20578-1-AP

antibody from Proteintech Group

Targeting: APOB

Provider product page for 20578-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [36]
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Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 20578-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#20578-1-AP, RRID:AB_10732938
Product name: APOB antibody
Antibody type: Polyclonal
Description: APOB antibody (Cat. #20578-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

APOB protein structure - 20578-1-AP shown in red.

Submitted references HNF4A-Bridging the Gap Between Intestinal Metaplasia and Gastric Cancer.

Zhao Y, Tang H, Xu J, Sun F, Zhao Y, Li Y
Evolutionary bioinformatics online 2024;20:11769343241249017

Traditional Chinese Medicine formula Dai-Zong-Fang alleviating hepatic steatosis in db/db mice via gut microbiota modulation.

Zhang LW, Zhu LL, Zhu XY, Fu SQ, Liu XM
Frontiers in pharmacology 2024;15:1337057

Comparison of proteomic landscape of extracellular vesicles in pleural effusions isolated by three strategies.

Yao X, Liao B, Chen F, Liu L, Wu K, Hao Y, Li Y, Wang Y, Fan R, Yin J, Liu L, Guo Y
Frontiers in bioengineering and biotechnology 2023;11:1108952

Mechanical injury accentuates lipid deposition in ApoE(-/-) mice and advance aortic valve stenosis: A novel modified aortic valve stenosis model.

Wen D, Hu L, Shan J, Zhang H, Hu L, Yuan A, Pu J, Xue S
Frontiers in cardiovascular medicine 2023;10:1119746

Metabolic characteristics of voriconazole - Induced liver injury in rats.

Du Q, Teng M, Yang L, Meng C, Qiu Y, Wang C, Chen J, Wang T, Chen S, Luo Y, Sun J, Dong Y
Chemico-biological interactions 2023 Sep 25;383:110693

Long-term and liver-selected ginsenoside C-K nanoparticles retard NAFLD progression by restoring lipid homeostasis.

Yue C, Li D, Fan S, Tao F, Yu Y, Lu W, Chen Q, Yuan A, Wu J, Zhao G, Dong H, Hu Y
Biomaterials 2023 Oct;301:122291

Discovery of lipid profiles in plasma-derived extracellular vesicles as biomarkers for breast cancer diagnosis.

Liu L, Kawashima M, Sugimoto M, Sonomura K, Pu F, Li W, Takeda M, Goto T, Kawaguchi K, Sato TA, Toi M
Cancer science 2023 Oct;114(10):4020-4031

Inflammatory Cell-Derived MYDGF Attenuates Endothelial LDL Transcytosis to Protect Against Atherogenesis.

Xu J, Ma H, Shi L, Zhou H, Cheng Y, Tong J, Meng B, Xu X, He K, Ding S, Zhang J, Yue L, Xiang G
Arteriosclerosis, thrombosis, and vascular biology 2023 Nov;43(11):e443-e467

Manganese regulation of COPII condensation controls circulating lipid homeostasis.

Wang X, Huang R, Wang Y, Zhou W, Hu Y, Yao Y, Cheng K, Li X, Xu B, Zhang J, Xu Y, Zeng F, Zhu Y, Chen XW
Nature cell biology 2023 Nov;25(11):1650-1663

CM3-SII polysaccharide obtained from Cordyceps militaris ameliorates hyperlipidemia in heterozygous LDLR-deficient hamsters by modulating gut microbiota and NPC1L1 and PPARα levels.

Yu WQ, Wang XL, Ji HH, Miao M, Zhang BH, Li H, Zhang ZY, Ji CF, Guo SD
International journal of biological macromolecules 2023 Jun 1;239:124293

Si-Ni-San reverses dietary fat absorption defects in a murine model of depression.

Liu Y, Lv B, Tang K, Qu H, Yu F, Shi Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115677

Fenofibrate enhances lipid deposition via modulating PPARγ, SREBP-1c, and gut microbiota in ob/ob mice fed a high-fat diet.

Zhang Y, Jia XB, Liu YC, Yu WQ, Si YH, Guo SD
Frontiers in nutrition 2022;9:971581

Characteristics of Exosomes and the Vascular Landscape Regulate Exosome Sequestration by Peripheral Tissues and Brain.

