15303-1-AP

antibody from Proteintech Group

Targeting: GBP1

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

15303-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#15303-1-AP, RRID:AB_2247448

Product name

GBP1 antibody

Antibody type

Polyclonal

Description

KD/KO validated GBP1 antibody (Cat. #15303-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB,ELISA.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Identification of MUC1-C as a Target for Suppressing Progression of Head and Neck Squamous Cell Carcinomas.

Nakashoji A, Haratake N, Bhattacharya A, Mao W, Xu K, Wang K, Daimon T, Ozawa H, Shigeta K, Fushimi A, Yamashita N, Morimoto Y, Shimokawa M, Saito S, Egloff AM, Uppaluri R, Long MD, Kufe D
Cancer research communications 2024 May 14;4(5):1268-1281

---

Function and mechanism of GBP1 in the development and progression of cervical cancer.

Wang S, Zhang Y, Ma X, Feng Y
Journal of translational medicine 2024 Jan 2;22(1):11

---

Guanylate-binding protein 1 acts as a pro-viral factor for the life cycle of hepatitis C virus.

Bender D, Koulouri A, Wen X, Glitscher M, Schollmeier A, Fernandes da Costa L, Murra RO, Carra GP, Haberger V, Praefcke GJK, Hildt E
PLoS pathogens 2024 Feb;20(2):e1011976

---

Pyroptosis-Related Signature Predicts the Progression of Ulcerative Colitis and Colitis-Associated Colorectal Cancer as well as the Anti-TNF Therapeutic Response.

Ning Y, Lin K, Fang J, Chen X, Hu X, Liu L, Zhao Q, Wang H, Wang F
Journal of immunology research 2023;2023:7040113

---

Molecular characterization of cancer-intrinsic immune evasion genes indicates prognosis and tumour microenvironment infiltration in osteosarcoma.

Zhao X, Zhang J, Liu J, Luo S, Ding R, Miao X, Wu T, Jia J, Cheng X
Aging 2023 Oct 4;15(19):10272-10290

---

CircSETD3 mediates acquired resistance to gefitinib in non-small lung cancer cells by FXR1/ECT2 pathway.

Wen C, Li Y, Huang Y, Wang N, He S, Bao M, Zhou H, Wu L
The international journal of biochemistry & cell biology 2023 Jan;154:106344

---

Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy.

Li G, Choi JE, Kryczek I, Sun Y, Liao P, Li S, Wei S, Grove S, Vatan L, Nelson R, Schaefer G, Allen SG, Sankar K, Fecher LA, Mendiratta-Lala M, Frankel TL, Qin A, Waninger JJ, Tezel A, Alva A, Lao CD, Ramnath N, Cieslik M, Harms PW, Green MD, Chinnaiyan AM, Zou W
Cancer cell 2023 Feb 13;41(2):304-322.e7

---

In vivo interferon-gamma induced changes in gene expression dramatically alter neutrophil phenotype.

Ambruso DR, Briones NJ, Baroffio AF, Murphy JR, Tran AD, Gowan K, Sanford B, Ellison M, Jones KL
PloS one 2022;17(2):e0263370

---

Knockdown of GBP1 inhibits BCG-induced apoptosis in macrophage RAW 264.7 cells via p38/JNK pathway.

Wang J, Liu Z, Li W, Yu J, Zhang D
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2022 Jan;97:105158

---

Class Ⅰ histone deacetylase inhibitor regulate of Mycobacteria-Driven guanylate-binding protein 1 gene expression.

Wei M, Qin Y, Qian K, Shang S, Zhao Y, Xie T, Xi J, Tang B
Microbial pathogenesis 2022 Aug;169:105655

---

Constitutive TRIM22 Expression in the Respiratory Tract Confers a Pre-Existing Defence Against Influenza A Virus Infection.

Charman M, McFarlane S, Wojtus JK, Sloan E, Dewar R, Leeming G, Al-Saadi M, Hunter L, Carroll MW, Stewart JP, Digard P, Hutchinson E, Boutell C
Frontiers in cellular and infection microbiology 2021;11:689707

---

LIMIT is an immunogenic lncRNA in cancer immunity and immunotherapy.

