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- References [12]
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- Validations
- Western blot [1]
- Immunoprecipitation [1]
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- Product number
- 16989-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16989-1-AP, RRID:AB_2286640
- Product name
- SPATA22 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SPATA22 antibody (Cat. #16989-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references RNase H1 facilitates recombinase recruitment by degrading DNA-RNA hybrids during meiosis.
SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early meiotic recombination.
A truncating variant of RAD51B associated with primary ovarian insufficiency provides insights into its meiotic and somatic functions.
Nutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation in vitro.
Proteostasis regulated by testis-specific ribosomal protein RPL39L maintains mouse spermatogenesis.
Meiosis-Specific C19orf57/4930432K21Rik/BRME1 Modulates Localization of RAD51 and DMC1 to DSBs in Mouse Meiotic Recombination.
A cell-based high-content screen identifies isocotoin as a small molecule inhibitor of the meiosis-specific MEIOB-SPATA22 complex†.
A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1.
The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells.
A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination.
MEIOB exhibits single-stranded DNA-binding and exonuclease activities and is essential for meiotic recombination.
Spata22, a novel vertebrate-specific gene, is required for meiotic progress in mouse germ cells.
Liu C, Wang L, Li Y, Guo M, Hu J, Wang T, Li M, Yang Z, Lin R, Xu W, Chen Y, Luo M, Gao F, Chen JY, Sun Q, Liu H, Sun B, Li W
Nucleic acids research 2023 Aug 11;51(14):7357-7375
Nucleic acids research 2023 Aug 11;51(14):7357-7375
SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early meiotic recombination.
Guan Y, Lin H, Leu NA, Ruthel G, Fuchs SY, Busino L, Luo M, Wang PJ
Nucleic acids research 2022 May 20;50(9):5129-5144
Nucleic acids research 2022 May 20;50(9):5129-5144
A truncating variant of RAD51B associated with primary ovarian insufficiency provides insights into its meiotic and somatic functions.
Franca MM, Condezo YB, Elzaiat M, Felipe-Medina N, Sánchez-Sáez F, Muñoz S, Sainz-Urruela R, Martín-Hervás MR, García-Valiente R, Sánchez-Martín MA, Astudillo A, Mendez J, Llano E, Veitia RA, Mendonca BB, Pendás AM
Cell death and differentiation 2022 Dec;29(12):2347-2361
Cell death and differentiation 2022 Dec;29(12):2347-2361
Nutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation in vitro.
Zhang X, Gunewardena S, Wang N
Nature communications 2021 Mar 19;12(1):1758
Nature communications 2021 Mar 19;12(1):1758
Proteostasis regulated by testis-specific ribosomal protein RPL39L maintains mouse spermatogenesis.
Zou Q, Yang L, Shi R, Qi Y, Zhang X, Qi H
iScience 2021 Dec 17;24(12):103396
iScience 2021 Dec 17;24(12):103396
Meiosis-Specific C19orf57/4930432K21Rik/BRME1 Modulates Localization of RAD51 and DMC1 to DSBs in Mouse Meiotic Recombination.
Takemoto K, Tani N, Takada-Horisawa Y, Fujimura S, Tanno N, Yamane M, Okamura K, Sugimoto M, Araki K, Ishiguro KI
Cell reports 2020 May 26;31(8):107686
Cell reports 2020 May 26;31(8):107686
A cell-based high-content screen identifies isocotoin as a small molecule inhibitor of the meiosis-specific MEIOB-SPATA22 complex†.
Xu Y, Liu R, Leu NA, Zhang L, Ibragmova I, Schultz DC, Wang PJ
Biology of reproduction 2020 Aug 4;103(2):333-342
Biology of reproduction 2020 Aug 4;103(2):333-342
A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1.
Felipe-Medina N, Caburet S, Sánchez-Sáez F, Condezo YB, de Rooij DG, Gómez-H L, Garcia-Valiente R, Todeschini AL, Duque P, Sánchez-Martin MA, Shalev SA, Llano E, Veitia RA, Pendás AM
eLife 2020 Aug 26;9
eLife 2020 Aug 26;9
The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells.
Zhang J, Gurusaran M, Fujiwara Y, Zhang K, Echbarthi M, Vorontsov E, Guo R, Pendlebury DF, Alam I, Livera G, Emmanuelle M, Wang PJ, Nandakumar J, Davies OR, Shibuya H
Nature communications 2020 Apr 28;11(1):2055
Nature communications 2020 Apr 28;11(1):2055
A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination.
Zhang J, Fujiwara Y, Yamamoto S, Shibuya H
Nature communications 2019 Feb 13;10(1):722
Nature communications 2019 Feb 13;10(1):722
MEIOB exhibits single-stranded DNA-binding and exonuclease activities and is essential for meiotic recombination.
Luo M, Yang F, Leu NA, Landaiche J, Handel MA, Benavente R, La Salle S, Wang PJ
Nature communications 2013;4:2788
Nature communications 2013;4:2788
Spata22, a novel vertebrate-specific gene, is required for meiotic progress in mouse germ cells.
La Salle S, Palmer K, O'Brien M, Schimenti JC, Eppig J, Handel MA
Biology of reproduction 2012 Feb;86(2):45
Biology of reproduction 2012 Feb;86(2):45
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human testis tissue were subjected to SDS PAGE followed by western blot with 16989-1-AP(SPATA22 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SPATA22 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SPATA22. This antibody recognizes human, mouse antigen. The SPATA22 antibody has been validated for the following applications: ELISA, WB, IP analysis.
