N, Liu Y, Meng C, He MY, Hale S, Karki R, Lin Z, Mosterio M, Garcia BA, Kridel R, Liao D, Zheng G
Journal of medicinal chemistry 2024 Aug 8;67(15):12784-12806
Journal of medicinal chemistry 2024 Aug 8;67(15):12784-12806
A CLIC1 network coordinates matrix stiffness and the Warburg effect to promote tumor growth in pancreatic cancer.
Zheng JH, Zhu YH, Yang J, Ji PX, Zhao RK, Duan ZH, Yao HF, Jia QY, Yin YF, Hu LP, Li Q, Jiang SH, Huo YM, Liu W, Sun YW, Liu DJ
Cell reports 2024 Aug 27;43(8):114633
Cell reports 2024 Aug 27;43(8):114633
A novel HMGA2/MPC-1/mTOR signaling pathway promotes cell growth via facilitating Cr (VI)-induced glycolysis.
Zhao S, Zhang Y, Bao S, Jiang L, Li Q, Kong Y, Cao J
Chemico-biological interactions 2024 Aug 25;399:111141
Chemico-biological interactions 2024 Aug 25;399:111141
N(6)-methyladenosine-modified SRPK1 promotes aerobic glycolysis of lung adenocarcinoma via PKM splicing.
Wang A, Zeng Y, Zhang W, Zhao J, Gao L, Li J, Zhu J, Liu Z, Huang JA
Cellular & molecular biology letters 2024 Aug 2;29(1):106
Cellular & molecular biology letters 2024 Aug 2;29(1):106
The Protective Effect of Quercetin against the Cytotoxicity Induced by Fumonisin B1 in Sertoli Cells.
Ma J, Huang R, Zhang H, Liu D, Dong X, Xiong Y, Xiong X, Lan D, Fu W, He H, Li J, Yin S
International journal of molecular sciences 2024 Aug 12;25(16)
International journal of molecular sciences 2024 Aug 12;25(16)
The mechanism of extracellular CypB promotes glioblastoma adaptation to glutamine deprivation microenvironment.
Yin H, Liu Y, Dong Q, Wang H, Yan Y, Wang X, Wan X, Yuan G, Pan Y
Cancer letters 2024 Aug 10;597:216862
Cancer letters 2024 Aug 10;597:216862
Mitochondrial dysfunction induced by HIF-1α under hypoxia contributes to the development of gastric mucosal lesions.
Xiao Y, Liu X, Xie K, Luo J, Zhang Y, Huang X, Luo J, Tan S
Clinical and translational medicine 2024 Apr;14(4):e1653
Clinical and translational medicine 2024 Apr;14(4):e1653
Gli1(+) Progenitors Mediate Glucocorticoid-Induced Osteoporosis In Vivo.
Yang P, Shen F, You C, Lou F, Shi Y
International journal of molecular sciences 2024 Apr 16;25(8)
International journal of molecular sciences 2024 Apr 16;25(8)
Identification and validation of a lactate metabolism-related six-gene prognostic signature in intrahepatic cholangiocarcinoma.
Sang C, Yan L, Lin J, Lin Y, Gao Q, Shen X
Journal of cancer research and clinical oncology 2024 Apr 16;150(4):199
Journal of cancer research and clinical oncology 2024 Apr 16;150(4):199
Palmitoylation alters LDHA activity and pancreatic cancer response to chemotherapy.
Chen L, Xing X, Zhu Y, Chen Y, Pei H, Song Q, Li J, Zhang P
Cancer letters 2024 Apr 10;587:216696
Cancer letters 2024 Apr 10;587:216696
Metabolic reprogramming of cancer-associated fibroblasts in pancreatic cancer contributes to the intratumor heterogeneity of PET-CT.
Meng Q, Fang Z, Mao X, Tang R, Liang C, Hua J, Wang W, Shi S, Yu X, Xu J
Computational and structural biotechnology journal 2023;21:2631-2639
Computational and structural biotechnology journal 2023;21:2631-2639
Increased α-HB links colorectal cancer and diabetes by potentiating NF-κB signaling.
Lv X, Ding P, Li L, Li L, Zhou D, Wang X, Chen J, Zhang W, Wang Q, Liao T, Wen W, Zhou D, Ji QH, He X, Lei QY, Hu W
Molecular metabolism 2023 Sep;75:101766
Molecular metabolism 2023 Sep;75:101766
α-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure.
Zhang N, Zhang Y, Xu J, Wang P, Wu B, Lu S, Lu X, You S, Huang X, Li M, Zou Y, Liu M, Zhao Y, Sun G, Wang W, Geng D, Liu J, Cao L, Sun Y
Cell research 2023 Sep;33(9):679-698
Cell research 2023 Sep;33(9):679-698
Immune regulator IRF1 contributes to ZBP1-, AIM2-, RIPK1-, and NLRP12-PANoptosome activation and inflammatory cell death (PANoptosis).
Sharma BR, Karki R, Rajesh Y, Kanneganti TD
The Journal of biological chemistry 2023 Sep;299(9):105141
The Journal of biological chemistry 2023 Sep;299(9):105141
Osteogenic microenvironment affects palatal development through glycolysis.
Peng X, Chen J, Wang Y, Wang X, Zhao X, Zheng X, Wang Z, Yuan D, Du J
Differentiation; research in biological diversity 2023 Sep-Oct;133:1-11
Differentiation; research in biological diversity 2023 Sep-Oct;133:1-11
NAD(H) homeostasis underlies host protection mediated by glycolytic myeloid cells in tuberculosis.
Pacl HT, Chinta KC, Reddy VP, Nadeem S, Sevalkar RR, Nargan K, Lumamba K, Naidoo T, Glasgow JN, Agarwal A, Steyn AJC
Nature communications 2023 Sep 6;14(1):5472
Nature communications 2023 Sep 6;14(1):5472
LncRNA CCAT1 facilitates the progression of gastric cancer via PTBP1-mediated glycolysis enhancement.
Zhang C, Wang H, Liu Q, Dai S, Tian G, Wei X, Li X, Zhao L, Shan B
Journal of experimental & clinical cancer research : CR 2023 Sep 23;42(1):246
Journal of experimental & clinical cancer research : CR 2023 Sep 23;42(1):246
Dexamethasone protects against Aspergillus fumigatus-induced severe asthma via modulating pulmonary immunometabolism.
Gan PXL, Liao W, Lim HF, Wong WSF
Pharmacological research 2023 Oct;196:106929
Pharmacological research 2023 Oct;196:106929
Chaetocochin J exhibits anti-hepatocellular carcinoma effect independent of hypoxia.
Hu P, Hu L, Chen Y, Wang F, Xiao Y, Tong Z, Li H, Xiang M, Tong Q, Zhang Y
Bioorganic chemistry 2023 Oct;139:106701
Bioorganic chemistry 2023 Oct;139:106701
LDHA-regulated tumor-macrophage symbiosis promotes glioblastoma progression.
Khan F, Lin Y, Ali H, Pang L, Dunterman M, Hsu WH, Frenis K, Rowe RG, Wainwright D, McCortney K, Billingham L, Miska J, Horbinski C, Lesniak M, Chen P
Research square 2023 Oct 5;
Research square 2023 Oct 5;
MYL9 promotes squamous cervical cancer migration and invasion by enhancing aerobic glycolysis.
Wen B, Luo L, Zeng Z, Luo X
The Journal of international medical research 2023 Nov;51(11):3000605231208582
The Journal of international medical research 2023 Nov;51(11):3000605231208582
Heat shock protein B7 (HSPB7) inhibits lung adenocarcinoma progression by inhibiting glycolysis.
Chen Z, Li P, Shen L, Jiang X
Oncology reports 2023 Nov;50(5)
Oncology reports 2023 Nov;50(5)
GPR37 promotes colorectal cancer liver metastases by enhancing the glycolysis and histone lactylation via Hippo pathway.
