10819-1-AP

antibody from Proteintech Group

Targeting: KPNA2 IPOA1, QIP2, RCH1, SRP1alpha

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

10819-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#10819-1-AP, RRID:AB_2265526

Product name

KPNA2 antibody

Antibody type

Polyclonal

Description

KD/KO validated KPNA2 antibody (Cat. #10819-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

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ZNF143 facilitates the growth and migration of glioma cells by regulating KPNA2-mediated Hippo signalling.

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Scientific reports 2023 Jul 9;13(1):11097

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KPNA2 Silencing, Regulated by E3 Ubiquitin Ligase FBXW7, Alleviates Endothelial Dysfunction and Inflammation Through Inhibiting the Nuclear Translocation of p65 and IRF3: A Possible Therapeutic Approach for Atherosclerosis.

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Mann JR, McKenna ED, Mawrie D, Papakis V, Alessandrini F, Anderson EN, Mayers R, Ball HE, Kaspi E, Lubinski K, Baron DM, Tellez L, Landers JE, Pandey UB, Kiskinis E
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Overexpression of Karyopherin α2 in small cell carcinoma of the cervix correlates with poor prognosis.

Liao LM, Gu ZB, Fang M, Yao GJ, Huang L
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CREB3L1 promotes tumor growth and metastasis of anaplastic thyroid carcinoma by remodeling the tumor microenvironment.

Pan Z, Xu T, Bao L, Hu X, Jin T, Chen J, Chen J, Qian Y, Lu X, Li L, Zheng G, Zhang Y, Zou X, Song F, Zheng C, Jiang L, Wang J, Tan Z, Huang P, Ge M
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lncRNA THAP7-AS1, transcriptionally activated by SP1 and post-transcriptionally stabilized by METTL3-mediated m6A modification, exerts oncogenic properties by improving CUL4B entry into the nucleus.

Liu HT, Zou YX, Zhu WJ, Sen-Liu, Zhang GH, Ma RR, Guo XY, Gao P
Cell death and differentiation 2022 Mar;29(3):627-641

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Nuclear accumulation of KPNA2 impacts radioresistance through positive regulation of the PLSCR1-STAT1 loop in lung adenocarcinoma.

Liao WC, Lin TJ, Liu YC, Wei YS, Chen GY, Feng HP, Chang YF, Chang HT, Wang CL, Chi HC, Wang CI, Lin KH, Ou Yang WT, Yu CJ
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BBOX1-AS1 Accelerates Nasopharyngeal Carcinoma Progression by Sponging miR-3940-3p and Enhancing KPNA2 Upregulation.

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Neddylation of PTEN regulates its nuclear import and promotes tumor development.

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Centromere Protein A (CENPA) Regulates Metabolic Reprogramming in the Colon Cancer Cells by Transcriptionally Activating Karyopherin Subunit Alpha 2 (KPNA2).

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USP1 inhibition destabilizes KPNA2 and suppresses breast cancer metastasis.

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mTORC1 alters the expression of glycolytic genes by regulating KPNA2 abundances.

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Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

HepG2 cells were subjected to SDS PAGE followed by western blot with 10819-1-AP(KPNA2 antibody) at dilution of 1:1000

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human colon cancer using 10819-1-AP(KPNA2 antibody) at dilution of 1:100 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The KPNA2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human KPNA2. This antibody recognizes human,mouse,rat antigen. The KPNA2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.

Appendix

10819-1-AP.pdf

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