60112.1

antibody from STEMCELL Technologies Inc

Targeting: CD19

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Antibody Data

Product number

60112.1

Provider

STEMCELL Technologies Inc

Product name

Anti-Mouse CD19 Antibody, Clone 1D3

Antibody type

Monoclonal

Description

The 1D3 antibody reacts with mouse CD19, an ~95 kDa type 1 transmembrane glycoprotein expressed on the surface of B cells throughout all stages of development, from early pre-B cells to plasma cells. Expression is down-regulated but persists in terminally differentiated plasma cells. CD19 is also found on follicular dendritic cells. By associating with CD21 and CD81, CD19 functions as a co-receptor for the B cell receptor and is involved in B cell activation and differentiation. Activation of CD19 is accompanied by phosphorylation of the cytoplasmic domain, which promotes binding to kinases and the induction of intracellular signaling cascades. Mutations in CD19 can result in severe immunodeficiency syndromes. Clone 1D3 recognizes the same epitope as clone 6D5 in cross-competition assays.

Reactivity

Mouse

Host

Mouse

Isotype

IgG

Vial size

100 µg

Storage

2 - 8°C