Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS5749 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- GPR38 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids 367-412 of Human GPR38.
- Description
- Motilin is a widely conserved 22 amino acid peptide hormone secreted from enterochromaffin cells of the gastrointestinal tract. Within the intestines, motilin potentiates intestinal motility by inducing contractions of the duodenum and through binding to surface receptors, designated GPR38 (G-protein coupled receptor 38). These motilin receptors are predominantly expressed in stomach, thyroid and bone marrow, and they are related to other G-protein coupled receptors located in the pituitary and hypothalamus, which mediate the signaling for growth hormone secretagogues. The gene encoding GPR38 is alternately spliced at the carboxy terminus to generate two related proteins that are designated GPR38-A and GPR38-B. Sequence comparisons of the two isoforms indicate that GPR38-A contains seven transmembrane domains while GPR38-B is predicted to contains only five transmembrane regions. Consistent with other G-protein coupled receptors, GPR38 activates phospholipase C signal transduction pathways and induces intracellular calcium mobilization after binding of motilin.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of GPR38 pAb at 1:500 dilutionLane1:HEK293T cell lysateLane2:sp2/0 cell lysateLane3:NIH-3T3 cell lysate