CABT-BL7406

antibody from Creative Diagnostics

Targeting: CSF2RA alphaGMR, CD116, CSF2R

Flow cytometry (Recommended by provider)

Antibody Data

Product number

CABT-BL7406

Provider

Creative Diagnostics

Product name

Anti-CSF2RA Monoclonal antibody, clone 5I2

Antibody type

Monoclonal

Description

The human IL-3, IL-5 and GM-CSF receptors are each composed of both unique a subunits and a common beta subunit. The a subunits are low affinity ligand binding proteins while the beta subunits do not themselves bind ligand, but are required for high affinity binding by the a subunits. In contrast, the mouse IL-3 receptor has two distinct beta subunits, one that functions only in IL-3 mediated cell signaling and a second that is shared with IL-5 and GM-CSF. The murine beta-subunits are 91% homologous at the amino acid level but only 56% homologous to the human beta subunit. Although neither the murine nor the human beta subunit contains tyrosine kinase domains, both activate tyrosine phosphorylation mediated signaling pathways.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG