Antibody data
- Antibody Data
- Antigen structure
- References [18]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 10819-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10819-1-AP, RRID:AB_2265526
- Product name
- KPNA2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated KPNA2 antibody (Cat. #10819-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references lncRNA THAP7-AS1, transcriptionally activated by SP1 and post-transcriptionally stabilized by METTL3-mediated m6A modification, exerts oncogenic properties by improving CUL4B entry into the nucleus.
Neddylation of PTEN regulates its nuclear import and promotes tumor development.
Centromere Protein A (CENPA) Regulates Metabolic Reprogramming in the Colon Cancer Cells by Transcriptionally Activating Karyopherin Subunit Alpha 2 (KPNA2).
African Swine Fever Virus MGF360-12L Inhibits Type I Interferon Production by Blocking the Interaction of Importin α and NF-κB Signaling Pathway.
Development and validation of a five-gene model to predict postoperative brain metastasis in operable lung adenocarcinoma.
Karyopherin α 2 promotes proliferation, migration and invasion through activating NF-κB/p65 signaling pathways in melanoma cells.
Nuclear CD44 Mediated by Importin β Participated in Naïve Genes Transcriptional Regulation in C3A-iCSCs.
USP1 inhibition destabilizes KPNA2 and suppresses breast cancer metastasis.
Antiviral Immune Response as a Trigger of FUS Proteinopathy in Amyotrophic Lateral Sclerosis.
Argininosuccinate synthetase 1 contributes to gastric cancer invasion and progression by modulating autophagy.
Association of overexpressed karyopherin alpha 2 with poor survival and its contribution to interleukin-1β-induced matrix metalloproteinase expression in oral cancer.
Karyopherin alpha 2 expression is a novel diagnostic and prognostic factor for colorectal cancer.
Nuclear import of Nkx2-2 is mediated by multiple pathways.
mTORC1 alters the expression of glycolytic genes by regulating KPNA2 abundances.
Quantitative proteomics reveals a novel role of karyopherin alpha 2 in cell migration through the regulation of vimentin-pErk protein complex levels in lung cancer.
Quantitative proteomics reveals regulation of karyopherin subunit alpha-2 (KPNA2) and its potential novel cargo proteins in nonsmall cell lung cancer.
Importin subunit alpha-2 is identified as a potential biomarker for non-small cell lung cancer by integration of the cancer cell secretome and tissue transcriptome.
Importin-α1 as a novel prognostic target for hepatocellular carcinoma.
Liu HT, Zou YX, Zhu WJ, Sen-Liu, Zhang GH, Ma RR, Guo XY, Gao P
Cell death and differentiation 2021 Oct 4;
Cell death and differentiation 2021 Oct 4;
Neddylation of PTEN regulates its nuclear import and promotes tumor development.
Xie P, Peng Z, Chen Y, Li H, Du M, Tan Y, Zhang X, Lu Z, Cui CP, Liu CH, He F, Zhang L
Cell research 2021 Mar;31(3):291-311
Cell research 2021 Mar;31(3):291-311
Centromere Protein A (CENPA) Regulates Metabolic Reprogramming in the Colon Cancer Cells by Transcriptionally Activating Karyopherin Subunit Alpha 2 (KPNA2).
Liang YC, Su Q, Liu YJ, Xiao H, Yin HZ
The American journal of pathology 2021 Dec;191(12):2117-2132
The American journal of pathology 2021 Dec;191(12):2117-2132
African Swine Fever Virus MGF360-12L Inhibits Type I Interferon Production by Blocking the Interaction of Importin α and NF-κB Signaling Pathway.
Zhuo Y, Guo Z, Ba T, Zhang C, He L, Zeng C, Dai H
Virologica Sinica 2021 Apr;36(2):176-186
Virologica Sinica 2021 Apr;36(2):176-186
Development and validation of a five-gene model to predict postoperative brain metastasis in operable lung adenocarcinoma.
Fu F, Zhang Y, Gao Z, Zhao Y, Wen Z, Han H, Li Y, Chen H
International journal of cancer 2020 Jul 15;147(2):584-592
International journal of cancer 2020 Jul 15;147(2):584-592
Karyopherin α 2 promotes proliferation, migration and invasion through activating NF-κB/p65 signaling pathways in melanoma cells.
Yang F, Li S, Cheng Y, Li J, Han X
Life sciences 2020 Jul 1;252:117611
Life sciences 2020 Jul 1;252:117611
Nuclear CD44 Mediated by Importin β Participated in Naïve Genes Transcriptional Regulation in C3A-iCSCs.
Su M, Wang P, Wang X, Zhang M, Wei S, Liu K, Han S, Han X, Deng Y, Shen L
International journal of biological sciences 2019;15(6):1252-1260
International journal of biological sciences 2019;15(6):1252-1260
USP1 inhibition destabilizes KPNA2 and suppresses breast cancer metastasis.
Ma A, Tang M, Zhang L, Wang B, Yang Z, Liu Y, Xu G, Wu L, Jing T, Xu X, Yang S, Liu Y
Oncogene 2019 Mar;38(13):2405-2419
Oncogene 2019 Mar;38(13):2405-2419
Antiviral Immune Response as a Trigger of FUS Proteinopathy in Amyotrophic Lateral Sclerosis.
Shelkovnikova TA, An H, Skelt L, Tregoning JS, Humphreys IR, Buchman VL
Cell reports 2019 Dec 24;29(13):4496-4508.e4
Cell reports 2019 Dec 24;29(13):4496-4508.e4
Argininosuccinate synthetase 1 contributes to gastric cancer invasion and progression by modulating autophagy.
Tsai CY, Chi HC, Chi LM, Yang HY, Tsai MM, Lee KF, Huang HW, Chou LF, Cheng AJ, Yang CW, Wang CS, Lin KH
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 May;32(5):2601-2614
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 May;32(5):2601-2614
Association of overexpressed karyopherin alpha 2 with poor survival and its contribution to interleukin-1β-induced matrix metalloproteinase expression in oral cancer.
Wang CI, Yu CJ, Huang Y, Yi JS, Cheng HW, Kao HK, Lao WW, Chang KP
Head & neck 2018 Aug;40(8):1719-1733
Head & neck 2018 Aug;40(8):1719-1733
Karyopherin alpha 2 expression is a novel diagnostic and prognostic factor for colorectal cancer.
Yu L, Wang G, Zhang Q, Gao L, Huang R, Chen Y, Tang Q, Liu J, Liu C, Wang H, Wang X
Oncology letters 2017 Mar;13(3):1194-1200
Oncology letters 2017 Mar;13(3):1194-1200
Nuclear import of Nkx2-2 is mediated by multiple pathways.
Lin W, Xu P, Guo Y, Jia Q, Tao T
Biochemical and biophysical research communications 2017 Jan 22;482(4):1511-1516
Biochemical and biophysical research communications 2017 Jan 22;482(4):1511-1516
mTORC1 alters the expression of glycolytic genes by regulating KPNA2 abundances.
Chen X, Zhu Y, Wang Z, Zhu H, Pan Q, Su S, Dong Y, Li L, Zhang H, Wu L, Lou X, Liu S
Journal of proteomics 2016 Mar 16;136:13-24
Journal of proteomics 2016 Mar 16;136:13-24
Quantitative proteomics reveals a novel role of karyopherin alpha 2 in cell migration through the regulation of vimentin-pErk protein complex levels in lung cancer.
Wang CI, Wang CL, Wu YC, Feng HP, Liu PJ, Chang YS, Yu JS, Yu CJ
Journal of proteome research 2015 Apr 3;14(4):1739-51
Journal of proteome research 2015 Apr 3;14(4):1739-51
Quantitative proteomics reveals regulation of karyopherin subunit alpha-2 (KPNA2) and its potential novel cargo proteins in nonsmall cell lung cancer.
Wang CI, Chien KY, Wang CL, Liu HP, Cheng CC, Chang YS, Yu JS, Yu CJ
Molecular & cellular proteomics : MCP 2012 Nov;11(11):1105-22
Molecular & cellular proteomics : MCP 2012 Nov;11(11):1105-22
Importin subunit alpha-2 is identified as a potential biomarker for non-small cell lung cancer by integration of the cancer cell secretome and tissue transcriptome.
Wang CI, Wang CL, Wang CW, Chen CD, Wu CC, Liang Y, Tsai YH, Chang YS, Yu JS, Yu CJ
International journal of cancer 2011 May 15;128(10):2364-72
International journal of cancer 2011 May 15;128(10):2364-72
Importin-α1 as a novel prognostic target for hepatocellular carcinoma.
Yoshitake K, Tanaka S, Mogushi K, Aihara A, Murakata A, Matsumura S, Mitsunori Y, Yasen M, Ban D, Noguchi N, Irie T, Kudo A, Nakamura N, Tanaka H, Arii S
Annals of surgical oncology 2011 Jul;18(7):2093-103
Annals of surgical oncology 2011 Jul;18(7):2093-103
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 10819-1-AP(KPNA2 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 10819-1-AP(KPNA2 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The KPNA2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human KPNA2. This antibody recognizes human,mouse,rat antigen. The KPNA2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.