Banks WA, Sharma P, Hansen KM, Ludwig N, Whiteside TL
International journal of molecular sciences 2022 Oct 19;23(20)

Liver RBFOX2 regulates cholesterol homeostasis via Scarb1 alternative splicing in mice.

Paterson HAB, Yu S, Artigas N, Prado MA, Haberman N, Wang YF, Jobbins AM, Pahita E, Mokochinski J, Hall Z, Guerin M, Paulo JA, Ng SS, Villarroya F, Rashid ST, Le Goff W, Lenhard B, Cebola I, Finley D, Gygi SP, Sibley CR, Vernia S
Nature metabolism 2022 Dec;4(12):1812-1829

The Cordyceps militaris-Derived Polysaccharide CM1 Alleviates Atherosclerosis in LDLR((-/-)) Mice by Improving Hyperlipidemia.

Yin F, Lin P, Yu WQ, Shen N, Li Y, Guo SD
Frontiers in molecular biosciences 2021;8:783807

Deficiency of intestinal Bmal1 prevents obesity induced by high-fat feeding.

Yu F, Wang Z, Zhang T, Chen X, Xu H, Wang F, Guo L, Chen M, Liu K, Wu B
Nature communications 2021 Sep 7;12(1):5323

MMP-12 siRNA improves the homeostasis of the small intestine and metabolic dysfunction in high-fat diet feeding-induced obese mice.

Song M, Zhang S, Tao Z, Li J, Shi Y, Xiong Y, Zhang W, Liu C, Chen S
Biomaterials 2021 Nov;278:121183

Quantitative proteomics of plasma and liver reveals the mechanism of turmeric in preventing hyperlipidemia in mice.

Wang M, Wang R, Li L, Yan Y, Jia S, Jiang H, Du Z
Food & function 2021 Nov 1;12(21):10484-10499

The miR-378c-Samd1 circuit promotes phenotypic modulation of vascular smooth muscle cells and foam cells formation in atherosclerosis lesions.

Tian S, Cao Y, Wang J, Bi Y, Zhong J, Meng X, Sun W, Yang R, Gan L, Wang X, Li H, Wang R
Scientific reports 2021 May 18;11(1):10548

Enterically derived high-density lipoprotein restrains liver injury through the portal vein.

Han YH, Onufer EJ, Huang LH, Sprung RW, Davidson WS, Czepielewski RS, Wohltmann M, Sorci-Thomas MG, Warner BW, Randolph GJ
Science (New York, N.Y.) 2021 Jul 23;373(6553)

Celastrol inhibits intestinal lipid absorption by reprofiling the gut microbiota to attenuate high-fat diet-induced obesity.

Hua H, Zhang Y, Zhao F, Chen K, Wu T, Liu Q, Huang S, Zhang A, Jia Z
iScience 2021 Feb 19;24(2):102077

Polysaccharide CM1 from Cordyceps militaris hinders adipocyte differentiation and alleviates hyperlipidemia in LDLR((+/-)) hamsters.

Yu WQ, Yin F, Shen N, Lin P, Xia B, Li YJ, Guo SD
Lipids in health and disease 2021 Dec 13;20(1):178

GP73 is a TBC-domain Rab GTPase-activating protein contributing to the pathogenesis of non-alcoholic fatty liver disease without obesity.

Peng Y, Zeng Q, Wan L, Ma E, Li H, Yang X, Zhang Y, Huang L, Lin H, Feng J, Xu Y, Li J, Liu M, Liu J, Lin C, Sun Z, Cheng G, Zhang X, Liu J, Li D, Wei M, Mo Y, Mu X, Deng X, Zhang D, Dong S, Huang H, Fang Y, Gao Q, Yang X, Wu F, Zhong H, Wei C
Nature communications 2021 Dec 1;12(1):7004

TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis.

Huang D, Xu B, Liu L, Wu L, Zhu Y, Ghanbarpour A, Wang Y, Chen FJ, Lyu J, Hu Y, Kang Y, Zhou W, Wang X, Ding W, Li X, Jiang Z, Chen J, Zhang X, Zhou H, Li JZ, Guo C, Zheng W, Zhang X, Li P, Melia T, Reinisch K, Chen XW
Cell metabolism 2021 Aug 3;33(8):1655-1670.e8

MD2 blockade prevents modified LDL-induced retinal injury in diabetes by suppressing NADPH oxidase-4 interaction with Toll-like receptor-4.