Zhou J, Xu W, Wu Y, Wang M, Zhang N, Wang L, Feng Y, Zhang T, Wang L, Mao A
Oncogene 2023 Nov;42(45):3319-3330
Oncogene 2023 Nov;42(45):3319-3330
CTRP6 regulates M1 macrophage polarization via the PPAR-γ/NF-κB pathway and reprogramming glycolysis in recurrent spontaneous abortion.
Yan S, Ding J, Wang Z, Zhang F, Li J, Zhang Y, Wu S, Yang L, Pang X, Zhang Y, Yang J
International immunopharmacology 2023 Nov;124(Pt A):110840
International immunopharmacology 2023 Nov;124(Pt A):110840
Progesterone Activates the Histone Lactylation-Hif1α-glycolysis Feedback Loop to Promote Decidualization.
Zhao W, Wang Y, Liu J, Yang Q, Zhang S, Hu X, Shi Z, Zhang Z, Tian J, Chu D, An L
Endocrinology 2023 Nov 20;165(1)
Endocrinology 2023 Nov 20;165(1)
Inhibition of ATF4-mediated elevation of both autophagy and AKT/mTOR was involved in antitumorigenic activity of curcumin.
Yang J, Hasenbilige, Bao S, Luo S, Jiang L, Li Q, Kong Y, Cao J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Mar;173:113609
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Mar;173:113609
Ectopic endometriotic stromal cells-derived lactate induces M2 macrophage polarization via Mettl3/Trib1/ERK/STAT3 signalling pathway in endometriosis.
Gou Y, Wang H, Wang T, Wang H, Wang B, Jiao N, Yu Y, Cao Y, Wang H, Zhang Z
Immunology 2023 Mar;168(3):389-402
Immunology 2023 Mar;168(3):389-402
LPLUNC1 reduces glycolysis in nasopharyngeal carcinoma cells through the PHB1-p53/c-Myc axis.
Oyang L, Ouyang L, Yang L, Lin J, Xia L, Tan S, Wu N, Han Y, Yang Y, Li J, Chen X, Tang Y, Su M, Luo X, Li J, Xiong W, Zeng Z, Liao Q, Zhou Y
Cancer science 2023 Mar;114(3):870-884
Cancer science 2023 Mar;114(3):870-884
Extracellular Calcium-Induced Calcium Transient Regulating the Proliferation of Osteoblasts through Glycolysis Metabolism Pathways.
Gao X, Di X, Li J, Kang Y, Xie W, Sun L, Zhang J
International journal of molecular sciences 2023 Mar 5;24(5)
International journal of molecular sciences 2023 Mar 5;24(5)
Environmentally relevant perinatal exposure to DBP accelerated spermatogenesis by promoting the glycolipid metabolism of Sertoli cells in male offspring mice.
Ma T, Xia Y, Wang B, Yang F, Ding J, Wu J, Han X, Wang J, Li D
Toxicology letters 2023 Mar 15;377:16-28
Toxicology letters 2023 Mar 15;377:16-28
PDK1 regulates the progression of esophageal squamous cell carcinoma through metabolic reprogramming.
Ma Y, Zhang X, Han X, Hao Z, Ji R, Li J, Guo W, Zhang Y, Guan F, Ma S
Molecular carcinogenesis 2023 Jun;62(6):866-881
Molecular carcinogenesis 2023 Jun;62(6):866-881
LncRNA GLTC targets LDHA for succinylation and enzymatic activity to promote progression and radioiodine resistance in papillary thyroid cancer.
Shi L, Duan R, Sun Z, Jia Q, Wu W, Wang F, Liu J, Zhang H, Xue X
Cell death and differentiation 2023 Jun;30(6):1517-1532
Cell death and differentiation 2023 Jun;30(6):1517-1532
C11orf54 promotes DNA repair via blocking CMA-mediated degradation of HIF1A.
Tan J, Wang W, Liu X, Xu J, Che Y, Liu Y, Hu J, Hu L, Li J, Zhou Q
Communications biology 2023 Jun 5;6(1):606
Communications biology 2023 Jun 5;6(1):606
Targeting ACYP1-mediated glycolysis reverses lenvatinib resistance and restricts hepatocellular carcinoma progression.
Wang S, Zhou L, Ji N, Sun C, Sun L, Sun J, Du Y, Zhang N, Li Y, Liu W, Lu W
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2023 Jul;69:100976
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2023 Jul;69:100976
Adipocytes promote pancreatic cancer migration and invasion through fatty acid metabolic reprogramming.
Cai Z, Li Y, Ma M, Wang L, Wang H, Liu M, Jiang C
Oncology reports 2023 Jul;50(1)
Oncology reports 2023 Jul;50(1)
Loss of SPRY2 contributes to cancer-associated fibroblasts activation and promotes breast cancer development.
Dai H, Xu W, Wang L, Li X, Sheng X, Zhu L, Li Y, Dong X, Zhou W, Han C, Mao Y, Yao L
Breast cancer research : BCR 2023 Jul 28;25(1):90
Breast cancer research : BCR 2023 Jul 28;25(1):90
Enhanced autophagy reversed aflatoxin B1-induced decrease in lactate secretion of dairy goat Sertoli cells.
Han S, Zhang H, Liu X, Wen F, Li B, Bie Z, Qiu H, Hu J
Ecotoxicology and environmental safety 2023 Jul 1;259:115063
Ecotoxicology and environmental safety 2023 Jul 1;259:115063
Novel function of Roxadustat (FG-4592) as an anti-shock drug in sepsis by regulating mitochondrial oxidative stress and energy metabolism.
Long G, Pei Z, Wu M, Wei K, Du Y, Wang Q, Zhang Y, Huang S, Chen H, Xia W, Jia Z
Biochimica et biophysica acta. General subjects 2023 Jan;1867(1):130264
Biochimica et biophysica acta. General subjects 2023 Jan;1867(1):130264
ER stress-enhanced HMGA2 plays an important role in Cr (VI)-induced glycolysis and inhibited oxidative phosphorylation by targeting the transcription of ATF4.
Luo S, Zhang C, Gao Z, Jiang L, Li Q, Shi X, Kong Y, Cao J
Chemico-biological interactions 2023 Jan 5;369:110293
Chemico-biological interactions 2023 Jan 5;369:110293
AMPK regulates homeostasis of invasion and viability in trophoblasts by redirecting glucose metabolism: Implications for pre-eclampsia.
Xu P, Zheng Y, Liao J, Hu M, Yang Y, Zhang B, Kilby MD, Fu H, Liu Y, Zhang F, Xiong L, Liu X, Jin H, Wu Y, Huang J, Han T, Wen L, Gao R, Fu Y, Fan X, Qi H, Baker PN, Tong C
Cell proliferation 2023 Feb;56(2):e13358
Cell proliferation 2023 Feb;56(2):e13358
PKM2-mediated neuronal hyperglycolysis enhances the risk of Parkinson's disease in diabetic rats.
Zhao Y, Wang Y, Wu Y, Tao C, Xu R, Chen Y, Qian L, Xu T, Lian X
Journal of pharmaceutical analysis 2023 Feb;13(2):187-200
Journal of pharmaceutical analysis 2023 Feb;13(2):187-200
Glycolysis-related lncRNA TMEM105 upregulates LDHA to facilitate breast cancer liver metastasis via sponging miR-1208.
Han J, Chen X, Wang J, Liu B
Cell death & disease 2023 Feb 3;14(2):80
Cell death & disease 2023 Feb 3;14(2):80
mTOR inhibitor, gemcitabine and PD-L1 antibody blockade combination therapy suppresses pancreatic cancer progression via metabolic reprogramming and immune microenvironment remodeling in Trp53(flox/+)LSL-Kras(G12D/+)Pdx-1-Cre murine models.
