67228-1-Ig

antibody from Proteintech Group

Targeting: ABCC1 GS-X, MRP, MRP1

Provider product page for 67228-1-Ig

Western blot

ELISA

Antibody data

Antibody Data
Antigen structure
References [25]
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Product number: 67228-1-Ig - Provider product page
Provider: Proteintech Group
Product name: MRP1,ABCC1 antibody
Antibody type: Monoclonal
Description: MRP1,ABCC1 antibody (Cat. #67228-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human and has been validated for the following applications: WB, ELISA.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 1G4A2
Vial size: 20ul, 150ul

ABCC1 protein structure - 67228-1-Ig shown in red.

Submitted references Chrysin sensitizes glioblastoma cells and spheroids to temozolomide treatment by reducing EMT and stemness phenotypes, as well as targeting multidrug resistance proteins.

Aksüt Y, Şengelen A, Gürsoy DM, Öğütcü İ, Kuvet Ö, Pekmez M
Frontiers in pharmacology 2025;16:1643186

GDF15 promotes the resistance of epithelial ovarian cancer cells to gemcitabine via DHCR24-mediated cholesterol metabolism to elevate ABCB1 and ABCC1 levels in lipid rafts.

Guo L, He Y, Xin H
American journal of cancer research 2025;15(2):452-469

C1GALT1 expression predicts poor survival in osteosarcoma and is crucial for ABCC1 transporter-mediated doxorubicin resistance.

Liu CW, Huang JH, Chang HH, Chen CH, Tsai YH, Chen WL, Lin JA, Chang HL, Chen CC, Lin MC, Huang MC, Lin NY
The Journal of pathology 2025 Mar;265(3):289-301

Blocking XIAP:CASP7-p19 selectively induces apoptosis of CASP3/DR malignancies by a novel reversible small molecule.

Chen SH, Wu SY, Chang YX, Lui EN, Chang CK, Lin SW, Hsiao M, Yang JM, Liang PH
Cell death & disease 2025 Jun 18;16(1):459

Layered Double Hydroxide LDH-Loaded miR-141-3p Targets RAB10 Suppressing Cellular Autophagy to Reverse Paclitaxel Resistance in Breast Cancer.

Tao S, Ji Y, Li R, Xiao Y, Wu H, Ye R, Shi J, Geng C, Tang G, Ran R, Zhu C, Wang W, Chen C, Yang Q
ACS omega 2025 Feb 18;10(6):5886-5899

Pharmacokinetic and Pharmacodynamic Evaluation of PZ-2891, an Anti-Alzheimer's Disease Agonist of PANK2.

Chen Y, Ma H, Jin M, Zhang S, Qu S, Wang G, Aa J
Pharmaceuticals (Basel, Switzerland) 2025 Dec 9;18(12)

Mechanisms of resistance to trastuzumab deruxtecan in breast cancer elucidated by multi-omic molecular profiling.

Sledge GW, Xiu J, Mahtani RL, Sandoval Leon AC, Meric-Bernstam F, Ribeiro JR, Kulkarni NN, Rampa DR, Lee J, Ueno NT, Oberley MJ, Radovich M, Spetzler DB
NPJ breast cancer 2025 Dec 20;12(1):1

[Layered double hydroxide-loaded si-NEAT1 regulates paclitaxel resistance and tumor-associated macrophage polarization in breast cancer by targeting miR-133b/PD-L1].

Zhang Z, Wu Q, Xie M, Ye R, Geng C, Shi J, Yang Q, Wang W, Shi Y
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2025 Aug 20;45(8):1718-1731

SiRNF8 Delivered by DNA Framework Nucleic Acid Effectively Sensitizes Chemotherapy in Colon Cancer.

Guo Z, Song H, Tian Y, Xu J, Zhang G, Guo Y, Shen R, Wang D
International journal of nanomedicine 2024;19:171-188

Pan-cancer analysis of ABCC1 as a potential prognostic and immunological biomarker.

Wang T, Rao D, Fu C, Luo Y, Lu J, Liang H, Xia L, Huang W
Translational oncology 2024 Mar;41:101882

Overcoming flumatinib resistance in chronic myeloid leukaemia: Insights into cellular mechanisms and ivermectin's therapeutic potential.

Huang J, Xiao J, He L, Dai W, Xiao J, Li Y, He Y, Yu L
Journal of cellular and molecular medicine 2024 Jul;28(14):e18539

Exploring bat-inspired cyclic tryptophan diketopiperazines as ABCB1 Inhibitors.

