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- Antibody Data
- Antigen structure
- References [10]
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- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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- Product number
- 11631-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11631-1-AP, RRID:AB_2301692
- Product name
- Septin 5 antibody
- Antibody type
- Polyclonal
- Description
- Septin 5 antibody (Cat. #11631-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references SEPT5 overexpression predicts poor prognosis and promotes progression through feedback regulation of HIF-1α in clear cell renal cell carcinoma.
Septin5 deletion enhances β-cell exocytosis by releasing microtubule-tethered insulin granules onto plasma membrane.
Pharmacological inhibition of Septins with Forchlorfenuron attenuates thrombus formation in experimental thrombotic mice models with modulating multiple signaling pathways in platelets.
Forchlorfenuron-Induced Mitochondrial Respiration Inhibition and Metabolic Shifts in Endometrial Cancer.
Integrated proteomics and metabolomics analysis of D-pinitol function during hippocampal damage in streptozocin-induced aging-accelerated mice.
S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5.
Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aβ.
Synergistic Neuroprotective Effect of Endogenously-Produced Hydroxytyrosol and Synaptic Vesicle Proteins on Pheochromocytoma Cell Line Against Salsolinol.
Characterization of septin expression in normal and fibrotic kidneys.
Cyclin-dependent kinase 5 phosphorylation of human septin SEPT5 (hCDCrel-1) modulates exocytosis.
Liu W, Ni Y, Wang W, Cui K, Duan Q, Bai Z, Shahzad A, Liu X, Dong Y, Xu Z, Zhang J, Peng D, Teng Z, Gao Y, Yang Z, Zhang Q
Cellular signalling 2025 Mar;127:111591
Cellular signalling 2025 Mar;127:111591
Septin5 deletion enhances β-cell exocytosis by releasing microtubule-tethered insulin granules onto plasma membrane.
Xie L, Kang F, Qin T, Kang Y, Liang T, Xie H, Froese CD, Xie H, Au A, Yip CM, Trimble WS, Gaisano HY
Nature communications 2025 Mar 19;16(1):2725
Nature communications 2025 Mar 19;16(1):2725
Pharmacological inhibition of Septins with Forchlorfenuron attenuates thrombus formation in experimental thrombotic mice models with modulating multiple signaling pathways in platelets.
Hao Z, Yan M, Tuerhong R, Zhang L, Zhang Z, Alam H, Wu J, Qin Y, Zhao F, Shi L
Journal of advanced research 2025 Jul;73:517-533
Journal of advanced research 2025 Jul;73:517-533
Forchlorfenuron-Induced Mitochondrial Respiration Inhibition and Metabolic Shifts in Endometrial Cancer.
Kim K, Khazan N, Rowswell-Turner RB, Singh RK, Moore T, Strawderman MS, Miller JP, Snyder CWA, Awada A, Moore RG
Cancers 2024 Feb 28;16(5)
Cancers 2024 Feb 28;16(5)
Integrated proteomics and metabolomics analysis of D-pinitol function during hippocampal damage in streptozocin-induced aging-accelerated mice.
Li X, Gao Y, Li B, Zhao W, Cai Q, Yin W, Zeng S, Li X, Gao H, Cheng M
Frontiers in molecular neuroscience 2023;16:1251513
Frontiers in molecular neuroscience 2023;16:1251513
S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5.
Ferreira CB, Marttinen M, Coelho JE, Paldanius KMA, Takalo M, Mäkinen P, Leppänen L, Miranda-Lourenço C, Fonseca-Gomes J, Tanqueiro SR, Vaz SH, Belo RF, Sebastião AM, Leinonen V, Soininen H, Pike I, Haapasalo A, Lopes LV, de Mendonça A, Diógenes MJ, Hiltunen M
Neurobiology of disease 2022 Feb;163:105603
Neurobiology of disease 2022 Feb;163:105603
Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aβ.
Marttinen M, Ferreira CB, Paldanius KMA, Takalo M, Natunen T, Mäkinen P, Leppänen L, Leinonen V, Tanigaki K, Kang G, Hiroi N, Soininen H, Rilla K, Haapasalo A, Hiltunen M
Cells 2020 Nov 15;9(11)
Cells 2020 Nov 15;9(11)
Synergistic Neuroprotective Effect of Endogenously-Produced Hydroxytyrosol and Synaptic Vesicle Proteins on Pheochromocytoma Cell Line Against Salsolinol.
Manzoor R, Rasool A, Ahmed M, Kaleem U, Duru LN, Ma H, Deng Y
Molecules (Basel, Switzerland) 2020 Apr 8;25(7)
Molecules (Basel, Switzerland) 2020 Apr 8;25(7)
Characterization of septin expression in normal and fibrotic kidneys.
Neubauer K, Neubauer B, Seidl M, Zieger B
Cytoskeleton (Hoboken, N.J.) 2019 Jan;76(1):143-153
Cytoskeleton (Hoboken, N.J.) 2019 Jan;76(1):143-153
Cyclin-dependent kinase 5 phosphorylation of human septin SEPT5 (hCDCrel-1) modulates exocytosis.
Amin ND, Zheng YL, Kesavapany S, Kanungo J, Guszczynski T, Sihag RK, Rudrabhatla P, Albers W, Grant P, Pant HC
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Apr 2;28(14):3631-43
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Apr 2;28(14):3631-43
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 11631-1-AP(SEPT5 antibody) at dilution of 1:800
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-SEPT5 (IP:11631-1-AP, 3ug; Detection:11631-1-AP 1:300) with mouse brain tissue lysate 1000ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SEPT5 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SEPT5. This antibody recognizes human,mouse,rat antigen. The SEPT5 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