Qiu J, Feng M, Yang G, Cao Z, Liu Y, You L, Zhang T
Cancer letters 2023 Feb 1;554:216020
Cancer letters 2023 Feb 1;554:216020
SIRT3 promotes metabolic maturation of human iPSC-derived cardiomyocytes via OPA1-controlled mitochondrial dynamics.
Wang R, Xu H, Tan B, Yi Q, Sun Y, Xiang H, Chen T, Liu H, Xie Q, Wang L, Tian J, Zhu J
Free radical biology & medicine 2023 Feb 1;195:270-282
Free radical biology & medicine 2023 Feb 1;195:270-282
Efferocytosis-induced lactate enables the proliferation of pro-resolving macrophages to mediate tissue repair.
Ngai D, Schilperoort M, Tabas I
Nature metabolism 2023 Dec;5(12):2206-2219
Nature metabolism 2023 Dec;5(12):2206-2219
BMP4 participates in the pathogenesis of PCOS by regulating glucose metabolism and autophagy in granulosa cells under hyperandrogenic environment.
Gu R, Dai F, Xiang C, Chen J, Yang D, Tan W, Wang Z, Liu H, Cheng Y
The Journal of steroid biochemistry and molecular biology 2023 Dec;235:106410
The Journal of steroid biochemistry and molecular biology 2023 Dec;235:106410
NR3C2 inhibits the proliferation of colorectal cancer via regulating glucose metabolism and phosphorylating AMPK.
Liu H, Lei W, Li Z, Wang X, Zhou L
Journal of cellular and molecular medicine 2023 Apr;27(8):1069-1082
Journal of cellular and molecular medicine 2023 Apr;27(8):1069-1082
Targeting pancreatic cancer with combinatorial treatment of CPI-613 and inhibitors of lactate metabolism.
Kumstel S, Schreiber T, Goldstein L, Stenzel J, Lindner T, Joksch M, Zhang X, Wendt EHU, Schönrogge M, Krause B, Vollmar B, Zechner D
PloS one 2022;17(4):e0266601
PloS one 2022;17(4):e0266601
Alpha-solanine Anti-tumor Effects in Non-small Cell Lung Cancer Through Regulating the Energy Metabolism Pathway.
Zou T, Gu L, Yang L, Wei J, Zhao Y, Shen J, Li M, Wu X, Du F, Chen Y, Ye Y, Xiao Z, Wu Z
Recent patents on anti-cancer drug discovery 2022;17(4):396-409
Recent patents on anti-cancer drug discovery 2022;17(4):396-409
TRIM16 promotes aerobic glycolysis and pancreatic cancer metastasis by modulating the NIK-SIX1 axis in a ligase-independent manner.
Zhou B, Huang Y, Feng Q, Zhu H, Xu Z, Chen L, Peng X, Yang W, Xu D, Qiu Y
American journal of cancer research 2022;12(11):5205-5225
American journal of cancer research 2022;12(11):5205-5225
Transcriptional Repression of Aerobic Glycolysis by OVOL2 in Breast Cancer.
Zhang X, Luo F, Luo S, Li L, Ren X, Lin J, Liang Y, Ma C, Ding L, Zhang D, Ye T, Lin Y, Jin B, Gao S, Ye Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Sep;9(27):e2200705
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Sep;9(27):e2200705
Hnrnpk maintains chondrocytes survival and function during growth plate development via regulating Hif1α-glycolysis axis.
Chen Y, Wu J, Zhang S, Gao W, Liao Z, Zhou T, Li Y, Su D, Liu H, Yang X, Su P, Xu C
Cell death & disease 2022 Sep 20;13(9):803
Cell death & disease 2022 Sep 20;13(9):803
Metabolism-Based Molecular Subtyping Endows Effective Ketogenic Therapy in p53-Mutant Colon Cancer.
Tang M, Xu H, Huang H, Kuang H, Wang C, Li Q, Zhang X, Ge Y, Song M, Zhang X, Wang Z, Ma C, Kang J, Zhang W, Wang Y, Zhang B, Zhang X, Chen Y, Cong M, Melino G, Wang X, Zhou F, Sun Q, Shi H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Oct;9(29):e2201992
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Oct;9(29):e2201992
HMGA2 mediates Cr (VI)-induced metabolic reprogramming through binding to mitochondrial D-Loop region.
Bao S, Zhang C, Luo S, Jiang L, Li Q, Kong Y, Cao J
Ecotoxicology and environmental safety 2022 Oct 1;244:114085
Ecotoxicology and environmental safety 2022 Oct 1;244:114085
Curcumin attenuates Cr (VI)-induced cell growth and migration by targeting autophagy-dependent reprogrammed metabolism.
Dlamini MB, Bao S, Gao Z, Mei J, Ge H, Jiang L, Geng C, Li Q, Shi X, Liu Y, Cao J
Journal of biochemical and molecular toxicology 2022 Nov;36(11):e23193
Journal of biochemical and molecular toxicology 2022 Nov;36(11):e23193
Therapeutic targeting of glutamate dehydrogenase 1 that links metabolic reprogramming and Snail-mediated epithelial-mesenchymal transition in drug-resistant lung cancer.
Wang Q, Wu M, Li H, Rao X, Ao L, Wang H, Yao L, Wang X, Hong X, Wang J, Aa J, Sun M, Wang G, Liu J, Zhou F
Pharmacological research 2022 Nov;185:106490
Pharmacological research 2022 Nov;185:106490
Quantitative proteomics identified circulating biomarkers in lung adenocarcinoma diagnosis.
Chen H, Lai X, Zhu Y, Huang H, Zeng L, Zhang L
Clinical proteomics 2022 Nov 21;19(1):44
Clinical proteomics 2022 Nov 21;19(1):44
Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.
Fan TW, Daneshmandi S, Cassel TA, Uddin MB, Sledziona J, Thompson PT, Lin P, Higashi RM, Lane AN
Journal of immunology (Baltimore, Md. : 1950) 2022 Nov 1;209(9):1674-1690
Journal of immunology (Baltimore, Md. : 1950) 2022 Nov 1;209(9):1674-1690
Jumonji-C domain-containing protein 5 suppresses proliferation and aerobic glycolysis in pancreatic cancer cells in a c-Myc-dependent manner.
Wang H, Wang J, Liu J, Wang Y, Xia G, Huang X
Cellular signalling 2022 May;93:110282
Cellular signalling 2022 May;93:110282
Berberine Modulates Macrophage Activation by Inducing Glycolysis.
Li M, Zhang H, Zhang Y, Fan J, Zhu J, Gu X, Li Z, Zhang C, Liu Z, Li Y, Zang M, Jin G, Li G, Mi Y
Journal of immunology (Baltimore, Md. : 1950) 2022 May 15;208(10):2309-2318
Journal of immunology (Baltimore, Md. : 1950) 2022 May 15;208(10):2309-2318
A positive feedback circuit comprising p21 and HIF-1α aggravates hypoxia-induced radioresistance of glioblastoma by promoting Glut1/LDHA-mediated glycolysis.
Jin X, Kuang Y, Li L, Li H, Zhao T, He Y, Di C, Kang J, Yuan L, Yu B, Li Q
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Mar;36(3):e22229
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Mar;36(3):e22229
MYB proto-oncogene like 2 promotes hepatocellular carcinoma growth and glycolysis via binding to the Optic atrophy 3 promoter and activating its expression.
Liu M, Du Q, Mao G, Dai N, Zhang F
Bioengineered 2022 Mar;13(3):5344-5356
Bioengineered 2022 Mar;13(3):5344-5356
Short isoform thymic stromal lymphopoietin reduces inflammation and aerobic glycolysis of asthmatic airway epithelium by antagonizing long isoform thymic stromal lymphopoietin.
Yu C, Huang W, Zhou Z, Liang S, Zhou Z, Liu J, Zhao H, Liu L, Dong H, Zou F, Cai S
Respiratory research 2022 Mar 29;23(1):75
Respiratory research 2022 Mar 29;23(1):75
Tanshinone IIA inhibits cell growth by suppressing SIX1-induced aerobic glycolysis in non-small cell lung cancer cells.
