21799-1-AP

antibody from Proteintech Group

Targeting: LDHA

Provider product page for 21799-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [45]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [2]

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Product number: 21799-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#21799-1-AP, RRID:AB_10858925
Product name: LDHA antibody
Antibody type: Polyclonal
Description: LDHA antibody (Cat. #21799-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

LDHA protein structure - 21799-1-AP shown in red.

Submitted references Serine/Arginine-Rich Splicing Factor 7 Knockdown Inhibits Aerobic Glycolysis and Growth in HepG2 Cells by Regulating PKM2 Expression.

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Time of exercise differentially impacts bone growth in mice.

Yu S, Tang Q, Lu X, Chen G, Xie M, Yang J, Yin Y, Zheng W, Wang J, Han Y, Zhang L, Chen L
Nature metabolism 2024 Jun;6(6):1036-1052

CENPL accelerates cell proliferation, cell cycle, apoptosis, and glycolysis via the MEK1/2-ERK1/2 pathway in hepatocellular carcinoma.

He K, Xie M, Hong W, Li Y, Yin Y, Gao X, He Y, Chen Y, You C, Li J
The international journal of biochemistry & cell biology 2024 Jan;166:106481

Candida albicans Infection Disrupts the Metabolism of Vaginal Epithelial Cells and Inhibits Cellular Glycolysis.

Zhao Y, Wang P, Sun X, Zhao M, Chen Y, Gao X
Microorganisms 2024 Jan 30;12(2)

Formaldehyde aggravates airway inflammation through induction of glycolysis in an experimental model of asthma exacerbated by lipopolysaccharide.

Xuan L, Ren L, Zhang W, Du P, Li B, An Z
The Science of the total environment 2024 Feb 20;912:168947

Data-Independent Acquisition Proteomics and N-Terminomics Methods Reveal Alterations in Mitochondrial Function and Metabolism in Ischemic-Reperfused Hearts.

Hartley B, Bassiouni W, Roczkowsky A, Fahlman R, Schulz R, Julien O
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E. Coli LPS-induced calcium signaling regulates the expression of hypoxia-inducible factor 1α in periodontal ligament fibroblasts in a non-hypoxia-dependent manner.

Yang X, Cai X, Lin J, Zheng Y, Liao Z, Lin W, He X, Zhang Y, Ren X, Liu C
International immunopharmacology 2024 Feb 15;128:111418

Tripartite-motif 3 represses ovarian cancer progression by downregulating lactate dehydrogenase A and inhibiting AKT signaling.

Cong Y, Cui X, Shi Y, Pan X, Huang K, Geng Z, Xu P, Ge L, Zhu J, Xu J, Jia X
Molecular and cellular biochemistry 2024 Dec;479(12):3405-3424

CD137 Signaling Mediates Pulmonary Artery Endothelial Cell Proliferation Under Hypoxia By Regulating Mitochondrial Dynamics.

Xia H, Duan J, Li M, Chen N, Zhong W, Zhou Y, Chen R, Yuan W
Journal of cardiovascular translational research 2024 Aug;17(4):859-869

Multi-omics and chemical profiling approaches to understand the material foundation and pharmacological mechanism of sophorae tonkinensis radix et rhizome-induced liver injury in mice.

Rao SW, Liu CJ, Liang D, Duan YY, Chen ZH, Li JJ, Pang HQ, Zhang FX, Shi W
Journal of ethnopharmacology 2024 Aug 10;330:118224

Cytoplasmic localization of SETDB1‑induced Warburg effect via c‑MYC‑LDHA axis enhances migration and invasion in breast carcinoma.

Yang W, Wei Y, Wang T, Xu Y, Jin X, Qian H, Yang S, He S
International journal of molecular medicine 2024 Apr;53(4)

Porcine reproductive and respiratory syndrome virus-mediated lactate facilitates virus replication by targeting MAVS.

Zhang L, Liu X, Mao J, Sun Y, Gao Y, Bai J, Jiang P
Veterinary microbiology 2023 Sep;284:109846

Aldolase B-driven lactagenesis and CEACAM6 activation promote cell renewal and chemoresistance in colorectal cancer through the Warburg effect.

Chu YD, Cheng LC, Lim SN, Lai MW, Yeh CT, Lin WR
Cell death & disease 2023 Oct 10;14(10):660

USP51 facilitates colorectal cancer stemness and chemoresistance by forming a positive feed-forward loop with HIF1A.

Mu M, Zhang Q, Li J, Zhao C, Li X, Chen Z, Sun X, Yu J
Cell death and differentiation 2023 Nov;30(11):2393-2407

Lactate activates the mitochondrial electron transport chain independently of its metabolism.

Cai X, Ng CP, Jones O, Fung TS, Ryu KW, Li D, Thompson CB
Molecular cell 2023 Nov 2;83(21):3904-3920.e7

The PRMT6/PARP1/CRL4B Complex Regulates the Circadian Clock and Promotes Breast Tumorigenesis.