Li G, Kryczek I, Nam J, Li X, Li S, Li J, Wei S, Grove S, Vatan L, Zhou J, Du W, Lin H, Wang T, Subramanian C, Moon JJ, Cieslik M, Cohen M, Zou W
Nature cell biology 2021 May;23(5):526-537

---

Identification of the interferon-inducible GTPase GBP1 as major restriction factor for the Hepatitis E virus.

Glitscher M, Himmelsbach K, Woytinek K, Schollmeier A, Johne R, Praefcke GJK, Hildt E
Journal of virology 2021 Mar 10;95(7)

---

Mechanistic insight into bacterial entrapment by septin cage reconstitution.

Lobato-Márquez D, Xu J, Güler GÖ, Ojiakor A, Pilhofer M, Mostowy S
Nature communications 2021 Jul 23;12(1):4511

---

Toxoplasma gondii GRA60 is an effector protein that modulates host cell autonomous immunity and contributes to virulence.

Nyonda MA, Hammoudi PM, Ye S, Maire J, Marq JB, Yamamoto M, Soldati-Favre D
Cellular microbiology 2021 Feb;23(2):e13278

---

Cross-talk of pyroptosis and tumor immune landscape in lung adenocarcinoma.

Wang X, Lin W, Liu T, Xu Z, Wang Z, Cao Z, Feng X, Gao Y, He J
Translational lung cancer research 2021 Dec;10(12):4423-4444

---

GBP1 promotes erlotinib resistance via PGK1‑activated EMT signaling in non‑small cell lung cancer.

Cheng L, Gou L, Wei T, Zhang J
International journal of oncology 2020 Sep;57(3):858-870

---

Immune profiling reveals prognostic genes in high-grade serous ovarian cancer.

Wu Y, Xia L, Zhao P, Deng Y, Guo Q, Zhu J, Chen X, Ju X, Wu X
Aging 2020 Jun 16;12(12):11398-11415

---

Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms.

Wandel MP, Kim BH, Park ES, Boyle KB, Nayak K, Lagrange B, Herod A, Henry T, Zilbauer M, Rohde J, MacMicking JD, Randow F
Nature immunology 2020 Aug;21(8):880-891

---

Myxovirus resistance protein A inhibits hepatitis C virus replication through JAK-STAT pathway activation.

Wang H, Xin X, Wang M, Han L, Li J, Hao Y, Zheng C, Shen C
Archives of virology 2018 Jun;163(6):1429-1438

---

GBPs Inhibit Motility of Shigella flexneri but Are Targeted for Degradation by the Bacterial Ubiquitin Ligase IpaH9.8.

Wandel MP, Pathe C, Werner EI, Ellison CJ, Boyle KB, von der Malsburg A, Rohde J, Randow F
Cell host & microbe 2017 Oct 11;22(4):507-518.e5

---

Mcl-1 stabilization confers resistance to taxol in human gastric cancer.

Shuang W, Hou L, Zhu Y, Li Q, Hu W
Oncotarget 2017 Oct 10;8(47):82981-82990

---

Guanine nucleotide-binding protein 1 is one of the key molecules contributing to cancer cell radioresistance.

Fukumoto M, Amanuma T, Kuwahara Y, Shimura T, Suzuki M, Mori S, Kumamoto H, Saito Y, Ohkubo Y, Duan Z, Sano K, Oguchi T, Kainuma K, Usami S, Kinoshita K, Lee I, Fukumoto M
Cancer science 2014 Oct;105(10):1351-9

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

human brain tissue were subjected to SDS PAGE followed by western blot with 15303-1-AP(GBP1 antibody) at dilution of 1:500

Sample type

tissue

Immunocytochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunofluorescent analysis of MCF-7 cells, using GBP1 antibody 15303-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human endometrial cancer using 15303-1-AP(GBP1 antibody) at dilution of 1:50 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human endometrial cancer using 15303-1-AP(GBP1 antibody) at dilution of 1:50 (under 40x lens)

Sample type

tissue