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- Antibody Data
- Antigen structure
- References [9]
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- Validations
- Immunohistochemistry [1]
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- Product number
- HPA001023 - Provider product page
- Provider
- Atlas Antibodies
- Proper citation
- Atlas Antibodies Cat#HPA001023, RRID:AB_1079606
- Product name
- Anti-PHF6
- Antibody type
- Polyclonal
- Description
- Polyclonal Antibody against Human PHF6, Gene description: PHD finger protein 6, Alternative Gene Names: BFLS, BORJ, CENP-31, KIAA1823, MGC14797, Validated applications: ICC, IHC, WB, Uniprot ID: Q8IWS0, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µl
- Concentration
- 0.1 mg/ml
- Storage
- Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Handling
- The antibody solution should be gently mixed before use.
Submitted references PHF6-mediated transcriptional control of NSC via Ephrin receptors is impaired in the intellectual disability syndrome BFLS
Molecular and clinical analyses of PHF6 mutant myeloid neoplasia provide their pathogenesis and therapeutic targeting
R274X-mutated Phf6 increased the self-renewal and skewed T cell differentiation of hematopoietic stem cells
Functional mapping of PHF6 complexes in chromatin remodeling, replication dynamics, and DNA repair
PHF6 and JAK3 mutations cooperate to drive T-cell acute lymphoblastic leukemia progression
Transgenic mice with an R342X mutation in Phf6 display clinical features of Börjeson–Forssman–Lehmann Syndrome
Loss of PHF6 leads to aberrant development of human neuron-like cells
Phf6 Loss Enhances HSC Self-Renewal Driving Tumor Initiation and Leukemia Stem Cell Activity in T-ALL
The Human Protein Atlas—a tool for pathology
Rasool D, Burban A, Sharanek A, Madrigal A, Hu J, Yan K, Qu D, Voss A, Slack R, Thomas T, Bonni A, Picketts D, Soleimani V, Najafabadi H, Jahani-Asl A
EMBO Reports 2024;25(3):1256-1281
EMBO Reports 2024;25(3):1256-1281
Molecular and clinical analyses of PHF6 mutant myeloid neoplasia provide their pathogenesis and therapeutic targeting
Kubota Y, Gu X, Terkawi L, Bodo J, Przychodzen B, Awada H, Williams N, Gurnari C, Kawashima N, Aly M, Durmaz A, Mori M, Ponvilawan B, Kewan T, Bahaj W, Meggendorfer M, Jha B, Visconte V, Rogers H, Haferlach T, Maciejewski J
Nature Communications 2024;15(1)
Nature Communications 2024;15(1)
R274X-mutated Phf6 increased the self-renewal and skewed T cell differentiation of hematopoietic stem cells
Lan Y, Yuan S, Guo T, Hou S, Zhao F, Yang W, Cao Y, Chu Y, Jiang E, Yuan W, Wang X
iScience 2023;26(6):106817
iScience 2023;26(6):106817
Functional mapping of PHF6 complexes in chromatin remodeling, replication dynamics, and DNA repair
Alvarez S, da Silva Almeida A, Albero R, Biswas M, Barreto-Galvez A, Gunning T, Shaikh A, Aparicio T, Wendorff A, Piovan E, Van Vlierberghe P, Gygi S, Gautier J, Madireddy A, A. Ferrando A
Blood 2022;139(23):3418-3429
Blood 2022;139(23):3418-3429
PHF6 and JAK3 mutations cooperate to drive T-cell acute lymphoblastic leukemia progression
Yuan S, Wang X, Hou S, Guo T, Lan Y, Yang S, Zhao F, Gao J, Wang Y, Chu Y, Shi J, Cheng T, Yuan W
Leukemia 2021;36(2):370-382
Leukemia 2021;36(2):370-382
Transgenic mice with an R342X mutation in Phf6 display clinical features of Börjeson–Forssman–Lehmann Syndrome
Ahmed R, Sarwar S, Hu J, Cardin V, Qiu L, Zapata G, Vandeleur L, Yan K, Lerch J, Corbett M, Gecz J, Picketts D
Human Molecular Genetics 2021;30(7):575-594
Human Molecular Genetics 2021;30(7):575-594
Loss of PHF6 leads to aberrant development of human neuron-like cells
Fliedner A, Gregor A, Ferrazzi F, Ekici A, Sticht H, Zweier C
Scientific Reports 2020;10(1)
Scientific Reports 2020;10(1)
Phf6 Loss Enhances HSC Self-Renewal Driving Tumor Initiation and Leukemia Stem Cell Activity in T-ALL
Wendorff A, Quinn S, Rashkovan M, Madubata C, Ambesi-Impiombato A, Litzow M, Tallman M, Paietta E, Paganin M, Basso G, Gastier-Foster J, Loh M, Rabadan R, Van Vlierberghe P, Ferrando A
Cancer Discovery 2019;9(3):436-451
Cancer Discovery 2019;9(3):436-451
The Human Protein Atlas—a tool for pathology
Pontén F, Jirström K, Uhlen M
The Journal of Pathology 2008;216(4):387-393
The Journal of Pathology 2008;216(4):387-393
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Supportive validation
- Submitted by
- Atlas Antibodies (provider)
- Enhanced method
- Orthogonal validation
- Main image
- Experimental details
- Immunohistochemistry analysis in human epididymis and liver tissues using HPA001023 antibody. Corresponding PHF6 RNA-seq data are presented for the same tissues.
- Sample type
- Human
- Protocol
- Protocol
