Antibody data

Product number
Ab104445 - Provider product page
Provider
Aladdin Scientific
Product name
GABARAPL1 Antibody
Antibody type
Polyclonal
Description
Rabbit anti Human GABARAPL1 Antibody, Polyclonal, could be used for WB, IHC, Flow and so on.Application:WB: 1/1000IHC: 1/100-1/500Flow: 1/10-1/50Protein FunctionUbiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.Post-translationalThe precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAPL1-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAPL1-II (By similarity). ATG4B also mediates the delipidation required for GABARAPL1 recycling when autophagosomes fuse with lysosomes. The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine.
Reactivity
Human
Host
Rabbit
Conjugate
Unconjugated
Antigen sequence
AA 1-117
Vial size
100μl,10μl,1ml,50μl
Concentration
0,5 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Store at -20°C long term (24months). Upon delivery aliquot. Avoid freeze/thaw cycle.
GABARAPL1 protein structure - Ab104445 shown in red.