Yang T, Huang W, Ma T, Yin X, Zhang J, Huo M, Hu T, Gao T, Liu W, Zhang D, Yu H, Teng X, Zhang M, Qin H, Yang Y, Yuan B, Wang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 May;10(14):e2202737

A tissue injury sensing and repair pathway distinct from host pathogen defense.

Liu S, Hur YH, Cai X, Cong Q, Yang Y, Xu C, Bilate AM, Gonzales KAU, Parigi SM, Cowley CJ, Hurwitz B, Luo JD, Tseng T, Gur-Cohen S, Sribour M, Omelchenko T, Levorse J, Pasolli HA, Thompson CB, Mucida D, Fuchs E
Cell 2023 May 11;186(10):2127-2143.e22

The function of lactate dehydrogenase A in retinal neurons: implications to retinal degenerative diseases.

Rajala A, Bhat MA, Teel K, Gopinadhan Nair GK, Purcell L, Rajala RVS
PNAS nexus 2023 Mar;2(3):pgad038

LPLUNC1 reduces glycolysis in nasopharyngeal carcinoma cells through the PHB1-p53/c-Myc axis.

Oyang L, Ouyang L, Yang L, Lin J, Xia L, Tan S, Wu N, Han Y, Yang Y, Li J, Chen X, Tang Y, Su M, Luo X, Li J, Xiong W, Zeng Z, Liao Q, Zhou Y
Cancer science 2023 Mar;114(3):870-884

LDHA is a prognostic biomarker on the immune response in pancreatic adenocarcinoma and associated with m6A modification.

Tan Z, Liu J, Xu J, Zhang B, Yu X, Wang W, Liang C
Journal of cancer research and clinical oncology 2023 Jul;149(8):4853-4865

Lactate metabolism is essential in early-onset mitochondrial myopathy.

Chen Z, Bordieanu B, Kesavan R, Lesner NP, Venigalla SSK, Shelton SD, DeBerardinis RJ, Mishra P
Science advances 2023 Jan 4;9(1):eadd3216

IDH2 stabilizes HIF-1α-induced metabolic reprogramming and promotes chemoresistance in urothelial cancer.

Shigeta K, Hasegawa M, Hishiki T, Naito Y, Baba Y, Mikami S, Matsumoto K, Mizuno R, Miyajima A, Kikuchi E, Saya H, Kosaka T, Oya M
The EMBO journal 2023 Feb 15;42(4):e110620

Apelin-13 Attenuates Lipopolysaccharide-Induced Inflammatory Responses and Acute Lung Injury by Regulating PFKFB3-Driven Glycolysis Induced by NOX4-Dependent ROS.

Yuan Y, Wang W, Zhang Y, Hong Q, Huang W, Li L, Xie Z, Chen Y, Li X, Meng Y
Journal of inflammation research 2022;15:2121-2139

CD147 Mediates 5-Fluorouracil Resistance in Colorectal Cancer by Reprogramming Glycolipid Metabolism.

Dong S, Li S, Wang X, Liang S, Zhang W, Li L, Xu Q, Shi B, Cheng Z, Zhang X, Zhong M, Zhang G, Hu S
Frontiers in oncology 2022;12:813852

Effect of propiconazole on neutrophil extracellular traps formation: Assessing the role of autophagy.

Ma Y, Li S, Ye S, Hu D, Luo S, Wei L, Xiao F
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Oct;168:113354

The Mixture of Ferulic Acid and P-Coumaric Acid Suppresses Colorectal Cancer through lncRNA 495810/PKM2 Mediated Aerobic Glycolysis.

Cui K, Wu H, Fan J, Zhang L, Li H, Guo H, Yang R, Li Z
International journal of molecular sciences 2022 Oct 11;23(20)

Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis.

Jiang B, Zhang J, Zhao G, Liu M, Hu J, Lin F, Wang J, Zhao W, Ma H, Zhang C, Wu C, Yao L, Liu Q, Chen X, Cao Y, Zheng Y, Zhang C, Han A, Lin D, Li Q
Molecular cell 2022 May 19;82(10):1821-1835.e6

RETRACTED: PINK1 deficiency in gastric cancer compromises mitophagy, promotes the Warburg effect, and facilitates M2 polarization of macrophages.

Xu Y, Lu J, Tang Y, Xie W, Zhang H, Wang B, Zhang S, Hou W, Zou C, Jiang P, Zhang W
Cancer letters 2022 Mar 31;529:19-36

Loss of miR-31-5p drives hematopoietic stem cell malignant transformation and restoration eliminates leukemia stem cells in mice.

Zhu B, Zhong W, Cao X, Pan G, Xu M, Zheng J, Chen H, Feng X, Luo C, Lu C, Xiao J, Lin W, Lai C, Li M, Du X, Yi Q, Yan D
Science translational medicine 2022 Jan 26;14(629):eabh2548

The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis.

