Antibody data
- Antibody Data
- Antigen structure
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- Product number
- CABT-B12163 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Human anti-Human CSF2RA recombinant monoclonal antibody, clone SFB322 [FITC]
- Antibody type
- Monoclonal
- Description
- It recognozes CD116, the \u03b1 subunit of GM-CSF receptor, which serves as a receptor for GM-CSF cytokine. GM-CSF is involved in innate and adaptive immune responses to infection, stimuli such as presence of LPS, and inflammatory diseases, such as asthma, rheumatoid arthritis, and multiple sclerosis. The GM-CSF receptor comprises of cytokine-specific \u03b1 subunit, CD116, and \u03b2c subunit, which is a common subunit shared by interleukin-3 (IL-3) and IL-5. The human CD116 is a 378 residue glycoprotein with an extracellular N-terminal Ig-like domain, two fibronectin (FnIII) domains, and a 54 residue intracellular domain. Expression of CD116 is found on myeloid cells including monocytes, macrophages, neutrophils, eosinophils, dendritic cells, fibroblasts, endothelial cells, and myeloid leukemias. Additional information: It displays negligible binding to Fc receptors.
- Reactivity
- Human
- Host
- Human
- Conjugate
- Green dye
- Isotype
- IgG
- Antibody clone number
- SFB322
- Vial size
- for 100 tests
- Storage
- Store protected from light at 2ÿ8 °C. Do not freeze.
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