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- Product number
- CABT-BL7275 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Anti-CD47 Monoclonal antibody, clone njbq402
- Antibody type
- Monoclonal
- Description
- CD47 (integrin-associated protein, IAP) is an ubiquitously expressed cell surface transmembrane glycoprotein interacting with several integrins and regulating their functions. Engagement of CD47 by soluble ligands or counter receptors modulates various signaling pathways, such as activation of heterotrimeric G proteins. Binding secreted thrombospondin-1, CD47 counteracts graft vascularization. CD47 acts also as a ligand for CD172a (signal regulatory protein alpha, SIRP alpha), an immune inhibitory receptor on macrophages
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