AGTO-G035E

antibody from Creative Biolabs
Targeting: GPC3 DGSX, OCI-5, SDYS, SGB, SGBS, SGBS1
Provider product page for AGTO-G035E
No application information provided.

Antibody data

Product number
AGTO-G035E - Provider product page
Provider
Creative Biolabs
Product name
Anti-Gpc3 immunotoxin (scFv)-PE
Antibody type
Monoclonal
Description
This immunotoxin was achieved by conjugating/fusing the Anti-Gpc3 scFv to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating liver cancer.
Reactivity
Mouse
Host
Mouse
GPC3 protein structure - AGTO-G035E shown in red.