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- Antigen structure
- References [20]
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- Western blot [1]
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- Immunoprecipitation [1]
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- Product number
- 14388-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14388-1-AP, RRID:AB_2084484
- Product name
- Casein Kinase 1 Delta antibody
- Antibody type
- Polyclonal
- Description
- Casein Kinase 1 Delta antibody (Cat. #14388-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Elevated Bile Acids Induce Circadian Rhythm Sleep Disorders in Chronic Liver Diseases.
CK1δ-Dependent SNAPIN Dysregulation Drives Lysosomal Failure in HIV-1 Vpr-Exposed Neurons: A Targetable Mechanism in HAND.
Unveiling the role of melatonin-related gene CSNK1D in osteoclastogenesis and its implications for osteoporosis treatment.
Increased granulovacuolar degeneration in the thalamus and higher neurofibrillary tangle Braak stages in bipolar disorder.
Phosphorylation of Shiftless by casein kinase 1 δ/ε is required for its antiviral activity.
A highly selective and orally bioavailable casein kinase 1 alpha degrader through p53 signaling pathway targets B-cell lymphoma cells.
CDK2 heterobifunctional degraders co-degrade CDK2 and cyclin E resulting in efficacy in CCNE1-amplified and overexpressed cancers.
Pharmacological targeting of casein kinase 1δ suppresses oncogenic NRAS-driven melanoma.
CK1δ/ε kinases regulate TDP-43 phosphorylation and are therapeutic targets for ALS-related TDP-43 hyperphosphorylation.
The COPII coat protein SEC24D is required for autophagosome closure in mammals.
Casein Kinase 1δ Phosphorylates TDP-43 and Suppresses Its Function in Tau mRNA Processing.
Casein Kinase 2 Mediates HIV- and Opioid-Induced Pathologic Phosphorylation of TAR DNA Binding Protein 43 in the Basal Ganglia.
CHMP2B regulates TDP-43 phosphorylation and cytotoxicity independent of autophagy via CK1.
β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma.
SPOP-mediated ubiquitination and degradation of PDK1 suppresses AKT kinase activity and oncogenic functions.
Casein Kinase 1 Family Member CK1δ/Hrr25 Is Required for Autophagosome Completion.
Mitotic ER Exit Site Disassembly and Reassembly Are Regulated by the Phosphorylation Status of TANGO1.
Casein Kinase 1δ/ε Inhibitor, PF670462 Attenuates the Fibrogenic Effects of Transforming Growth Factor-β in Pulmonary Fibrosis.
Casein kinase 1 (α, δ and ε) localize at the spindle poles, but may not be essential for mammalian oocyte meiotic progression.
DNA damage regulates UHRF1 stability via the SCF(β-TrCP) E3 ligase.
Zhou L, Yan M, Luo Q, Qiu W, Guo YR, Guo XQ, Yu HB, Huo JR, Feng YL, Wang DP, Sun T, Wang KF, Shi JY, Shang X, Wu MN, Wang L, Cao JM
Cellular and molecular gastroenterology and hepatology 2025;19(3):101439
Cellular and molecular gastroenterology and hepatology 2025;19(3):101439
CK1δ-Dependent SNAPIN Dysregulation Drives Lysosomal Failure in HIV-1 Vpr-Exposed Neurons: A Targetable Mechanism in HAND.
Sawaya BE, Santerre M
bioRxiv : the preprint server for biology 2025 Jul 16;
bioRxiv : the preprint server for biology 2025 Jul 16;
Unveiling the role of melatonin-related gene CSNK1D in osteoclastogenesis and its implications for osteoporosis treatment.
Zhang J, Wu S, Xing F, Kong N, Zhao Y, Duan X, Li Y, Wang K, Tian R, Yang P
Experimental physiology 2025 Feb;110(2):261-276
Experimental physiology 2025 Feb;110(2):261-276
Increased granulovacuolar degeneration in the thalamus and higher neurofibrillary tangle Braak stages in bipolar disorder.
Nagakura A, Kawakami I, Kimura A, Ikeda K, Oshima K, Kubota-Sakashita M, Kato T
Psychiatry and clinical neurosciences 2025 Dec;79(12):801-807
Psychiatry and clinical neurosciences 2025 Dec;79(12):801-807
Phosphorylation of Shiftless by casein kinase 1 δ/ε is required for its antiviral activity.
Wang Y, Fu S, Wang X, Gao G
Journal of virology 2025 Dec 23;99(12):e0186425
Journal of virology 2025 Dec 23;99(12):e0186425
A highly selective and orally bioavailable casein kinase 1 alpha degrader through p53 signaling pathway targets B-cell lymphoma cells.
Feng S, Kong R, Wang C, Hao Q, Xie X, Wang H, Han J, Zhang Y, Elsner J, Mendy D, Haughey M, Krenitsky P, Plantevin-Krenitsky V, Papa P, Mercurio F, Xie W, Zhou X
Leukemia 2025 Aug;39(8):1972-1986
Leukemia 2025 Aug;39(8):1972-1986
CDK2 heterobifunctional degraders co-degrade CDK2 and cyclin E resulting in efficacy in CCNE1-amplified and overexpressed cancers.