Qi H, Chen Z, Qin Y, Wang X, Zhang Z, Li Y
Oncology letters 2022 Jun;23(6):184
Oncology letters 2022 Jun;23(6):184
Development of a one-plasmid system to replace the endogenous protein with point mutation for post-translational modification studies.
Ishrat I, Cheng A, Yu F, Guo J, Zhang P, Zhang K, Yang Z
Molecular biology reports 2022 Jan;49(1):1-7
Molecular biology reports 2022 Jan;49(1):1-7
Protein arginine methyltransferase 3 promotes glycolysis and hepatocellular carcinoma growth by enhancing arginine methylation of lactate dehydrogenase A.
Lei Y, Han P, Chen Y, Wang H, Wang S, Wang M, Liu J, Yan W, Tian D, Liu M
Clinical and translational medicine 2022 Jan;12(1):e686
Clinical and translational medicine 2022 Jan;12(1):e686
ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer.
Dong S, Liang S, Cheng Z, Zhang X, Luo L, Li L, Zhang W, Li S, Xu Q, Zhong M, Zhu J, Zhang G, Hu S
Journal of experimental & clinical cancer research : CR 2022 Jan 8;41(1):15
Journal of experimental & clinical cancer research : CR 2022 Jan 8;41(1):15
The anti-MDR efficacy of YAN against A549/Taxol cells is associated with its inhibition on glycolysis and is further enhanced by 2-deoxy-d-glucose.
Gao M, Yang Y, Gao Y, Liu T, Guan Q, Zhou T, Shi Y, Hao M, Li Z, Zuo D, Zhang W, Wu Y
Chemico-biological interactions 2022 Feb 25;354:109843
Chemico-biological interactions 2022 Feb 25;354:109843
Metabolic enzyme LDHA activates Rac1 GTPase as a noncanonical mechanism to promote cancer.
Liu J, Zhang C, Zhang T, Chang CY, Wang J, Bazile L, Zhang L, Haffty BG, Hu W, Feng Z
Nature metabolism 2022 Dec;4(12):1830-1846
Nature metabolism 2022 Dec;4(12):1830-1846
Long non-coding RNA CTSLP8 mediates ovarian cancer progression and chemotherapy resistance by modulating cellular glycolysis and regulating c-Myc expression through PKM2.
Li X, Zhang Y, Wang X, Lin F, Cheng X, Wang Z, Wang X
Cell biology and toxicology 2022 Dec;38(6):1027-1045
Cell biology and toxicology 2022 Dec;38(6):1027-1045
SMYD3 associates with the NuRD (MTA1/2) complex to regulate transcription and promote proliferation and invasiveness in hepatocellular carcinoma cells.
Yang Y, Qiu R, Zhao S, Shen L, Tang B, Weng Q, Xu Z, Zheng L, Chen W, Shu G, Wang Y, Zhao Z, Chen M, Ji J
BMC biology 2022 Dec 27;20(1):294
BMC biology 2022 Dec 27;20(1):294
Aerobic glycolysis and tumor progression of hepatocellular carcinoma are mediated by ubiquitin of P53 K48-linked regulated by TRIM37.
Ge Y, Zhao R, Li B, Xiao B, Zhou L, Zuo S
Experimental cell research 2022 Dec 15;421(2):113377
Experimental cell research 2022 Dec 15;421(2):113377
Nonylphenol inhibited HIF-1alpha regulated aerobic glycolysis and induced ROS mediated apoptosis in rat Sertoli cells.
Jiang Q, Di Q, Shan D, Xu Q
Ecotoxicology and environmental safety 2022 Aug;241:113822
Ecotoxicology and environmental safety 2022 Aug;241:113822
Glycometabolic reprogramming-mediated proangiogenic phenotype enhancement of cancer-associated fibroblasts in oral squamous cell carcinoma: role of PGC-1α/PFKFB3 axis.
Li X, Jiang E, Zhao H, Chen Y, Xu Y, Feng C, Li J, Shang Z
British journal of cancer 2022 Aug;127(3):449-461
British journal of cancer 2022 Aug;127(3):449-461
Sirolimus increases the anti-cancer effect of Huai Er by regulating hypoxia inducible factor-1α-mediated glycolysis in hepatocellular carcinoma.
Zhou L, Zhao Y, Pan LC, Wang J, Shi XJ, Du GS, He Q
World journal of gastroenterology 2022 Aug 28;28(32):4600-4619
World journal of gastroenterology 2022 Aug 28;28(32):4600-4619
Capsaicin ameliorates inflammation in a TRPV1-independent mechanism by inhibiting PKM2-LDHA-mediated Warburg effect in sepsis.
Zhang Q, Luo P, Xia F, Tang H, Chen J, Zhang J, Liu D, Zhu Y, Liu Y, Gu L, Zheng L, Li Z, Yang F, Dai L, Liao F, Xu C, Wang J
Cell chemical biology 2022 Aug 18;29(8):1248-1259.e6
Cell chemical biology 2022 Aug 18;29(8):1248-1259.e6
Tubular epithelial cell-derived extracellular vesicles induce macrophage glycolysis by stabilizing HIF-1α in diabetic kidney disease.
Jia Y, Chen J, Zheng Z, Tao Y, Zhang S, Zou M, Yang Y, Xue M, Hu F, Li Y, Zhang Q, Xue Y, Zheng Z
Molecular medicine (Cambridge, Mass.) 2022 Aug 12;28(1):95
Molecular medicine (Cambridge, Mass.) 2022 Aug 12;28(1):95
HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine.
Santos RX, Melis V, Goatman EA, Leith M, Baddeley TC, Storey JMD, Riedel G, Wischik CM, Harrington CR
Biomedicines 2022 Apr 7;10(4)
Biomedicines 2022 Apr 7;10(4)
CYLD deficiency enhances metabolic reprogramming and tumor progression in nasopharyngeal carcinoma via PFKFB3.
Wang L, Lin Y, Zhou X, Chen Y, Li X, Luo W, Zhou Y, Cai L
Cancer letters 2022 Apr 28;532:215586
Cancer letters 2022 Apr 28;532:215586
Enhancement of anaerobic glycolysis - a role of PGC-1α4 in resistance exercise.
Koh JH, Pataky MW, Dasari S, Klaus KA, Vuckovic I, Ruegsegger GN, Kumar AP, Robinson MM, Nair KS
Nature communications 2022 Apr 28;13(1):2324
Nature communications 2022 Apr 28;13(1):2324
SIX1 Activation Is Involved in Cell Proliferation, Migration, and Anti-inflammation of Acute Ischemia/Reperfusion Injury in Mice.
Jin Y, Zhang M, Li M, Zhang H, Zhao L, Qian C, Li S, Zhang H, Gao M, Pan B, Li R, Wan X, Cao C
Frontiers in molecular biosciences 2021;8:725319
Frontiers in molecular biosciences 2021;8:725319
Study on the Antitumor Effect and Glycolysis of Andrographolide in Anaplastic Thyroid Carcinoma.
Yang K, Wu K, Feng J, Yutian L, Zhu X, Xu D
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5526581
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5526581
Protective Effects of Hif2 Inhibitor PT-2385 on a Neurological Disorder Induced by Deficiency of Irp2.
Shen J, Xu L, Li Y, Dong W, Cai J, Liu Y, Zhao H, Xu T, Holtz EM, Chang Y, Qiao T, Li K
Frontiers in neuroscience 2021;15:715222
Frontiers in neuroscience 2021;15:715222
Myosin 1b promotes migration, invasion and glycolysis in cervical cancer via ERK/HIF-1α pathway.
