Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS6570 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- CSF2RA polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human CSF2RA.
- Description
- The human IL-3, IL-5 and GM-CSF receptors are each composed of both unique a subunits and a common ÉÇ subunit. The a subunits are low affinity ligand binding proteins while the ÉÇ subunits do not themselves bind ligand, but are required for high affinity binding by the a subunits. In contrast, the mouse IL-3 receptor has two distinct ÉÇ subunits, one that functions only in IL-3 mediated cell signaling and a second that is shared with IL-5 and GM-CSF. The murine ÉÇ-subunits are 91% homologous at the amino acid level but only 56% homologous to the human ÉÇ subunit. Although neither the murine nor the human ÉÇ subunit contains tyrosine kinase domains, both activate tyrosine phosphorylation mediated signaling pathways.
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- Western blot analysis of extracts of HepG2 cell lines, using CSF2RA antibody.