EME1

This gene encodes a protein that complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein to form an endonuclease complex. The encoded protein interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. This protein may be involved in repairing DNA damage and in maintaining genomic stability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Description

essential meiotic structure-specific endonuclease 1

Protein family

Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Peptideatlas)

Chromosome

17:q21.33 (50373220 - 50381483)

Ensembl ID

ENSG00000154920  (ver. 99.38)

Orthologs

Mouse Eme1: ENSMUSG00000039055

UniProt

Q96AY2

neXtProt

NX_Q96AY2

Human splice variants
Mouse splice variants