Koh JYP, Itahana Y, Krah A, Mostafa H, Ong M, Iwamura S, Vincent DM, Radha Krishnan S, Ye W, Yim PWC, Khopade TM, Chen K, Kong PS, Wang LF, Bates RW, Kimura Y, Viswanathan R, Bond PJ, Itahana K
Communications chemistry 2024 Jul 13;7(1):158

Identification of Fasudil as a collaborator to promote the anti-tumor effect of lenvatinib in hepatocellular carcinoma by inhibiting GLI2-mediated hedgehog signaling pathway.

Huang Y, Wang S, Zhang X, Yang C, Wang S, Cheng H, Ke A, Gao C, Guo K
Pharmacological research 2024 Feb;200:107082

Aryl Hydrocarbon Receptor Alleviates Hepatic Fibrosis by Inducing Hepatic Stellate Cell Ferroptosis.

Liu S
Journal of cellular and molecular medicine 2024 Dec;28(23):e70278

HIF1α/VEGF Feedback Loop Contributes to 5-Fluorouracil Resistance.

Shi B, Xu FF, Xiang CP, Li CY, Fan P, Wang H
Frontiers in pharmacology 2022;13:851401

Clinical Significance and Potential Mechanisms of ATP Binding Cassette Subfamily C Genes in Hepatocellular Carcinoma.

Zhou X, Huang JM, Li TM, Liu JQ, Wei ZL, Lan CL, Zhu GZ, Liao XW, Ye XP, Peng T
Frontiers in genetics 2022;13:805961

Prrx1 promotes resistance to temozolomide by upregulating ABCC1 and inducing vasculogenic mimicry in glioma.

Chen Z, Zhang Y, Chen Y, Lin W, Zhang Y, Cai G, Sun X, Zheng K, He J, Ai T, Wang J, Zhao L, Ke Y
American journal of cancer research 2022;12(8):3892-3912

NCAPG2 Maintains Cancer Stemness and Promotes Erlotinib Resistance in Lung Adenocarcinoma.

Jiang S, Huang J, He H, Liu Y, Liang L, Sun X, Li Y, Cong L, Qing B, Jiang Y
Cancers 2022 Sep 9;14(18)

S-20, a steroidal saponin from the berries of black nightshade, exerts anti-multidrug resistance activity in K562/ADR cells through autophagic cell death and ERK activation.

Wang Y, Xu J, Wang Y, Xiang L, He X
Food & function 2022 Feb 21;13(4):2200-2215

Biotransformation of graphene oxide within lung fluids could intensify its synergistic biotoxicity effect with cadmium by inhibiting cellular efflux of cadmium.

Zhu J, Liu L, Ma J, Fu Q, Zheng Z, Du E, Xu Y, Zhang Z
Environmental pollution (Barking, Essex : 1987) 2022 Aug 1;306:119421

Apatinib Suppresses Gastric Cancer Stem Cells Properties by Inhibiting the Sonic Hedgehog Pathway.

Cao W, Li Y, Sun H, Yang C, Zhu J, Xie C, Li X, Wu J, Geng S, Wang L, Sun L, Geng G, Han H, Zhong C
Frontiers in cell and developmental biology 2021;9:679806

The nicotinamide phosphoribosyltransferase antagonist FK866 inhibits growth of prostate tumour spheroids and increases doxorubicin retention without changes in drug transporter and cancer stem cell protein expression.

Sauer H, Kampmann H, Khosravi F, Sharifpanah F, Wartenberg M
Clinical and experimental pharmacology & physiology 2021 Mar;48(3):422-434

Cancer-associated fibroblasts-mediated ATF4 expression promotes malignancy and gemcitabine resistance in pancreatic cancer via the TGF-β1/SMAD2/3 pathway and ABCC1 transactivation.

Wei L, Lin Q, Lu Y, Li G, Huang L, Fu Z, Chen R, Zhou Q
Cell death & disease 2021 Mar 29;12(4):334

Overexpression of close homolog of L1 enhances the chemosensitivity of lung cancer cells via inhibition of the Akt pathway.

Cai X, Hu B, Liu S, Liu M, Huang Y, Lei P, Zhang Z, He Z, Zhang L, Huang R
Oncology letters 2020 Oct;20(4):111

Targeting G6PD reverses paclitaxel resistance in ovarian cancer by suppressing GSTP1.

Feng Q, Li X, Sun W, Sun M, Li Z, Sheng H, Xie F, Zhang S, Shan C
Biochemical pharmacology 2020 Aug;178:114092

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