Zhu Y, Jin L, Shi R, Li J, Wang Y, Zhang L, Liang CZ, Narayana VK, De Souza DP, Thorne RF, Zhang LR, Zhang XD, Wu M
Molecular cell 2022 Feb 3;82(3):542-554.e6

XIST sponges miR-320d to promote chordoma progression by regulating ARF6.

Wang Y, Tang Z, Guo W
Journal of bone oncology 2022 Aug;35:100447

HIF-1α mediates renal fibrosis by regulating metabolic remodeling of renal tubule epithelial cells.

Liu D, Sun H, Li K, Zhao Z, Liu Z, Zhang G, Ge Y, Zhang J, Wang D, Leng Y
Biochemical and biophysical research communications 2022 Aug 27;618:15-23

Identification of Glycolysis-Related lncRNAs and the Novel lncRNA WAC-AS1 Promotes Glycolysis and Tumor Progression in Hepatocellular Carcinoma.

Xia X, Zhang H, Xia P, Zhu Y, Liu J, Xu K, Yuan Y
Frontiers in oncology 2021;11:733595

MiR-489-3p Reduced Pancreatic Cancer Proliferation and Metastasis By Targeting PKM2 and LDHA Involving Glycolysis.

Zhang D, He Z, Shen Y, Wang J, Liu T, Jiang J
Frontiers in oncology 2021;11:651535

MiR-223-3p targets FOXO3a to inhibit radiosensitivity in prostate cancer by activating glycolysis.

Zhou K, Wei Y, Li X, Yang X
Life sciences 2021 Oct 1;282:119798

Collagen prolyl 4-hydroxylase 2 predicts worse prognosis and promotes glycolysis in cervical cancer.

Li Q, Wang Q, Zhang Q, Zhang J, Zhang J
American journal of translational research 2019;11(11):6938-6951

MicroRNA-31-5p enhances the Warburg effect via targeting FIH.

Zhu B, Cao X, Zhang W, Pan G, Yi Q, Zhong W, Yan D
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jan;33(1):545-556

Protective effects of Weipixiao decoction against MNNG-induced gastric precancerous lesions in rats.

Cai T, Zhang C, Zeng X, Zhao Z, Yan Y, Yu X, Wu L, Lin L, Pan H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Dec;120:109427

Energy Metabolism in the Bone is Associated with Histomorphometric Changes in Rats with Hyperthyroidism.

Hu Z, Du M, Lai W, Liang Y, Liu Q, Mo Y, Bei J, Li S, Yang Y, Xu J, Cui L
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;46(4):1471-1482

Yes-associated protein (YAP) binds to HIF-1α and sustains HIF-1α protein stability to promote hepatocellular carcinoma cell glycolysis under hypoxic stress.

Zhang X, Li Y, Ma Y, Yang L, Wang T, Meng X, Zong Z, Sun X, Hua X, Li H
Journal of experimental & clinical cancer research : CR 2018 Sep 4;37(1):216

CUE domain-containing protein 2 promotes the Warburg effect and tumorigenesis.

Zhong X, Tian S, Zhang X, Diao X, Dong F, Yang J, Li Z, Sun L, Wang L, He X, Wu G, Hu X, Wang L, Song L, Zhang H, Pan X, Li A, Gao P
EMBO reports 2017 May;18(5):809-825

Menin enhances c-Myc-mediated transcription to promote cancer progression.

Wu G, Yuan M, Shen S, Ma X, Fang J, Zhu L, Sun L, Liu Z, He X, Huang D, Li T, Li C, Wu J, Hu X, Li Z, Song L, Qu K, Zhang H, Gao P
Nature communications 2017 May 5;8:15278

Hypoxia-induced regulation of placental REDD1 and mTOR was impaired in a rat model of estrogen-induced cholestasis.

Zhou F, Chen H, Wang X, Yu P, Hu Y
Archives of gynecology and obstetrics 2016 Nov;294(6):1219-1226

HBXIP and LSD1 Scaffolded by lncRNA Hotair Mediate Transcriptional Activation by c-Myc.

Li Y, Wang Z, Shi H, Li H, Li L, Fang R, Cai X, Liu B, Zhang X, Ye L
Cancer research 2016 Jan 15;76(2):293-304

Expression of hypoxia-regulated genes and glycometabolic genes in placenta from patients with intrahepatic cholestasis of pregnancy.

Wei W, Hu YY
Placenta 2014 Sep;35(9):732-6

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 21799-1-AP(LDHA antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using LDHA antibody 21799-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human skeletal muscle using 21799-1-AP(LDHA antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human skeletal muscle using 21799-1-AP(LDHA antibody) at dilution of 1:50 (under 40x lens)
Sample type: tissue