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Western blot
ImmunocytochemistryAntibody data
- Antibody Data
- Antigen structure
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- Validations
- Western blot [1]
- ELISA [1]
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- Product number
- RA0324 - Provider product page
- Provider
- Oursmab
- Product name
- Ligelizumab (Biosimilar Reference Antibody) (IGHE)
- Antibody type
- Monoclonal
- Description
- Ligelizumab (also known as QGE031) is an investigational, humanized monoclonal antibody that targets immunoglobulin E (IgE) with higher affinity than the clinically established antibody omalizumab. It binds to the C¦Å3 domain of IgE, the same region that interacts with the high-affinity IgE receptor (Fc¦ÅRI) on mast cells and basophils. By doing so, ligelizumab prevents IgE from binding to Fc¦ÅRI, thereby inhibiting the allergen-induced cross-linking and activation of these cells that leads to the release of histamine and other inflammatory mediators. It is being developed for the treatment of moderate-to-severe allergic asthma, chronic spontaneous urticaria (CSU), and other IgE-mediated allergic conditions.
- Reactivity
- Human
- Isotype
- IgG
- Vial size
- 100 ¦Ìg,1 mg,5 mg-500,10 mg,25 mg,50 mg,484 mg
- Concentration
- Bottled at the concentration indicated on the vial.
- Storage
- Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.
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Supportive validation
- Submitted by
- Oursmab (provider)
- Main image
- Experimental details
- Ligelizumab (Biosimilar Reference Antibody) (IGHE)-RA0324-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
Supportive validation
- Submitted by
- Oursmab (provider)
- Main image
- Experimental details
- ELISA plate pre-coated Antigen protein, can bind Ligelizumab (Biosimilar Reference Antibody) (IGHE)-RA0324 in a linear range of 15.63¨C125 ng/mL.
