NLRP10

Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq, Jul 2008]

Description

NLR family pyrin domain containing 10

Tissue specificity

Group enriched (breast, skin)

Subcell location

Nucleoplasm, Nuclear membrane

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins

Chromosome

11 (7957537 - 7965426)

Ensembl ID

ENSG00000182261  (ver. 103.38)

Orthologs

Mouse Nlrp10: ENSMUSG00000049709

UniProt

Q86W26

neXtProt

NX_Q86W26

Human splice variants
Mouse splice variants

Protein structure