66447-1-Ig

antibody from Proteintech Group

Targeting: HLA-G

Provider product page for 66447-1-Ig

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Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [22]
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Product number: 66447-1-Ig - Provider product page
Provider: Proteintech Group
Product name: HLA-G antibody
Antibody type: Monoclonal
Description: HLA-G antibody (Cat. #66447-1-Ig) is a mouse monoclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 1E5A10
Vial size: 20ul, 150ul

HLA-G protein structure - 66447-1-Ig shown in red.

Submitted references Suppression of GATA3 promotes epithelial-mesenchymal transition and simultaneous cellular senescence in human extravillous trophoblasts.

Chen EX, Hu SC, Xu JQ, Liu KY, Tang J, Shen XP, Liang X, Xie YL, Ge LX, Luo X, Wang YX, Xiang YL, Ding YB
Biochimica et biophysica acta. Molecular cell research 2024 Oct;1871(7):119768

IDO-1 impairs antitumor immunity of natural killer cells in triple-negative breast cancer via up-regulation of HLA-G.

Jing R, Bai S, Zhang P, Ren H, Jia L, Li W, Zheng G
Breast cancer (Tokyo, Japan) 2024 Jan;31(1):135-147

DOCK1 insufficiency disrupts trophoblast function and pregnancy outcomes via DUSP4-ERK pathway.

Xu Y, Liu X, Zeng W, Zhu Y, Dong J, Wu F, Chen C, Sharma S, Lin Y
Life science alliance 2024 Feb;7(2)

Single-cell profiling reveals immune disturbances landscape and HLA-F-mediated immune tolerance at the maternal-fetal interface in preeclampsia.

Luo F, Liu F, Guo Y, Xu W, Li Y, Yi J, Fournier T, Degrelle S, Zitouni H, Hernandez I, Liu X, Huang Y, Yue J
Frontiers in immunology 2023;14:1234577

Downregulation of CLDN1 impairs trophoblast invasion and endovascular trophoblast differentiation in early-onset preeclampsia.

Jin P, Zhou Y, Liu Z, Chen X, Qi H
Placenta 2023 Sep 7;140:20-29

The Enzyme 15-Hydroxyprostaglandin Dehydrogenase Inhibits a Shift to the Mesenchymal Pattern of Trophoblasts and Decidual Stromal Cells Accompanied by Prostaglandin Transporter in Preeclampsia.

Pang H, Lei D, Chen T, Liu Y, Fan C
International journal of molecular sciences 2023 Mar 7;24(6)

miR-101-5p suppresses trophoblast cell migration and invasion via modulating the DUSP6-ERK1/2 axis in preeclampsia.

Xu J, Wang J, Chen M, Chao B, He J, Bai Y, Luo X, Liu H, Xie L, Tao Y, Qi H, Luo X
Journal of assisted reproduction and genetics 2023 Jul;40(7):1597-1610

CCL21/CCR7 Axis Contributes to Trophoblastic Cell Migration and Invasion in Preeclampsia by Affecting the Epithelial Mesenchymal Transition via the ERK1/2 Signaling Pathway.

Liu Z, He J, Jin P, Ran Y, Yin N, Qi H
Biology 2023 Jan 18;12(2)

Profilin1 Regulates Trophoblast Invasion and Macrophage Differentiation.

Chen X, Song QL, Wang JY, Ji R, Li ZH, Cao ML, Mu XF, Guo DY, Zhang Y, Yang J
The American journal of pathology 2023 Aug;193(8):1059-1071

Ubiquitin-specific protease 7 prevents recurrent spontaneous abortion by targeting enhancer of zeste homolog 2 to regulate trophoblast proliferation, apoptosis, migration, and invasion through the Wnt/β-catenin pathway†.

Zhou M, Gao Y, Wu S, Chen J, Ding J, Wang Y, Yang J
Biology of reproduction 2023 Aug 10;109(2):204-214

Deletion of ACLY Disrupts Histone Acetylation and IL-10 Secretion in Trophoblasts, Which Inhibits M2 Polarization of Macrophages: A Possible Role in Recurrent Spontaneous Abortion.

