CABT-B12164

antibody from Creative Diagnostics

Targeting: CSF2RA alphaGMR, CD116, CSF2R

Flow cytometry (Recommended by provider)

Antibody Data

Product number

CABT-B12164

Provider

Creative Diagnostics

Product name

Human anti-Human CSF2RA recombinant monoclonal antibody, clone SFB322 [PE]

Antibody type

Monoclonal

Description

It recognozes CD116, the \u03b1 subunit of GM-CSF receptor, which serves as a receptor for GM-CSF cytokine. GM-CSF is involved in innate and adaptive immune responses to infection, stimuli such as presence of LPS, and inflammatory diseases, such as asthma, rheumatoid arthritis, and multiple sclerosis. The GM-CSF receptor comprises of cytokine-specific \u03b1 subunit, CD116, and \u03b2c subunit, which is a common subunit shared by interleukin-3 (IL-3) and IL-5. The human CD116 is a 378 residue glycoprotein with an extracellular N-terminal Ig-like domain, two fibronectin (FnIII) domains, and a 54 residue intracellular domain. Expression of CD116 is found on myeloid cells including monocytes, macrophages, neutrophils, eosinophils, dendritic cells, fibroblasts, endothelial cells, and myeloid leukemias. Additional information: It displays negligible binding to Fc receptors.

Reactivity

Human

Host

Human

Conjugate

Yellow dye

Isotype

IgG

Antibody clone number

SFB322

Vial size

for 100 tests

Storage

Store protected from light at 2ÿ8 °C. Do not freeze.