Chen H, Yan T, Song Z, Ying S, Wu B, Ju X, Yang X, Qu J, Wu W, Zhang Z, Wang Y
Experimental & molecular medicine 2021 Apr;53(4):681-694

Extracellular vesicle-mediated delivery of miR-101 inhibits lung metastasis in osteosarcoma.

Zhang K, Dong C, Chen M, Yang T, Wang X, Gao Y, Wang L, Wen Y, Chen G, Wang X, Yu X, Zhang Y, Wang P, Shang M, Han K, Zhou Y
Theranostics 2020;10(1):411-425

Comprehensive lipidomics in apoM(-/-) mice reveals an overall state of metabolic distress and attenuated hepatic lipid secretion into the circulation.

Shi Y, Lam SM, Liu H, Luo G, Zhang J, Yao S, Li J, Zheng L, Xu N, Zhang X, Shui G
Journal of genetics and genomics = Yi chuan xue bao 2020 Sep 20;47(9):523-534

Effect and mechanism of ginsenoside Rg1-regulating hepatic steatosis in HepG2 cells induced by free fatty acid.

Gao Y, Zhang S, Li J, Zhao J, Xiao Q, Zhu Y, Zhang J, Huang W
Bioscience, biotechnology, and biochemistry 2020 Nov;84(11):2228-2240

Macrophage-derived myeloid differentiation protein 2 plays an essential role in ox-LDL-induced inflammation and atherosclerosis.

Chen T, Huang W, Qian J, Luo W, Shan P, Cai Y, Lin K, Wu G, Liang G
EBioMedicine 2020 Mar;53:102706

Small sequence variations between two mammalian paralogs of the small GTPase SAR1 underlie functional differences in coat protein complex II assembly.

Melville DB, Studer S, Schekman R
The Journal of biological chemistry 2020 Jun 19;295(25):8401-8412

Hepatic HuR modulates lipid homeostasis in response to high-fat diet.

Zhang Z, Zong C, Jiang M, Hu H, Cheng X, Ni J, Yi X, Jiang B, Tian F, Chang MW, Su W, Zhu L, Li J, Xiang X, Miao C, Gorospe M, de Cabo R, Dou Y, Ju Z, Yang J, Jiang C, Yang Z, Wang W
Nature communications 2020 Jun 16;11(1):3067

Downregulation of GNAI3 Promotes the Pathogenesis of Methionine/Choline-Deficient Diet-Induced Nonalcoholic Fatty Liver Disease.

Zhu H, Ge K, Lu J, Jia C
Gut and liver 2020 Jul 15;14(4):492-499

Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine.

Wang Y, Song W, Wang J, Wang T, Xiong X, Qi Z, Fu W, Yang X, Chen YG
The Journal of experimental medicine 2020 Feb 3;217(2)

Hepatic loss of Lissencephaly 1 (Lis1) induces fatty liver and accelerates liver tumorigenesis in mice.

Li X, Liu L, Li R, Wu A, Lu J, Wu Q, Jia J, Zhao M, Song H
The Journal of biological chemistry 2018 Apr 6;293(14):5160-5171

AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity.

Luo H, Jiang M, Lian G, Liu Q, Shi M, Li TY, Song L, Ye J, He Y, Yao L, Zhang C, Lin ZZ, Zhang CS, Zhao TJ, Jia WP, Li P, Lin SY, Lin SC
Cell metabolism 2018 Apr 3;27(4):843-853.e6

Rab8a Deficiency in Skeletal Muscle Causes Hyperlipidemia and Hepatosteatosis by Impairing Muscle Lipid Uptake and Storage.

Chen Q, Rong P, Xu D, Zhu S, Chen L, Xie B, Du Q, Quan C, Sheng Y, Zhao TJ, Li P, Wang HY, Chen S
Diabetes 2017 Sep;66(9):2387-2399

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HepG2 cells were subjected to SDS PAGE followed by western blot with 20578-1-AP(APOB antibody) at dilution of 1:300
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The APOB antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human APOB. This antibody recognizes human, mouse antigen. The APOB antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 20578-1-AP.pdf

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