Wen LJ, Hu XL, Li CY, Liu J, Li ZY, Li YZ, Zhou JY
American journal of translational research 2021;13(11):12536-12548
American journal of translational research 2021;13(11):12536-12548
Trametinib Inhibits the Growth and Aerobic Glycolysis of Glioma Cells by Targeting the PKM2/c-Myc Axis.
Gao M, Yang J, Gong H, Lin Y, Liu J
Frontiers in pharmacology 2021;12:760055
Frontiers in pharmacology 2021;12:760055
Anlotinib Inhibits PFKFB3-Driven Glycolysis in Myofibroblasts to Reverse Pulmonary Fibrosis.
Chen W, Zhang J, Zhong W, Liu Y, Lu Y, Zeng Z, Huang H, Wan X, Meng X, Zou F, Cai S, Dong H
Frontiers in pharmacology 2021;12:744826
Frontiers in pharmacology 2021;12:744826
A Novel Integrated Metabolism-Immunity Gene Expression Model Predicts the Prognosis of Lung Adenocarcinoma Patients.
Chen S, Duan Y, Wu Y, Yang D, An J
Frontiers in pharmacology 2021;12:728368
Frontiers in pharmacology 2021;12:728368
The Role of cAMP-PKA Pathway in Lactate-Induced Intramuscular Triglyceride Accumulation and Mitochondria Content Increase in Mice.
Chen S, Zhou L, Sun J, Qu Y, Chen M
Frontiers in physiology 2021;12:709135
Frontiers in physiology 2021;12:709135
Alpha-Enolase Protects Hepatocyte Against Heat Stress Through Focal Adhesion Kinase-Mediated Phosphatidylinositol 3-Kinase/Akt Pathway.
Zeng T, Cao Y, Gu T, Chen L, Tian Y, Li G, Shen J, Tao Z, Lu L
Frontiers in genetics 2021;12:693780
Frontiers in genetics 2021;12:693780
Qian Yang Yu Yin Granule Improves Renal Injury of Hypertension by Regulating Metabolic Reprogramming Mediated by HIF-1α/PKM2 Positive Feedback Loop.
Qian L, Ren S, Xu Z, Zheng Y, Wu L, Yang Y, Wang Y, Li J, Yan S, Fang Z
Frontiers in pharmacology 2021;12:667433
Frontiers in pharmacology 2021;12:667433
Biochanin A Inhibits Glioblastoma Growth via Restricting Glycolysis and Mitochondrial Oxidative Phosphorylation.
Dong Q, Li Q, Duan L, Yin H, Wang X, Liu Y, Wang B, Li K, Yao X, Yuan G, Pan Y
Frontiers in oncology 2021;11:652008
Frontiers in oncology 2021;11:652008
The Warburg effect as a therapeutic target for bladder cancers and intratumoral heterogeneity in associated molecular targets.
Burns JE, Hurst CD, Knowles MA, Phillips RM, Allison SJ
Cancer science 2021 Sep;112(9):3822-3834
Cancer science 2021 Sep;112(9):3822-3834
Dual Inhibition of Endoplasmic Reticulum Stress and Oxidation Stress Manipulates the Polarization of Macrophages under Hypoxia to Sensitize Immunotherapy.
Jiang M, Li X, Zhang J, Lu Y, Shi Y, Zhu C, Liu Y, Qin B, Luo Z, Du Y, Luo L, Peng L, You J
ACS nano 2021 Sep 28;15(9):14522-14534
ACS nano 2021 Sep 28;15(9):14522-14534
Normalizing HIF-1α Signaling Improves Cellular Glucose Metabolism and Blocks the Pathological Pathways of Hyperglycemic Damage.
Iacobini C, Vitale M, Pugliese G, Menini S
Biomedicines 2021 Sep 2;9(9)
Biomedicines 2021 Sep 2;9(9)
A requirement for autophagy in HMGA2-induced metabolic reprogramming to support Cd-induced migration.
Hasenbilige, Mei J, Dlamini MB, Gao Z, Jiang L, Li Q, Geng C, Shi X, Liu Y, Kong Y, Cao J
Toxicology 2021 Oct;462:152928
Toxicology 2021 Oct;462:152928
Dysfunctional lactate metabolism in human alveolar type II cells from idiopathic pulmonary fibrosis lung explant tissue.
Newton DA, Lottes RG, Ryan RM, Spyropoulos DD, Baatz JE
Respiratory research 2021 Oct 28;22(1):278
Respiratory research 2021 Oct 28;22(1):278
2-Deoxy-D-glucose impedes T cell-induced apoptosis of keratinocytes in oral lichen planus.
Wang F, Zhang J, Zhou G
Journal of cellular and molecular medicine 2021 Nov;25(21):10257-10267
Journal of cellular and molecular medicine 2021 Nov;25(21):10257-10267
Reciprocal regulation of LOXL2 and HIF1α drives the Warburg effect to support pancreatic cancer aggressiveness.
Li R, Li H, Zhu L, Zhang X, Liu D, Li Q, Ni B, Hu L, Zhang Z, Zhang Y, Wang X, Jiang SH
Cell death & disease 2021 Nov 26;12(12):1106
Cell death & disease 2021 Nov 26;12(12):1106
Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice.
Lei Y, Guerra Martinez C, Torres-Odio S, Bell SL, Birdwell CE, Bryant JD, Tong CW, Watson RO, West LC, West AP
Science advances 2021 May;7(22)
Science advances 2021 May;7(22)
ETV4 promotes breast cancer cell stemness by activating glycolysis and CXCR4-mediated sonic Hedgehog signaling.
Zhu T, Zheng J, Zhuo W, Pan P, Li M, Zhang W, Zhou H, Gao Y, Li X, Liu Z
Cell death discovery 2021 May 29;7(1):126
Cell death discovery 2021 May 29;7(1):126
Expression of lactate dehydrogenase A and B isoforms in the mouse kidney.
Osis G, Traylor AM, Black LM, Spangler D, George JF, Zarjou A, Verlander JW, Agarwal A
American journal of physiology. Renal physiology 2021 May 1;320(5):F706-F718
American journal of physiology. Renal physiology 2021 May 1;320(5):F706-F718
Long noncoding RNA LINC00518 induces radioresistance by regulating glycolysis through an miR-33a-3p/HIF-1α negative feedback loop in melanoma.
Liu Y, He D, Xiao M, Zhu Y, Zhou J, Cao K
Cell death & disease 2021 Mar 4;12(3):245
Cell death & disease 2021 Mar 4;12(3):245
Trim21-mediated HIF-1α degradation attenuates aerobic glycolysis to inhibit renal cancer tumorigenesis and metastasis.
Chen X, Li Z, Yong H, Wang W, Wang D, Chu S, Li M, Hou P, Zheng J, Bai J
Cancer letters 2021 Jun 28;508:115-126
Cancer letters 2021 Jun 28;508:115-126
Cynaroside prevents macrophage polarization into pro-inflammatory phenotype and alleviates cecal ligation and puncture-induced liver injury by targeting PKM2/HIF-1α axis.
Pei L, Le Y, Chen H, Feng J, Liu Z, Zhu J, Wang C, Chen L, Dou X, Lu D
Fitoterapia 2021 Jul;152:104922
Fitoterapia 2021 Jul;152:104922
Hypoxia-induced FOXO4/LDHA axis modulates gastric cancer cell glycolysis and progression.
Wang XH, Jiang ZH, Yang HM, Zhang Y, Xu LH
Clinical and translational medicine 2021 Jan;11(1):e279
Clinical and translational medicine 2021 Jan;11(1):e279
OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development.
Wu Z, Zuo M, Zeng L, Cui K, Liu B, Yan C, Chen L, Dong J, Shangguan F, Hu W, He H, Lu B, Song Z
EMBO reports 2021 Jan 7;22(1):e50827
EMBO reports 2021 Jan 7;22(1):e50827
Di-methylation of CD147-K234 Promotes the Progression of NSCLC by Enhancing Lactate Export.