Chen X, Song QL, Li ZH, Ji R, Wang JY, Ge C, Xiao ZN, Guo DY, Yang J
Oxidative medicine and cellular longevity 2022;2022:5216786

The diversity of trophoblast cells and niches of placenta accreta spectrum disorders revealed by single-cell RNA sequencing.

Ma J, Liu Y, Guo Z, Sun R, Yang X, Zheng W, Ma Y, Rong Y, Wang H, Yang H, Xiao Z
Frontiers in cell and developmental biology 2022;10:1044198

ANKRD37 inhibits trophoblast migration and invasion by regulating the NF-κB pathway in preeclampsia.

Tan W, Fu H, Zhou X, Duan Y, Yin N, Huang J, Liu X
The journal of gene medicine 2022 May;24(5):e3416

MiR-187 regulates the proliferation, migration and invasion of human trophoblast cells by repressing BCL6-mediated activation of PI3K/AKT signaling.

Chen X, Song QL, Ji R, Wang JY, Li ZH, Guo D, Yin TL, Wang SJ, Yang J
Placenta 2022 Feb;118:20-31

Elabela: Negative Regulation of Ferroptosis in Trophoblasts via the Ferritinophagy Pathway Implicated in the Pathogenesis of Preeclampsia.

Yang H, Zhang X, Ding Y, Xiong H, Xiang S, Wang Y, Li H, Liu Z, He J, Tao Y, Yang H, Qi H
Cells 2022 Dec 26;12(1)

miR21 modulates the Hippo signaling pathway via interference with PP2A Bβ to inhibit trophoblast invasion and cause preeclampsia.

Hu M, Zheng Y, Liao J, Wen L, Cheng J, Huang J, Huang B, Lin L, Long Y, Wu Y, Ye X, Fu Y, Qi H, Baker PN, Tong C
Molecular therapy. Nucleic acids 2022 Dec 13;30:143-161

Advanced Maternal Age-associated SIRT1 Deficiency Compromises Trophoblast Epithelial-Mesenchymal Transition through an Increase in Vimentin Acetylation.

Xiong L, Ye X, Chen Z, Fu H, Li S, Xu P, Yu J, Wen L, Gao R, Fu Y, Qi H, Kilby MD, Saffery R, Baker PN, Tong C
Aging cell 2021 Oct;20(10):e13491

Alpha-actinin-4 is essential for maintaining normal trophoblast proliferation and differentiation during early pregnancy.

Peng W, Liu Y, Qi H, Li Q
Reproductive biology and endocrinology : RB&E 2021 Mar 23;19(1):48

Cyclin G2 upregulation impairs migration, invasion, and network formation through RNF123/Dvl2/JNK signaling in the trophoblast cell line HTR8/SVneo, a possible role in preeclampsia.

Sun M, Gao J, Meng T, Liu S, Chen H, Liu Q, Xing X, Zhao C, Luo Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21169

Iodothyronine deiodinase 2 (DiO(2)) regulates trophoblast cell line cycle, invasion and apoptosis; and its downregulation is associated with early recurrent miscarriage.

Adu-Gyamfi EA, Lamptey J, Chen XM, Li FF, Li C, Ruan LL, Yang XN, Liu TH, Wang YX, Ding YB
Placenta 2021 Aug;111:54-68

Stomatin-like protein 2 (SLP2) regulates the proliferation and invasion of trophoblast cells by modulating mitochondrial functions.

Zhang X, Li BY, Fu LJ, Adu-Gyamfi EA, Xu BR, Liu TH, Chen XM, Lan X, Wang YX, Xu HB, Ding YB
Placenta 2020 Oct;100:13-23

Trophoblastic proliferation and invasion regulated by ACTN4 is impaired in early onset preeclampsia.

Peng W, Tong C, Li L, Huang C, Ran Y, Chen X, Bai Y, Liu Y, Zhao J, Tan B, Luo X, Wang H, Wen L, Zhang C, Zhang H, Ding Y, Qi H, Baker PN
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 May;33(5):6327-6338

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