Kwiatkowski N, Liang T, Sha Z, Collier PN, Yang A, Sathappa M, Paul A, Su L, Zheng X, Aversa R, Li K, Mehovic R, Kolodzy C, Breitkopf SB, Chen D, Howarth CL, Yuan K, Jo H, Growney JD, Weiss M, Williams J
Cell chemical biology 2025 Apr 17;32(4):556-569.e24
Cell chemical biology 2025 Apr 17;32(4):556-569.e24
Pharmacological targeting of casein kinase 1δ suppresses oncogenic NRAS-driven melanoma.
Wen Y, Wang H, Yang X, Zhu Y, Li M, Ma X, Huang L, Wan R, Zhang C, Li S, Jia H, Guo Q, Lu X, Li Z, Shen X, Zhang Q, Si L, Yin C, Liu T
Nature communications 2024 Nov 21;15(1):10088
Nature communications 2024 Nov 21;15(1):10088
CK1δ/ε kinases regulate TDP-43 phosphorylation and are therapeutic targets for ALS-related TDP-43 hyperphosphorylation.
Ko VI, Ong K, Cleveland DW, Yu H, Ravits JM
Neurobiology of disease 2024 Jun 15;196:106516
Neurobiology of disease 2024 Jun 15;196:106516
The COPII coat protein SEC24D is required for autophagosome closure in mammals.
He T, Ji C, Zhang W, Li X, Liu Y, Wang X, Zhang H, Wang J
FEBS letters 2024 Dec;598(23):2897-2909
FEBS letters 2024 Dec;598(23):2897-2909
Casein Kinase 1δ Phosphorylates TDP-43 and Suppresses Its Function in Tau mRNA Processing.
Yang M, Qi R, Liu Y, Shen X, Zhao Y, Jin N, Wu R, Liu F, Gu J
Journal of Alzheimer's disease : JAD 2023;91(4):1527-1539
Journal of Alzheimer's disease : JAD 2023;91(4):1527-1539
Casein Kinase 2 Mediates HIV- and Opioid-Induced Pathologic Phosphorylation of TAR DNA Binding Protein 43 in the Basal Ganglia.
Ohene-Nyako M, Nass SR, Richard HT, Lukande R, Nicol MR, McRae M, Knapp PE, Hauser KF
ASN neuro 2023 Jan-Dec;15:17590914231158218
ASN neuro 2023 Jan-Dec;15:17590914231158218
CHMP2B regulates TDP-43 phosphorylation and cytotoxicity independent of autophagy via CK1.
Deng X, Sun X, Yue W, Duan Y, Hu R, Zhang K, Ni J, Cui J, Wang Q, Chen Y, Li A, Fang Y
The Journal of cell biology 2022 Jan 3;221(1)
The Journal of cell biology 2022 Jan 3;221(1)
β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma.
Lu Y, Li X, Liu H, Xue J, Zeng Z, Dong X, Zhang T, Wu G, Yang K, Xu S
Oncogene 2021 Feb;40(7):1269-1283
Oncogene 2021 Feb;40(7):1269-1283
SPOP-mediated ubiquitination and degradation of PDK1 suppresses AKT kinase activity and oncogenic functions.
Jiang Q, Zheng N, Bu L, Zhang X, Zhang X, Wu Y, Su Y, Wang L, Zhang X, Ren S, Dai X, Wu D, Xie W, Wei W, Zhu Y, Guo J
Molecular cancer 2021 Aug 5;20(1):100
Molecular cancer 2021 Aug 5;20(1):100
Casein Kinase 1 Family Member CK1δ/Hrr25 Is Required for Autophagosome Completion.
Li Y, Chen X, Xiong Q, Chen Y, Zhao H, Tahir M, Song J, Zhou B, Wang J
Frontiers in cell and developmental biology 2020;8:460
Frontiers in cell and developmental biology 2020;8:460
Mitotic ER Exit Site Disassembly and Reassembly Are Regulated by the Phosphorylation Status of TANGO1.
Maeda M, Komatsu Y, Saito K
Developmental cell 2020 Oct 26;55(2):237-250.e5
Developmental cell 2020 Oct 26;55(2):237-250.e5
Casein Kinase 1δ/ε Inhibitor, PF670462 Attenuates the Fibrogenic Effects of Transforming Growth Factor-β in Pulmonary Fibrosis.
Keenan CR, Langenbach SY, Jativa F, Harris T, Li M, Chen Q, Xia Y, Gao B, Schuliga MJ, Jaffar J, Prodanovic D, Tu Y, Berhan A, Lee PVS, Westall GP, Stewart AG
Frontiers in pharmacology 2018;9:738
Frontiers in pharmacology 2018;9:738
Casein kinase 1 (α, δ and ε) localize at the spindle poles, but may not be essential for mammalian oocyte meiotic progression.
Qi ST, Wang ZB, Huang L, Liang LF, Xian YX, Ouyang YC, Hou Y, Sun QY, Wang WH
Cell cycle (Georgetown, Tex.) 2015;14(11):1675-85
Cell cycle (Georgetown, Tex.) 2015;14(11):1675-85
DNA damage regulates UHRF1 stability via the SCF(β-TrCP) E3 ligase.
Chen H, Ma H, Inuzuka H, Diao J, Lan F, Shi YG, Wei W, Shi Y
Molecular and cellular biology 2013 Mar;33(6):1139-48
Molecular and cellular biology 2013 Mar;33(6):1139-48
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 14388-1-AP(CSNK1D antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using CSNK1D antibody 14388-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-CSNK1D (IP:14388-1-AP, 3ug; Detection:14388-1-AP 1:1000) with HeLa cells lysate 2000ug.
- Sample type
- cell line