Wang K, Huang W, Chen R, Lin P, Zhang T, Ni YF, Li H, Wu J, Sun XX, Geng JJ, Zhu YM, Nan G, Zhang W, Chen X, Zhu P, Bian H, Chen ZN
Cell metabolism 2021 Jan 5;33(1):160-173.e6
Cell metabolism 2021 Jan 5;33(1):160-173.e6
Short-form RON (sf-RON) enhances glucose metabolism to promote cell proliferation via activating β-catenin/SIX1 signaling pathway in gastric cancer.
Wang Z, Yang Y, Hu S, He J, Wu Z, Qi Z, Huang M, Liu R, Lin Y, Tan C, Xu M, Zhang Z
Cell biology and toxicology 2021 Feb;37(1):35-49
Cell biology and toxicology 2021 Feb;37(1):35-49
Jiedu Sangen decoction inhibits chemoresistance to 5-fluorouracil of colorectal cancer cells by suppressing glycolysis via PI3K/AKT/HIF-1α signaling pathway.
Sun LT, Zhang LY, Shan FY, Shen MH, Ruan SM
Chinese journal of natural medicines 2021 Feb;19(2):143-152
Chinese journal of natural medicines 2021 Feb;19(2):143-152
Loss of DSTYK activates Wnt/β-catenin signaling and glycolysis in lung adenocarcinoma.
Zhong C, Chen M, Chen Y, Yao F, Fang W
Cell death & disease 2021 Dec 1;12(12):1122
Cell death & disease 2021 Dec 1;12(12):1122
The deubiquitinase USP38 promotes cell proliferation through stabilizing c-Myc.
Xu Z, Hu H, Fang D, Wang J, Zhao K
The international journal of biochemistry & cell biology 2021 Aug;137:106023
The international journal of biochemistry & cell biology 2021 Aug;137:106023
STAT3/LINC00671 axis regulates papillary thyroid tumor growth and metastasis via LDHA-mediated glycolysis.
Huo N, Cong R, Sun ZJ, Li WC, Zhu X, Xue CY, Chen Z, Ma LY, Chu Z, Han YC, Kang XF, Jia SH, Du N, Kang L, Xu XJ
Cell death & disease 2021 Aug 17;12(9):799
Cell death & disease 2021 Aug 17;12(9):799
Contribution of Connexin Hemichannels to the Pathogenesis of Acute Lung Injury.
Wang S, Sun Y, Bai Y, Zhou N, Chen N, Miller EJ, Zhang Y, Li W
Mediators of inflammation 2020;2020:8094347
Mediators of inflammation 2020;2020:8094347
PCK1 Regulates Glycolysis and Tumor Progression in Clear Cell Renal Cell Carcinoma Through LDHA.
Shi L, An S, Liu Y, Liu J, Wang F
OncoTargets and therapy 2020;13:2613-2627
OncoTargets and therapy 2020;13:2613-2627
Long Noncoding RNA MIR210HG Promotes the Warburg Effect and Tumor Growth by Enhancing HIF-1α Translation in Triple-Negative Breast Cancer.
Du Y, Wei N, Ma R, Jiang SH, Song D
Frontiers in oncology 2020;10:580176
Frontiers in oncology 2020;10:580176
High fat diet impairs spermatogenesis by regulating glucose and lipid metabolism in Sertoli cells.
Luo D, Zhang M, Su X, Liu L, Zhou X, Zhang X, Zheng D, Yu C, Guan Q
Life sciences 2020 Sep 15;257:118028
Life sciences 2020 Sep 15;257:118028
ATF4-mediated autophagy-dependent glycolysis plays an important role in attenuating apoptosis induced by Cr (VI) in A549 cells.
Gao Z, Dlamini MB, Ge H, Jiang L, Geng C, Li Q, Shi X, Liu Y, Cao J
Toxicology letters 2020 Oct 1;331:178-187
Toxicology letters 2020 Oct 1;331:178-187
MiR-103a-3p promotes tumour glycolysis in colorectal cancer via hippo/YAP1/HIF1A axis.
Sun Z, Zhang Q, Yuan W, Li X, Chen C, Guo Y, Shao B, Dang Q, Zhou Q, Wang Q, Wang G, Liu J, Kan Q
Journal of experimental & clinical cancer research : CR 2020 Nov 20;39(1):250
Journal of experimental & clinical cancer research : CR 2020 Nov 20;39(1):250
Correlation of hyperpolarized (13) C-MRI data with tissue extract measurements.
Lee CY, Lau JYC, Geraghty BJ, Chen AP, Gu YP, Cunningham CH
NMR in biomedicine 2020 May;33(5):e4269
NMR in biomedicine 2020 May;33(5):e4269
Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis.
Li ST, Huang D, Shen S, Cai Y, Xing S, Wu G, Jiang Z, Hao Y, Yuan M, Wang N, Zhu L, Yan R, Yang D, Wang L, Liu Z, Hu X, Zhou R, Qu K, Li A, Duan X, Zhang H, Gao P
Nature metabolism 2020 Mar;2(3):256-269
Nature metabolism 2020 Mar;2(3):256-269
All-trans retinoic acid enhances the effect of Fra-1 to inhibit cell proliferation and metabolism in cervical cancer.
Dou Y, Huang D, Zeng X, Zhou Y, Jiang X, Yue C, He J, Xiao S
Biotechnology letters 2020 Jun;42(6):1051-1060
Biotechnology letters 2020 Jun;42(6):1051-1060
Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2.
Wang C, Li Y, Yan S, Wang H, Shao X, Xiao M, Yang B, Qin G, Kong R, Chen R, Zhang N
Nature communications 2020 Jun 22;11(1):3162
Nature communications 2020 Jun 22;11(1):3162
CD38 is involved in cell energy metabolism via activating the PI3K/AKT/mTOR signaling pathway in cervical cancer cells.
Liao S, Liang L, Yue C, He J, He Z, Jin X, Luo G, Zhou Y
International journal of oncology 2020 Jul;57(1):338-354
International journal of oncology 2020 Jul;57(1):338-354
HIF1α/PLD2 axis linked to glycolysis induces T-cell immunity in oral lichen planus.
Wang F, Zhang J, Zhou G
Biochimica et biophysica acta. General subjects 2020 Jul;1864(7):129602
Biochimica et biophysica acta. General subjects 2020 Jul;1864(7):129602
TAB1 regulates glycolysis and activation of macrophages in diabetic nephropathy.
Zeng H, Qi X, Xu X, Wu Y
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2020 Dec;69(12):1215-1234
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2020 Dec;69(12):1215-1234
Ginsenoside Rh4 suppresses aerobic glycolysis and the expression of PD-L1 via targeting AKT in esophageal cancer.
Deng X, Zhao J, Qu L, Duan Z, Fu R, Zhu C, Fan D
Biochemical pharmacology 2020 Aug;178:114038
Biochemical pharmacology 2020 Aug;178:114038
Bcl2 inhibitor ABT737 reverses the Warburg effect via the Sirt3-HIF1α axis to promote oxidative stress-induced apoptosis in ovarian cancer cells.
Dong D, Dong Y, Fu J, Lu S, Yuan C, Xia M, Sun L
Life sciences 2020 Aug 15;255:117846
Life sciences 2020 Aug 15;255:117846
In vivo [U-(13)C]glucose labeling to assess heart metabolism in murine models of pressure and volume overload.
Schnelle M, Chong M, Zoccarato A, Elkenani M, Sawyer GJ, Hasenfuss G, Ludwig C, Shah AM
American journal of physiology. Heart and circulatory physiology 2020 Aug 1;319(2):H422-H431
American journal of physiology. Heart and circulatory physiology 2020 Aug 1;319(2):H422-H431
Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression.
Weng ML, Chen WK, Chen XY, Lu H, Sun ZR, Yu Q, Sun PF, Xu YJ, Zhu MM, Jiang N, Zhang J, Zhang JP, Song YL, Ma D, Zhang XP, Miao CH
Nature communications 2020 Apr 20;11(1):1869
Nature communications 2020 Apr 20;11(1):1869
Metabolomic Study on Nude Mice Models of Gastric Cancer Treated with Modified Si Jun Zi Tang via HILIC UHPLC-Q-TOF/MS Analysis.
Nie S, Zhao Y, Qiu X, Wang W, Yao Y, Yi M, Wang D
Evidence-based complementary and alternative medicine : eCAM 2019;2019:3817879
Evidence-based complementary and alternative medicine : eCAM 2019;2019:3817879
Proteomic analysis of human periodontal ligament cells under hypoxia.
Li Q, Luo T, Lu W, Yi X, Zhao Z, Liu J
Proteome science 2019;17:3
Proteome science 2019;17:3
The KLF14 Transcription Factor Regulates Glycolysis by Downregulating LDHB in Colorectal Cancer.
Wu G, Yuan S, Chen Z, Chen G, Fan Q, Dong H, Ye F, Li J, Zhu X
International journal of biological sciences 2019;15(3):628-635
International journal of biological sciences 2019;15(3):628-635
Recombinant Viral Capsid Protein L2 (rVL2) of HPV 16 Suppresses Cell Proliferation and Glucose Metabolism via ITGB7/C/EBPβ Signaling Pathway in Cervical Cancer Cell Lines.
Chai Z, Yang Y, Gu Z, Cai X, Ye W, Kong L, Qiu X, Ying L, Wang Z, Wang L
OncoTargets and therapy 2019;12:10415-10425
OncoTargets and therapy 2019;12:10415-10425
LINC01123, a c-Myc-activated long non-coding RNA, promotes proliferation and aerobic glycolysis of non-small cell lung cancer through miR-199a-5p/c-Myc axis.
Hua Q, Jin M, Mi B, Xu F, Li T, Zhao L, Liu J, Huang G
Journal of hematology & oncology 2019 Sep 5;12(1):91
Journal of hematology & oncology 2019 Sep 5;12(1):91
ROS/KRAS/AMPK Signaling Contributes to Gemcitabine-Induced Stem-like Cell Properties in Pancreatic Cancer.
Zhao H, Wu S, Li H, Duan Q, Zhang Z, Shen Q, Wang C, Yin T
Molecular therapy oncolytics 2019 Sep 27;14:299-312
Molecular therapy oncolytics 2019 Sep 27;14:299-312
Accelerated Metabolite Levels of Aerobic Glycolysis and the Pentose Phosphate Pathway Are Required for Efficient Replication of Infectious Spleen and Kidney Necrosis Virus in Chinese Perch Brain Cells.
Guo X, Wu S, Li N, Lin Q, Liu L, Liang H, Niu Y, Huang Z, Fu X
Biomolecules 2019 Sep 2;9(9)
Biomolecules 2019 Sep 2;9(9)
Apatinib inhibits glycolysis by suppressing the VEGFR2/AKT1/SOX5/GLUT4 signaling pathway in ovarian cancer cells.
Chen L, Cheng X, Tu W, Qi Z, Li H, Liu F, Yang Y, Zhang Z, Wang Z
Cellular oncology (Dordrecht, Netherlands) 2019 Oct;42(5):679-690
Cellular oncology (Dordrecht, Netherlands) 2019 Oct;42(5):679-690
Metabolic adaptation to glycolysis is a basic defense mechanism of macrophages for Mycobacterium tuberculosis infection.
Osada-Oka M, Goda N, Saiga H, Yamamoto M, Takeda K, Ozeki Y, Yamaguchi T, Soga T, Tateishi Y, Miura K, Okuzaki D, Kobayashi K, Matsumoto S
International immunology 2019 Nov 8;31(12):781-793
International immunology 2019 Nov 8;31(12):781-793
Homeodomain-interacting protein kinase 2 suppresses proliferation and aerobic glycolysis via ERK/cMyc axis in pancreatic cancer.
Qin Y, Hu Q, Ji S, Xu J, Dai W, Liu W, Xu W, Sun Q, Zhang Z, Ni Q, Yu X, Zhang B, Xu X
Cell proliferation 2019 May;52(3):e12603
Cell proliferation 2019 May;52(3):e12603
Cloxiquine, a traditional antituberculosis agent, suppresses the growth and metastasis of melanoma cells through activation of PPARγ.
Zhang W, Shao W, Dong Z, Zhang S, Liu C, Chen S
Cell death & disease 2019 May 28;10(6):404
Cell death & disease 2019 May 28;10(6):404
p53/Lactate dehydrogenase A axis negatively regulates aerobic glycolysis and tumor progression in breast cancer expressing wild-type p53.
Zhou Y, Niu W, Luo Y, Li H, Xie Y, Wang H, Liu Y, Fan S, Li Z, Xiong W, Li X, Ren C, Tan M, Li G, Zhou M
Cancer science 2019 Mar;110(3):939-949
Cancer science 2019 Mar;110(3):939-949
The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression.
Ma B, Cheng H, Mu C, Geng G, Zhao T, Luo Q, Ma K, Chang R, Liu Q, Gao R, Nie J, Xie J, Han J, Chen L, Ma G, Zhu Y, Chen Q
Nature communications 2019 Mar 4;10(1):1034
Nature communications 2019 Mar 4;10(1):1034
Type Iγ phosphatidylinositol phosphate kinase promotes tumor growth by facilitating Warburg effect in colorectal cancer.
Peng W, Huang W, Ge X, Xue L, Zhao W, Xue J
EBioMedicine 2019 Jun;44:375-386
EBioMedicine 2019 Jun;44:375-386
UHRF1 promotes aerobic glycolysis and proliferation via suppression of SIRT4 in pancreatic cancer.
Hu Q, Qin Y, Ji S, Xu W, Liu W, Sun Q, Zhang Z, Liu M, Ni Q, Yu X, Xu X
Cancer letters 2019 Jun 28;452:226-236
Cancer letters 2019 Jun 28;452:226-236
Blockade of glycolysis-dependent contraction by oroxylin a via inhibition of lactate dehydrogenase-a in hepatic stellate cells.
Wang F, Jia Y, Li M, Wang L, Shao J, Guo Q, Tan S, Ding H, Chen A, Zhang F, Zheng S
Cell communication and signaling : CCS 2019 Feb 11;17(1):11
Cell communication and signaling : CCS 2019 Feb 11;17(1):11
Carpesium abrotanoides (L.) Root as a Potential Source of Natural Anticancer Compounds: Targeting Glucose Metabolism and PKM2/HIF-1α Axis of Breast Cancer Cells.
Chai XX, Le YF, Wang JC, Mei CX, Feng JF, Zhao H, Wang C, Lu DZ
Journal of food science 2019 Dec;84(12):3825-3832
Journal of food science 2019 Dec;84(12):3825-3832
Sideroflexin 4 affects Fe-S cluster biogenesis, iron metabolism, mitochondrial respiration and heme biosynthetic enzymes.
Paul BT, Tesfay L, Winkler CR, Torti FM, Torti SV
Scientific reports 2019 Dec 23;9(1):19634
Scientific reports 2019 Dec 23;9(1):19634
The anti-androgenic effects of cypermethrin mediated by non-classical testosterone pathway activation of mitogen-activated protein kinase cascade in mouse Sertoli cells.
Wang Q, Wang HX, Shen JY, Zhang R, Hong JW, Li Z, Chen G, Li MX, Ding Z, Li J, Zhang JP, Zhang MR, Xu LC
Ecotoxicology and environmental safety 2019 Aug 15;177:58-65
Ecotoxicology and environmental safety 2019 Aug 15;177:58-65
Resveratrol Inhibits ROS-Promoted Activation and Glycolysis of Pancreatic Stellate Cells via Suppression of miR-21.
Yan B, Cheng L, Jiang Z, Chen K, Zhou C, Sun L, Cao J, Qian W, Li J, Shan T, Lei J, Ma Q, Ma J
Oxidative medicine and cellular longevity 2018;2018:1346958
Oxidative medicine and cellular longevity 2018;2018:1346958
Cryptotanshinone suppresses cell proliferation and glucose metabolism via STAT3/SIRT3 signaling pathway in ovarian cancer cells.
Yang Y, Cao Y, Chen L, Liu F, Qi Z, Cheng X, Wang Z
Cancer medicine 2018 Sep;7(9):4610-4618
Cancer medicine 2018 Sep;7(9):4610-4618
miR‑199a‑3p/Sp1/LDHA axis controls aerobic glycolysis in testicular tumor cells.
Zhou S, Min Z, Sun K, Qu S, Zhou J, Duan H, Liu H, Liu X, Gong Z, Li D
International journal of molecular medicine 2018 Oct;42(4):2163-2174
International journal of molecular medicine 2018 Oct;42(4):2163-2174
NKILA lncRNA promotes tumor immune evasion by sensitizing T cells to activation-induced cell death.
Huang D, Chen J, Yang L, Ouyang Q, Li J, Lao L, Zhao J, Liu J, Lu Y, Xing Y, Chen F, Su F, Yao H, Liu Q, Su S, Song E
Nature immunology 2018 Oct;19(10):1112-1125
Nature immunology 2018 Oct;19(10):1112-1125
Anti-Cancer Effects of Emodin on HepG2 Cells as Revealed by (1)H NMR Based Metabolic Profiling.
Xing YX, Li MH, Tao L, Ruan LY, Hong W, Chen C, Zhao WL, Xu H, Chen JF, Wang JS
Journal of proteome research 2018 May 4;17(5):1943-1952
Journal of proteome research 2018 May 4;17(5):1943-1952
BRD7 inhibits the Warburg effect and tumor progression through inactivation of HIF1α/LDHA axis in breast cancer.
Niu W, Luo Y, Wang X, Zhou Y, Li H, Wang H, Fu Y, Liu S, Yin S, Li J, Zhao R, Liu Y, Fan S, Li Z, Xiong W, Li X, Li G, Ren C, Tan M, Zhou M
Cell death & disease 2018 May 1;9(5):519
Cell death & disease 2018 May 1;9(5):519
The lncRNA MACC1-AS1 promotes gastric cancer cell metabolic plasticity via AMPK/Lin28 mediated mRNA stability of MACC1.
Zhao Y, Liu Y, Lin L, Huang Q, He W, Zhang S, Dong S, Wen Z, Rao J, Liao W, Shi M
Molecular cancer 2018 Mar 6;17(1):69
Molecular cancer 2018 Mar 6;17(1):69
Transcriptional Regulation of the Warburg Effect in Cancer by SIX1.
Li L, Liang Y, Kang L, Liu Y, Gao S, Chen S, Li Y, You W, Dong Q, Hong T, Yan Z, Jin S, Wang T, Zhao W, Mai H, Huang J, Han X, Ji Q, Song Q, Yang C, Zhao S, Xu X, Ye Q
Cancer cell 2018 Mar 12;33(3):368-385.e7
Cancer cell 2018 Mar 12;33(3):368-385.e7
Klotho negatively regulated aerobic glycolysis in colorectal cancer via ERK/HIF1α axis.
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Cell communication and signaling : CCS 2018 Jun 8;16(1):26
Cell communication and signaling : CCS 2018 Jun 8;16(1):26
Programmed death ligand 1 promotes lymph node metastasis and glucose metabolism in cervical cancer by activating integrin β4/SNAI1/SIRT3 signaling pathway.
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Oncogene 2018 Jul;37(30):4164-4180
Oncogene 2018 Jul;37(30):4164-4180
Detachment from the primary site and suspension in ascites as the initial step in metabolic reprogramming and metastasis to the omentum in ovarian cancer.
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Oncology letters 2018 Jan;15(1):1357-1361
Oncology letters 2018 Jan;15(1):1357-1361
RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis.
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Nature cell biology 2018 Feb;20(2):186-197
Nature cell biology 2018 Feb;20(2):186-197
TCF7L2 positively regulates aerobic glycolysis via the EGLN2/HIF-1α axis and indicates prognosis in pancreatic cancer.
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Cell death & disease 2018 Feb 23;9(3):321
Cell death & disease 2018 Feb 23;9(3):321
Nalmefene attenuates malignant potential in colorectal cancer cell via inhibition of opioid receptor.
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Acta biochimica et biophysica Sinica 2018 Feb 1;50(2):156-163
Acta biochimica et biophysica Sinica 2018 Feb 1;50(2):156-163
PPARγ maintains the metabolic heterogeneity and homeostasis of renal tubules.
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EBioMedicine 2018 Dec;38:178-190
EBioMedicine 2018 Dec;38:178-190
GPx1 is involved in the induction of protective autophagy in pancreatic cancer cells in response to glucose deprivation.
Meng Q, Xu J, Liang C, Liu J, Hua J, Zhang Y, Ni Q, Shi S, Yu X
Cell death & disease 2018 Dec 11;9(12):1187
Cell death & disease 2018 Dec 11;9(12):1187
AAED1 modulates proliferation and glycolysis in gastric cancer.
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Oncology reports 2018 Aug;40(2):1156-1164
Oncology reports 2018 Aug;40(2):1156-1164
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Medicine 2018 Apr;97(14):e0268
Medicine 2018 Apr;97(14):e0268
A new facet of NDRG1 in pancreatic ductal adenocarcinoma: Suppression of glycolytic metabolism.
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International journal of oncology 2017 May;50(5):1792-1800
International journal of oncology 2017 May;50(5):1792-1800
Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission.
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The EMBO journal 2017 May 15;36(10):1330-1347
The EMBO journal 2017 May 15;36(10):1330-1347
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Toxicology 2017 May 1;382:108-116
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Cancer letters 2017 Mar 1;388:303-311
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Biochimica et biophysica acta. Molecular basis of disease 2017 Jun;1863(6):1410-1421
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Acta biochimica et biophysica Sinica 2017 Feb 6;49(2):119-127
Ischemia/Reperfusion-Induced Translocation of PKCβII to Mitochondria as an Important Mediator of a Protective Signaling Mechanism in an Ischemia-Resistant Region of the Hippocampus.
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Neurochemical research 2017 Aug;42(8):2392-2403
miR-30a-5p suppresses breast tumor growth and metastasis through inhibition of LDHA-mediated Warburg effect.
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Cancer letters 2017 Aug 1;400:89-98
Cancer letters 2017 Aug 1;400:89-98
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American journal of cancer research 2016;6(10):2289-2298
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Scientific reports 2016 Mar 9;6:22831
Scientific reports 2016 Mar 9;6:22831
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Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Jun;37(6):8367-74
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Oncotarget 2016 Aug 23;7(34):54838-54851
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Journal of hematology & oncology 2015 Mar 8;8:22
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Oncotarget 2015 Jun 20;6(17):15610-27
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Medical oncology (Northwood, London, England) 2015 Jul;32(7):187
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Cell research 2015 Apr;25(4):429-44
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Nature communications 2014 Oct 10;5:5212
Nature communications 2014 Oct 10;5:5212
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A431 cells were subjected to SDS PAGE followed by western blot with 19987-1-AP(LDHA-Specific antibody) at dilution of 1:2000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells using 19987-1-AP( LDHA-Specific Antibody) at dilution of 1:100 and Rhodamine-Goat anti-Rabbit IgG
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human heart using 19987-1-AP(LDHA-Specific antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human heart using 19987-1-AP(LDHA-Specific antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The LDHA-Specific antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human LDHA-Specific. This antibody recognizes human, mouse, rat antigen. The LDHA-Specific antibody has been validated for the following applications: ELISA, WB, IHC, IF, FC analysis.
